{"id":14968,"date":"2017-07-19T08:43:46","date_gmt":"2017-07-19T00:43:46","guid":{"rendered":"\/\/www.gsbet888.com\/?p=14968"},"modified":"2019-08-02T18:52:57","modified_gmt":"2019-08-02T10:52:57","slug":"%e5%b0%8f%e5%88%86%e5%ad%90%e8%8d%af%e7%89%a9%ef%bc%88%e4%b8%80%ef%bc%89","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2017\/07\/%e5%b0%8f%e5%88%86%e5%ad%90%e8%8d%af%e7%89%a9%ef%bc%88%e4%b8%80%ef%bc%89.html","title":{"rendered":"\u5c0f\u5206\u5b50\u836f\u7269\uff08\u4e00\uff09"},"content":{"rendered":"<h4>\u524d\u8a00<\/h4>\n<p>\u8fd1\u671f\u5c0f\u7f16\u5c06\u4f1a\u4e3a\u5927\u5bb6\u63a8\u51fa\u201c\u5c0f\u5206\u5b50\u836f\u7269\u201d\u4e13\u9898\uff0c\u4e3b\u8981\u4ecb\u7ecd\u4e00\u4e9b\u91cd\u8981\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u867d\u7136\u6709\u4e9b\u836f\u7269\u65e9\u5df2\u4e0d\u518d\u4f7f\u7528\uff0c\u53d6\u800c\u4ee3\u4e4b\u7684\u662f\u7597\u6548\u66f4\u597d\u3001\u6bd2\u526f\u4f5c\u7528\u66f4\u5c0f\u7684\u65b0\u578b\u836f\u7269\uff0c\u4f46\u662f\u901a\u8fc7\u4ecb\u7ecd\u8fd9\u4e9b\u836f\u7269\u80cc\u540e\u7684\u6545\u4e8b\uff0c\u5927\u5bb6\u53ef\u4ee5\u6df1\u523b\u4f53\u4f1a\u5230\u5316\u5b66\u4ee5\u53ca\u5316\u5b66\u5bb6\u5728\u836f\u7269\u53d1\u73b0\u8fc7\u7a0b\u4e2d\u6240\u53d1\u6325\u7684\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n<p><strong>\u7cbe\u795e\u7c7b\u75be\u75c5<\/strong>\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u5411\u6765\u90fd\u662f\u5f88\u96be\u7684\uff0c\u6839\u6e90\u662f\u4eba\u7c7b\u5bf9\u4e8e\u5927\u8111\u884c\u4e3a\u7684\u4e86\u89e3\u76f8\u5bf9\u4e8e\u5176\u4ed6\u5668\u5b98\u800c\u8a00\u5b9e\u5728\u592a\u5c11\u3002\u5927\u8111\u4f5c\u4e3a\u4e00\u4e2a\u6781\u5176\u91cd\u8981\u800c\u53c8\u654f\u611f\u7684\u5668\u5b98\uff0c\u5f88\u96be\u76f4\u63a5\u901a\u8fc7\u7269\u7406\u6216\u5316\u5b66\u7684\u65b9\u6cd5\u8fdb\u884c\u7814\u7a76\u3002\u7cbe\u795e\u7c7b\u75be\u75c5\uff0c\u4f8b\u5982\u7126\u8651\u75c7\u3001\u6291\u90c1\u75c7\u3001\u7cbe\u795e\u5206\u88c2\u75c7\u7b49\u8fc4\u4eca\u90fd\u6ca1\u6709\u6839\u6cbb\u7684\u529e\u6cd5\uff0c\u53ea\u80fd\u901a\u8fc7\u836f\u7269\u6cbb\u7597\u3001\u5fc3\u7406\u6cbb\u7597\u7b49\u65b9\u5f0f\u7f13\u89e3\u548c\u63a7\u5236\u75c5\u60c5\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4>\u5df4\u6bd4\u59a5\u7c7b<\/h4>\n<p>\u9996\u5148\u4ecb\u7ecd\u7684\u662f\u5df4\u6bd4\u59a5\u7c7b\u836f\u7269\uff08Barbiturates\uff09\uff0c\u5728\u5df4\u6bd4\u59a5\u7c7b\u836f\u7269\u53d1\u73b0\u4e4b\u524d\uff0c\u6cbb\u7597\u7cbe\u795e\u75be\u75c5\u4e3b\u8981\u4f9d\u8d56\u9ebb\u9189\u5242\u548c\u9152\u7cbe\u3002\u5fb7\u56fd\u5316\u5b66\u5bb6AdolfvonBaeyer\u5229\u7528\u4e19\u4e8c\u9178\u4e0e\u5c3f\u7d20\u6700\u5148\u5408\u6210\u4e86\u4e00\u79cd\u65b0\u7269\u8d28\u5df4\u6bd4\u59a5\u9178\uff08BarbituricAcid\uff09\uff0c\u867d\u7136\u5f53\u65f6Baeyer\u5e76\u6ca1\u6709\u5c06\u5176\u4f5c\u4e3a\u836f\u7269\u4f7f\u7528\u7684\u610f\u8bc6\uff0c\u4f46\u4ed6\u8fd8\u662f\u5408\u6210\u4e86\u4e00\u7cfb\u5217\u7684\u884d\u751f\u7269\uff0c\u76f4\u52301903\u5e74EmilFischer\u548c\u4ed6\u7684\u540c\u4e8bJosephvonMering\u53d1\u73b0\u4e86\u5df4\u6bd4\u59a5\u884d\u751f\u7269\u5177\u6709\u9547\u9759\u5b89\u7720\u7684\u6f5c\u5728\u836f\u7528\u4ef7\u503c\uff0c\u968f\u5373\u5df4\u6bd4\u59a5\u5c31\u88ab\u5546\u54c1\u5316\uff0c\u4f5c\u4e3a\u5b89\u7720\u836f\u5e7f\u6cdb\u4f7f\u7528\uff08\u5982\u56fe1\u6240\u793a\uff09\u3002<\/p>\n<p><a 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href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/3-5.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-14971 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/3-5.png\" alt=\"\" width=\"555\" height=\"269\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/3-5.png 555w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/3-5-300x145.png 300w\" sizes=\"(max-width: 555px) 100vw, 555px\" \/><\/a><\/p>\n<p style=\"text-align: center\">\u56fe2\u66fe\u7ecf\u5e7f\u6cdb\u4f7f\u7528\u7684\u82ef\u4e8c\u6c2e\u44ec\u7c7b\u836f\u7269<\/p>\n<p>LeoH. 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Sternbach,\u00a0<em>J. Med. Chem<\/em>., <strong>1979<\/strong>, 22 (1), 1\u20137. DOI:10.1021\/jm00187a001<\/li>\n<li>[2] E. J. Corey,B.Czak\u00f3,L. K\u00fcrti, <em>Molecules and Medicine<\/em>, John Wiley &amp; Sons, Ltd.,\u00a0Hoboken, <strong>2007<\/strong>.<\/li>\n<li>[3]K. C. Nicolaou, Tamsyn Montagnon,<em>Molecules That Changed the World<\/em>, WILEY-VCH\u00a0Verlag GmbH &amp; Co. KGaA, Weinheim, <strong>2008<\/strong>.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"\u524d\u8a00 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Sternbach,\u00a0J. Med. Chem., 1979, 22 (1), 1\u20137. DOI:10.1021\/jm00187a001 [2] E. J. Corey,B.Czak\u00f3,L. K\u00fcrti, Molecules and Medicine, John Wiley &amp; Sons, Ltd.,\u00a0Hoboken, 2007. [3]K. C. Nicolaou, Tamsyn Montagnon,Molecules That Changed the World, WILEY-VCH\u00a0Verlag GmbH &amp; Co. 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