{"id":12335,"date":"2016-12-01T08:24:40","date_gmt":"2016-12-01T00:24:40","guid":{"rendered":"\/\/www.gsbet888.com\/?p=12335"},"modified":"2019-08-02T18:53:45","modified_gmt":"2019-08-02T10:53:45","slug":"li-a3%e5%81%b6%e8%81%94%e5%8f%8d%e5%ba%94%e6%9d%8e%e6%9c%9d%e5%86%9b","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2016\/12\/li-a3%e5%81%b6%e8%81%94%e5%8f%8d%e5%ba%94%e6%9d%8e%e6%9c%9d%e5%86%9b.html","title":{"rendered":"Li A3\u5076\u8054\u53cd\u5e94(\u674e\u671d\u519b)"},"content":{"rendered":"

\u6982\u8981<\/strong><\/h4>\n

Li A3<\/sup>\u5076\u8054\u53cd\u5e94\u4e3a\u919b(Aldehyde)\u3001\u7094(Alkyne)\u3001\u80fa(Amine)\u5728\u5404\u7c7b\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u5242\u4f5c\u7528\u4e0b\u7684\u76f4\u63a5\u8131\u6c34\u7f29\u5408\u751f\u6210\u7094\u4e19\u80fa\u7684\u53cd\u5e94\u3002\u53cd\u5e94\u53ef\u5728\u6c34\u76f8\u5a92\u4ecb\u4e2d\u8fdb\u884c\u3002\u5404\u7c7b\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u5242\u5982CuBr, RuCl3<\/sub>\u7b49\u5747\u53ef\u6709\u6548\u5730\u50ac\u5316\u8be5\u53cd\u5e94\u3002\u8be5\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\uff0c\u539f\u5b50\u5229\u7528\u7387\u9ad8\uff0c\u526f\u4ea7\u7269\u53ea\u6709\u6c34\u3002\u800c\u4e14\uff0c\u4e0e\u53e6\u4e00\u79cd\u6784\u5efa\u7094\u4e19\u57fa\u5316\u5408\u7269\u7684\u91cd\u8981\u65b9\u6cd5\u5b66Nicholas\u76f8\u6bd4\uff0c\u53ef\u6709\u6548\u5730\u907f\u514d\u4f7f\u7528\u5267\u6bd2\u7684Co2<\/sub>(CO)8<\/sub>(\u6bd2\u6027\u8981\u8fdc\u5927\u4e8e<\/strong>KCN<\/strong>\uff0c\u76ee\u524d\u4ecd\u65e0\u7279\u6548\u89e3\u6bd2\u5242<\/strong>)\uff0c\u5e76\u4e14\u53cd\u5e94\u4e2d\uff0c\u91cd\u91d1\u5c5e\u50ac\u5316\u5242\u5747\u91c7\u7528\u50ac\u5316\u91cf\uff0c\u56e0\u800c\u5bf9\u73af\u5883\u66f4\u4e3a\u53cb\u597d\u3002<\/p>\n

\u57fa\u672c\u6587\u732e<\/strong><\/h4>\n

C, Wei, Z, Li., C. J. Li, Synlett., 2004, 1472. doi: 10.1055\/s-2004-829531.<\/p>\n

\u53cd\u5e94\u673a\u7406<\/strong><\/h4>\n

\"2\"<\/a><\/p>\n

\u53cd\u5e94\u673a\u7406\u6d89\u53ca\u7094\u6de6\u5bf9\u919b\u4e9a\u80fa\u6b63\u79bb\u5b50\u7684\u4eb2\u6838\u52a0\u6210\u3002\u7531\u4e8e\u673a\u7406\u8f83\u4e3a\u7b80\u5355\uff0c\u5c0f\u7f16\u5728\u6b64\u4e0d\u8be6\u7ec6\u63cf\u8ff0\u3002<\/p>\n

\u53cd\u5e94\u5b9e\u4f8b<\/strong><\/h4>\n

N-\u82b3\u57fa\u7094\u4e19\u80fa\u7684\u5408\u6210[1]\n

\"3\"<\/a><\/p>\n

\u591a\u73af\u5421\u54af\u7684\u5408\u6210[2]\n

\"4\"<\/a><\/p>\n

\u4e0d\u5bf9\u79f0A3<\/sup>\u5076\u8054 (AA3<\/sup>-coupling) [3]\n

\"5\"<\/a><\/p>\n

(S)-(+)conline\u7684\u5168\u5408\u6210[4]\n

\"6\"<\/a><\/p>\n

\u5b9e\u9a8c\u6b65\u9aa4<\/strong><\/h4>\n

\u5c06\u919b(1 eq.)\u4e0e\u80fa(1.2 eq.)\u7684\u6df7\u5408\u7269\u572860 \u00b0C\u4e0b\u52a0\u70ed2\u5c0f\u65f6\uff0c\u964d\u81f3\u5ba4\u6e29\u3002\u5728\u6c2e\u6c14\u6c14\u6c1b\u4e0b\u52a0\u5165\u4e09\u6c2f\u5316\u948c(0.03eq.)\u3001\u6eb4\u5316\u4e9a\u94dc(0.3eq.)\u3001\u7094(1.2 eq.)\u4e0e\u8131\u6c14\u7684\u6c34(2 mL)\u3002\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\u6405\u62cc10\u5206\u949f\uff0c\u4e4b\u540e\u5347\u6e29\u81f340 \u00b0C\u8fc7\u591c\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u53cd\u5e94\u6db2\u5012\u5165\u6c34\u4e2d\uff0c\u7528\u4e59\u919a\u6216\u4e8c\u6c2f\u7532\u70f7\u8403\u53d6\u3002\u5408\u5e76\u6709\u673a\u76f8\uff0c\u4f9d\u6b21\u7528\u6c34\u6d17\u6da4\u3001\u65e0\u6c34\u786b\u9178\u9541\u5e72\u71e5\u3002\u771f\u7a7a\u6d53\u7f29\u9664\u53bb\u6eb6\u5242\u3002\u6700\u540e\u7ecf\u5feb\u901f\u67f1\u8272\u8c31(\u6b63\u5df1\u70f7\/\u4e59\u9178\u4e59\u916f 40\/1 v\/v)\u5206\u79bb, \u83b7\u5f97\u6700\u7ec8\u76ee\u6807\u4ea7\u7269.<\/p>\n

\u5b9e\u9a8c\u6280\u5de7<\/strong><\/h4>\n

 <\/p>\n

\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n

1 C.-J. Li, C. Wei, Chem. Commun., 2002, 268. DOI: 10.1039\/b108851n.<\/p>\n

    \n
  1. Y. Ju, C.-J. Li, R. S. Varma, QSAR Comb. Sci., 2004, 23. DOI: 10.1002\/sqar.200420034.<\/li>\n
  2. S. Nakamura, M. Ohara, Y. Nakamura, N. Shibata, T. Toru, Chem.- Eur. J., 2010, 16, 2360. DOI: 10.1002\/chem.200903550.<\/li>\n
  3. Gommermann, P. Knochel, Chem. Commun., 2004, 2324. DOI: 10.1039\/b409951f.<\/li>\n<\/ol>\n

    \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 Li A3\u5076\u8054\u53cd\u5e94\u4e3a\u919b(Aldehyde)\u3001\u7094(Alkyne)\u3001\u80fa(Amine)\u5728\u5404\u7c7b\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u5242\u4f5c\u7528\u4e0b\u7684\u76f4\u63a5\u8131\u6c34\u7f29\u5408\u751f\u6210\u7094\u4e19\u80fa\u7684\u53cd\u5e94\u3002\u53cd\u5e94\u53ef\u5728\u6c34\u76f8\u5a92\u4ecb\u4e2d\u8fdb\u884c\u3002\u5404\u7c7b\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u5242\u5982CuBr, RuCl3\u7b49\u5747\u53ef\u6709\u6548\u5730\u50ac\u5316\u8be5\u53cd\u5e94\u3002\u8be5\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\uff0c\u539f\u5b50\u5229\u7528\u7387\u9ad8\uff0c\u526f\u4ea7\u7269\u53ea\u6709\u6c34\u3002\u800c\u4e14\uff0c\u4e0e\u53e6\u4e00\u79cd\u6784\u5efa\u7094\u4e19\u57fa\u5316\u5408\u7269\u7684\u91cd\u8981\u65b9\u6cd5\u5b66Nicholas\u76f8\u6bd4\uff0c\u53ef\u6709\u6548\u5730\u907f\u514d\u4f7f\u7528\u5267\u6bd2\u7684Co2(CO)8(\u6bd2\u6027\u8981\u8fdc\u5927\u4e8eKCN\uff0c\u76ee\u524d\u4ecd\u65e0\u7279\u6548\u89e3\u6bd2\u5242)\uff0c\u5e76\u4e14\u53cd\u5e94\u4e2d\uff0c\u91cd\u91d1\u5c5e\u50ac\u5316\u5242\u5747\u91c7\u7528\u50ac\u5316\u91cf\uff0c\u56e0\u800c\u5bf9\u73af\u5883\u66f4\u4e3a\u53cb\u597d\u3002 \u57fa\u672c\u6587\u732e C, Wei, Z, Li., C. J. Li, Synlett., 2004, 1472. doi: 10.1055\/s-2004-829531. \u53cd\u5e94\u673a\u7406 \u53cd\u5e94\u673a\u7406\u6d89\u53ca\u7094\u6de6\u5bf9\u919b\u4e9a\u80fa\u6b63\u79bb\u5b50\u7684\u4eb2\u6838\u52a0\u6210\u3002\u7531\u4e8e\u673a\u7406\u8f83\u4e3a\u7b80\u5355\uff0c\u5c0f\u7f16\u5728\u6b64\u4e0d\u8be6\u7ec6\u63cf\u8ff0\u3002 \u53cd\u5e94\u5b9e\u4f8b N-\u82b3\u57fa\u7094\u4e19\u80fa\u7684\u5408\u6210[1] \u591a\u73af\u5421\u54af\u7684\u5408\u6210[2] \u4e0d\u5bf9\u79f0A3\u5076\u8054 (AA3-coupling) [3] (S)-(+)conline\u7684\u5168\u5408\u6210[4] \u5b9e\u9a8c\u6b65\u9aa4 \u5c06\u919b(1 eq.)\u4e0e\u80fa(1.2 eq.)\u7684\u6df7\u5408\u7269\u572860 \u00b0C\u4e0b\u52a0\u70ed2\u5c0f\u65f6\uff0c\u964d\u81f3\u5ba4\u6e29\u3002\u5728\u6c2e\u6c14\u6c14\u6c1b\u4e0b\u52a0\u5165\u4e09\u6c2f\u5316\u948c(0.03eq.)\u3001\u6eb4\u5316\u4e9a\u94dc(0.3eq.)\u3001\u7094(1.2 eq.)\u4e0e\u8131\u6c14\u7684\u6c34(2 mL)\u3002\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\u6405\u62cc10\u5206\u949f\uff0c\u4e4b\u540e\u5347\u6e29\u81f340 \u00b0C\u8fc7\u591c\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u53cd\u5e94\u6db2\u5012\u5165\u6c34\u4e2d\uff0c\u7528\u4e59\u919a\u6216\u4e8c\u6c2f\u7532\u70f7\u8403\u53d6\u3002\u5408\u5e76\u6709\u673a\u76f8\uff0c\u4f9d\u6b21\u7528\u6c34\u6d17\u6da4\u3001\u65e0\u6c34\u786b\u9178\u9541\u5e72\u71e5\u3002\u771f\u7a7a\u6d53\u7f29\u9664\u53bb\u6eb6\u5242\u3002\u6700\u540e\u7ecf\u5feb\u901f\u67f1\u8272\u8c31(\u6b63\u5df1\u70f7\/\u4e59\u9178\u4e59\u916f 40\/1 v\/v)\u5206\u79bb, \u83b7\u5f97\u6700\u7ec8\u76ee\u6807\u4ea7\u7269. \u5b9e\u9a8c\u6280\u5de7   \u53c2\u8003\u6587\u732e 1 C.-J. Li, C. Wei, Chem. Commun., 2002, 268. DOI: 10.1039\/b108851n. Y. Ju, C.-J. Li, R. S. Varma, QSAR Comb. Sci., 2004, 23. DOI: 10.1002\/sqar.200420034. S. Nakamura, M. Ohara, Y. Nakamura, N. Shibata, T. Toru, Chem.- Eur. J., 2010, 16, 2360. DOI: 10.1002\/chem.200903550. Gommermann, P. Knochel, Chem. Commun., 2004, 2324. DOI: 10.1039\/b409951f. \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01","protected":false},"author":21,"featured_media":12363,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":true,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[3,2],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2016\/11\/1-3-1.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-3cX","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/12335"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=12335"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/12335\/revisions"}],"predecessor-version":[{"id":27548,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/12335\/revisions\/27548"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/12363"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=12335"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=12335"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=12335"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}