{"id":14673,"date":"2017-06-27T09:56:12","date_gmt":"2017-06-27T01:56:12","guid":{"rendered":"\/\/www.gsbet888.com\/?p=14673"},"modified":"2019-08-02T18:53:03","modified_gmt":"2019-08-02T10:53:03","slug":"%e5%a6%82%e4%bd%95%e5%bf%ab%e9%80%9f%e6%a3%80%e7%b4%a2%e5%87%ba%e5%90%ab%e6%9c%89%e6%96%b9%e6%b3%95%e5%ad%a6%e7%89%87%e6%ae%b5%e7%9a%84%e8%8d%af%e7%89%a9%e7%bb%93%e6%9e%84","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/chemtool\/2017\/06\/%e5%a6%82%e4%bd%95%e5%bf%ab%e9%80%9f%e6%a3%80%e7%b4%a2%e5%87%ba%e5%90%ab%e6%9c%89%e6%96%b9%e6%b3%95%e5%ad%a6%e7%89%87%e6%ae%b5%e7%9a%84%e8%8d%af%e7%89%a9%e7%bb%93%e6%9e%84.html","title":{"rendered":"\u5982\u4f55\u5feb\u901f\u68c0\u7d22\u51fa\u542b\u6709\u65b9\u6cd5\u5b66\u7247\u6bb5\u7684\u836f\u7269\u7ed3\u6784"},"content":{"rendered":"

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

\u53ef\u4ee5\u770b\u5230\u5728\u5176\u4ed6\u540d\u5b57\u4e00\u680f\uff0c\u4f1a\u6709Parocoxib\u548cSC 69124\u8fd9\u7c7b\u7684\u540d\u79f0\u3002\u524d\u8005\u662f\u8be5\u836f\u7269\u7684\u56fd\u9645\u975e\u4e13\u6709\u540d\uff0c\u53c8\u79f0\u4e3a\u901a\u7528\u540d\uff0c\u540e\u8005\u662f\u836f\u7269\u7684\u7814\u53d1\u4ee3\u7801\u3002\u4e00\u822c\u5177\u6709\u8fd9\u79cd\u5f62\u5f0f\u540d\u79f0\u7684\u5c31\u662f\u836f\u7269\u65e0\u7591\u3002\u6240\u4ee5\u5982\u679c\u4f60\u6253\u5f00\u540e\u53ea\u80fd\u770b\u5230\u4e00\u5927\u4e32IUPAC\u547d\u540d\u6cd5\u7684\u540d\u79f0\uff0c\u800c\u6ca1\u6709\u8fd9\u79cd\u7684\u8bdd\u90a3\u53ef\u4ee5\u8fc5\u901f\u8df3\u8fc7\uff0c\u67e5\u627e\u4e0b\u4e00\u4e2a\uff0c\u76f4\u5230\u8db3\u591f\u4e3a\u6b62\u3002<\/p>\n

 <\/p>\n

\u7ecf\u8fc7\u5bf9\u524d30\u4e2a\u5de6\u53f3\u7684\u5316\u5408\u7269\u8fdb\u884c\u7b5b\u9009\uff0c\u5c0f\u7f16\u9009\u51fa\u4e86\u56db\u4e2a\u7ed3\u6784\u8fd8\u5bb9\u6613\u753b\u7684\u836f\u7269\uff0c\u5b8c\u5168\u6ee1\u8db3\u8bba\u6587\u53d1\u8868\u3002\u4ee5\u4e0a\u6b65\u9aa4\u7ecf\u8fc7\u4ed4\u7ec6\u62c6\u89e3\uff0c\u5411\u8bfb\u8005\u8fdb\u884c\u4e86\u89e3\u91ca\u5206\u6790\uff0c\u901a\u8fc7\u5b66\u4e60\u638c\u63e1\u8fd9\u7c7b\u68c0\u7d22\u601d\u8def\u548c\u65b9\u6cd5\uff0c\u76f8\u4fe1\u5404\u4f4d\u8bfb\u8005\u53ef\u4ee5\u6709\u6548\u5730\u5229\u7528Scifinder\u8fdb\u884c\u8be5\u7c7b\u68c0\u7d22\u4efb\u52a1\u3002\u5176\u4e2d\u9700\u8981\u638c\u63e1\u7684\u8981\u70b9\u5c31\u662f\u5229\u7528\u4f60\u6240\u9700\u8981\u76ee\u6807\u7684\u7279\u70b9\u6765\u8fdb\u884c\u9010\u7ea7\u9650\u5b9a\uff0c\u5728\u8fd9\u91cc\u662f\u5229\u7528\u4e86\u4e0a\u5e02\u836f\u7269\u7684\u53ef\u5546\u4e1a\u8d2d\u4e70\u7279\u6027\u548c\u6587\u732e\u6570\u91cf\u7279\u70b9\uff0c\u8fc5\u901f\u800c\u6709\u6548\u7f29\u5c0f\u76ee\u6807\u8303\u56f4\uff0c\u8fbe\u5230\u68c0\u7d22\u76ee\u7684\u3002<\/p>\n

\"\"<\/a><\/p>\n

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\u6211\u4eec\u5229\u7528RSC\u63d0\u4f9b\u7684Merck Index Online<\/a>\uff08https:\/\/www.rsc.org\/Merck-Index\/\uff09\u5bf9\u8fd9\u4e2a\u68c0\u7d22\u4efb\u52a1\u518d\u6b21\u8fdb\u884c\u5c1d\u8bd5\u3002<\/p>\n

\"\"<\/a><\/p>\n

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\"\"<\/a><\/p>\n

\u753b\u51fa\u6211\u4eec\u9700\u8981\u7684\u7ed3\u6784\u7247\u6bb5\uff1b<\/p>\n

\"\"<\/a><\/p>\n

\u9009\u62e9\u4e9a\u7ed3\u6784\u68c0\u7d22\uff1b<\/p>\n

\"\"<\/a><\/p>\n

\u8fd4\u56de7\u6761\u7ed3\u679c\uff0c\u4ed4\u7ec6\u67e5\u770b\u4e00\u4e0b\u5982\u4e0b\u56fe\uff1b<\/p>\n

\"\"<\/a><\/p>\n

\u53ef\u4ee5\u770b\u5230\uff0c\u786e\u5b9e\u90fd\u662f\u6211\u4eec\u9700\u8981\u7684\u7ed3\u6784\u7247\u6bb5\u7684\u836f\u7269\uff0c\u4efb\u52a1\u8fbe\u6210\uff0c\u8017\u65f630\u79d2\u4ee5\u5185\uff0c\u6548\u7387\u63d0\u9ad8\u3002<\/p>\n

 <\/p>\n

\u5728\u6b64\uff0c\u6211\u4eec\u603b\u7ed3\u4e00\u4e0b\uff0c\u5c0f\u7f16\u63d0\u4f9b\u4e86\u4e24\u79cd\u65b9\u6cd5\u6765\u89e3\u51b3\u6211\u4eec\u8fd9\u4e2a\u95ee\u9898\uff0c\u7528Merck Index<\/a>\u5728\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\u4e0a\u6548\u7387\u786e\u5b9e\u8d85\u8fc7Scifinder\u5f88\u591a\uff0c\u800c\u4e14\u5176\u4ed6\u65b9\u9762\u4f18\u52bf\u4e5f\u5f88\u660e\u663e\u3002\u4f46\u662f\u6709\u4e24\u70b9\u9700\u8981\u6307\u51fa\uff0c\u7b2c\u4e00\uff0cMerck Index<\/a>\u5728\u5176\u4ed6\u68c0\u7d22\u65b9\u9762\u540c\u6837\u6709\u4f18\u52bf\uff0c\u7b2c\u4e8c\uff0c\u8fd9\u4e0d\u4ee3\u8868\u4ecb\u7ecdScifinder\u7684\u65b9\u6cd5\u5c31\u662f\u591a\u4f59\u7684\uff0c\u8fd9\u4e24\u4e2a\u95ee\u9898\u5728\u6b64\u4e0d\u8be6\u7ec6\u5c55\u5f00\uff0c\u6709\u673a\u4f1a\u5c0f\u7f16\u518d\u8c08\u3002\u5b66\u597d\u4fe1\u606f\u68c0\u7d22\u9700\u8981\u4e0d\u505c\u5730\u5c1d\u8bd5\u4e0e\u6539\u8fdb\uff0c\u6ca1\u6709\u4e00\u52b3\u6c38\u9038\u7684\u65b9\u6cd5\uff0c\u5c0f\u7f16\u5728\u6b64\u53ea\u662f\u63d0\u4f9b\u4e00\u70b9\u6d45\u89c1\uff0c\u5e0c\u671b\u8bfb\u8005\u770b\u540e\u80fd\u901a\u8fc7\u81ea\u5df1\u5b9e\u8df5\u66f4\u597d\u5730\u89e3\u51b3\u8fd9\u7c7b\u95ee\u9898\u3002<\/p>\n

 <\/p>\n[1]\u00a0\u00a0\u00a0 Wang, J.; Hou, T. J. Chem. Inf. Model. <\/em>2010,<\/strong>50<\/em>, 55.<\/p>\n

 <\/p>\n

\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01 <\/p>\n","protected":false},"excerpt":{"rendered":"\u6700\u8fd1\uff0c\u5c0f\u7f16\u7ecf\u5e38\u5728\u4e00\u4e9b\u5b66\u672f\u8ba8\u8bba\u7fa4\u4e2d\u7684\u770b\u5230\u6709\u7814\u7a76\u5408\u6210\u65b9\u6cd5\u5b66\u7684\u540c\u5b66\u8be2\u95ee\u4e00\u4e2a\u95ee\u9898\uff0c\u5c31\u662f\u5982\u4f55\u68c0\u7d22\u51fa\u542b\u6709\u4ed6\u4eec\u81ea\u5df1\u65b9\u6cd5\u5b66\u6784\u5efa\u51fa\u7684\u7247\u6bb5\u7684\u836f\u7269\u7ed3\u6784\u6765\u3002\u51fa\u73b0\u8fd9\u4e00\u9700\u6c42\u5f53\u7136\u5f88\u6b63\u5e38\uff0c\u56e0\u4e3a\u5982\u4eca\u8bb8\u591a\u7684\u65b9\u6cd5\u5b66\u7814\u7a76\u5e76\u975e\u662f\u4e3b\u52a8\u8fdb\u884c\u63a2\u7d22\u7684\u7ed3\u679c\uff0c\u800c\u662f\u5c5e\u4e8e\u5076\u7136\u53d1\u73b0\uff0c\u90a3\u4e48\u5982\u4f55\u5c06\u81ea\u5df1\u7684\u53d1\u73b0\u5305\u88c5\u6210\u5177\u6709\u91cd\u8981\u610f\u4e49\u7684\u7814\u7a76\u6210\u679c\u5462\uff0c\u5c31\u9700\u8981\u8bf4\u660e\u8be5\u65b9\u6cd5\u5b66\u80fd\u591f\u5408\u6210\u7684\u201c\u6709\u7528\u201d\u7684\u5206\u5b50\u3002\u54ea\u4e9b\u662f\u6709\u7528\u7684\u5206\u5b50\uff1f\u4e0a\u5e02\u836f\u7269\u7531\u4e8e\u5177\u6709\u5de8\u5927\u7684\u7ecf\u6d4e\u4ef7\u503c\u548c\u793e\u4f1a\u4ef7\u503c\u6beb\u65e0\u7591\u95ee\u662f\u9996\u9009\uff0c\u4e00\u4e9b\u5728\u7814\u7684\u836f\u7269\u6216\u8005\u5176\u4ed6\u7684\u529f\u80fd\u5206\u5b50\u5f53\u7136\u4e5f\u80fd\u5728\u65b9\u6cd5\u5b66\u8bba\u6587\u7684\u80cc\u666f\u90e8\u5206\u505a\u51fa\u5f88\u597d\u7684\u4f50\u8bc1\uff0c\u4e00\u822c\u4e5f\u662f\u53ef\u4ee5\u7528\u4e8e\u8bf4\u660e\u95ee\u9898\u7684\u3002\u90a3\u4e48\uff0c\u5c0f\u7f16\u5728\u6b64\u5c31\u7ed3\u5408\u4e00\u4e9b\u81ea\u5df1\u68c0\u7d22\u7684\u7ecf\u9a8c\uff0c\u7ed9\u5927\u5bb6\u63d0\u4f9b\u4e00\u4e2a\u5feb\u901f\u89e3\u51b3\u8be5\u95ee\u9898\u7684\u65b9\u6cd5\uff0c\u5f53\u7136\uff0c\u8fd9\u53ea\u662f\u5c0f\u7f16\u81ea\u5df1\u601d\u8003\u7684\u7ed3\u679c\uff0c\u5982\u679c\u8bfb\u8005\u6709\u66f4\u52a0\u6709\u6548\u7684\u65b9\u6cd5\uff0c\u6b22\u8fce\u5927\u5bb6\u63d0\u4f9b\u4ea4\u6d41\u3002 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\u9996\u5148\uff0c\u6211\u4eec\u5728\u7ed3\u6784\u68c0\u7d22\u6846\u4e2d\u8f93\u5165\u8be5\u7ed3\u6784\uff0c\u9009\u62e9\u4e9a\u7ed3\u6784\u68c0\u7d22\u5373\u53ef\uff1b \u679c\u4e0d\u5176\u7136\uff0c\u5f97\u5230\u7684\u7ed3\u679c\u6570\u91cf\u5341\u5206\u5e9e\u5927\uff0c\u670916\u4e07\u4e4b\u591a\uff0c\u624b\u5de5\u7b5b\u9009\u7684\u8bdd\u770b\u5b8c\u4f30\u8ba1\u90fd\u5f97\u7334\u5e74\u9a6c\u6708\u4e86\uff0c\u73b0\u5728\u6211\u4eec\u5c31\u9700\u8981\u5229\u7528\u4e00\u4e9b\u7b80\u5355\u624b\u6bb5\u6765\u8fc5\u901f\u51cf\u5c11\u76ee\u6807\u96c6\u5408\u7684\u6570\u91cf\uff1b \u7531\u4e8e\u8003\u8651\u5230\u4e0a\u5e02\u836f\u7269\u663e\u7136\u662f\u5546\u4e1a\u53ef\u4ee5\u83b7\u5f97\u7684\uff0c\u6211\u4eec\u5229\u7528Refine\u91cc\u7684\u8fd9\u4e00\u9009\u9879\u5bf9\u7ed3\u679c\u8fdb\u884c\u9650\u5b9a\uff0c\u53ef\u4ee5\u4e00\u6b21\u6027\u53bb\u6389\u7edd\u5927\u591a\u6570\u4e0d\u76f8\u5e72\u5316\u5408\u7269\uff0c\u770b\u4e0b\u7ed3\u679c\u5982\u4f55\uff1b \u6548\u679c\u663e\u8457\uff0c\u5728\u9650\u5b9a\u4e4b\u540e\uff0c\u5316\u5408\u7269\u51cf\u5c11\u4e3a2\u4e07\u4e0d\u5230\uff0c\u51cf\u5c11\u4e86\u5c06\u8fd190%\u3002\u867d\u7136\u51cf\u5c11\u4e86\u76f8\u5bf9\u6bd4\u4f8b\u5f88\u5927\uff0c\u4f46\u662f\u5269\u4e0b\u7684\u7edd\u5bf9\u6570\u91cf\u4f9d\u7136\u5e9e\u5927\uff0c\u6240\u4ee5\u6211\u4eec\u9700\u8981\u8fdb\u4e00\u6b65\u8fdb\u884c\u9650\u5b9a\uff0c\u4f9d\u846b\u82a6\u753b\u74e2\uff0c\u8fd9\u6b21\u6211\u4eec\u8bd5\u4e00\u4e0b\u7528\u540c\u4f4d\u7d20\u9009\u9879\uff0c\u9009\u62e9\u4e0d\u542b\u540c\u4f4d\u7d20\u7684\u5316\u5408\u7269\uff0c\u8bd5\u8bd5\u770b\u7ed3\u679c\u5982\u4f55\uff1b 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[1]\u00a0\u00a0\u00a0 Wang, J.; Hou, T. 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