{"id":14043,"date":"2017-05-24T15:21:30","date_gmt":"2017-05-24T07:21:30","guid":{"rendered":"\/\/www.gsbet888.com\/?p=14043"},"modified":"2019-08-02T18:53:14","modified_gmt":"2019-08-02T10:53:14","slug":"%e5%88%9a%e6%80%a7%e7%8e%af%e7%8a%b6%e5%a4%9a%e8%82%bd%e7%9a%84%e5%90%88%e6%88%90%e6%b3%95-%e3%80%8c%e6%81%b6%e5%94%91%e5%ab%81%e6%8e%a5%e6%b3%95%e3%80%8d","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2017\/05\/%e5%88%9a%e6%80%a7%e7%8e%af%e7%8a%b6%e5%a4%9a%e8%82%bd%e7%9a%84%e5%90%88%e6%88%90%e6%b3%95-%e3%80%8c%e6%81%b6%e5%94%91%e5%ab%81%e6%8e%a5%e6%b3%95%e3%80%8d.html","title":{"rendered":"\u521a\u6027\u73af\u72b6\u591a\u80bd\u7684\u5408\u6210\u6cd5-\u300c\u6076\u5511\u5ac1\u63a5\u6cd5\u300d"},"content":{"rendered":"
\u591a\u4f26\u591a\u5927\u5b66\u30fbAndrei Yudin<\/a>\u7b49\u4eba\u3001\u901a\u8fc71,3,4-\u6076\u4e8c\u5511\uff08odz\uff09\u5b9e\u73b0\u5bf9\u94fe\u72b6\u591a\u80bd\u7684\u4e24\u7aef\u7684\u73af\u5316\u8fde\u63a5\uff0c\u5355\u6b65\u5408\u6210\u4e86\u5927\u73af\u591a\u80bd\u5206\u5b50\u3002\u5f15\u5165\u7684oda\u5e73\u9762\u6027\u7ed3\u6784\u53ef\u4ee5\u7a33\u5b9a\u73af\u72b6\u591a\u80bd\u7684\u5206\u5b50\u5185\u6c22\u952e\uff0c\u8fd9\u6837\u6709\u5229\u4e8e\u4fc3\u6210\u521a\u6027\u7684\u8f6c\u89d2\u7ed3\u6784\uff0c\u4ece\u800c\u5229\u4e8e\u5408\u6210\u9ad8\u819c\u6e17\u900f\u6027\u7684\u591a\u80bd\u5316\u5408\u7269\u3002<\/b><\/p>\n \u201cOxazole grafts in peptide macrocycles\u201d \u5927\u73af\u72b6\u7684\u591a\u80bd\u7531\u4e8e\u5176size\u6bd4\u8f83\u5927\uff0c\u7ed3\u6784\u4e5f\u5f88\u590d\u6742\uff0c\u5408\u6210\u56f0\u96be\uff0c\u4f46\u662f\u5176\u8fd8\u6709\u6297\u86cb\u767d\u9176\u7684\u7279\u6027\uff0c\u80fd\u4f5c\u4e3a\u86cb\u767d\u8d28 – 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odz\u73af\u5316\u7684[PGLGF]\u4ea7\u7269\u4e2d\uff0cGly2-NH\u4e0ePhe5-NH\u4e4b\u95f4\u5f62\u6210\u4e86\u6c22\u952e\uff0c\u5e76\u4e14\u4f5c\u8005\u8ba4\u4e3a\u5f62\u6210\u6c22\u952e\u540e\u7684\u4ea7\u7269\u62e5\u6709\u5355\u4e00\u914d\u4f4d\u6784\u8c61\u3002\u53cd\u5e94\u8bd5\u5242\u919b\u7684\u78b3\u5728\u751f\u6210\u4ea7\u7269\u4e2d\u662f\u4e00\u4e2a\u624b\u6027\u70b9\uff0c\u56e0\u6b64\u53ef\u4ee5\u5f62\u6210\u975e\u5bf9\u6620\u5f02\u6784\u4ea7\u7269\uff0c\u800c\u4f5c\u8005\u53d1\u73b0\u975e\u5bf9\u6620\u5f02\u6784\u4f53\u4e4b\u95f4\u5177\u6709\u540c\u6837\u7684\u6c22\u952e\u7ed3\u5408\u6784\u578b\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u7528\u4e8e\u6bd4\u8f83\u5408\u6210\u7684\uff0c\u4e0d\u4f7f\u7528odz\uff0c\u5355\u7eaf\u7684\u9170\u80fa\u73af\u5316\u4f53cyclo[PGLGFA]\uff0c\u53ea\u6709\u5728Leu3-NH\u4e0a\u89c2\u6d4b\u5230\u4e86\u6c22\u952e\u7684\u5b58\u5728\uff0c\u5e76\u4e14\u4f34\u6709\u591a\u4e2a\u914d\u4f4d\u73b0\u8c61\u7684\u4ea7\u751f\u3002\u5373\u4f7f\u6539\u53d8\u591a\u80bd\u7684\u6c28\u57fa\u9178\u6392\u5217\u987a\u5e8f\uff0c\u4e5f\u80fd\u5f97\u5230\u76f8\u4f3c\u7684\u7ed3\u8bba\uff0c\u56e0\u6b64\u4f5c\u8005\u8ba4\u4e3a\u8fd9\u662f\u7531\u4e8e\u5f15\u5165odz\u800c\u5f97\u5230\u7684\u7279\u5f02\u6027\u7ed3\u679c\u3002<\/p>\n \u5728\u5bf9\u542b\u6709proline\u6c28\u57fa\u9178\u7684odz\u73af\u5316\u4f53\u6765\u8bf4\uff0c\u4e5f\u89c2\u6d4b\u5230\u4e86\u591a\u4e2a\u4e0d\u540c\u6784\u8c61\u7684\u6df7\u5408\u7269\u3002\u5728\u7ecf\u8fc7NBO\u89e3\u6790<\/a>\u540e\u53d1\u73b0\uff0cproline\u7684N\u539f\u5b50\u4e0eGly2-NH\u3001odz\u7684\u6c27\u539f\u5b50\u4e4b\u95f4\u5b58\u5728\u6c22\u952e\u7ed3\u5408\u3002<\/p>\n \u5229\u7528PAMPA\u6cd5\uff08parallel artificial membrane permeability assay\uff09\u8fdb\u884c\u819c\u900f\u6027\u8bc4\u4ef7\u3001\u5927\u90e8\u5206\u7684odz\u73af\u5316\u7269\u663e\u793a\u51fa\u4e86\u8f83\u9ad8\u7684\u819c\u900f\u6027\u3002\u800c\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u666e\u901a\u7684\u4e0d\u542b\u6709odz\u7684\u591a\u80bd\u73af\u5316\u4f53\uff0c5\u4e2a\u4e2d4\u4e2a\u4e0d\u5177\u6709\u819c\u900f\u6027\u3002\u4eceX\u5c04\u7ebf\u5355\u6676\u884d\u5c04\u4e2d\uff0c\u4f5c\u8005\u63a8\u6d4b\u662f\u919b\u7531\u6765\u7684\u4fa7\u94fe\u4f5c\u4e3a\u4eb2\u6c34\u57fa\u8d77\u4f5c\u7528\uff0c\u56e0\u6b64\u5728\u5bf9\u919b\u7684\u4fa7\u94fe\u8fdb\u884c\u8ba8\u8bba\u540e\u53d1\u73b0\uff0cEt\u57fa\u6539\u6210Bn\u57fa\uff0c\u6216\u8005iBu\u57fa\u540e\uff0c\u819c\u900f\u8fc7\u6027\u63d0\u9ad8\u4e86\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u5728\u90a3\u4e2a\u4f4d\u70b9\u8fdb\u884ctuning\u7684\u8bdd\uff0c\u662f\u53ef\u4ee5\u6539\u5584\u836f\u7269\u7684\u7269\u7406\u6027\u8d28\u7684\u3002<\/p>\n \u6700\u540e\u901a\u8fc7\u6bd4\u8f83\u6781\u6027\u8868\u9762\u79ef\u503c\uff08\uff05PSA\uff09\uff0c\u53d1\u73b0odz\u73af\u5316\u4f53\u4e0e\u666e\u901a\u9170\u80fa\u73af\u5316\u4f53\u6ca1\u6709\u5927\u7684\u5dee\u5f02\uff0c\u4e5f\u5c31\u662f\u8bf4\uff0c\u819c\u900f\u6027\u7684\u63d0\u9ad8\u4e0e\u6781\u6027\u53d8\u5316\u65e0\u5173\uff0c\u800c\u662f\u56e0\u4e3a\u4e0eodz\u90e8\u4f4d\u5f62\u6210\u7684\u7279\u6b8a\u7684\u6c22\u952e\u7ed3\u5408\u7279\u6027\u5bfc\u81f4\u7684\u3002<\/p>\n <\/p>\n
\nFrost, J. R.; Scully, C. C. G.; Yudin, A. K.*\u00a0Nat. Chem.<\/i>\u00a02016<\/b>,\u00a08<\/i>, 1105. doi:10.1038\/nchem.2636<\/a><\/p><\/blockquote>\n\u95ee\u9898\u70b9\u4e0e\u5de5\u4f5c\u610f\u4e49<\/b><\/h4>\n
\u5177\u4f53\u5b9e\u65bd\u624b\u6cd5<\/b><\/h4>\n
<\/p>\n
\u4e3b\u5f20\u7684\u6709\u6548\u6027\u9a8c\u8bc1<\/b><\/h4>\n
\u2460\u6700\u4f73\u53cd\u5e94\u6761\u4ef6\u7684\u7b5b\u9009\u30fb\u4ea7\u7269\u7684\u7ed3\u6784\u9274\u5b9a<\/b><\/h5>\n
\u2461\u5e95\u7269\u62d3\u5c55\u7814\u7a76<\/b><\/h5>\n
<\/p>\n
\u2462\u5206\u5b50\u5185\u6c22\u952e\u7684\u7279\u6027\u8bc4\u4ef7<\/b><\/h5>\n
<\/p>\n
\u2463\u819c\u900f\u6027\u8bc4\u4ef7<\/b><\/h5>\n
\u5c0f\u7f16\u4e2a\u4eba\u770b\u6cd5<\/b><\/h4>\n
\n
\u76f8\u5173\u7814\u7a76\u7684\u9605\u8bfb\uff1f<\/b><\/h4>\n
\n
\u53c2\u8003\u6587\u732e<\/b><\/h4>\n
\n