本文投稿作者alberto-caeiro
David A. Evans，美国有机化学家，现为哈佛大学教授。现代有机全合成界泰斗级人物，许多合成化学家出自其门下。（照片：实验室主页）
经历
- 1963 奥伯林大学（Oberlin College）B. S.;
- 1967 加州理工学院（California Institute of Technology）Ph. D.;
- 1967-1972 加州大学洛杉矶分校 助教;
- 1972-1974 加州大学洛杉矶分校 副教授
- 1974 加州大学洛杉矶分校 教授
- 1974-1983 加州理工学院 教授
- 1983-1990 哈佛大学 教授
- 1990-2008 哈佛大学名誉教授（Abbott and James Lawrence Professor of Chemistry）
- 1995-1998 哈佛大学化学系主任
获奖经历
- 1971 Camille and Henry Dreyfus Teacher-Scholar Award
- 1972 Alfred P. Sloan Foundation Fellow
- 1973 Distinguished Teaching Award, UCLA Alumni Association
- 1982 ACS Award for Creative Work in Synthetic Organic Chemistry
- 1983 M.A., Honorary, Harvard University, Cambridge, MA
- 1984 Allen R. Day Award, Philadelphia Organic Chemists Club, Philadelphia, PA
- 1984 Elected to National Academy of Sciences
- 1988 Arthur C. Cope Scholar Award, American Chemical Society
- 1988 American Academy of Arts and Sciences
- 1992 C. S. Hamilton Award, University of Nebraska
- 1992 Mack Award, Ohio State University
- 1992 Fellow, American Association for the Advancement of Science
- 1992 Pfizer Research Award for Synthetic Organic Chemistry, Pfizer, Inc.
- 1996 Remsen Award, Maryland Section, American Chemical Society
- 1997 Yamada Prize, University of Tokyo, Japan
- 1998 Tetrahedron Prize
- 1998 Robert Robinson Award from the Royal Society of Chemistry, UK
- 1999 The Prelog Medal, ETH, Zurich Switzerland
- 2000 Arthur C. Cope Award, American Chemical Society
- 2001 Elected to The Royal Society of Chemistry
- 2002 California Institute of Technology, Distinguished Alumni Award
- 2003 The Nagoya Medal, Nagoya University, Japan
- 2003 Karl Ziegler Prize, Max Planck, Muelheim, Germany
- 2005 Willard Gibbs Medal, Chicago Section of the American Chemical Society
- 2006 Ryoji Noyori Prize, Society of Synthetic Organic Chemistry, Japan
- 2006 Thomson Scientific Laureate in Chemistry, Thomson Scientific
- 2006 Glenn T. Seaborg Medal, awarded by the University of California, Los Angeles
- 2007 Herbert C. Brown Award for Creative Research in Synthetic Methods, sponsored by the American Chemical Society
- 2007 Phi Beta Kappa Teaching Prize for Contributions to Undergraduate Education 2008 Elected Fellow of the Royal Society of Chemistry, UK
- 2008 Humboldt Research Award for Senior Scientists, the Alexander von Humboldt Foundation
- 2008 Elected Fellow of the Royal Society of Chemistry, UK
- 2010 ACS Award for Creativity in Molecular Design and Synthesis
- 2012 Welch Prize in Chemistry, awarded by the Welch Foundation
- 2013 Roger Adams Award
研究概要
新型反应的开发及复杂天然产物的全合成
Evans教授最有名的人名反应当属Evans-Aldol Reaction[1]（mechanismfrom Strategic Applicationsof Named Reactions inOrganic Synthesis），图1。通过使用从氨基酸得到的手性噁唑烷酮辅基，可以得到顺式的aldol产物。这种条件下的aldol反应可靠性高，可以运用到大量反应中，并且立体化学容易预测，因此，在许多复杂天然产物的合成中都有良好的运用。Evans-Aldol反应和不对称烯丙基硼化反应一起，在链式化合物的合成与立体结构的控制中，仍然被经常使用着。
图1：Evans-Aldol Reaction
通过自己组开发的方法学，David A. Evans教授完成了许多复杂天然产物的全合成，下图仅为部分全合成工作。
图2：David A. Evans部分全合成工作
评论&其他
- David A. Evans教授是美国有机合成界当之无愧的大牛之一，培养了许多优秀的有机化学家，在美国的有机合成化学领域大多数化学家就有属于分属Corey派和Evans派之说。
- David A. Evans教授还是现今有机化学中使用最为广泛的软件——ChemDraw的开发者之一[2]。
相关文献
- (a) Evans, D. A.; Vogel, E.; Nelson, J. V.J. Am. Chem. Soc.1979,101, 6120.DOI:10.1021/ja00514a045.; (b) Evans, D. A.; Bartroli, J.; Shih, T. L.J. Am. Chem. Soc.1981,103, 2127.DOI: 10.1021/ja00398a058.; (c) Evans, D. A.Aldrichimica Acta1982,15, 23.; (d) Recent Review: Heravi, M. M.; Zadsirjan, V.Tetrahedron: Asymmetry2013,24, 1149.;
- Evans, D. A.Angew. Chem. Int. Ed.2014,53, 11140.DOI: 10.1002/anie.201405820
本文版权属于Chem-Station化学空间， 欢迎点击按钮分享，未经许可，谢绝转载！
No comments yet.