{"id":13593,"date":"2017-05-16T08:39:31","date_gmt":"2017-05-16T00:39:31","guid":{"rendered":"\/\/www.gsbet888.com\/?p=13593"},"modified":"2019-08-02T18:53:24","modified_gmt":"2019-08-02T10:53:24","slug":"conia-dauben-wittig-%e7%83%af%e5%9f%ba%e5%8c%96","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2017\/05\/conia-dauben-wittig-%e7%83%af%e5%9f%ba%e5%8c%96.html","title":{"rendered":"Conia-Dauben-Wittig \u70ef\u57fa\u5316"},"content":{"rendered":"

\u6982\u8981<\/strong><\/p>\n

Conia-Dauben-Wittig \u70ef\u57fa\u5316\u662f\u7fb0\u57fa\u5316\u5408\u7269\u5728\u620a\u9187\u94a0\uff08\u5e38\u7528\u53d4\u620a\u9187\u94a0\u4e0e\u6b63\u620a\u9187\u94a0\uff0c\u5728\u53cd\u5e94\u8fc7\u7a0b\u4e2d\uff0c\u901a\u5e38\u7531\u91d1\u5c5e\u94a0\u4e0e\u620a\u9187\u539f\u4f4d\u4ea7\u751f\uff09\u6761\u4ef6\u4e0b\uff0c\u78f7ylid \u4e0e\u7fb0\u57fa\u5316\u5408\u7269\u4f5c\u7528\uff0c\u751f\u6210\u76f8\u5e94\u70ef\u57fa\u5316\u5408\u7269\u7684\u53cd\u5e94\u3002\u8be5\u53cd\u5e94\u6761\u4ef6\u9002\u7528\u4e8e\u4f4d\u963b\u8f83\u5927\u53ca\u6613\u70ef\u9187\u5316\u7684\u7fb0\u57fa\u5316\u5408\u7269\u5982\u916e\u9178\u7b49\u5e95\u7269\u7684\u70ef\u57fa\u5316\u3002<\/p>\n

\u57fa\u672c\u6587\u732e<\/strong><\/h4>\n[1] J.M. Conia, J.C. Limasset, Bull. Soc. Chim. Fr., 1967, 6, 1936.
\n[2] W.G., Dauben, D.M. Walker, J. Org. Chem., 1981, 46, 1103. doi:
\n10.1021\/jo00319a013.<\/p>\n

\u53cd\u5e94\u673a\u7406<\/strong><\/h4>\n

\"\"<\/a><\/p>\n

\u7531\u4e8e\u4f4d\u963b\u8f83\u5927\u53ca\u6613\u70ef\u9187\u5316\u7684\u7fb0\u57fa\u5e95\u7269\u5b58\u5728\u65f6\uff0c\u56e0\u4e3a\u78b3\u4eb2\u6838\u8bd5\u5242ylid \u8f83\u5f3a\u7684\u78b1\u6027\uff0c\u4f7f\u8fd9\u7c7b\u5e95\u7269\u6781\u6613\u53d1\u751f\u53bb\u8d28\u5b50\u5316\uff0c\u751f\u6210\u76f8\u5e94\u7684\u70ef\u9187\u8d1f\u79bb\u5b50\uff0c\u4ece\u800c\u65e0\u6cd5\u8fdb\u884c\u540e\u7eed\u7684\u70ef\u57fa\u5316\u53cd\u5e94\u3002\u800c\u91c7\u7528\u620a\u9187\u94a0\u4f5c\u4e3a\u78b1\u65f6\uff0c\u7531\u4e8e\u5176\u78b1\u6027\uff08\u4e0e\u78b3\u4eb2\u6838\u8bd5\u5242\u76f8\u6bd4\uff09\u8f83\u5f31\uff0c\u56e0\u6b64\uff0c\u5728\u53bb\u8d28\u5b50\u5316\u540e\uff0c\u4ea7\u751f\u7684\u70ef\u9187\u8d1f\u79bb\u5b50\u53ef\u91cd\u65b0\u8d28\u5b50\u5316\uff0c\u6062\u590d\u539f\u6765\u7684\u916e\u5f0f\u7ed3\u6784\u3002\u5373\u53bb\u8d28\u5b50\u5316\u4e0e\u70ef\u9187\u5316\u4e4b\u95f4\u5b58\u5728\u53ef\u9006\u5e73\u8861\u3002\u4ece\u800c\u4f7f\u53cd\u5e94\u4f53\u7cfb\u4e2d\u4e00\u76f4\u5b58\u5728\u4e00\u90e8\u5206\u6e38\u79bb\u7684\u916e\u7fb0\u57fa\u7ed3\u6784\uff0c\u53ef\u4ee5\u8fdb\u4e00\u6b65\u53c2\u4e0e\u540e\u7eed\u7684\u70ef\u57fa\u5316\u53cd\u5e94\u3002\u56e0\u800c\uff0cConia-Dauben-Wittig \u70ef\u57fa\u5316\u6761\u4ef6\u6210\u529f\u89e3\u51b3\u4e86\u6613\u70ef\u9187\u5316\u7684\u5e95\u7269\u7684\u70ef\u57fa\u5316\u53cd\u5e94\u3002<\/p>\n

\u53cd\u5e94\u5b9e\u4f8b<\/strong><\/h4>\n

\u73af\u4e19\u57fa\u7532\u919b\u7684\u70ef\u5316[1]\n

\"\"<\/a><\/p>\n

epiisocomene \u7684\u5168\u5408\u6210[2]\n

\"\"<\/a><\/p>\n

\u5b9e\u9a8c\u6b65\u9aa4<\/strong><\/h4>\n

\u5c06\u6eb4\u5316\u7532\u57fa\u4e09\u82ef\u57fa\u93fb\uff082eq\uff09\u60ac\u6d6e\u5728\u5e72\u71e5\u7684\u5747\u4e09\u7532\u82ef\u4e2d\uff0c\u52a0\u5165\u65b0\u5236\u76841-\u620a\u9187\u94a0\uff082M,0.6eq\uff09\u6eb6\u6db2\u3002\u5c06\u6240\u5f97\u5747\u76f8\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\u6405\u62cc30min\uff0c\u518d\u7f13\u6162\u52a0\u5165\u73af\u4e19\u57fa\u7532\u919b\uff081eq\uff09\u7684\u5747\u4e09\u7532\u82ef\uff0810 mL\uff09\u6eb6\u6db2\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u5728\u6c29\u6c14\u6c14\u6c1b\u4e0b\u56de\u6d412h\uff0c\u5c06\u53cd\u5e94\u6db2\u51b7\u5374\uff0c\u5728\u53cd\u5e94\u74f6\u4e0a\u5b89\u88c540cm \u7684Vigreux \u5206\u998f\u67f1\u3001\u84b8\u998f\u5934\u53ca\u6e29\u5ea6\u8ba1\uff0c\u5e76\u5c06\u7a7a\u6c14\u51b7\u51dd\u7ba1\u4e0e\u63a5\u6536\u74f6\uff08\u6d78\u6ca1\u5728\u5e72\u51b0-\u4e19\u916e\u6d74\u4e2d\uff09\u8fde\u63a5\u3002\u518d\u6b21\u5bf9\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u8fdb\u884c\u52a0\u70ed\uff0c\u5f53\u84b8\u998f\u6e29\u5ea6\u9ad8\u4e8e38oC \u65f6\uff0c\u5f00\u59cb\u6536\u96c6\u998f\u5206\uff0c\u7ea61h \u540e\uff08\u84b8\u998f\u65f6\u95f4\u8d85\u8fc71h \u540e\uff0c\u4f1a\u6709\u5747\u4e09\u7532\u82ef\u4e0e1-\u620a\u9187\u84b8\u51fa\uff09\uff0c\u6e29\u5ea6\u8fbe\u523039.5oC\uff0c\u505c\u6b62\u6536\u96c6\u998f\u5206\uff0c\u83b7\u5f97\u6700\u7ec8\u76ee\u6807\u4ea7\u7269\u3002<\/p>\n

\u5b9e\u9a8c\u6280\u5de7<\/strong><\/h4>\n

\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n[1]T. Tsunoda, T. Hudlicky, Synlett, 1990, 322. doi: 10.1055\/s-1990-21077.
\n[2] B.C. Ranu, M. Kavka, L.A. Higgs, T. Hudlicky, Tetrahedron Lett, 1984, 25, 2447.
\ndoi: 10.1016\/S0040-4039(01)81201-6.<\/p>\n

 <\/p>\n

\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 Conia-Dauben-Wittig \u70ef\u57fa\u5316\u662f\u7fb0\u57fa\u5316\u5408\u7269\u5728\u620a\u9187\u94a0\uff08\u5e38\u7528\u53d4\u620a\u9187\u94a0\u4e0e\u6b63\u620a\u9187\u94a0\uff0c\u5728\u53cd\u5e94\u8fc7\u7a0b\u4e2d\uff0c\u901a\u5e38\u7531\u91d1\u5c5e\u94a0\u4e0e\u620a\u9187\u539f\u4f4d\u4ea7\u751f\uff09\u6761\u4ef6\u4e0b\uff0c\u78f7ylid \u4e0e\u7fb0\u57fa\u5316\u5408\u7269\u4f5c\u7528\uff0c\u751f\u6210\u76f8\u5e94\u70ef\u57fa\u5316\u5408\u7269\u7684\u53cd\u5e94\u3002\u8be5\u53cd\u5e94\u6761\u4ef6\u9002\u7528\u4e8e\u4f4d\u963b\u8f83\u5927\u53ca\u6613\u70ef\u9187\u5316\u7684\u7fb0\u57fa\u5316\u5408\u7269\u5982\u916e\u9178\u7b49\u5e95\u7269\u7684\u70ef\u57fa\u5316\u3002 \u57fa\u672c\u6587\u732e [1] J.M. Conia, J.C. Limasset, Bull. Soc. Chim. Fr., 1967, 6, 1936. [2] W.G., Dauben, D.M. Walker, J. Org. Chem., 1981, 46, 1103. doi: 10.1021\/jo00319a013. \u53cd\u5e94\u673a\u7406 \u7531\u4e8e\u4f4d\u963b\u8f83\u5927\u53ca\u6613\u70ef\u9187\u5316\u7684\u7fb0\u57fa\u5e95\u7269\u5b58\u5728\u65f6\uff0c\u56e0\u4e3a\u78b3\u4eb2\u6838\u8bd5\u5242ylid \u8f83\u5f3a\u7684\u78b1\u6027\uff0c\u4f7f\u8fd9\u7c7b\u5e95\u7269\u6781\u6613\u53d1\u751f\u53bb\u8d28\u5b50\u5316\uff0c\u751f\u6210\u76f8\u5e94\u7684\u70ef\u9187\u8d1f\u79bb\u5b50\uff0c\u4ece\u800c\u65e0\u6cd5\u8fdb\u884c\u540e\u7eed\u7684\u70ef\u57fa\u5316\u53cd\u5e94\u3002\u800c\u91c7\u7528\u620a\u9187\u94a0\u4f5c\u4e3a\u78b1\u65f6\uff0c\u7531\u4e8e\u5176\u78b1\u6027\uff08\u4e0e\u78b3\u4eb2\u6838\u8bd5\u5242\u76f8\u6bd4\uff09\u8f83\u5f31\uff0c\u56e0\u6b64\uff0c\u5728\u53bb\u8d28\u5b50\u5316\u540e\uff0c\u4ea7\u751f\u7684\u70ef\u9187\u8d1f\u79bb\u5b50\u53ef\u91cd\u65b0\u8d28\u5b50\u5316\uff0c\u6062\u590d\u539f\u6765\u7684\u916e\u5f0f\u7ed3\u6784\u3002\u5373\u53bb\u8d28\u5b50\u5316\u4e0e\u70ef\u9187\u5316\u4e4b\u95f4\u5b58\u5728\u53ef\u9006\u5e73\u8861\u3002\u4ece\u800c\u4f7f\u53cd\u5e94\u4f53\u7cfb\u4e2d\u4e00\u76f4\u5b58\u5728\u4e00\u90e8\u5206\u6e38\u79bb\u7684\u916e\u7fb0\u57fa\u7ed3\u6784\uff0c\u53ef\u4ee5\u8fdb\u4e00\u6b65\u53c2\u4e0e\u540e\u7eed\u7684\u70ef\u57fa\u5316\u53cd\u5e94\u3002\u56e0\u800c\uff0cConia-Dauben-Wittig \u70ef\u57fa\u5316\u6761\u4ef6\u6210\u529f\u89e3\u51b3\u4e86\u6613\u70ef\u9187\u5316\u7684\u5e95\u7269\u7684\u70ef\u57fa\u5316\u53cd\u5e94\u3002 \u53cd\u5e94\u5b9e\u4f8b \u73af\u4e19\u57fa\u7532\u919b\u7684\u70ef\u5316[1] epiisocomene \u7684\u5168\u5408\u6210[2] \u5b9e\u9a8c\u6b65\u9aa4 \u5c06\u6eb4\u5316\u7532\u57fa\u4e09\u82ef\u57fa\u93fb\uff082eq\uff09\u60ac\u6d6e\u5728\u5e72\u71e5\u7684\u5747\u4e09\u7532\u82ef\u4e2d\uff0c\u52a0\u5165\u65b0\u5236\u76841-\u620a\u9187\u94a0\uff082M,0.6eq\uff09\u6eb6\u6db2\u3002\u5c06\u6240\u5f97\u5747\u76f8\u6df7\u5408\u7269\u5728\u5ba4\u6e29\u4e0b\u6405\u62cc30min\uff0c\u518d\u7f13\u6162\u52a0\u5165\u73af\u4e19\u57fa\u7532\u919b\uff081eq\uff09\u7684\u5747\u4e09\u7532\u82ef\uff0810 mL\uff09\u6eb6\u6db2\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u5728\u6c29\u6c14\u6c14\u6c1b\u4e0b\u56de\u6d412h\uff0c\u5c06\u53cd\u5e94\u6db2\u51b7\u5374\uff0c\u5728\u53cd\u5e94\u74f6\u4e0a\u5b89\u88c540cm \u7684Vigreux \u5206\u998f\u67f1\u3001\u84b8\u998f\u5934\u53ca\u6e29\u5ea6\u8ba1\uff0c\u5e76\u5c06\u7a7a\u6c14\u51b7\u51dd\u7ba1\u4e0e\u63a5\u6536\u74f6\uff08\u6d78\u6ca1\u5728\u5e72\u51b0-\u4e19\u916e\u6d74\u4e2d\uff09\u8fde\u63a5\u3002\u518d\u6b21\u5bf9\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u8fdb\u884c\u52a0\u70ed\uff0c\u5f53\u84b8\u998f\u6e29\u5ea6\u9ad8\u4e8e38oC \u65f6\uff0c\u5f00\u59cb\u6536\u96c6\u998f\u5206\uff0c\u7ea61h \u540e\uff08\u84b8\u998f\u65f6\u95f4\u8d85\u8fc71h \u540e\uff0c\u4f1a\u6709\u5747\u4e09\u7532\u82ef\u4e0e1-\u620a\u9187\u84b8\u51fa\uff09\uff0c\u6e29\u5ea6\u8fbe\u523039.5oC\uff0c\u505c\u6b62\u6536\u96c6\u998f\u5206\uff0c\u83b7\u5f97\u6700\u7ec8\u76ee\u6807\u4ea7\u7269\u3002 \u5b9e\u9a8c\u6280\u5de7 \u53c2\u8003\u6587\u732e [1]T. Tsunoda, T. Hudlicky, Synlett, 1990, 322. doi: 10.1055\/s-1990-21077. [2] B.C. Ranu, M. Kavka, L.A. Higgs, T. 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