{"id":13147,"date":"2017-02-21T07:17:18","date_gmt":"2017-02-20T23:17:18","guid":{"rendered":"\/\/www.gsbet888.com\/?p=13147"},"modified":"2019-08-02T18:53:33","modified_gmt":"2019-08-02T10:53:33","slug":"crabtrees-catalyst","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2017\/02\/crabtrees-catalyst.html","title":{"rendered":"Crabtree\u2019s Catalyst"},"content":{"rendered":"<h4>\u6982\u8981<\/h4>\n[Ir(cod)(PCy<sub>3<\/sub>)(Py)]PF<sub>6<\/sub>\u88ab\u79f0\u4e3a<strong>Crabtree\u50ac\u5316\u5242<\/strong>\uff0c\u662f\u4e00\u79cd\u53d6\u7528\u5f88\u65b9\u4fbf\u7684\u79bb\u5b50\u578b\u914d\u4f53\u3002\u8be5\u50ac\u5316\u5242\u4f5c\u4e3a\u5747\u76f8\u8fd8\u539f\u50ac\u5316\u5242\u4f7f\u7528\uff0c\u7531\u8036\u9c81\u5927\u5b66\u7684Robert H. Crabtree\u5f00\u53d1\u3002<\/p>\n<p>\u8be5\u50ac\u5316\u5242\u7684\u4f18\u70b9\u662f\uff0c\u76f8\u6bd4\u4e8eWilkinson\u50ac\u5316\u5242\uff0c\u5bf9\u8fd8\u539f\u8f83\u56f0\u96be\u7684\u56db\u53d6\u4ee3\u7684\u70ef\u70c3\u4e5f\u80fd\u5b9e\u73b0\u5747\u76f8\u50ac\u5316\u8fd8\u539f\u3002\u540c\u65f6\u5982\u679c\u5e95\u7269\u4e2d\u542b\u6709\u5bfc\u5411\u57fa\u56e2\u7684\u8bdd\uff0c\u4e5f\u80fd\u8fdb\u884c\u5bfc\u5411\u6027\u7684\u9009\u62e9\u6027\u8fd8\u539f\u3002<\/p>\n<h4><\/h4>\n<h4>\u57fa\u672c\u6587\u732e<\/h4>\n<ul>\n<li>\u00a0Crabtree, R. H. <em>Acc. Chem. Res<\/em>.\u00a0<strong>1979<\/strong>, <em>12<\/em>, 331. doi:<a href=\"http:\/\/dx.doi.org\/10.1021\/ar50141a005\">10.1021\/ar50141a005<\/a><\/li>\n<li>\u00a0Crabtree, R. H. Davis, M. W. <em>J. Org. Chem.<\/em> <strong>1986<\/strong>,\u00a0<em>51<\/em>, 2655. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/jo00364a007\">10.1021\/jo00364a007<\/a><\/li>\n<\/ul>\n<p>&lt;Review of Directed Hydrogenation&gt;<\/p>\n<ul>\n<li>\u00a0Brown, J. M. <em>Angew. Chem. Int. Ed.<\/em> <strong>1987<\/strong>,\u00a0<em>26<\/em>, 190. doi:<a href=\"http:\/\/dx.doi.org\/10.1002\/anie.198701901\">10.1002\/anie.198701901<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h4>\u53cd\u5e94\u5b9e\u4f8b<\/h4>\n<p>\u6d3b\u6027\u9ad8\uff0c\u5bf9\u4e8e\u56db\u53d6\u4ee3\u7684\u70ef\u70c3\u4e5f\u80fd\u5747\u76f8\u50ac\u5316\u8fd8\u539f\u662f\u5176\u4e00\u5927\u7279\u70b9\u3002<\/p>\n<p>(-)-Calyciphylline N\u7684\u5408\u6210[1]: \u53cd\u5e94\u4e2d\u4f7f\u7528\u4e86\u542b\u6709\u914d\u4f4d\u6027\u66f4\u4f4e\u7684BARF\u9634\u79bb\u5b50\u4f46\u662f\u6d3b\u6027\u66f4\u5f3a\u7684\u50ac\u5316\u5242[2]\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-13149 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/02\/crabtree_cat_3.png\" width=\"481\" height=\"135\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/02\/crabtree_cat_3.png 481w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/02\/crabtree_cat_3-300x84.png 300w\" sizes=\"(max-width: 481px) 100vw, 481px\" \/><\/p>\n<p>\u7f9f\u57fa\u4f5c\u4e3a\u5bfc\u5411\u57fa\u56e2\u7684\u9009\u62e9\u6027\u8fd8\u539f\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-13150 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/02\/crabtree_cat_4.gif\" width=\"296\" height=\"128\" \/><\/p>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n[1] Shvartsbart, A.; Smith, A. B., III <em>J. Am. Chem. Soc. <\/em><strong>2014<\/strong>,\u00a0<em>136<\/em>, 870. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/ja411539w\">10.1021\/ja411539w<br \/>\n<\/a>[2] Wustenberg, B.; Pfaltz, A. <em>Adv. Synth. Catal.<\/em> <strong>2008<\/strong>,\u00a0<em>350<\/em>, 174. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1002\/adsc.200700438\">10.1002\/adsc.200700438<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 [Ir(cod)(PCy3)(Py)]PF6\u88ab\u79f0\u4e3aCrabtree\u50ac\u5316\u5242\uff0c\u662f\u4e00\u79cd\u53d6\u7528\u5f88\u65b9\u4fbf\u7684\u79bb\u5b50\u578b\u914d\u4f53\u3002\u8be5\u50ac\u5316\u5242\u4f5c\u4e3a\u5747\u76f8\u8fd8\u539f\u50ac\u5316\u5242\u4f7f\u7528\uff0c\u7531\u8036\u9c81\u5927\u5b66\u7684Robert H. Crabtree\u5f00\u53d1\u3002 \u8be5\u50ac\u5316\u5242\u7684\u4f18\u70b9\u662f\uff0c\u76f8\u6bd4\u4e8eWilkinson\u50ac\u5316\u5242\uff0c\u5bf9\u8fd8\u539f\u8f83\u56f0\u96be\u7684\u56db\u53d6\u4ee3\u7684\u70ef\u70c3\u4e5f\u80fd\u5b9e\u73b0\u5747\u76f8\u50ac\u5316\u8fd8\u539f\u3002\u540c\u65f6\u5982\u679c\u5e95\u7269\u4e2d\u542b\u6709\u5bfc\u5411\u57fa\u56e2\u7684\u8bdd\uff0c\u4e5f\u80fd\u8fdb\u884c\u5bfc\u5411\u6027\u7684\u9009\u62e9\u6027\u8fd8\u539f\u3002 \u57fa\u672c\u6587\u732e \u00a0Crabtree, R. H. Acc. Chem. Res.\u00a01979, 12, 331. doi:10.1021\/ar50141a005 \u00a0Crabtree, R. H. Davis, M. W. J. Org. Chem. 1986,\u00a051, 2655. DOI: 10.1021\/jo00364a007 &lt;Review of Directed Hydrogenation&gt; \u00a0Brown, J. M. Angew. Chem. Int. Ed. 1987,\u00a026, 190. doi:10.1002\/anie.198701901 &nbsp; \u53cd\u5e94\u5b9e\u4f8b \u6d3b\u6027\u9ad8\uff0c\u5bf9\u4e8e\u56db\u53d6\u4ee3\u7684\u70ef\u70c3\u4e5f\u80fd\u5747\u76f8\u50ac\u5316\u8fd8\u539f\u662f\u5176\u4e00\u5927\u7279\u70b9\u3002 (-)-Calyciphylline N\u7684\u5408\u6210[1]: \u53cd\u5e94\u4e2d\u4f7f\u7528\u4e86\u542b\u6709\u914d\u4f4d\u6027\u66f4\u4f4e\u7684BARF\u9634\u79bb\u5b50\u4f46\u662f\u6d3b\u6027\u66f4\u5f3a\u7684\u50ac\u5316\u5242[2]\u3002 \u7f9f\u57fa\u4f5c\u4e3a\u5bfc\u5411\u57fa\u56e2\u7684\u9009\u62e9\u6027\u8fd8\u539f\u3002 \u53c2\u8003\u6587\u732e [1] Shvartsbart, A.; Smith, A. B., III J. Am. Chem. Soc. 2014,\u00a0136, 870. DOI:\u00a010.1021\/ja411539w [2] Wustenberg, B.; Pfaltz, A. Adv. Synth. Catal. 2008,\u00a0350, 174. DOI:\u00a010.1002\/adsc.200700438 &nbsp; \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01","protected":false},"author":5,"featured_media":13148,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2,91],"tags":[481,1713],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/02\/2014-11-27_16-06-18.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-3q3","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/13147"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=13147"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/13147\/revisions"}],"predecessor-version":[{"id":27502,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/13147\/revisions\/27502"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/13148"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=13147"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=13147"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=13147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}