{"id":10688,"date":"2016-08-04T06:49:10","date_gmt":"2016-08-03T22:49:10","guid":{"rendered":"\/\/www.gsbet888.com\/?p=10688"},"modified":"2019-08-02T18:54:09","modified_gmt":"2019-08-02T10:54:09","slug":"kharasch-addition","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2016\/08\/kharasch-addition.html","title":{"rendered":"Kharasch Addition"},"content":{"rendered":"<p>Cu(I)\u6216Ru(II)\u7b49\u4f4e\u539f\u5b50\u4ef7\u7684\u91d1\u5c5e\u50ac\u5316\u5242\u6d3b\u5316\u591a\u5364\u4ee3\u7684\u70f7\u70c3\u53cd\u5e94\u540e\uff0c\u5bf9\u70ef\u70c3\u8fdb\u884c\u7684\u81ea\u7531\u57fa\u52a0\u6210\u53cd\u5e94\u3002<\/p>\n<p>\u8fd9\u662f\u4e00\u4e2a\u539f\u5b50\u79fb\u52a8\u7684\u81ea\u7531\u57fa\u805a\u5408\u53cd\u5e94\u7684\u57fa\u7840\u53cd\u5e94\u4e4b\u4e00\u3002<\/p>\n<h4>\u57fa\u672c\u6587\u732e<\/h4>\n<ul>\n<li>\u00a0Kharasch, M.; Jensen, E.; Urry, W.\u00a0<em>Science<\/em>\u00a0<strong>1945<\/strong>,\u00a0<em>102<\/em>\u00a0, 128. doi:<a href=\"http:\/\/dx.doi.org\/10.1126\/science.102.2640.128\">10.1126\/science.102.2640.128<\/a><\/li>\n<li>\u00a0Kharasch, M. S.; Jensen, E. V.; Urry, W. H.\u00a0<em>J. Am. Chem. Soc.<\/em>\u00a0<strong>1947<\/strong>,\u00a0<em>69<\/em>\u00a0, 1100. doi:<a href=\"http:\/\/dx.doi.org\/10.1021\/ja01197a035\">10.1021\/ja01197a035<\/a><\/li>\n<li>\u00a0Kharasch, M. S.; Kuderna, B. M.; Urry, W.\u00a0<em>J. Org. Chem.<\/em>\u00a0<strong>1948<\/strong>,\u00a0<em>13<\/em>, 895. doi:<a href=\"http:\/\/dx.doi.org\/10.1021\/jo01164a020\">10.1021\/jo01164a020<\/a><\/li>\n<li>\u00a0Minisci, F.\u00a0<em>Acc. Chem. Res.<\/em>\u00a0<strong>1975<\/strong>,\u00a0<em>8<\/em>, 165. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/ar50089a004\">10.1021\/ar50089a004<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h4>\u53cd\u5e94\u673a\u7406<\/h4>\n<p>\u5728\u4e0e\u70ef\u70c3\u8fdb\u884c\u52a0\u6210\u540e\u751f\u6210\u7684\u81ea\u7531\u57fa\u4e0e\u591a\u5364\u4ee3\u70f7\u70c3\u7684\u5364\u7d20\u53cd\u5e94\u518d\u6b21\u5f62\u6210\u81ea\u7531\u57fa\u91cd\u590d\u53cd\u5e94\u5faa\u73af\u3002\u5177\u4f53\u53c2\u7167\u4e0b\u56fe\u6240\u793a<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-10690 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2016\/08\/Kharasch_2.gif\" alt=\"Kharasch_2\" width=\"301\" height=\"211\" \/><\/p>\n<h4>\u53cd\u5e94\u5b9e\u4f8b<\/h4>\n<p>\u751f\u7269\u78b1\u7684\u5408\u6210\u5e94\u7528[1]\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-10691 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2016\/08\/Kharasch_3.gif\" alt=\"Kharasch_3\" width=\"484\" height=\"162\" \/><\/p>\n<div class=\"page\" title=\"Page 11\">\n<div class=\"section\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p>Synthesis of (\u03b3,\u03b3\u2212difluoroallyl)carbonyl compounds[2]\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-10693\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2016\/08\/A1FD4C7D-1860-4414-8ADB-E1EAB6FCEF4B.png\" alt=\"A1FD4C7D-1860-4414-8ADB-E1EAB6FCEF4B\" width=\"462\" height=\"160\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2016\/08\/A1FD4C7D-1860-4414-8ADB-E1EAB6FCEF4B.png 462w, https:\/\/assets.www.gsbet888.com\/uploads\/2016\/08\/A1FD4C7D-1860-4414-8ADB-E1EAB6FCEF4B-300x104.png 300w\" sizes=\"(max-width: 462px) 100vw, 462px\" \/><\/p>\n<h4>\u5b9e\u9a8c\u6b65\u9aa4<\/h4>\n<p>&nbsp;<\/p>\n<h4>\u5b9e\u9a8c\u6280\u5de7<\/h4>\n<p>&nbsp;<\/p>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n[1] Nagashima, H.; Ara, K.-i.; Wakamatsu, H.; Itoh, K.\u00a0<em>J. Chem. Soc., Chem. Commun.<\/em>\u00a0<strong>1985<\/strong>, 518. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1039\/C39850000518\">10.1039\/C39850000518<\/a><\/p>\n[2] Okano, <em>JOC<\/em> <strong>1993<\/strong>, <em>58<\/em>, 5164<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"Cu(I)\u6216Ru(II)\u7b49\u4f4e\u539f\u5b50\u4ef7\u7684\u91d1\u5c5e\u50ac\u5316\u5242\u6d3b\u5316\u591a\u5364\u4ee3\u7684\u70f7\u70c3\u53cd\u5e94\u540e\uff0c\u5bf9\u70ef\u70c3\u8fdb\u884c\u7684\u81ea\u7531\u57fa\u52a0\u6210\u53cd\u5e94\u3002 \u8fd9\u662f\u4e00\u4e2a\u539f\u5b50\u79fb\u52a8\u7684\u81ea\u7531\u57fa\u805a\u5408\u53cd\u5e94\u7684\u57fa\u7840\u53cd\u5e94\u4e4b\u4e00\u3002 \u57fa\u672c\u6587\u732e \u00a0Kharasch, M.; Jensen, E.; Urry, W.\u00a0Science\u00a01945,\u00a0102\u00a0, 128. doi:10.1126\/science.102.2640.128 \u00a0Kharasch, M. S.; Jensen, E. V.; Urry, W. H.\u00a0J. Am. Chem. Soc.\u00a01947,\u00a069\u00a0, 1100. doi:10.1021\/ja01197a035 \u00a0Kharasch, M. S.; Kuderna, B. M.; Urry, W.\u00a0J. Org. Chem.\u00a01948,\u00a013, 895. doi:10.1021\/jo01164a020 \u00a0Minisci, F.\u00a0Acc. Chem. Res.\u00a01975,\u00a08, 165. DOI:\u00a010.1021\/ar50089a004 &nbsp; \u53cd\u5e94\u673a\u7406 \u5728\u4e0e\u70ef\u70c3\u8fdb\u884c\u52a0\u6210\u540e\u751f\u6210\u7684\u81ea\u7531\u57fa\u4e0e\u591a\u5364\u4ee3\u70f7\u70c3\u7684\u5364\u7d20\u53cd\u5e94\u518d\u6b21\u5f62\u6210\u81ea\u7531\u57fa\u91cd\u590d\u53cd\u5e94\u5faa\u73af\u3002\u5177\u4f53\u53c2\u7167\u4e0b\u56fe\u6240\u793a \u53cd\u5e94\u5b9e\u4f8b \u751f\u7269\u78b1\u7684\u5408\u6210\u5e94\u7528[1] Synthesis of (\u03b3,\u03b3\u2212difluoroallyl)carbonyl compounds[2] \u5b9e\u9a8c\u6b65\u9aa4 &nbsp; \u5b9e\u9a8c\u6280\u5de7 &nbsp; \u53c2\u8003\u6587\u732e [1] Nagashima, H.; Ara, K.-i.; Wakamatsu, H.; Itoh, K.\u00a0J. Chem. Soc., Chem. Commun.\u00a01985, 518. DOI:\u00a010.1039\/C39850000518 [2] Okano, JOC 1993, 58, 5164 &nbsp; \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01","protected":false},"author":5,"featured_media":10689,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2],"tags":[992],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2016\/08\/2014-10-26_18-06-05.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-2Mo","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/10688"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=10688"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/10688\/revisions"}],"predecessor-version":[{"id":27633,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/10688\/revisions\/27633"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/10689"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=10688"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=10688"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=10688"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}