{"id":14058,"date":"2017-06-08T08:45:08","date_gmt":"2017-06-08T00:45:08","guid":{"rendered":"\/\/www.gsbet888.com\/?p=14058"},"modified":"2019-08-02T18:53:13","modified_gmt":"2019-08-02T10:53:13","slug":"sakai-lombardo-reaction-%ef%bc%88%e7%83%af%e7%83%83%e5%90%88%e6%88%90%ef%bc%89","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2017\/06\/sakai-lombardo-reaction-%ef%bc%88%e7%83%af%e7%83%83%e5%90%88%e6%88%90%ef%bc%89.html","title":{"rendered":"Takai-Lombardo Reaction \uff08\u70ef\u70c3\u5408\u6210\uff09"},"content":{"rendered":"<h4>\u6982\u8981<\/h4>\n<p><em>gem<\/em>-\u4e8c\u5364\u4ee3\u70f7\u70c3\u8f6c\u5316\u4e3a\u6709\u673a\u949b\u6d3b\u6027\u4e2d\u95f4\u4f53\u540e\uff0c\u518d\u4e0e\u7fb0\u57fa\u8bd5\u5242\u53cd\u5e94\u5408\u6210\u70ef\u70c3\u7684\u624b\u6cd5\u3002<\/p>\n<p>\u591a\u6570\u7684\u70ef\u70c3\u5316\u53cd\u5e94\u90fd\u53ea\u9002\u7528\u4e8e\u919b\u7fb0\u57fa\u6216\u8005\u916e\u7fb0\u57fa\uff0c\u800c\u82ef\u6761\u4ef6\u53ef\u4ee5\u7528\u4e8e\u916f\u57fa\u4e0e\u9170\u80fa\u57fa\u56e2\u7684\u7fb0\u57fa\u7684\u70ef\u70c3\u5316\u53cd\u5e94\u3002\u7531\u4e8e\u53cd\u5e94\u4e2d\u6240\u7528\u7684\u8bd5\u5242\u7684\u78b1\u6027\u6bd4\u8f83\u5f31\uff0c\u6240\u4ee5\u4e5f\u53ef\u4ee5\u7528\u4e8e\u4e00\u4e9b\u5bb9\u6613\u53d1\u751f\u70ef\u9187\u5316\u4e92\u53d8\u7684\u5e95\u7269\u3002<\/p>\n<p>\u7c7b\u4f3c\u7684\u53cd\u5e94\u6709<a href=\"\/\/www.gsbet888.com\/reactions\/%E6%9C%89%E6%9C%BA%E9%87%91%E5%B1%9E%E5%8F%8D%E5%BA%94-reactions\/2014\/06\/tebbe-%E8%AF%95%E5%89%82-tebbe-reagent.html\">Tebbe\u8bd5\u5242<\/a>\u548c<a href=\"\/\/www.gsbet888.com\/reactions\/%E7%BC%A9%E5%90%88%E5%8F%8D%E5%BA%94\/2014\/09\/post-2825.html\">Petasis\u53cd\u5e94<\/a>\uff0c\u76f8\u6bd4\u4e8e\u8fd9\u4e24\u79cd\u53ea\u80fd\u9002\u7528\u4e8e\u65e0\u53d6\u4ee3\u7684\u70ef\u70c3\u5408\u6210\uff0c\u672c\u65b9\u6cd5\u53ef\u4ee5\u7528\u4e8e\u4e00\u4e9b\u53d6\u4ee3\u70ef\u70c3\u7684\u5408\u6210\uff0c\u5f97\u5230Z-\u5f0f\u9009\u62e9\u6027\u7684\u4ea7\u7269\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4>\u57fa\u672c\u6587\u732e<\/h4>\n<ul>\n<li>Takai, K.; Hotta, Y.; Ohshima, K.; Nozaki, H.\u00a0<em>Tetrahedron Lett.<\/em>\u00a0<strong>1978<\/strong>,\u00a0<em>19<\/em>, 2417. doi:<a href=\"http:\/\/dx.doi.org\/10.1016\/S0040-4039(01)94789-6\">10.1016\/S0040-4039(01)94789-6<\/a><\/li>\n<li>Lombardo, L.\u00a0<em>Tetrahedron Lett.<\/em><strong>1982<\/strong>,\u00a0<em>23<\/em>, 4293. doi:<a href=\"http:\/\/dx.doi.org\/10.1016\/S0040-4039(00)88728-6\">10.1016\/S0040-4039(00)88728-6<\/a><\/li>\n<li>Okazoe, T.; Takai, K.; Oshima, K.; Utimoto, K.\u00a0<em>J. Org. Chem.<\/em><strong>1987<\/strong>,\u00a0<em>52<\/em>, 4410. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/jo00228a055\">10.1021\/jo00228a055<\/a><\/li>\n<li>Lombardo, L.\u00a0<em>Org. Synth.<\/em><strong>1987<\/strong>,\u00a0<em>65<\/em>, 81.\u00a0<a href=\"http:\/\/www.orgsyn.org\/Content\/pdfs\/procedures\/CV8P0386.pdf\">[PDF]<\/a><\/li>\n<li>Takai, K.; Kakiuchi, T.; Kataoka, Y.; Uchimoto, K.\u00a0<em>J. Org. Chem.<\/em><strong>1994<\/strong>,\u00a0<em>59<\/em>, 2668. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/jo00089a002%20\">10.1021\/jo00089a002\u00a0<\/a><\/li>\n<li>Hartley, R. C.; McKiernan, G. J.\u00a0<em>JCS Perkin Trans. 1<\/em><strong>2002<\/strong>, 2763. doi:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1039\/B009709H\">10.1039\/B009709H<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h4>\u53cd\u5e94\u673a\u7406<\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/05\/takai_lombardo_2.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-14060 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/05\/takai_lombardo_2.gif\" alt=\"\" width=\"425\" height=\"136\" \/><\/a><\/p>\n<h4>\u53cd\u5e94\u5b9e\u4f8b<\/h4>\n<p>Tetrodotoxin\u7684\u5408\u6210[1]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/05\/takai_lombardo_3.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-14061 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/05\/takai_lombardo_3.gif\" alt=\"\" width=\"354\" height=\"146\" \/><\/a><\/p>\n<h4>\u5b9e\u9a8c\u6b65\u9aa4<\/h4>\n<p>&nbsp;<\/p>\n<h4>\u5b9e\u9a8c\u6280\u5de7<\/h4>\n<p>&nbsp;<\/p>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n[1] Hinman, A.; Du Bois, J.\u00a0<em>J. Am. Chem. Soc.\u00a0<\/em><strong>2003<\/strong>,\u00a0<em>125<\/em>, 11510. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/ja0368305%20\">10.1021\/ja0368305<\/a><\/p>\n<p>&nbsp;<\/p>\n<h4>\u76f8\u5173\u53cd\u5e94<\/h4>\n<ul class=\"list\">\n<li><a href=\"\/\/www.gsbet888.com\/reactions\/2017\/05\/\u6b66\u7530\u70ef\u5408\u6210-takeda-olefination.html\">\u6b66\u7530\u70ef\u5408\u6210 Takeda Olefination<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h4>\u76f8\u5173\u4e66\u7c4d \uff08\u65e5\u672c\u4e9a\u9a6c\u900a\u5b98\u7f51\uff09<\/h4>\n<div class=\"amazonjs_item amazonjs_book\">\n<div class=\"amazonjs_image\"><a class=\"amazonjs_link\" title=\"Modern Carbonyl Olefination: Methods and Applications\" href=\"https:\/\/www.amazon.co.jp\/Modern-Carbonyl-Olefination-Methods-Applications\/dp\/352730634X?SubscriptionId=AKIAJUGVCC4IFT7YJWNA&amp;tag=chemstation-22&amp;linkCode=xm2&amp;camp=2025&amp;creative=165953&amp;creativeASIN=352730634X\" target=\"_blank\" rel=\"noopener noreferrer\" data-role=\"amazonjs_product\" data-asin=\"352730634X\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/images-fe.ssl-images-amazon.com\/images\/I\/41JGa8cvTGL._SL160_.jpg\" alt=\"Modern Carbonyl Olefination: Methods and Applications\" width=\"114\" height=\"160\" \/><\/a><\/div>\n<div class=\"amazonjs_info\">\n<h4><a class=\"amazonjs_link\" title=\"Modern Carbonyl Olefination: Methods and Applications\" href=\"https:\/\/www.amazon.co.jp\/Modern-Carbonyl-Olefination-Methods-Applications\/dp\/352730634X?SubscriptionId=AKIAJUGVCC4IFT7YJWNA&amp;tag=chemstation-22&amp;linkCode=xm2&amp;camp=2025&amp;creative=165953&amp;creativeASIN=352730634X\" target=\"_blank\" rel=\"noopener noreferrer\" data-role=\"amazonjs_product\" data-asin=\"352730634X\">Modern Carbonyl Olefination: Methods and Applications<\/a><\/h4>\n<ul>\n<li class=\"amazonjs_price\" title=\"\u4fa1\u683c\u304a\u3088\u3073\u767a\u9001\u53ef\u80fd\u6642\u671f\u306f\u8868\u793a\u3055\u308c\u305f\u65e5\u4ed8\/\u6642\u523b\u306e\u6642\u70b9\u306e\u3082\u306e\u3067\u3042\u308a\u3001\u5909\u66f4\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u5546\u54c1\u306e\u8ca9\u58f2\u306b\u304a\u3044\u3066\u306f\u3001\u8cfc\u5165\u306e\u6642\u70b9\u3067 [Amazon.co.jp \u307e\u305f\u306f Javari.jp] \u306b\u8868\u793a\u3055\u308c\u3066\u3044\u308b\u4fa1\u683c\u304a\u3088\u3073\u767a\u9001\u53ef\u80fd\u6642\u671f\u306e\u60c5\u5831\u304c\u9069\u7528\u3055\u308c\u307e\u3059\u3002\">\u4fa1\u683c\uffe5 22,482(2017\/05\/11 11:38\u6642\u70b9)<\/li>\n<li>\u51fa\u7248\u65e52004\/03\/05<\/li>\n<li>\u5546\u54c1\u30e9\u30f3\u30ad\u30f3\u30b0478,740\u4f4d<\/li>\n<li>\u30cf\u30fc\u30c9\u30ab\u30d0\u30fc365\u30da\u30fc\u30b8<\/li>\n<li>ISBN-10352730634X<\/li>\n<li>ISBN-139783527306343<\/li>\n<li>\u51fa\u7248\u793eWiley-VCH<\/li>\n<\/ul>\n<\/div>\n<p><a class=\"amazonjs_review\" title=\"Modern Carbonyl Olefination: Methods and Applications \u30ab\u30b9\u30bf\u30de\u30fc\u30ec\u30d3\u30e5\u30fc\" href=\"https:\/\/www.amazon.jp\/reviews\/iframe?akid=AKIAJUGVCC4IFT7YJWNA&amp;alinkCode=xm2&amp;asin=352730634X&amp;atag=chemstation-22&amp;exp=2017-05-12T02%3A38%3A00Z&amp;v=2&amp;sig=EKsbEnSQe1i0g%252Fnv02xgA6QD5hHj0%252FowxjygIp%252FKlfs%253D&amp;TB_iframe=true&amp;height=500&amp;width=600\" target=\"_blank\" rel=\"noopener noreferrer\">\u8d2d\u4e70\u8005\u8bc4\u4ef7<\/a><\/p>\n<div class=\"amazonjs_footer\"><\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h4>\u76f8\u5173\u94fe\u63a5<\/h4>\n<ul>\n<li><a href=\"http:\/\/de.wikipedia.org\/wiki\/Takai-Lombardo-Reaktion\">Takai-Lombardo Reaktion \u2013 Wikipedia(de)<\/a><\/li>\n<li><a href=\"http:\/\/www.tcichemicals.com\/eshop\/zh\/cn\/category_index\/12636\/\">\u949b-\u8bf1\u5bfc\u7fb0\u57fa\u70ef\u5316\u53cd\u5e94<\/a>\uff08TCI)<\/li>\n<li><a href=\"http:\/\/en.wikipedia.org\/wiki\/Organotitanium_compound\">Organotitanium Compound \u2013 Wikipedia<\/a><\/li>\n<li><a href=\"https:\/\/www.princeton.edu\/%7Eorggroup\/supergroup_pdf\/jinglongchenPresentation-upload.pdf\">Reagents for Alkylidenations<\/a>\u00a0(PDF)<\/li>\n<\/ul>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 gem-\u4e8c\u5364\u4ee3\u70f7\u70c3\u8f6c\u5316\u4e3a\u6709\u673a\u949b\u6d3b\u6027\u4e2d\u95f4\u4f53\u540e\uff0c\u518d\u4e0e\u7fb0\u57fa\u8bd5\u5242\u53cd\u5e94\u5408\u6210\u70ef\u70c3\u7684\u624b\u6cd5\u3002 \u591a\u6570\u7684\u70ef\u70c3\u5316\u53cd\u5e94\u90fd\u53ea\u9002\u7528\u4e8e\u919b\u7fb0\u57fa\u6216\u8005\u916e\u7fb0\u57fa\uff0c\u800c\u82ef\u6761\u4ef6\u53ef\u4ee5\u7528\u4e8e\u916f\u57fa\u4e0e\u9170\u80fa\u57fa\u56e2\u7684\u7fb0\u57fa\u7684\u70ef\u70c3\u5316\u53cd\u5e94\u3002\u7531\u4e8e\u53cd\u5e94\u4e2d\u6240\u7528\u7684\u8bd5\u5242\u7684\u78b1\u6027\u6bd4\u8f83\u5f31\uff0c\u6240\u4ee5\u4e5f\u53ef\u4ee5\u7528\u4e8e\u4e00\u4e9b\u5bb9\u6613\u53d1\u751f\u70ef\u9187\u5316\u4e92\u53d8\u7684\u5e95\u7269\u3002 \u7c7b\u4f3c\u7684\u53cd\u5e94\u6709Tebbe\u8bd5\u5242\u548cPetasis\u53cd\u5e94\uff0c\u76f8\u6bd4\u4e8e\u8fd9\u4e24\u79cd\u53ea\u80fd\u9002\u7528\u4e8e\u65e0\u53d6\u4ee3\u7684\u70ef\u70c3\u5408\u6210\uff0c\u672c\u65b9\u6cd5\u53ef\u4ee5\u7528\u4e8e\u4e00\u4e9b\u53d6\u4ee3\u70ef\u70c3\u7684\u5408\u6210\uff0c\u5f97\u5230Z-\u5f0f\u9009\u62e9\u6027\u7684\u4ea7\u7269\u3002 &nbsp; \u57fa\u672c\u6587\u732e Takai, K.; Hotta, Y.; Ohshima, K.; Nozaki, H.\u00a0Tetrahedron Lett.\u00a01978,\u00a019, 2417. doi:10.1016\/S0040-4039(01)94789-6 Lombardo, L.\u00a0Tetrahedron Lett.1982,\u00a023, 4293. doi:10.1016\/S0040-4039(00)88728-6 Okazoe, T.; Takai, K.; Oshima, K.; Utimoto, K.\u00a0J. Org. Chem.1987,\u00a052, 4410. DOI:\u00a010.1021\/jo00228a055 Lombardo, L.\u00a0Org. Synth.1987,\u00a065, 81.\u00a0[PDF] Takai, K.; Kakiuchi, T.; Kataoka, Y.; Uchimoto, K.\u00a0J. Org. Chem.1994,\u00a059, 2668. DOI:\u00a010.1021\/jo00089a002\u00a0 Hartley, R. C.; McKiernan, G. J.\u00a0JCS Perkin Trans. 12002, 2763. doi:\u00a010.1039\/B009709H &nbsp; \u53cd\u5e94\u673a\u7406 \u53cd\u5e94\u5b9e\u4f8b Tetrodotoxin\u7684\u5408\u6210[1] \u5b9e\u9a8c\u6b65\u9aa4 &nbsp; \u5b9e\u9a8c\u6280\u5de7 &nbsp; \u53c2\u8003\u6587\u732e [1] Hinman, A.; Du Bois, J.\u00a0J. Am. Chem. Soc.\u00a02003,\u00a0125, 11510. DOI:\u00a010.1021\/ja0368305 &nbsp; \u76f8\u5173\u53cd\u5e94 \u6b66\u7530\u70ef\u5408\u6210 Takeda Olefination &nbsp; \u76f8\u5173\u4e66\u7c4d \uff08\u65e5\u672c\u4e9a\u9a6c\u900a\u5b98\u7f51\uff09 Modern Carbonyl Olefination: Methods and Applications \u4fa1\u683c\uffe5 22,482(2017\/05\/11 11:38\u6642\u70b9) \u51fa\u7248\u65e52004\/03\/05 \u5546\u54c1\u30e9\u30f3\u30ad\u30f3\u30b0478,740\u4f4d \u30cf\u30fc\u30c9\u30ab\u30d0\u30fc365\u30da\u30fc\u30b8 ISBN-10352730634X ISBN-139783527306343 \u51fa\u7248\u793eWiley-VCH \u8d2d\u4e70\u8005\u8bc4\u4ef7 &nbsp; \u76f8\u5173\u94fe\u63a5 Takai-Lombardo Reaktion \u2013 [&hellip;]","protected":false},"author":5,"featured_media":14059,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2],"tags":[71,74,1818],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/05\/2014-08-21_14-28-46.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-3EK","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/14058"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=14058"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/14058\/revisions"}],"predecessor-version":[{"id":27431,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/14058\/revisions\/27431"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/14059"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=14058"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=14058"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=14058"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}