{"id":10081,"date":"2016-07-07T11:32:16","date_gmt":"2016-07-07T03:32:16","guid":{"rendered":"\/\/www.gsbet888.com\/?p=10081"},"modified":"2019-08-02T18:54:19","modified_gmt":"2019-08-02T10:54:19","slug":"post-10081","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2016\/07\/post-10081.html","title":{"rendered":"Hantzsch\u4e8c\u6c22\u5421\u5576\u5408\u6210\u6cd5\uff08Hantzsch Dihydropyridine Synthesis\uff09"},"content":{"rendered":"<h4>\u6982\u8981<\/h4>\n<p>\u03b2-\u916e\u916f\u4e0e\u919b\uff0c\u542b\u6c2e\u5316\u5408\u7269\u7684\u591a\u7ec4\u5206\u53cd\u5e94\uff0c\u53cd\u5e94\u751f\u6210\u4e8c\u6c22\u5421\u5576\u5316\u5408\u7269\u3002\u4e8c\u6c22\u5421\u5576\u7ee7\u7eed\u88ab\u6c27\u5316\u53ef\u4ee5\u8f6c\u5316\u6210\u5421\u5576\u4ea7\u7269\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4>\u57fa\u672c\u6587\u732e<\/h4>\n<ul>\n<li>Hantzsch, A. <em>Ber.<\/em> <strong>1881<\/strong>, <em>14<\/em>, 1637.\u00a0doi:<a href=\"http:\/\/dx.doi.org\/10.1002\/cber.18810140214%20\">10.1002\/cber.18810140214<br \/>\n<\/a><\/li>\n<li>Hantzsch, A. <em>Ann.<\/em> <strong>1882<\/strong>, <em>215<\/em>, 1,\u00a072.<\/li>\n<li>Singer, A.; McElvain, S. M. <em>Org. Synth.<\/em> <strong>1934<\/strong>,\u00a0<em>14<\/em>, 30. [website]<\/li>\n<li>Kellog, R. M. et al. <em>J. Org. Chem.<\/em> <strong>1980<\/strong>,\u00a0<em>45<\/em>, 2854. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/jo01302a020\">10.1021\/jo01302a020<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h4>\u53cd\u5e94\u673a\u7406<\/h4>\n<p>\u9996\u5148\u901a\u8fc7<a href=\"\/\/www.gsbet888.com\/reactions\/2014\/03\/%E5%85%8B%E8%84%91%E6%96%87%E7%9B%96%E5%B0%94%E7%BC%A9%E5%90%88%E5%8F%8D%E5%BA%94%EF%BC%88knoevenagel-condensation%EF%BC%89.html\">Knoevenagel\u7f29\u5408<\/a>\u751f\u6210\u7f3a\u7535\u5b50\u7684\u70ef\u70c3\uff0c\u7136\u540e\u4e0e\u6c28\u53cd\u5e94\u751f\u6210\u70ef\u80fa\uff0c\u7136\u540e\u8fdb\u884cMicheal\u52a0\u6210\uff0c\u8131\u6c34\u7f29\u5408\u5f97\u5230\u4ea7\u7269\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-10083 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2016\/06\/hantzsch_py_3.gif\" alt=\"hantzsch_py_3\" width=\"523\" height=\"324\" \/><\/p>\n<h4>\u53cd\u5fdc\u4f8b<\/h4>\n<p>Nifedipine\u7684\u4e00\u6b65\u5408\u6210\u6cd5<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-10084 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2016\/06\/hantzsch_py_2.gif\" alt=\"hantzsch_py_2\" width=\"426\" height=\"125\" \/><\/p>\n<h4>\u5b9e\u9a8c\u6b65\u9aa4<\/h4>\n<p>&nbsp;<\/p>\n<h4>\u5b9e\u9a8c\u6280\u5de7<\/h4>\n<p>&nbsp;<\/p>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<p>&nbsp;<\/p>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 \u03b2-\u916e\u916f\u4e0e\u919b\uff0c\u542b\u6c2e\u5316\u5408\u7269\u7684\u591a\u7ec4\u5206\u53cd\u5e94\uff0c\u53cd\u5e94\u751f\u6210\u4e8c\u6c22\u5421\u5576\u5316\u5408\u7269\u3002\u4e8c\u6c22\u5421\u5576\u7ee7\u7eed\u88ab\u6c27\u5316\u53ef\u4ee5\u8f6c\u5316\u6210\u5421\u5576\u4ea7\u7269\u3002 &nbsp; \u57fa\u672c\u6587\u732e Hantzsch, A. Ber. 1881, 14, 1637.\u00a0doi:10.1002\/cber.18810140214 Hantzsch, A. Ann. 1882, 215, 1,\u00a072. Singer, A.; McElvain, S. M. Org. Synth. 1934,\u00a014, 30. [website] Kellog, R. M. et al. J. Org. Chem. 1980,\u00a045, 2854. DOI: 10.1021\/jo01302a020 &nbsp; \u53cd\u5e94\u673a\u7406 \u9996\u5148\u901a\u8fc7Knoevenagel\u7f29\u5408\u751f\u6210\u7f3a\u7535\u5b50\u7684\u70ef\u70c3\uff0c\u7136\u540e\u4e0e\u6c28\u53cd\u5e94\u751f\u6210\u70ef\u80fa\uff0c\u7136\u540e\u8fdb\u884cMicheal\u52a0\u6210\uff0c\u8131\u6c34\u7f29\u5408\u5f97\u5230\u4ea7\u7269\u3002 \u53cd\u5fdc\u4f8b Nifedipine\u7684\u4e00\u6b65\u5408\u6210\u6cd5 \u5b9e\u9a8c\u6b65\u9aa4 &nbsp; \u5b9e\u9a8c\u6280\u5de7 &nbsp; \u53c2\u8003\u6587\u732e &nbsp; \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01","protected":false},"author":5,"featured_media":10082,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2],"tags":[333],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2016\/06\/2014-10-28_14-05-13.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-2CB","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/10081"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=10081"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/10081\/revisions"}],"predecessor-version":[{"id":27670,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/10081\/revisions\/27670"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/10082"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=10081"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=10081"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=10081"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}