{"id":11425,"date":"2016-11-07T08:40:24","date_gmt":"2016-11-07T00:40:24","guid":{"rendered":"\/\/www.gsbet888.com\/?p=11425"},"modified":"2019-08-02T18:53:58","modified_gmt":"2019-08-02T10:53:58","slug":"%e5%bc%a0%e9%94%8b%e3%80%80feng-zhang","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemists\/2016\/11\/%e5%bc%a0%e9%94%8b%e3%80%80feng-zhang.html","title":{"rendered":"\u5f20\u950b\u3000Feng Zhang"},"content":{"rendered":"<p>\u5f20\u950b\uff08Feng Zhang, 1982\u5e74\uff0c\u4e2d\u56fd\u751f\uff09\u3001\u7f8e\u56fd\u751f\u7269\u5316\u5b66\u5bb6\u3001\u8111\u795e\u7ecf\u79d1\u5b66\u5bb6\u3002MIT\uff0cBroad\u7814\u7a76\u6240\uff0cMcGovern\u7814\u7a76\u6240\u52a9\u6559\u6388\u3002\uff08\u5199\u771f\uff1a<a href=\"https:\/\/mcgovern.mit.edu\/principal-investigators\/feng-zhang\">McGovern Institute<\/a>\uff09<\/p>\n<h4><span id=\"more-42300\"><\/span><br \/>\n\u7ecf\u5386<\/h4>\n<ul>\n<li>2004 \u54c8\u4f5b\u5927\u5b66 \u6bd5\u4e1a\uff08<a href=\"http:\/\/baike.baidu.com\/link?url=09LMdWrhr73gy-WMwCtZYD2lehO12QJ_3jANocu3cN_OoWsBLmfnHc0wO0zKEDfJ3F52zbfn3-FB0kqou78F-Bj8GgquVF5iGdGNlZf9-V-wDX8D49OZPD05-jkaQOMx\">\u5e84\u5c0f\u5a01<\/a> \u6559\u6388\uff09<\/li>\n<li>2009 \u65af\u5766\u798f\u5927\u5b66 \u535a\u58eb\u5b66\u4f4d\uff08<a href=\"http:\/\/www.chem-station.com\/chemist-db\/2016\/09\/karl-deisseroth.html\">Karl Deisseroth<\/a>\u6559\u6388\uff09<\/li>\n<li>2011- MIT \u52a9\u6559\u6388<\/li>\n<li>2011- Broad\u7814\u7a76\u6240<\/li>\n<li>2011- McGovern\u7814\u7a76\u6240<\/li>\n<li><a href=\"http:\/\/www.editasmedicine.com\/\">Editas Medicine<\/a>\u516c\u53f8\u521b\u59cb\u4eba<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h4>\u83b7\u5956\u7ecf\u5386<\/h4>\n<p>200x National Institutes of Health Director\u2019s Pioneer Award<br \/>\n2012 Perl-UNC Neuroscience Prize<br \/>\n2013 MIT Technology Reviews\u2019s TR3<br \/>\n2014 Alan T. Waterman Award<br \/>\n2014 Jacob Heskel Gabbay Award in Biotechnology and Medicine<br \/>\n2015 Tsuneko &amp; Reiji Okazaki Award<br \/>\n2016 Canada Gairdner International Award<br \/>\n2016 Tang Prize<br \/>\n2016 \u6c64\u68ee\u8def\u900f\u793e\u5f15\u7528\u8363\u8a89\u5956<\/p>\n<p>&nbsp;<\/p>\n<h4>\u7814\u7a76\u6982\u8981<\/h4>\n<h5>\u5149\u9057\u4f20\u5b66\u6280\u672f\u7684\u5f00\u62d3<\/h5>\n<p>\u5728Karl Disseroth\u7814\u8bfb\u535a\u671f\u95f4\uff0c\u5f20\u950b\u5c31\u4e0eEd Boyen\u5171\u540c\u53d1\u73b0\u4e86\u5177\u6709\u5149\u654f\u6027\u7684\u53e4\u7ec6\u83cc\u578b\u89c6\u7d2b\u7ea2\u8d28\u86cb\u767d\uff0c\u53ef\u7531\u5149\u654f\u79bb\u5b50\u901a\u9053\u63d2\u5165\u795e\u7ecf\u5143\u4e2d\u63a7\u5236\u5b83\u4eec[1]\u3002\u56e0\u4e3a\u8fd9\u4e00\u53d1\u73b0\uff0c\u4e5f\u6781\u5927\u7684\u63a8\u52a8\u4e86\u73b0\u4ee3\u5149\u9057\u4f20\u5b66\u7684\u53d1\u5c55[2]\u3002<\/p>\n<h5>\u57fa\u56e0\u7f16\u8bd1\u6280\u672f\u7684\u53d1\u73b0<\/h5>\n<p>\u57fa\u56e0\u7f16\u8bd1\u6280\u672fCRISPR\/Cas9\u7684\u53d1\u73b0\uff0c\u662f\u7531<a href=\"\/\/www.gsbet888.com\/chemists\/2015\/11\/emmanuel-charpentie.html\">Emamnauelle Charpentier<\/a>\u548c<a href=\"\/\/www.gsbet888.com\/chemists\/2015\/11\/post-7364.html\">Jennifer Doudna<\/a>\u4e24\u59d0\u59b9\u82b1\u57282012\u5e74\u5171\u540c\u53d1\u5e03\u5728Science\u6742\u5fd7\u4e0a\uff0c\u4e0e\u6b64\u540c\u65f6\uff0c\u5f20\u950b\u62ff\u5230\u4e86\u8fd9\u9879\u6280\u672f\u7684\u4e13\u5229\uff0c\u8fd9\u4e00\u53d1\u73b0\u5230\u73b0\u5728\u8fd8\u5728\u5b66\u672f\u7eb7\u4e89\uff0c\u4e13\u5229\u6743\u4e89\u593a\u5b98\u53f8\u4e2d\u3002<\/p>\n<p>\u5728\u90a3\u4e4b\u540e\uff0c<a href=\"\/\/www.gsbet888.com\/chemists\/2015\/11\/emmanuel-charpentie.html\">Charpentier<\/a>\u53ca<a href=\"\/\/www.gsbet888.com\/chemists\/2015\/11\/post-7364.html\">Doudna<\/a>\u5229\u7528\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u505a\u4e86\u4f18\u5316\uff0c\u4e5f\u901a\u8fc7\u8fd9\u4e00\u7ed3\u679c\u5728\u4e16\u754c\u4e0a\u9996\u6b21\u8bc1\u5b9e\u4e86\u8be5\u6280\u672f\u53ef\u5e94\u7528\u4e8e\u4eba\u4f53\u7ec6\u80de[3,4]\u3002<\/p>\n<p>2015\u5e74\uff0c\u76f8\u6bd4CRISPR\/Cas9\u4f53\u7cfb\uff0c\u4e1c\u4eac\u5927\u5b66\u7814\u7a76\u8005\u5f00\u53d1\u51fa\u4e86\u66f4\u7b80\u4fbf\u7684\u7684\u57fa\u56e0\u7f16\u8bd1\u6280\u672fCRISPR\/Cpf1\u4f53\u7cfb[5]\u3002<\/p>\n<div id=\"attachment_42302\" class=\"wp-caption aligncenter\">\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2016\/11\/CRISPR-Cpf1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-11948 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2016\/11\/CRISPR-Cpf1-680x535.jpg\" alt=\"crispr-cpf1\" width=\"680\" height=\"535\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2016\/11\/CRISPR-Cpf1-680x535.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2016\/11\/CRISPR-Cpf1-300x236.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2016\/11\/CRISPR-Cpf1-768x604.jpg 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2016\/11\/CRISPR-Cpf1.jpg 800w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p class=\"wp-caption-text\">\u56fe\u50cf\u6765\u81ea<a href=\"http:\/\/www.jst.go.jp\/pr\/announce\/20160422\/\">\u8fd9\u91cc<\/a><\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<h4>\u76f8\u5173\u52a8\u753b<\/h4>\n<p>&nbsp;<\/p>\n<h4>\u76f8\u5173\u6587\u732e<\/h4>\n<ol>\n<li>\u201cMillisecond-timescale, genetically targeted optical control of neural activity\u201d Boyden, E. S. ; Zhang, F.; Bamberg, E.; Nagel, G.; Deisseroth, K.\u00a0<em>Nature Neurosci.<\/em>\u00a0<strong>2005<\/strong>,\u00a0<em>8<\/em>, 1263. doi:<a href=\"http:\/\/dx.doi.org\/10.1038\/nn1525\">10.1038\/nn1525<\/a><\/li>\n<li>\u201cMethod of the Year 2010\u201d.\u00a0<em>Nature Methods<\/em>\u00a0<strong>2010<\/strong>,\u00a0<em>8<\/em>, 1. doi:<a href=\"http:\/\/dx.doi.org\/10.1038\/nmeth.f.321\">10.1038\/nmeth.f.321<\/a><\/li>\n<li>\u201cMultiplex Genome Engineering Using CRISPR\/Cas Systems\u201d Cong, L.; Ran, F. A.; Cox, D.; Lin, S.; Barretto, R.; Habib, N.; Hsu, P. D.; Wu, X.; Jiang, W.; Marraffini, L. A.; Zhang, F.\u00a0<em>Science<\/em>\u00a0<strong>2013<\/strong>,\u00a0<em>339<\/em>,819. doi:<a href=\"http:\/\/dx.doi.org\/10.1126\/science.1231143\">10.1126\/science.1231143<\/a><\/li>\n<li>\u201cDNA targeting specificity of RNA-guided Cas9 nucleases\u201d Hsu, P.\u00a0D.; Scott, D. A.; Weinstein, J. A.; Ran, F. A.; Konermann, S.; Agarwala, V.; Li, Y.; Fine, E. J.; Wu, X.; Shalem, O.; Cradick, T.\u00a0J.; Marraffini, L.\u00a0A.; Bao, G.; Zhang, F.\u00a0<em>Nature Biotechnol.\u00a0<\/em><strong>2013<\/strong>,\u00a0<em>31<\/em>, 827. doi:<a href=\"http:\/\/dx.doi.org\/10.1038\/nbt.2647\">10.1038\/nbt.2647<\/a><\/li>\n<li>\u201cCpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System\u201d Zetsche, B.; Gootenberg, J. S.; Abudayyeh, O. O.; Slaymaker, I. M.; Makarova, K. S.; Essletzbichler, P.; Volz,S. E.; Joung, J.; van der Oost, J.; Regev, A.; Koonin, E. V.; Zhang, F.\u00a0<em>Cell<\/em>\u00a0<strong>2015<\/strong>,\u00a0<em>163<\/em>, 739. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1016\/j.cell.2015.09.038\">10.1016\/j.cell.2015.09.038<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h4>\u76f8\u5173\u4e66\u7c4d<\/h4>\n[amazonjs asin=&#8221;1493926861&#8243; locale=&#8221;CN&#8221; title=&#8221;CRISPR: Methods and Protocols&#8221;]\n[amazonjs asin=&#8221;1621821315&#8243; locale=&#8221;CN&#8221; title=&#8221;CRISPR &#8211; Cas&#8221;]\n<h4>\u76f8\u5173\u94fe\u63a5<\/h4>\n<ul>\n<li><a href=\"http:\/\/zlab.mit.edu\/\">Zhang lab@MIT<\/a><\/li>\n<li><a href=\"http:\/\/www.broadinstitute.org\/history-leadership\/scientific-leadership\/core-members\/feng-zhang\">Feng Zhang@Broad Insitute<\/a><\/li>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Feng_Zhang\">Feng Zhang \u2013 Wikipedia<\/a><\/li>\n<li><a href=\"http:\/\/www.broadinstitute.org\/what-broad\/areas-focus\/project-spotlight\/crispr\">Project Spotlight CRISPR<\/a><\/li>\n<li><\/li>\n<\/ul>\n<div id=\"wp_rp_first\" class=\"wp_rp_wrap wp_rp_modern\"><\/div>\n<div class=\"wp_rp_wrap wp_rp_modern\"><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/div>\n<div class=\"wp_rp_wrap wp_rp_modern\"><\/div>\n","protected":false},"excerpt":{"rendered":"\u5f20\u950b\uff08Feng Zhang, 1982\u5e74\uff0c\u4e2d\u56fd\u751f\uff09\u3001\u7f8e\u56fd\u751f\u7269\u5316\u5b66\u5bb6\u3001\u8111\u795e\u7ecf\u79d1\u5b66\u5bb6\u3002MIT\uff0cBroad\u7814\u7a76\u6240\uff0cMcGovern\u7814\u7a76\u6240\u52a9\u6559\u6388\u3002\uff08\u5199\u771f\uff1aMcGovern Institute\uff09 \u7ecf\u5386 2004 \u54c8\u4f5b\u5927\u5b66 \u6bd5\u4e1a\uff08\u5e84\u5c0f\u5a01 \u6559\u6388\uff09 2009 \u65af\u5766\u798f\u5927\u5b66 \u535a\u58eb\u5b66\u4f4d\uff08Karl Deisseroth\u6559\u6388\uff09 2011- MIT \u52a9\u6559\u6388 2011- Broad\u7814\u7a76\u6240 2011- McGovern\u7814\u7a76\u6240 Editas Medicine\u516c\u53f8\u521b\u59cb\u4eba &nbsp; \u83b7\u5956\u7ecf\u5386 200x National Institutes of Health Director\u2019s Pioneer Award 2012 Perl-UNC Neuroscience Prize 2013 MIT Technology Reviews\u2019s TR3 2014 Alan T. Waterman Award 2014 Jacob Heskel Gabbay Award in Biotechnology and Medicine 2015 Tsuneko &amp; Reiji Okazaki Award 2016 Canada Gairdner International Award 2016 Tang Prize 2016 \u6c64\u68ee\u8def\u900f\u793e\u5f15\u7528\u8363\u8a89\u5956 &nbsp; \u7814\u7a76\u6982\u8981 \u5149\u9057\u4f20\u5b66\u6280\u672f\u7684\u5f00\u62d3 \u5728Karl Disseroth\u7814\u8bfb\u535a\u671f\u95f4\uff0c\u5f20\u950b\u5c31\u4e0eEd Boyen\u5171\u540c\u53d1\u73b0\u4e86\u5177\u6709\u5149\u654f\u6027\u7684\u53e4\u7ec6\u83cc\u578b\u89c6\u7d2b\u7ea2\u8d28\u86cb\u767d\uff0c\u53ef\u7531\u5149\u654f\u79bb\u5b50\u901a\u9053\u63d2\u5165\u795e\u7ecf\u5143\u4e2d\u63a7\u5236\u5b83\u4eec[1]\u3002\u56e0\u4e3a\u8fd9\u4e00\u53d1\u73b0\uff0c\u4e5f\u6781\u5927\u7684\u63a8\u52a8\u4e86\u73b0\u4ee3\u5149\u9057\u4f20\u5b66\u7684\u53d1\u5c55[2]\u3002 \u57fa\u56e0\u7f16\u8bd1\u6280\u672f\u7684\u53d1\u73b0 \u57fa\u56e0\u7f16\u8bd1\u6280\u672fCRISPR\/Cas9\u7684\u53d1\u73b0\uff0c\u662f\u7531Emamnauelle Charpentier\u548cJennifer Doudna\u4e24\u59d0\u59b9\u82b1\u57282012\u5e74\u5171\u540c\u53d1\u5e03\u5728Science\u6742\u5fd7\u4e0a\uff0c\u4e0e\u6b64\u540c\u65f6\uff0c\u5f20\u950b\u62ff\u5230\u4e86\u8fd9\u9879\u6280\u672f\u7684\u4e13\u5229\uff0c\u8fd9\u4e00\u53d1\u73b0\u5230\u73b0\u5728\u8fd8\u5728\u5b66\u672f\u7eb7\u4e89\uff0c\u4e13\u5229\u6743\u4e89\u593a\u5b98\u53f8\u4e2d\u3002 \u5728\u90a3\u4e4b\u540e\uff0cCharpentier\u53caDoudna\u5229\u7528\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u505a\u4e86\u4f18\u5316\uff0c\u4e5f\u901a\u8fc7\u8fd9\u4e00\u7ed3\u679c\u5728\u4e16\u754c\u4e0a\u9996\u6b21\u8bc1\u5b9e\u4e86\u8be5\u6280\u672f\u53ef\u5e94\u7528\u4e8e\u4eba\u4f53\u7ec6\u80de[3,4]\u3002 2015\u5e74\uff0c\u76f8\u6bd4CRISPR\/Cas9\u4f53\u7cfb\uff0c\u4e1c\u4eac\u5927\u5b66\u7814\u7a76\u8005\u5f00\u53d1\u51fa\u4e86\u66f4\u7b80\u4fbf\u7684\u7684\u57fa\u56e0\u7f16\u8bd1\u6280\u672fCRISPR\/Cpf1\u4f53\u7cfb[5]\u3002 \u56fe\u50cf\u6765\u81ea\u8fd9\u91cc &nbsp; \u76f8\u5173\u52a8\u753b &nbsp; \u76f8\u5173\u6587\u732e \u201cMillisecond-timescale, genetically targeted optical control of neural activity\u201d Boyden, E. S. ; Zhang, F.; Bamberg, E.; Nagel, G.; Deisseroth, K.\u00a0Nature Neurosci.\u00a02005,\u00a08, 1263. [&hellip;]","protected":false},"author":3,"featured_media":11949,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[212],"tags":[1116,1582,1583,647],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2016\/11\/Feng_Zhang_0.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-2Yh","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/11425"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=11425"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/11425\/revisions"}],"predecessor-version":[{"id":27591,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/11425\/revisions\/27591"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/11949"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=11425"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=11425"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=11425"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}