{"id":12905,"date":"2017-01-20T07:36:47","date_gmt":"2017-01-19T23:36:47","guid":{"rendered":"\/\/www.gsbet888.com\/?p=12905"},"modified":"2019-08-02T18:53:36","modified_gmt":"2019-08-02T10:53:36","slug":"zhang-enyne-cycloisomerization","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2017\/01\/zhang-enyne-cycloisomerization.html","title":{"rendered":"Zhang enyne cycloisomerization"},"content":{"rendered":"

\u6982\u8981<\/strong><\/p>\n

\u5728\u94d1\u50ac\u5316\u5242\u4f5c\u7528\u4e0b\u70ef\u7094\u5316\u5408\u7269\u53ef\u4ee5\u53d1\u751f\u73af\u5316\u5f02\u6784\u5316\u53cd\u5e94\uff0c\u6b64\u53cd\u5e94\u88ab\u79f0\u4f5cZhang enyne cycloisomerization\u3002\u8be5\u53cd\u5e94\u53ef\u4ee5\u65b9\u4fbf\u7684\u5b9e\u73b0\u70ef\u70c3\u548c\u7094\u70c3\u5206\u5b50\u5185\u7684\u4e0d\u5bf9\u79f0\u73af\u5316\uff0c\u5177\u6709\u5f88\u597d\u7684\u533a\u57df\u9009\u62e9\u6027\u4ee5\u53ca\u7acb\u4f53\u9009\u62e9\u6027\uff0c\u9ad8\u6548\u5730\u6784\u7b51\u4e00\u7cfb\u5217\u4e94\u5143\u73af\u5316\u5408\u7269\u3002\u8be5\u53cd\u5e94\u7531\u5357\u65b9\u79d1\u6280\u5927\u5b66\u5f20\u7eea\u7a46\u6559\u6388\u53d1\u5c55\uff0c2014\u5e74\u88ab\u56fd\u9645\u5316\u5b66\u6743\u5a01\u8457\u4f5c\u300aName Reactions\u300b\u6536\u5f55\uff0c\u5e76\u88ab\u547d\u540d\u4e3a\u201cZhang enyne cycloisomerization\u201d\u3002<\/p>\n

\u57fa\u672c\u6587\u732e<\/strong><\/h4>\n
    \n
  1. Cao, P.; Wang, B.; Zhang, X. J. Am. Chem. Soc.<\/em>2000<\/strong>, 122<\/em>, 6490\u20136491.DOI<\/strong>:10.1021\/ja994220s<\/li>\n
  2. Cao, P.; Zhang, X. Angew. Chem. Int. Ed. <\/em>2000<\/strong>, 39<\/em>, 4104\u20134106.DOI<\/strong>:10.1002\/1521-3773(20001117)39:22<4104::AID-ANIE4104>3.0.CO;2-X<\/li>\n<\/ol>\n

    \u53cd\u5e94\u673a\u7406<\/strong>[<\/sup><\/strong>\u57fa\u672c\u6587\u732e<\/sup><\/strong>1]<\/sup><\/strong><\/h4>\n

    <\/a><\/p>\n

    \u53cd\u5e94\u5b9e\u4f8b<\/strong><\/h4>\n

    1.(+)-pilocarline\u7684\u4e0d\u5bf9\u79f0\u5408\u6210[1]<\/sup><\/p>\n

    <\/a><\/sup><\/p>\n

    2.<\/p>\n

    <\/a><\/p>\n

    \u5b9e\u9a8c\u6b65\u9aa4[3]<\/sup><\/strong><\/h4>\n

    <\/a><\/p>\n

    \u5c06[Rh(COD)Cl]2<\/sub>\uff084.9mg\uff0c0.01mmol\uff0c5 mol%\uff09\uff0c(S)-BINAP\uff0813.8mg\uff0c0.022mmol\uff0c11 mol%\uff09\u6eb6\u4e8eSchlenk\u771f\u7a7a\u7ba1\u4e2d\u7684DCE \uff082mL\uff09\u4e2d\u3002\u540e\u5c06\u5e95\u7269\u4e8e\u5ba4\u6e29\u6c2e\u6c14\u6c1b\u56f4\u4e0b\u52a0\u5165\u5230\u4e0a\u8ff0\u6eb6\u6db2\u4e2d\u3002\u6405\u62cc1min\u540e\uff0c\u5c06AgSbF6<\/sub>\uff080.04mmol\uff0c20 mol%\uff09\u4e5f\u52a0\u5165\u5230\u4e0a\u8ff0\u53cd\u5e94\u4f53\u7cfb\u4e2d\u3002\u5ba4\u6e29\u53cd\u5e94\u5e76\u7528GC\u68c0\u6d4b\uff0c\u5f85\u53cd\u5e94\u5b8c\u6210\u540e\u76f4\u63a5\u8fc7\u7845\u80f6\u67f1\u3002<\/p>\n

     <\/p>\n

    \u53c2\u8003\u6587\u732e<\/strong><\/h4>\n
      \n
    1. Lei, A.; He, M., Zhang, X. J. Am. Chem. Soc.\u00a0<\/em>2002<\/strong>, 124<\/em>, 8198\u20138199.\u00a0DOI<\/strong>:10.1021\/ja020052j<\/a><\/li>\n
    2. Lei, A.; Waldkirch, J. P.; He, M.; Wu, S.; Zhang, X. Angew. Chem. Int. Ed. <\/em>2002<\/strong>, 41<\/em>,4526\u20134529.\u00a0DOI<\/strong>:10.1002\/1521-3773(20021202)41:23<4526::AID-ANIE4526>3.0.CO;2-K<\/a><\/li>\n
    3. Nicolaou, K. C.; Li, A.; Edmonds, D. J. Angew. Chem. Int. Ed. <\/em>2007<\/strong>, 46<\/em>, 3942\u20133945.\u00a0DOI<\/strong>:10.1002\/anie.200700586<\/a><\/li>\n<\/ol>\n

       <\/p>\n

      \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n

      <\/div>\n
      <\/div>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 \u5728\u94d1\u50ac\u5316\u5242\u4f5c\u7528\u4e0b\u70ef\u7094\u5316\u5408\u7269\u53ef\u4ee5\u53d1\u751f\u73af\u5316\u5f02\u6784\u5316\u53cd\u5e94\uff0c\u6b64\u53cd\u5e94\u88ab\u79f0\u4f5cZhang enyne cycloisomerization\u3002\u8be5\u53cd\u5e94\u53ef\u4ee5\u65b9\u4fbf\u7684\u5b9e\u73b0\u70ef\u70c3\u548c\u7094\u70c3\u5206\u5b50\u5185\u7684\u4e0d\u5bf9\u79f0\u73af\u5316\uff0c\u5177\u6709\u5f88\u597d\u7684\u533a\u57df\u9009\u62e9\u6027\u4ee5\u53ca\u7acb\u4f53\u9009\u62e9\u6027\uff0c\u9ad8\u6548\u5730\u6784\u7b51\u4e00\u7cfb\u5217\u4e94\u5143\u73af\u5316\u5408\u7269\u3002\u8be5\u53cd\u5e94\u7531\u5357\u65b9\u79d1\u6280\u5927\u5b66\u5f20\u7eea\u7a46\u6559\u6388\u53d1\u5c55\uff0c2014\u5e74\u88ab\u56fd\u9645\u5316\u5b66\u6743\u5a01\u8457\u4f5c\u300aName Reactions\u300b\u6536\u5f55\uff0c\u5e76\u88ab\u547d\u540d\u4e3a\u201cZhang enyne cycloisomerization\u201d\u3002 \u57fa\u672c\u6587\u732e Cao, P.; Wang, B.; Zhang, X. J. Am. Chem. Soc.2000, 122, 6490\u20136491.DOI:10.1021\/ja994220s Cao, P.; Zhang, X. Angew. Chem. Int. Ed. 2000, 39, 4104\u20134106.DOI:10.1002\/1521-3773(20001117)39:22<4104::AID-ANIE4104>3.0.CO;2-X \u53cd\u5e94\u673a\u7406[\u57fa\u672c\u6587\u732e1] \u53cd\u5e94\u5b9e\u4f8b 1.(+)-pilocarline\u7684\u4e0d\u5bf9\u79f0\u5408\u6210[1] 2. \u5b9e\u9a8c\u6b65\u9aa4[3] \u5c06[Rh(COD)Cl]2\uff084.9mg\uff0c0.01mmol\uff0c5 mol%\uff09\uff0c(S)-BINAP\uff0813.8mg\uff0c0.022mmol\uff0c11 mol%\uff09\u6eb6\u4e8eSchlenk\u771f\u7a7a\u7ba1\u4e2d\u7684DCE \uff082mL\uff09\u4e2d\u3002\u540e\u5c06\u5e95\u7269\u4e8e\u5ba4\u6e29\u6c2e\u6c14\u6c1b\u56f4\u4e0b\u52a0\u5165\u5230\u4e0a\u8ff0\u6eb6\u6db2\u4e2d\u3002\u6405\u62cc1min\u540e\uff0c\u5c06AgSbF6\uff080.04mmol\uff0c20 mol%\uff09\u4e5f\u52a0\u5165\u5230\u4e0a\u8ff0\u53cd\u5e94\u4f53\u7cfb\u4e2d\u3002\u5ba4\u6e29\u53cd\u5e94\u5e76\u7528GC\u68c0\u6d4b\uff0c\u5f85\u53cd\u5e94\u5b8c\u6210\u540e\u76f4\u63a5\u8fc7\u7845\u80f6\u67f1\u3002   \u53c2\u8003\u6587\u732e Lei, A.; He, M., Zhang, X. J. Am. Chem. Soc.\u00a02002, 124, 8198\u20138199.\u00a0DOI:10.1021\/ja020052j Lei, A.; Waldkirch, J. P.; He, M.; Wu, S.; Zhang, X. Angew. Chem. Int. Ed. 2002, 41,4526\u20134529.\u00a0DOI:10.1002\/1521-3773(20021202)41:23<4526::AID-ANIE4526>3.0.CO;2-K Nicolaou, K. C.; Li, A.; Edmonds, D. J. Angew. Chem. Int. Ed. 2007, 46, 3942\u20133945.\u00a0DOI:10.1002\/anie.200700586   \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01","protected":false},"author":19,"featured_media":12906,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":true,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2,9],"tags":[1688,1685,1686,1687,828],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/01\/1-1.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-3m9","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/12905"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=12905"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/12905\/revisions"}],"predecessor-version":[{"id":27516,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/12905\/revisions\/27516"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/12906"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=12905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=12905"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=12905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}