{"id":13025,"date":"2017-02-20T08:39:20","date_gmt":"2017-02-20T00:39:20","guid":{"rendered":"\/\/www.gsbet888.com\/?p=13025"},"modified":"2019-08-02T18:53:34","modified_gmt":"2019-08-02T10:53:34","slug":"%e7%a0%94%e7%a9%b6%e8%ae%ba%e6%96%87%e4%bb%8b%e7%bb%8d-%e5%90%88%e6%88%90%e5%90%96%e5%95%b6%e9%85%ae%e7%9a%84%e4%b8%80%e7%a7%8d%e6%96%b9%e6%b3%95","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2017\/02\/%e7%a0%94%e7%a9%b6%e8%ae%ba%e6%96%87%e4%bb%8b%e7%bb%8d-%e5%90%88%e6%88%90%e5%90%96%e5%95%b6%e9%85%ae%e7%9a%84%e4%b8%80%e7%a7%8d%e6%96%b9%e6%b3%95.html","title":{"rendered":"\u7814\u7a76\u8bba\u6587\u4ecb\u7ecd\u2014\u5408\u6210\u5416\u5576\u916e\u7684\u4e00\u79cd\u65b9\u6cd5"},"content":{"rendered":"

(\u5c0f\u7f16\u662f\u672c\u79d1\u751f\uff0c\u7b2c\u4e00\u6b21\u6295\u7a3f\uff0c\u6709\u7406\u89e3\u4e0d\u5230\u4f4d\u7684\u5730\u65b9\uff0c\u8bf7\u5927\u5bb6\u591a\u591a\u6307\u70b9\uff01)<\/strong><\/p>\n

\u6982\u8981<\/h4>\n

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Palladium\/Copper Co-catalyzed Oxidative C\u2013H\/C\u2013H Carbonylation of Diphenylamines: A Way To Access Acridones.\u00a0Jiangwei Wen, Shan Tang, Fan Zhang, Renyi Shi, and Aiwen Lei*\u00a0Org. Lett.<\/em>, 2017,\u00a0<\/strong>19<\/em>, \u00a094\u201397.\u00a0DOI: 10.1021\/acs.orglett.6b03356<\/a>
\n<\/cite><\/p><\/blockquote>\n

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\u8fd9\u4e9b\u542b\u6c2e\u5316\u5408\u7269\u5305\u62ec\u6297\u75c5\u6bd2\u524210-CMA (Figure 1, A)1<\/sup><\/strong>\u3001\u6297\u80bf\u7624\u836f\u7269Glyfoline\u548cAcronycine (Figure 1, B & C)2<\/sup><\/strong>\uff0c\u6b64\u5916\u5416\u5576\u916e\u8fd8\u662f\u5408\u6210\u751f\u7269\u6d3b\u6027\u6297\u764c\u836f\u7269(Figure 1, D)3<\/sup><\/strong>\u7684\u91cd\u8981\u524d\u4f53\u3002<\/p>\n

\u4f20\u7edf\u7684\u5416\u5576\u916e\u5408\u6210\u65b9\u6cd5<\/h4>\n

Sh\u016bKobayashi\u8bfe\u9898\u7ec4\u57282006\u5e74\u62a5\u9053\u4e86\u5408\u6210\u5416\u5576\u916e\u7684\u4e00\u79cd\u65b9\u6cd5\uff0c\u8be5\u65b9\u6cd5\u662f\u901a\u8fc7\u628a\u56e2\u7c07\u7684Pd\u56fa\u5b9a\u5728\u805a\u82ef\u4e59\u70ef\u4e0a\u4f5c\u4e3a\u50ac\u5316\u5242\uff0c\u8fd9\u79cd\u591a\u76f8\u50ac\u5316\u5242\u6d3b\u6027\u9ad8\u3001\u6613\u56de\u6536\uff0c\u4f46\u662f\u5408\u6210\u6b65\u9aa4\u8fc7\u4e8e\u7e41\u74104<\/sup><\/strong>\u3002<\/p>\n

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Anna M.Boguszewska-Chachulska\u8bfe\u9898\u7ec4\u57282010\u5e74\u4e5f\u62a5\u9053\u8fc7\u4e00\u79cd\u5408\u6210\u5416\u5576\u916e\u7684\u65b9\u6cd5\uff0c\u8be5\u65b9\u6cd5\u901a\u8fc7\u80fa\u57fa\u4e0e\u5364\u7d20\u7684\u4eb2\u6838\u53d6\u4ee3\uff0c\u7136\u540e\u5728POCl3<\/sub>\u548cCH3<\/sub>CN\u4f5c\u7528\u4e0b\u5173\u73af\u5f97\u5230\u5416\u5576\u916e\u884d\u751f\u72695<\/sup><\/strong>\u3002<\/p>\n

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<\/a><\/p>\n

O2<\/sub>\u4f5c\u6c27\u5316\u5242\uff0c\u50ac\u5316\u5242PdCl2<\/sub>\u80fd\u5f97\u523082%\u7684\u53ef\u89c2\u6536\u7387\uff0c\u66ff\u6362\u6210\u5176\u4ed6\u7684Pd\u50ac\u5316\u5242\u6548\u679c\u5747\u4e0d\u591f\u7406\u60f3(Entries 10-14)\uff0c\u968f\u540e\u8bfe\u9898\u7ec4\u4eba\u5458\u53c8\u5bf9\u5171\u50ac\u5316\u5242Cu\u8fdb\u884c\u4e86\u7b5b\u9009\u4f18\u5316\u540e\u53d1\u73b0Cu(OPiv)2<\/sub>\u5728\u6d3b\u6027\u4e0a\u8f83CuCl,CuBr,CuI,CuCN,CuO,Cu(OAc)2<\/sub>\u66f4\u4e3a\u7a81\u51fa\u3002<\/p>\n

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\u53c2\u8003\u6587\u732e<\/h4>\n
    \n
  1. Storch, E.; Kirchner, H. Eur. J. Immunol.\u00a0<\/em>1982<\/strong>, 12, 793.<\/li>\n
  2. Woo Chun, M.; Olmstead, K. K.; Choi, Y. S.; Lee, C. O.; Lee, C. K.; Kim, J.H.; Lee, J. Bioorg. Med. Chem. Lett<\/em>. 1997<\/strong>, 7, 789.<\/li>\n
  3. (a) Belmont, P.; Bosson, J.; Godet, T.; Tiano, M. Anti-Cancer Agents Med. Chem.\u00a0<\/em>2007<\/strong>, 7, 139. (b) Singh, P.; Kaur, P.; Kaur, S.\u00a0Bioorg. Med. Chem. <\/em>2009<\/strong>, 17, 2423.<\/li>\n
  4. Nishio, R.; Wessely, S.; Sugiura, M.; Kobayashi, S. J. Comb. Chem.\u00a0<\/em>2006<\/strong>, 8, 459.<\/li>\n
  5. Stankiewicz-Drogon, A.; D\u00f6rner, B.; Erker, T.;Boguszewska-Chachulska, A. M. J. Med. Chem.\u00a0<\/em>2010<\/strong>, 53, 3117.<\/li>\n<\/ol>\n

    \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"(\u5c0f\u7f16\u662f\u672c\u79d1\u751f\uff0c\u7b2c\u4e00\u6b21\u6295\u7a3f\uff0c\u6709\u7406\u89e3\u4e0d\u5230\u4f4d\u7684\u5730\u65b9\uff0c\u8bf7\u5927\u5bb6\u591a\u591a\u6307\u70b9\uff01) \u6982\u8981 \u96f7\u7231\u6587\u6559\u6388\u8bfe\u9898\u7ec4\u6700\u8fd1\u53d1\u5c55\u4e86\u4e00\u79cd\u9ad8\u6548\u7684Pd\/Cu\u5171\u50ac\u5316\u6c27\u5316\u4e8c\u82ef\u80fa\u7684\u4e24\u4e2aC(sp2)-H\u952e\u5f62\u6210\u7fb0\u57fa\u8fdb\u800c\u5408\u6210\u5416\u5576\u916e\u7684\u65b9\u6cd5\u3002\u8be5\u65b9\u6cd5\u5229\u7528\u6613\u5f97\u7684\u539f\u6599\uff0c\u6761\u4ef6\u6e29\u548c\uff0c\u901a\u8fc7\u9ad8\u6548\u548c\u539f\u5b50\u7ecf\u6d4e\u7684\u65b9\u5f0f\u5f97\u5230\u5416\u5576\u916e\u3002\u66f4\u503c\u4e00\u63d0\u7684\u662f\uff0c\u6b64\u53cd\u5e94\u5177\u6709\u4f18\u5f02\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u548c\u5e94\u7528\u4ef7\u503c\u3002 Palladium\/Copper Co-catalyzed Oxidative C\u2013H\/C\u2013H Carbonylation of Diphenylamines: A Way To Access Acridones.\u00a0Jiangwei Wen, Shan Tang, Fan Zhang, Renyi Shi, and Aiwen Lei*\u00a0Org. Lett., 2017,\u00a019, \u00a094\u201397.\u00a0DOI: 10.1021\/acs.orglett.6b03356 \u5416\u5576\u916e\u7684\u91cd\u8981\u7528\u9014\u53ca\u5408\u6210\u610f\u4e49 \u4f5c\u4e3a\u6700\u91cd\u8981\u7684\u6742\u73af\u5316\u5408\u7269\u4e4b\u4e00\uff0c\u5416\u5576\u916e\u5728\u67d3\u6599\u3001\u836f\u7269\u548c\u751f\u7269\u6750\u6599\u7b49\u9886\u57df\u7528\u9014\u6781\u5e7f\u3002\u6b64\u5916\uff0c\u5416\u5576\u916e\u8fd8\u662f\u5408\u6210\u542b\u6c2e\u5316\u5408\u7269\u7684\u7406\u60f3\u6a21\u5757\u3002 \u8fd9\u4e9b\u542b\u6c2e\u5316\u5408\u7269\u5305\u62ec\u6297\u75c5\u6bd2\u524210-CMA (Figure 1, A)1\u3001\u6297\u80bf\u7624\u836f\u7269Glyfoline\u548cAcronycine (Figure 1, B & C)2\uff0c\u6b64\u5916\u5416\u5576\u916e\u8fd8\u662f\u5408\u6210\u751f\u7269\u6d3b\u6027\u6297\u764c\u836f\u7269(Figure 1, D)3\u7684\u91cd\u8981\u524d\u4f53\u3002 \u4f20\u7edf\u7684\u5416\u5576\u916e\u5408\u6210\u65b9\u6cd5 Sh\u016bKobayashi\u8bfe\u9898\u7ec4\u57282006\u5e74\u62a5\u9053\u4e86\u5408\u6210\u5416\u5576\u916e\u7684\u4e00\u79cd\u65b9\u6cd5\uff0c\u8be5\u65b9\u6cd5\u662f\u901a\u8fc7\u628a\u56e2\u7c07\u7684Pd\u56fa\u5b9a\u5728\u805a\u82ef\u4e59\u70ef\u4e0a\u4f5c\u4e3a\u50ac\u5316\u5242\uff0c\u8fd9\u79cd\u591a\u76f8\u50ac\u5316\u5242\u6d3b\u6027\u9ad8\u3001\u6613\u56de\u6536\uff0c\u4f46\u662f\u5408\u6210\u6b65\u9aa4\u8fc7\u4e8e\u7e41\u74104\u3002 Anna M.Boguszewska-Chachulska\u8bfe\u9898\u7ec4\u57282010\u5e74\u4e5f\u62a5\u9053\u8fc7\u4e00\u79cd\u5408\u6210\u5416\u5576\u916e\u7684\u65b9\u6cd5\uff0c\u8be5\u65b9\u6cd5\u901a\u8fc7\u80fa\u57fa\u4e0e\u5364\u7d20\u7684\u4eb2\u6838\u53d6\u4ee3\uff0c\u7136\u540e\u5728POCl3\u548cCH3CN\u4f5c\u7528\u4e0b\u5173\u73af\u5f97\u5230\u5416\u5576\u916e\u884d\u751f\u72695\u3002 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CO\u4f5c\u4e3a\u7fb0\u57fa\u5316\u8bd5\u5242\uff0c\u5bf9\u53cd\u5e94\u7684\u50ac\u5316\u5242\u3001\u6c27\u5316\u5242\u3001\u6eb6\u5242\u3001\u6e29\u5ea6\u7b49\u53cd\u5e94\u6761\u4ef6\u8fdb\u884c\u4e86\u7b5b\u9009\u548c\u4f18\u5316\uff0c\u5e38\u89c1\u7684\u6eb6\u5242\u5982\u7532\u82ef\u3001DMF\u30011,4-\u4e8c\u6c27\u516d\u73af\u3001\u4e59\u9178\u3001DMA\u548cDMSO\u4e2d\uff0cDMSO\u6548\u679c\u6700\u4f73\u3002 O2\u4f5c\u6c27\u5316\u5242\uff0c\u50ac\u5316\u5242PdCl2\u80fd\u5f97\u523082%\u7684\u53ef\u89c2\u6536\u7387\uff0c\u66ff\u6362\u6210\u5176\u4ed6\u7684Pd\u50ac\u5316\u5242\u6548\u679c\u5747\u4e0d\u591f\u7406\u60f3(Entries 10-14)\uff0c\u968f\u540e\u8bfe\u9898\u7ec4\u4eba\u5458\u53c8\u5bf9\u5171\u50ac\u5316\u5242Cu\u8fdb\u884c\u4e86\u7b5b\u9009\u4f18\u5316\u540e\u53d1\u73b0Cu(OPiv)2\u5728\u6d3b\u6027\u4e0a\u8f83CuCl,CuBr,CuI,CuCN,CuO,Cu(OAc)2\u66f4\u4e3a\u7a81\u51fa\u3002 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\u53cd\u5e94\u673a\u7406\u6682\u65f6\u8fd8\u4e0d\u662f\u975e\u5e38\u6e05\u695a\uff0c\u5728\u73b0\u6709\u7684\u5b9e\u9a8c\u7ed3\u679c\u548c\u524d\u4eba\u7814\u7a76\u7684\u57fa\u7840\u4e0a\uff0c\u63d0\u51fa\u4e86\u4e0a\u56fe\u7684\u53cd\u5e94\u673a\u7406\u3002\u5927\u81f4\u8fc7\u7a0b\u53ef\u63cf\u8ff0\u4e3a\uff1aPdII\u7edc\u5408\u7269\u4e0e\u4e8c\u82ef\u80fa(1a)\u53cd\u5e94\u5f97\u5230\u4e2d\u95f4\u4f53I\uff0c\u4e2d\u95f4\u4f53I\u518d\u63a5\u7740\u4e0eCO\u53cd\u5e94\u5f62\u6210\u542b\u7fb0\u57fa\u7684\u4e2d\u95f4\u4f53II\uff0c\u968f\u540e\u7ecf\u5386\u4e00\u4e2a\u5206\u5b50\u5185\u53cd\u5e94\u548c\u8fd8\u539f\u6d88\u9664\u8fc7\u7a0b\u5f97\u5230\u5416\u5576\u916e(2a)\u548cPd0\uff0cPdII\u53ef\u4ee5\u901a\u8fc7CuII\u6c27\u5316Pd0\u518d\u751f\uff0c\u800cCuII\u53c8\u53ef\u4ee5\u901a\u8fc7DTBP\u6c27\u5316CuI\u518d\u751f\uff0c\u4ece\u800c\u5f62\u6210\u4e00\u4e2a\u5faa\u73af\u3002   \u7814\u7a76\u603b\u7ed3 \u96f7\u7231\u6587\u6559\u6388\u8bfe\u9898\u7ec4\u6700\u8fd1\u7684\u7814\u7a76\u6210\u679c\u63d0\u4f9b\u4e86\u4e00\u4e2a\u7b80\u4fbf\u3001\u9ad8\u6548\u3001\u539f\u5219\u7ecf\u6d4e\u578b\u9ad8\u7684\u5408\u6210\u5416\u5576\u916e\u7684\u65b9\u6cd5\uff0c\u6838\u5fc3\u662f\u6c27\u5316C-H\/C-H\u952e\u8fdb\u884c\u7fb0\u57fa\u5316\u3002\u5416\u5576\u916e\u53c8\u662f\u4e00\u7c7b\u6781\u5177\u5e94\u7528\u524d\u666f\uff0c\u5728\u5408\u6210\u4e0a\u4e5f\u5177\u6709\u91cd\u8981\u610f\u4e49\u7684\u5316\u5408\u7269\u3002   \u53c2\u8003\u6587\u732e Storch, E.; Kirchner, H. Eur. J. Immunol.\u00a01982, 12, 793. Woo Chun, M.; Olmstead, K. K.; Choi, Y. S.; Lee, C. O.; Lee, C. K.; Kim, J.H.; Lee, J. Bioorg. Med. Chem. Lett. 1997, 7, 789. 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