{"id":13903,"date":"2017-04-28T08:43:32","date_gmt":"2017-04-28T00:43:32","guid":{"rendered":"\/\/www.gsbet888.com\/?p=13903"},"modified":"2019-08-02T18:53:18","modified_gmt":"2019-08-02T10:53:18","slug":"lorcaserin-belviq-%e6%b2%bb%e7%96%97%e8%82%a5%e8%83%96%e7%9a%84%e4%b8%80%e7%a7%8d%e8%8d%af%e7%89%a9","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/molecule\/2017\/04\/lorcaserin-belviq-%e6%b2%bb%e7%96%97%e8%82%a5%e8%83%96%e7%9a%84%e4%b8%80%e7%a7%8d%e8%8d%af%e7%89%a9.html","title":{"rendered":"Lorcaserin (Belviq)\u2014\u6cbb\u7597\u80a5\u80d6\u7684\u4e00\u79cd\u836f\u7269"},"content":{"rendered":"
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\u56fe1\uff1a\u4e0a\u4e16\u7eaa70\u5e74\u4ee3\u66fe\u4e0a\u5e02\u7684\u67d0\u4e9b\u6cbb\u7597\u80a5\u80d6\u7684\u836f\u7269<\/p><\/div>\n <\/p>\n \u8fd1\u5e74\u6765\uff0c\u6cbb\u7597\u80a5\u80d6\u7c7b\u836f\u7269\u7684\u7814\u7a76\u53d6\u5f97\u4e00\u4e9b\u91cd\u5927\u8fdb\u5c55\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u836f\u7269\u5f97\u5230\u6279\u51c6\u751f\u4ea7\uff0c\u5e94\u7528\u4e0a\u4e5f\u53d6\u5f97\u4e86\u4e0d\u9519\u7684\u6548\u679c\u3002\u672c\u6587\u5c06\u5bf9\u5176\u4e2d\u7684\u4e00\u79cd\u836f\u7269Lorcaserin\uff08\u4e0b\u56fe\u6240\u793a\uff09\u8fdb\u884c\u8f83\u4e3a\u8be6\u7ec6\u4ecb\u7ecd\u3002<\/p>\n \u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u670d\u7528\u836f\u7269\u51cf\u91cd\u5e73\u5747\u7ea6\u4e3a5.5 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Lorcaserin\u786e\u5207\u7684\u836f\u7406\u4f5c\u7528\u5c1a\u672a\u5b8c\u5168\u5f04\u6e05\u695a\uff0c\u4f46\u5df2\u7ecf\u786e\u5b9a\u7684\u662f\u5b83\u53ef\u6709\u6548\u5730\u4f5c\u4e3a\u4e2d\u67a25-\u7f9f\u8272\u80fa\u4e9a\u578b2C\u53d7\u4f53\u7684\u6fc0\u52a8\u5242\u3002\u76ee\u524d\u5df2\u786e\u5b9a\u670914\u79cd\u53d7\u4f53\u4e9a\u578b\u5c5e\u4e8e5-HT\u53d7\u4f53\u578b\uff0c\u800cLorcaserin\u5c31\u5c5e\u4e8e5-HT2<\/sub>\u53d7\u4f53\u578b\u7684\u6fc0\u52a8\u5242\uff0c\u5b83\u5bf95HT2C<\/sub>\u53d7\u4f53\u7684\u9009\u62e9\u6027\u9ad8\u4e8e5-HT2A<\/sub>\u548c5-HT2B<\/sub>\u53d7\u4f53\u3002\u7531\u4e8e\u5176\u4ed6\u7c7b\u578b\u7684\u53d7\u4f53\u4f1a\u5f71\u54cd\u5fc3\u810f\u74e3\u819c\uff0c\u5bf9\u4eba\u4f53\u9020\u6210\u635f\u5bb3\uff0c\u56e0\u800c\u8fd9\u79cd\u9009\u62e9\u6027\u5bf9\u4e8eLorcaserin\u7684\u5b89\u5168\u6027\u81f3\u5173\u91cd\u8981\u3002\u5f535-HT2C<\/sub>\u53d7\u4f53\u88ab\u6fc0\u6d3b\u65f6\uff0c\u53ef\u51cf\u5c11\u670d\u836f\u8005\u7684\u98df\u7269\u6444\u5165\u548c\u70ed\u91cf\u5438\u6536\uff0c\u4ece\u800c\u8fbe\u5230\u51cf\u80a5\u7684\u76ee\u7684[3,6]<\/sup>\u3002\u5728\u836f\u7269\u5e2e\u52a9\u7684\u540c\u65f6\uff0c\u5982\u679c\u80fd\u517b\u6210\u5065\u5eb7\u7684\u751f\u6d3b\u65b9\u5f0f\uff0c\u51cf\u91cd\u6548\u679c\u4f1a\u66f4\u597d\u3002<\/p>\n <\/p>\n Lorcaserin\u7684\u5408\u6210\u53ef\u4ee5\u6709\u4e24\u79cd\u65b9\u6cd5\uff0c\u5176\u4e00\u662f\u5229\u7528\u5206\u5b50\u5185\u7684Heck\u53cd\u5e94\u3002\u9996\u5148\u5229\u7528\u4e09\u6c1f\u4e59\u9178\u9150\u4fdd\u62a4\u80fa\u57fa\u5f97\u5230\u5316\u5408\u72692<\/em><\/strong>\uff0c\u7898\u4ee3\u5f97\u5316\u5408\u72693<\/em><\/strong>\uff0c\u5229\u7528\u70ef\u4e19\u57fa\u6eb4\u5bf9\u80fa\u8fdb\u884c\u70c3\u57fa\u5316\uff0c\u5316\u5408\u72694<\/em><\/strong>\u52305<\/em><\/strong>\u901a\u8fc7\u5206\u5b50\u5185\u7684Heck\u53cd\u5e94\u5b8c\u6210\uff0c\u50ac\u5316\u52a0\u6c22\u8fd8\u539f\u53cc\u952e\u540e\u53bb\u4fdd\u62a4\u5373\u53ef\u5f97\u5230\u4e24\u79cd\u5bf9\u6620\u4f531:1\u7684\u6df7\u5408\u7269\u3002\u5229\u7528\u624b\u6027HPLC\u5206\u79bb\u5f97\u5230\u5355\u4e00\u6784\u578b\u7684R\u5f02\u6784\u4f53[7,8]<\/sup>\u3002\u7531\u4e8e\u73af\u5316\u524d\u4f534<\/em><\/strong>\u8f83\u6613\u5236\u5907\uff0c\u5e76\u4e14\u901a\u8fc7Heck\u53cd\u5e94\u5173\u73af\u6761\u4ef6\u8f83\u4e3a\u6e29\u548c\uff0c\u56e0\u800c\u66f4\u9002\u5408\u5728\u5b9e\u9a8c\u5ba4\u8fdb\u884c\u3002<\/p>\n \u56fe2\uff1a\u5206\u5b50\u5185Heck\u53cd\u5e94\u5408\u6210Lorcaserin<\/p><\/div>\n <\/p>\n \u5229\u7528Friedel-Crafts\u53cd\u5e94\u8fdb\u884c\u5408\u6210\u65f6\uff0c\u8d77\u59cb\u539f\u6599\u4e0e\u4e0a\u4e00\u8def\u7ebf\u76f8\u540c\uff0c\u9996\u5148\u901a\u8fc7-\u5364\u4ee3\u9170\u6c2f\u5bf9\u80fa\u8fdb\u884c\u9170\u57fa\u5316\u5f97\u5230\u4e2d\u95f4\u4f532<\/em><\/strong>\uff0c\u8fd9\u65f6\u6709\u4e24\u6761\u8def\u5f84\u53ef\u4f9b\u9009\u62e9\uff0c\u53ef\u4ee5\u5148\u8fd8\u539f\u7fb0\u57fa\u518d\u8fdb\u884c\u70f7\u57fa\u5316\uff0c\u4e5f\u53ef\u4ee5\u4fdd\u7559\u7fb0\u57fa\uff0c\u5173\u73af\u4e4b\u540e\u518d\u8fdb\u884c\u8fd8\u539f\u3002\u5b9e\u9a8c\u8bc1\u660e\uff0c\u7531\u5316\u5408\u72693<\/em><\/strong>\u5230\u5316\u5408\u72695<\/em><\/strong>\u7684\u8def\u5f84\u66f4\u597d[7,8]<\/sup>\u3002<\/p>\n<\/a>
<\/a><\/p>\n
\u4e8c\u3001\u836f\u7406\u4f5c\u7528<\/h4>\n
\u4e09\u3001\u5408\u6210\u8def\u7ebf<\/h4>\n
<\/a>