本文投稿作者 大白菜
Neil K.Garg是美国有机化学家,师承 Larry Overman教授,现为加州大学洛杉矶分校教授。(图片引自:实验室主页)
经历
- 2000 纽约大学 B.S (Marc Walters教授)
- 2005 加州理工学院 Ph.D ( Brian Stoltz教授)
- 2005-2007 加利福尼亚大学尔湾分校 博士后 ( Larry Overman 教授)
- 2007-2012 加州大学洛杉矶分校 助理教授
- 2012-2013 加州大学洛杉矶分校 副教授
- 2013-至今 加州大学洛杉矶分校 教授
获奖经历
- 2017 Royal Society of Chemical’s Higher Education Award
- 2017 Robert Fodter Cherry Award for Great Teaching, Finalist
- 2017 Elias J. Corey Award for Outstanding Original Contribution in Organic Synthesis
- 2016 Royal Society of Chemistry’s Merck Award
- 2016 Guggenheim Fellowship
- 2016 Thieme-IUPAC Prize
- 2015 Gold Shield Faculty Prize
- 2012 S. T. Li Prize for Achievements in Science and Technology
- 2012 ACS Green Chemistry Institute Pharmaceutical Roundtable Grantee Award
研究概要
- 1. Garg教授开发了非常规的亲电子体的过渡金属催化交叉偶联反应,主要包括非贵金属Ni催化活化惰性C-O(苯酚衍生物等),C-N键(酰胺,酯等)发生交叉偶联反应,如:首次发现Ni催化酰胺转化成酮和酯以及芳基磺酸氨的胺化。
- 2. Garg教授开发了张力活性杂环芳炔的中间体的形成(例如吡啶炔,吲哚炔等),以及进一步应用于复杂分子的合成。
- 3,Garg教授开展了以“断开的费舍尔吲哚合成法”为关键步骤的吲哚类生物碱衍生物的全合成研究
- 4. Garg教授早其主要研究一些其他复杂小分子的全合成,例如以下药物和天然产物
参考文献
- Kinetic Modeling of the Nickel-Catalyzed Esterification of Amides.Nicholas A. Weires, Daniel D. Caspi, and Neil K. Garg.ACS Catal.2017,Just Accepted.
- Suzuki–Miyaura Cross-Coupling of Aryl Carbamates and Sulfamates: Experimental and Computational Studies .Kyle W. Quasdorf, Aurora Antoft-Finch, Peng Liu, Amanda L. Silberstein, Anna Komaromi, Tom Blackburn, Stephen D. Ramgren, K. N. Houk, Victor Snieckus, and Neil K. Garg.J. Am. Chem. Soc.2011,133, 6352–6363
- Nickel-Catalysed Suzuki–Miyaura Coupling of Amides. Nicholas A. Weires, Emma L. Baker and Neil K. Garg.Nat. Chem.2016,8, 75–79
- Synthetic Studies Pertaining to the 2,3-Pyridyne and 4,5-Pyrimidyne.Jose M. Medina, Moritz K. Jackl, Robert B. Susick, and Neil K. Garg.Tetrahedron2016,72, 3629–3634
- Indolyne Experimental and Computational Studies: Synthetic Applications and Origins of Selectivities of Nucleophilic Additions.G-Yoon J. Im, Sarah M. Bronner, Adam E. Goetz, Robert S. Paton, Paul H.-Y. Cheong, K. N. Houk, and Neil K. GargJ. Am. Chem. Soc.2010,132, 17933–17944.
- Overturning Indolyne Regioselectivities and Synthesis of Indolactam V.Sarah M. Bronner, Adam E. Goetz, and Neil K. Garg.J. Am. Chem. Soc.2011,133, 3832–3835.
- Enantioselective Total Syntheses of Akuammiline Alkaloids (+)-Strictamine, (–)-2(S)-Cathafoline, and (–)-Aspidophylline A.Jesus Moreno,†Elias Picazo,†Lucas A. Morrill, Joel M. Smith, and Neil K. Garg.J. Am. Chem. Soc.2016,138, 1162–1165.
相关书籍
[amazonjs asin=”0692860541″ locale=”US” title=”The Organic Coloring Book”]
相关视频(youtube)
Challenge your perceptions | Neil Garg | TEDxUCLA (Youtube)
相关链接:
- Garg research group
- Neil Garg Group – Professor Product Portal
- Chemistry Tree – Neil K. Garg Family Tree – Academic Tree
- One Organic Chemist One Day: Neil K. Garg
本文版权属于Chem-Station化学空间, 欢迎点击按钮分享,未经许可,谢绝转载!
No comments yet.