{"id":1291,"date":"2014-05-29T09:04:26","date_gmt":"2014-05-29T01:04:26","guid":{"rendered":"\/\/www.gsbet888.com\/?p=1291"},"modified":"2019-08-02T18:56:54","modified_gmt":"2019-08-02T10:56:54","slug":"%e4%ba%a4%e5%8f%89%e7%be%9f%e9%86%9b%e7%bc%a9%e5%90%88%e5%8f%8d%e5%ba%94cross-aldol-reaction","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/%e5%8a%a0%e6%88%90%e5%8f%8d%e5%ba%94\/2014\/05\/%e4%ba%a4%e5%8f%89%e7%be%9f%e9%86%9b%e7%bc%a9%e5%90%88%e5%8f%8d%e5%ba%94cross-aldol-reaction.html","title":{"rendered":"\u4ea4\u53c9\u7f9f\u919b\u7f29\u5408\u53cd\u5e94Cross Aldol Reaction"},"content":{"rendered":"<ul>\n<li>\u6982\u8981<\/li>\n<\/ul>\n<p>\u5728LDA\u7b49\u5f3a\u78b1\u4e0b\uff0c\u5c06doner\u4e00\u4fa7\u7684\u7fb0\u57fa\u5316\u5408\u7269\u7684\u03b1\u4f4d\u5b8c\u5168\u8131\u6c22\u3001\u63d0\u524d\u5236\u5907\u91d1\u5c5e\u70ef\u9187\u76d0\uff0c\u6291\u5236\u5176\u81ea\u7f29\u5408\uff0c\u5f97\u5230\u4ea4\u53c9\u7f29\u5408\u4ea7\u7269\u7684\u65b9\u6cd5\u3002<\/p>\n<p>\u6839\u636e\u70ef\u9187\u76d0\u7684\u7acb\u4f53\u5dee\u5f02\u6027\u3001\u4e0e\u7acb\u4f53\u7279\u5f02\u7684\u919b\u53ca\u916e\u53cd\u5e94\uff0c\u53ef\u76f8\u5e94\u5f97\u5230<em>syn<\/em>\/<em>anti<\/em>-\u7f9f\u919b\u4f53\u3002<\/p>\n<p>\u7531\u8fc1\u79fb\u91d1\u5c5e\u5316\u53ef\u4ee5\u5236\u5907Li\u3001Na\u3001Mg\u3001Zn\u3001B\u3001Al\u3001Ti\u7b49\u5404\u79cd\u91d1\u5c5e\u70ef\u9187\u76d0\u3001\u5176\u4e2d\u53ea\u6709\u7845\u548c\u9521\u7684\u70ef\u9187\u76d0\u53ef\u4ee5\u5206\u79bb\u7cbe\u5236\u3002\u7279\u522b\u662f\u5728\u8def\u6613\u65af\u9178\u6027\u6761\u4ef6\u4e0b\u7845\u70ef\u9187\u76d0\u7684\u7f9f\u919b\u52a0\u6210\u53cd\u5e94\u901a\u5e38\u79f0\u4f5c<strong style=\"color: #ff6600\"><a style=\"color: #669900\" href=\"http:\/\/www.chem-station.com\/user-cgi-bin\/odoos\/ps_search.cgi?act=jump&amp;access=1&amp;url=http:\/\/www.chem-station.com\/odoos\/data\/mukaiyama_aldol.htm\">\u5411\u5c71\u7f9f\u919b\u7f29\u5408<\/a><\/strong>\u53cd\u5e94\u3002<\/p>\n<p>\u5728\u5168\u5408\u6210\u4e2d\uff0c\u8be5\u5076\u8054\u7f29\u5408\u7684\u4f8b\u5b50\u4e5f\u4e0d\u5c11\u3002\u5176\u4ed6\u7684\u4f8b\u5b50\u8be6\u89c1\u6587\u732e\u30fbReview\u3002<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>\u57fa\u672c\u6587\u732e<\/li>\n<\/ul>\n<p>\u30fbHeathcock, C. H.\u00a0<em>Comprehensive Organic Synthesis<\/em>\u00a0<strong style=\"color: #ff6600\">1991<\/strong>,\u00a0<em>2<\/em>, 133.<br \/>\n\u30fbKim, B. M. et al.\u00a0<em>Comprehensive Organic Synthesis<\/em>\u00a0<strong style=\"color: #ff6600\">1991<\/strong>,\u00a0<em>2<\/em>, 239.<br \/>\n\u30fbPaterson, I.\u00a0<em>Comprehensive Organic Synthesis<\/em>\u00a0<strong style=\"color: #ff6600\">1991<\/strong>,\u00a0<em>2<\/em>, 301.<br \/>\n\u30fbMahrwald, R. ed.\u00a0<a style=\"color: #669900\" href=\"http:\/\/amazon.co.jp\/o\/ASIN\/3527307141\/chemstation-22\/ref=nosim\"><em>Modern Aldol Reactions<\/em><\/a>\u00a0Wiley-VCH,\u00a0<strong style=\"color: #ff6600\">2004<\/strong><br \/>\n\u30fbReview: Palomo, C.; Oiarbide, M.; Garcia, J. M.\u00a0<em>Chem. Eur. J.<\/em>\u00a0<strong style=\"color: #ff6600\">2002<\/strong>,\u00a0<em>8<\/em>, 36.\u00a0<a style=\"color: #669900\" href=\"http:\/\/www3.interscience.wiley.com\/journal\/88513587\/abstract\">[abstract]<\/a><br \/>\n\u30fbReview: Palomo, C.; Oiarbide, M.; Garcia, J. M.\u00a0<em>Chem. Soc. Rev.<\/em>\u00a0<strong style=\"color: #ff6600\">2004<\/strong>,\u00a0<em>33<\/em>, 65. DOI:<a style=\"color: #669900\" href=\"http:\/\/dx.doi.org\/10.1039\/b202901d\">10.1039\/b202901d<\/a><br \/>\n\u30fbReview: Schetter, B.; Mahrwald, R.\u00a0<em>Angew. Chem. Int. Ed.<\/em>\u00a0<strong style=\"color: #ff6600\">2006<\/strong>,\u00a0<em>45<\/em>, 7506. doi:<a style=\"color: #669900\" href=\"http:\/\/dx.doi.org\/10.1002\/anie.200602780\">10.1002\/anie.200602780<\/a><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>\u53cd\u5e94\u673a\u7406<\/li>\n<\/ul>\n<p><strong style=\"color: #ff6600\">\u7528Zimmerman-Traxler\u516d\u5143\u73af\u8fc7\u6e21\u6001\u6a21\u578b<\/strong>(<em><a style=\"color: #669900\" href=\"http:\/\/dx.doi.org\/10.1021\/ja01565a041\">J. Am. Chem. Soc.<\/a><\/em>\u00a0<a style=\"color: #669900\" href=\"http:\/\/dx.doi.org\/10.1021\/ja01565a041\"><strong style=\"color: #ff6600\">1957<\/strong>,\u00a0<em>79<\/em>, 1920<\/a>.)\u80fd\u591f\u8f83\u597d\u7684\u89e3\u91ca\u8bf4\u660e\u5e95\u7269\u4e0e\u4ea7\u7269\u7acb\u4f53\u5316\u5b66\u89c1\u5f97\u5173\u7cfb\u3002\u56e0\u4e3a\u919b\u7684\u53d6\u4ee3\u57faequatorial\u5904\u5728\u5e73\u4f0f\u4f4d\u7f6e\u7684\u8fc7\u6e21\u6001\u7a33\u5b9a\uff0c\u6709\u70ef\u9187\u7684\u7acb\u4f53\u7279\u5f02\u6027\u51b3\u5b9a\u4ea7\u7269\u7684\u7acb\u4f53\u5316\u5b66\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u7531<strong style=\"color: #ff6600\"><i>Z<\/i>-\u70ef\u9187\u76d0\u5f97\u5230<em>syn\u6784\u578b\u7f9f\u919b\u4ea7\u7269<\/em>\u3001\u7531<i>E<\/i>-\u70ef\u9187\u76d0\u5f97\u5230<em>anti<\/em>\u6784\u578b<\/strong>\u4ea7\u7269\u3002<br \/>\n\u4e00\u822c\u800c\u8a00\uff0c\u4f7f\u7528M-O\u952e\u5f3a\u7684\u91d1\u5c5e\uff08\u786c\u9178\uff0c\u7edc\u5408\u80fd\u8f83\u5927\u7684\u91d1\u5c5e\uff09\u516d\u5143\u73af\u8fc7\u6e21\u6001\u7684\u73af\u8db3\u591f\u7a33\u56fa\uff0c\u7acb\u4f53\u9009\u62e9\u6027\u4f1a\u63d0\u9ad8\u3002<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/05\/on-ol-001.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1532\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/05\/on-ol-001.gif\" alt=\"on-ol-001\" width=\"463\" height=\"223\" \/><\/a><\/p>\n<p>\u52a0\u5165HMPA\u7b49\u4e0e\u9502\u7b49\u91d1\u5c5e\u914d\u4f4d\u80fd\u529b\u8f83\u5f3a\u7684\u914d\u4f4d\u6027\u6eb6\u5242\u3001\u53ef\u4f7f\u91d1\u5c5e\u70ef\u9187\u76d0\u5f97\u5230\u6781\u5316\uff0c\u63d0\u9ad8\u53cd\u5e94\u6027\u80fd\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u56e0\u5b83\u4e0d\u53ef\u80fd\u91c7\u53d6\u516d\u5143\u73af\u8fc7\u6e21\u6001\uff0c\u4f1a\u4f7f\u9009\u62e9\u6027\u53cd\u8f6c\uff0c\u5c31\u53d8\u5f97\u4f9d\u8d56\u4e8e\u5e95\u7269\u3002<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>\u53cd\u5e94\u5b9e\u4f8b<\/li>\n<\/ul>\n<p>\u542b\u6709\u53d6\u4ee3\u57fa\u7684\u540c\u7684\u70ef\u9187\u76d0\u5236\u5907\uff0c\u4f4d\u7f6e\u9009\u62e9\u6027\u662f\u5e38\u89c1\u95ee\u9898\uff0c \u901a\u8fc7\u70ed\u529b\u5b66\/\u901f\u5ea6\u8bba\u7684\u6761\u4ef6\u63a7\u5236\u4e5f\u80fd\u5b9e\u73b0\u9ad8\u4f4d\u7f6e\u9009\u62e9\u6027\u3002<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/05\/cross_aldol_3.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1533\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/05\/cross_aldol_3.gif\" alt=\"cross_aldol_3\" width=\"369\" height=\"128\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left\">\u787c\u7684\u70ef\u9187\u76d0B-O\u952e\u8f83\u77ed\uff0c\u80fd\u591f\u5f62\u6210\u7a33\u56fa\u7684\u516d\u5143\u73af\u3001\u76f8\u6bd4\u9502\u7684\u70ef\u9187\u76d0\u7acb\u4f53\u9009\u62e9\u6027\u4f1a\u63d0\u9ad8\u3002<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/05\/cross_aldol_4.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1534\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/05\/cross_aldol_4.gif\" alt=\"cross_aldol_4\" width=\"383\" height=\"106\" \/><\/a><\/p>\n<p>\u787c\u7684\u70ef\u9187\u76d0\uff0c\u901a\u8fc7\u4e0d\u540c\u8bd5\u5242\u5904\u7406\u53ef\u4ee5\u9009\u62e9\u6027\u7684\u5f97\u5230E\/Z\u5f0f\u70ef\u9187\u76d0[1]\n<p style=\"text-align: center\"><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/05\/cross_aldol_5.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1535\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/05\/cross_aldol_5.gif\" alt=\"cross_aldol_5\" width=\"486\" height=\"186\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Merrilactone A\u7684\u5408\u6210[2]\uff1a\u975e\u5bfe\u79f0\u5206\u5b50\u5185\u7f9f\u919b\u53cd\u5e94\u7684\u5e94\u7528\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/05\/cross_aldol_6.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1536 aligncenter\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/05\/cross_aldol_6.gif\" alt=\"cross_aldol_6\" width=\"469\" height=\"136\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>\u7fb0\u57fa\u5316\u5408\u7269\u7684\u5982\u679c\u4e0d\u80fd\u4ea7\u751f\u70ef\u9187\u5316\u5408\u7269(\u4f8b\u5982HCHO\u3001ArCHO\u3001Ar<sub>2<\/sub>CO\u7b49)\u3001\u5219\u5bb9\u6613\u53d1\u751f\u4ea4\u53c9\u7f9f\u919b\u53cd\u5e94\u3002(<strong style=\"color: #ff6600\">Claisen-Schmidt\u53cd\u5fdc<\/strong>) [3]\n<p style=\"text-align: center\"><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/05\/cross_aldol_7.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1537\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/05\/cross_aldol_7.gif\" alt=\"cross_aldol_7\" width=\"457\" height=\"86\" \/><\/a><\/p>\n<ul>\n<li>\u5b9e\u9a8c\u6b65\u9aa4<\/li>\n<\/ul>\n<ul>\n<li>\u5b9e\u9a8c\u6280\u5de7<\/li>\n<\/ul>\n<ul>\n<li>\u53c2\u8003\u6587\u732e<\/li>\n<\/ul>\n[1] Brown, H. C.; Dhar, R. K.; Bakshi, R. K.; Pandiarajan, P. K.; Singaram, B.\u00a0<em>J. Am. Chem. Soc.<\/em>\u00a0<strong style=\"color: #ff6600\">1989<\/strong>,<em>111<\/em>, 3441. DOI:\u00a0<a style=\"color: #669900\" href=\"http:\/\/dx.doi.org\/10.1021\/ja00191a058\">10.1021\/ja00191a058<\/a><br \/>\n[2] (a) Inoue, M.; Sato, T.; Hirama, M.\u00a0<em>Angew. Chem. Int. Ed.<\/em>\u00a0<strong style=\"color: #ff6600\">2006<\/strong>,\u00a0<em>45<\/em>, 4843. doi:<a style=\"color: #669900\" href=\"http:\/\/dx.doi.org\/10.1002\/anie.200601358\">10.1002\/anie.200601358<\/a>\u00a0(b) Inoue, M.; Lee, N.; Kasuya, S.; Sato, T.; Hirama, M.; Moriyama, M.; Fukuyama, Y.\u00a0<em>J. Org. Chem.<\/em>\u00a0<strong style=\"color: #ff6600\">2007<\/strong>,\u00a0<em>72<\/em>, 3065. DOI:\u00a0<a style=\"color: #669900\" href=\"http:\/\/dx.doi.org\/10.1021\/jo0700474\">10.1021\/jo0700474\u00a0<\/a><br \/>\n[3] (a) Schmidt, J. G.\u00a0<em>Ber.<\/em>\u00a0<strong style=\"color: #ff6600\">1880<\/strong>,\u00a0<em>13<\/em>, 2342. (b) Claisen, L.\u00a0<em>Ber.<\/em>\u00a0<strong style=\"color: #ff6600\">1890<\/strong>,\u00a0<em>23<\/em>, 976. <\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 \u5728LDA\u7b49\u5f3a\u78b1\u4e0b\uff0c\u5c06doner\u4e00\u4fa7\u7684\u7fb0\u57fa\u5316\u5408\u7269\u7684\u03b1\u4f4d\u5b8c\u5168\u8131\u6c22\u3001\u63d0\u524d\u5236\u5907\u91d1\u5c5e\u70ef\u9187\u76d0\uff0c\u6291\u5236\u5176\u81ea\u7f29\u5408\uff0c\u5f97\u5230\u4ea4\u53c9\u7f29\u5408\u4ea7\u7269\u7684\u65b9\u6cd5\u3002 \u6839\u636e\u70ef\u9187\u76d0\u7684\u7acb\u4f53\u5dee\u5f02\u6027\u3001\u4e0e\u7acb\u4f53\u7279\u5f02\u7684\u919b\u53ca\u916e\u53cd\u5e94\uff0c\u53ef\u76f8\u5e94\u5f97\u5230syn\/anti-\u7f9f\u919b\u4f53\u3002 \u7531\u8fc1\u79fb\u91d1\u5c5e\u5316\u53ef\u4ee5\u5236\u5907Li\u3001Na\u3001Mg\u3001Zn\u3001B\u3001Al\u3001Ti\u7b49\u5404\u79cd\u91d1\u5c5e\u70ef\u9187\u76d0\u3001\u5176\u4e2d\u53ea\u6709\u7845\u548c\u9521\u7684\u70ef\u9187\u76d0\u53ef\u4ee5\u5206\u79bb\u7cbe\u5236\u3002\u7279\u522b\u662f\u5728\u8def\u6613\u65af\u9178\u6027\u6761\u4ef6\u4e0b\u7845\u70ef\u9187\u76d0\u7684\u7f9f\u919b\u52a0\u6210\u53cd\u5e94\u901a\u5e38\u79f0\u4f5c\u5411\u5c71\u7f9f\u919b\u7f29\u5408\u53cd\u5e94\u3002 \u5728\u5168\u5408\u6210\u4e2d\uff0c\u8be5\u5076\u8054\u7f29\u5408\u7684\u4f8b\u5b50\u4e5f\u4e0d\u5c11\u3002\u5176\u4ed6\u7684\u4f8b\u5b50\u8be6\u89c1\u6587\u732e\u30fbReview\u3002 &nbsp; \u57fa\u672c\u6587\u732e \u30fbHeathcock, C. H.\u00a0Comprehensive Organic Synthesis\u00a01991,\u00a02, 133. \u30fbKim, B. M. et al.\u00a0Comprehensive Organic Synthesis\u00a01991,\u00a02, 239. \u30fbPaterson, I.\u00a0Comprehensive Organic Synthesis\u00a01991,\u00a02, 301. \u30fbMahrwald, R. ed.\u00a0Modern Aldol Reactions\u00a0Wiley-VCH,\u00a02004 \u30fbReview: Palomo, C.; Oiarbide, M.; Garcia, J. M.\u00a0Chem. Eur. J.\u00a02002,\u00a08, 36.\u00a0[abstract] \u30fbReview: Palomo, C.; Oiarbide, M.; Garcia, J. M.\u00a0Chem. Soc. Rev.\u00a02004,\u00a033, 65. DOI:10.1039\/b202901d \u30fbReview: Schetter, B.; Mahrwald, R.\u00a0Angew. Chem. Int. Ed.\u00a02006,\u00a045, 7506. doi:10.1002\/anie.200602780 &nbsp; \u53cd\u5e94\u673a\u7406 \u7528Zimmerman-Traxler\u516d\u5143\u73af\u8fc7\u6e21\u6001\u6a21\u578b(J. Am. Chem. Soc.\u00a01957,\u00a079, 1920.)\u80fd\u591f\u8f83\u597d\u7684\u89e3\u91ca\u8bf4\u660e\u5e95\u7269\u4e0e\u4ea7\u7269\u7acb\u4f53\u5316\u5b66\u89c1\u5f97\u5173\u7cfb\u3002\u56e0\u4e3a\u919b\u7684\u53d6\u4ee3\u57faequatorial\u5904\u5728\u5e73\u4f0f\u4f4d\u7f6e\u7684\u8fc7\u6e21\u6001\u7a33\u5b9a\uff0c\u6709\u70ef\u9187\u7684\u7acb\u4f53\u7279\u5f02\u6027\u51b3\u5b9a\u4ea7\u7269\u7684\u7acb\u4f53\u5316\u5b66\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u7531Z-\u70ef\u9187\u76d0\u5f97\u5230syn\u6784\u578b\u7f9f\u919b\u4ea7\u7269\u3001\u7531E-\u70ef\u9187\u76d0\u5f97\u5230anti\u6784\u578b\u4ea7\u7269\u3002 \u4e00\u822c\u800c\u8a00\uff0c\u4f7f\u7528M-O\u952e\u5f3a\u7684\u91d1\u5c5e\uff08\u786c\u9178\uff0c\u7edc\u5408\u80fd\u8f83\u5927\u7684\u91d1\u5c5e\uff09\u516d\u5143\u73af\u8fc7\u6e21\u6001\u7684\u73af\u8db3\u591f\u7a33\u56fa\uff0c\u7acb\u4f53\u9009\u62e9\u6027\u4f1a\u63d0\u9ad8\u3002 \u52a0\u5165HMPA\u7b49\u4e0e\u9502\u7b49\u91d1\u5c5e\u914d\u4f4d\u80fd\u529b\u8f83\u5f3a\u7684\u914d\u4f4d\u6027\u6eb6\u5242\u3001\u53ef\u4f7f\u91d1\u5c5e\u70ef\u9187\u76d0\u5f97\u5230\u6781\u5316\uff0c\u63d0\u9ad8\u53cd\u5e94\u6027\u80fd\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u56e0\u5b83\u4e0d\u53ef\u80fd\u91c7\u53d6\u516d\u5143\u73af\u8fc7\u6e21\u6001\uff0c\u4f1a\u4f7f\u9009\u62e9\u6027\u53cd\u8f6c\uff0c\u5c31\u53d8\u5f97\u4f9d\u8d56\u4e8e\u5e95\u7269\u3002 &nbsp; \u53cd\u5e94\u5b9e\u4f8b \u542b\u6709\u53d6\u4ee3\u57fa\u7684\u540c\u7684\u70ef\u9187\u76d0\u5236\u5907\uff0c\u4f4d\u7f6e\u9009\u62e9\u6027\u662f\u5e38\u89c1\u95ee\u9898\uff0c \u901a\u8fc7\u70ed\u529b\u5b66\/\u901f\u5ea6\u8bba\u7684\u6761\u4ef6\u63a7\u5236\u4e5f\u80fd\u5b9e\u73b0\u9ad8\u4f4d\u7f6e\u9009\u62e9\u6027\u3002 &nbsp; \u787c\u7684\u70ef\u9187\u76d0B-O\u952e\u8f83\u77ed\uff0c\u80fd\u591f\u5f62\u6210\u7a33\u56fa\u7684\u516d\u5143\u73af\u3001\u76f8\u6bd4\u9502\u7684\u70ef\u9187\u76d0\u7acb\u4f53\u9009\u62e9\u6027\u4f1a\u63d0\u9ad8\u3002 \u787c\u7684\u70ef\u9187\u76d0\uff0c\u901a\u8fc7\u4e0d\u540c\u8bd5\u5242\u5904\u7406\u53ef\u4ee5\u9009\u62e9\u6027\u7684\u5f97\u5230E\/Z\u5f0f\u70ef\u9187\u76d0[1] &nbsp; Merrilactone A\u7684\u5408\u6210[2]\uff1a\u975e\u5bfe\u79f0\u5206\u5b50\u5185\u7f9f\u919b\u53cd\u5e94\u7684\u5e94\u7528\u3002 &nbsp; \u7fb0\u57fa\u5316\u5408\u7269\u7684\u5982\u679c\u4e0d\u80fd\u4ea7\u751f\u70ef\u9187\u5316\u5408\u7269(\u4f8b\u5982HCHO\u3001ArCHO\u3001Ar2CO\u7b49)\u3001\u5219\u5bb9\u6613\u53d1\u751f\u4ea4\u53c9\u7f9f\u919b\u53cd\u5e94\u3002(Claisen-Schmidt\u53cd\u5fdc) [3] \u5b9e\u9a8c\u6b65\u9aa4 \u5b9e\u9a8c\u6280\u5de7 \u53c2\u8003\u6587\u732e [1] Brown, H. C.; Dhar, R. K.; Bakshi, R. K.; Pandiarajan, P. K.; Singaram, B.\u00a0J. Am. Chem. Soc.\u00a01989,111, 3441. 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