{"id":14990,"date":"2017-07-28T07:07:15","date_gmt":"2017-07-27T23:07:15","guid":{"rendered":"\/\/www.gsbet888.com\/?p=14990"},"modified":"2019-08-02T18:52:57","modified_gmt":"2019-08-02T10:52:57","slug":"%e9%9d%9e%e6%a0%b8%e7%b3%96%e4%bd%93%e5%a4%9a%e8%82%bd%e7%9a%84%e4%ba%ba%e5%b7%a5%e5%90%88%e6%88%90%e6%b3%95-phil-s-baran","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2017\/07\/%e9%9d%9e%e6%a0%b8%e7%b3%96%e4%bd%93%e5%a4%9a%e8%82%bd%e7%9a%84%e4%ba%ba%e5%b7%a5%e5%90%88%e6%88%90%e6%b3%95-phil-s-baran.html","title":{"rendered":"\u975e\u6838\u7cd6\u4f53\u591a\u80bd\u7684\u4eba\u5de5\u5408\u6210\u6cd5-Phil S. Baran"},"content":{"rendered":"<p><b>Scripps\u7814\u7a76\u6240\u30fb<a href=\"\/\/www.gsbet888.com\/chemists\/2014\/09\/\u8d39\u5c14\u00b7s\u00b7\u5df4\u4f26%E3%80%80phil-s\u00b7baran.html\">Phil S. Baran<\/a>\u7b49\u4eba\uff0c\u53d7\u5230\u751f\u7269\u4f53\u4e2d\u7684\u4e9a\u80fa\u5f15\u53d1\u7684\u73af\u5316\u53cd\u5e94\u7684\u542f\u53d1\uff0c\u5f00\u53d1\u51fa\u4e86\u5927\u73af\u591a\u80bd\u7684\u5408\u6210\u65b9\u6cd5\uff0c\u5408\u6210\u4e86\u591a\u79cd\u6784\u9020\u591a\u6837\u7684\u5927\u73af\u591a\u80bd\u3002\u53cd\u5e94\u7684\u4eae\u70b9\u662f\u5728\u6c34\u4e2d\u8fdb\u884c\u800c\u4e14\u6c28\u57fa\u9178\u4fa7\u94fe\u65e0\u9700\u4fdd\u62a4\u3002\u751f\u6210\u7684\u4e9a\u80fa\u53ef\u4ee5\u8fdb\u4e00\u6b65\u8fdb\u884c\u5b98\u80fd\u56e2\u4fee\u9970\uff0c\u5f97\u5230\u66f4\u591a\u529f\u80fd\u4e30\u5bcc\u7684\u4ea7\u7269\u3002<\/b><\/p>\n<blockquote><p>Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products<br \/>\nMalins, L. E.; deGruyiter, J. N.; Robbins, K. J.; Scola, P. M.; Eastgate, M.\u3000D.; Ghadiri, M. R.; Baran, P. S.* <i>J. Am. Chem. Soc.<\/i> <b>2017<\/b>, <i>139<\/i>, 5233. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/jacs.7b01624\">10.1021\/jacs.7b01624<\/a> \uff08\u5c01\u9762\u56fe\u7247\u6765\u81ea\u8bba\u6587\uff09<\/p><\/blockquote>\n<h4>\u95ee\u9898\u8bbe\u5b9a\u4e0e\u89e3\u51b3\u65b9\u6cd5<\/h4>\n<p>\u5206\u5b50\u91cf\u5728500~2000\u5de6\u53f3\u7684\u4e2d\u5206\u5b50\uff0c\u5177\u6709\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7684\u963b\u65ad\u529f\u80fd\uff0c\u8fd1\u5e74\u6765\u4f5c\u4e3a\u65b0\u836f\u7814\u53d1\u7684\u76ee\u6807\u5316\u5408\u7269\uff0c\u9700\u6c42\u9010\u6e10\u589e\u5927\u3002\u5176\u4e2d\u4ee5\u5177\u6709\u86cb\u767d\u9176\u8010\u53d7\u6027\uff0c\u819c\u900f\u8fc7\u6027\u4e0e\u836f\u7269\u7279\u6027\u7684\u5927\u73af\u72b6\u591a\u80bd\u4e3a\u4ee3\u8868\uff0c\u5907\u53d7\u77a9\u76ee\u3002<\/p>\n<p>Baran\u7b49\u4eba\u53c2\u8003\u4e86\u73af\u72b6\u591a\u80bd\u7684\u751f\u7269\u5408\u6210\u8def\u5f84\uff0c\u901a\u8fc7\u591a\u80bd\u672b\u7aef\u7684\u4e00\u7ea7\u80fa\u4e0e\u53e6\u4e00\u7aef\u7684\u919b\u57fa\u76f4\u63a5\u73af\u5316\u7684\u65b9\u6cd5\uff0c\u5f00\u53d1\u51fa\u4e86\u591a\u79cd\u591a\u6837\u7684\u5927\u73af\u72b6\u591a\u80bd\u7684\u5408\u6210\u624b\u6cd5\u3002\u539f\u6599\u4e0e\u4ea7\u7269imine\u5448\u5e73\u8861\u72b6\u6001\uff0c\u4f46\u662f\u6dfb\u52a0\u9002\u5f53\u7684\u4eb2\u6838\u8bd5\u5242\u540e\u80fd\u591f\u4f7f\u5f97\u53cd\u5e94\u5e73\u8861\u5411\u4ea7\u7269\u7aef\u8fdb\u884c\uff08\u5982\u6807\u9898\u56fe\u6240\u793a\uff09<\/p>\n<p>&nbsp;<\/p>\n<h4>\u5177\u4f53\u64cd\u4f5c\u624b\u6cd5<\/h4>\n<p><a href=\"\/\/www.gsbet888.com\/molecule\/2017\/07\/\u975e\u6838\u7cd6\u4f53\u591a\u80bd-non-ribosomal-peptide.html\"><b>\u975e\u6838\u7cd6\u4f53\u591a\u80bd\uff08non-ribosomal peptide\uff09<\/b><\/a>[1]\uff0c\u4e4b\u524d\u5c0f\u7f16\u4e5f\u6709\u8fc7\u4ecb\u7ecd\uff0c\u662f\u4e00\u7c7b\u5177\u6709\u591a\u6837\u6027\u7ed3\u6784\u4e0e\u751f\u7269\u6d3b\u6027\u7684\u591a\u80bd\u5316\u5408\u7269\u3002\u800c\u5176\u4e2d\u6709\u4e00\u90e8\u5206\u662f\u7ecf\u7531\u8fd8\u539f\u9176\u8fd8\u539f\uff0c\u518d\u73af\u5316\u5f62\u6210\u7684\uff08\u4e0b\u56fe\u6240\u793a\uff09\u3002\u800c\u672c\u8bba\u6587\u7684idea\u5c31\u662f\u6765\u81ea\u8fd9\u4e2a\u4f53\u5185\u5927\u73af\u591a\u80bd\u7684\u5408\u6210\u6cd5\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-14992 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/nonribosomal_imine_2-e1499358587763.png\" alt=\"\" width=\"456\" height=\"418\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/nonribosomal_imine_2-e1499358587763.png 456w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/nonribosomal_imine_2-e1499358587763-300x275.png 300w\" sizes=\"(max-width: 456px) 100vw, 456px\" \/><\/p>\n<p>\u4e3a\u4e86\u672c\u65b9\u6cd5\u7684\u6709\u6548\u6027\uff0c\u9996\u5148\u5fc5\u987b\u5408\u6210\u672b\u7aef\u5177\u6709\u919b\u57fa\u7ed3\u6784\u7684\u7ebf\u6027\u591a\u80bd\u5e95\u7269\u3002\u4f5c\u8005\u7528Rink amide\u6811\u8102\u8fdb\u884cFmoc\u56fa\u76f8\u5408\u6210\u6cd5\u5408\u6210\u4e86\u6240\u9700\u5e95\u7269\u3002(\u53c2\u7167\u4e0b\u56fe\u6240\u793a)<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-14993 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/nonribosomal_imine_4-e1499358728922.png\" alt=\"\" width=\"591\" height=\"336\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/nonribosomal_imine_4-e1499358728922.png 591w, 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mM\u7684\u6eb6\u6db2\u72b6\u6001\uff0c\u957f\u65f6\u95f4\u653e\u7f6e\u7684\u8bdd\uff0c\u591a\u80bd\u73af\u4e5f\u4f1a\u89e3\u79bb\uff0c\u4f34\u6709\u4ea7\u7387\u964d\u4f4e\u7b49\u7b49\u95ee\u9898\u7684\u53d1\u751f\u3002<\/p>\n<h5><b>\u2461\u5e95\u7269\u62d3\u5c55<\/b><\/h5>\n<p>\u5bf9\u4e8eTyr, His, Ser, Asp, Arg, Gln, \u30b7\u30b9\u30c1\u30f3\uff08Cys-Cys\uff09\u7b49\u3092\u542b\u6709\uff15\uff5e\uff11\uff10\u6b8b\u57fa\u7684\u591a\u80bd\u3001\u90fd\u53ef\u4ee5\u8fdb\u884cstrecker\u578b\u6216\u8005\u8fd8\u539f\u80fa\u5316\u73af\u5316\u53cd\u5e94\uff0c\u5e76\u4e14\u6c28\u57fa\u9178\u6b8b\u57fa\u65e0\u9700\u4efb\u4f55\u4fdd\u62a4\u57fa\u3002\u5bf9\u4e8e\u542b\u6709Lys\u7684\u5e95\u7269\uff0c\u53ea\u9700\u8981\u8c03\u6574\u597dpH\uff0c\u53cd\u5e94\u4e5f\u80fd\u57fa\u672c\u53d1\u751f\u5728N\u672b\u7aef\u7684\u80fa\u57fa\u4e0a\uff0c\u4f46\u662f\u4e5f\u6709\u4e00\u5c0f\u90e8\u5206\u4e0eLys\u4fa7\u94fe\u53cd\u5e94\uff0c\u751f\u6210\u7684\u526f\u4ea7\u7269\u7684\u5206\u79bb\u6bd4\u8f83\u56f0\u96be\u3002\u56e0\u6b64\u5728\u542b\u6709Lys\u7684\u5e95\u7269\u7684\u8bdd\uff0c\u6700\u597d\u662fLys\u4fa7\u94fe\u7684\u672b\u7aef\u80fa\u57fa\u4fdd\u62a4\u540e\u518d\u8fdb\u884c\u53cd\u5e94\u4e3a\u4f73\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-14994 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/nonribosomal_imine_5-e1499358794519.png\" alt=\"\" width=\"631\" height=\"352\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/nonribosomal_imine_5-e1499358794519.png 631w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/nonribosomal_imine_5-e1499358794519-300x167.png 300w\" sizes=\"(max-width: 631px) 100vw, 631px\" 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class=\"aligncenter wp-image-14995 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/nonribosomal_imine_7-e1499358971884.png\" alt=\"\" width=\"557\" height=\"253\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/nonribosomal_imine_7-e1499358971884.png 557w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/nonribosomal_imine_7-e1499358971884-300x136.png 300w\" sizes=\"(max-width: 557px) 100vw, 557px\" 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D.; Finking, R.; Marahie, M. <i>Nat. Prod. Rep.<\/i> <b>2003<\/b>, <i>20<\/i>, 275. DOI: <a href=\"http:\/\/dx.doi.org\/10.1039\/B111145K\">10.1039\/B111145K<\/a><\/li>\n<\/ol>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"Scripps\u7814\u7a76\u6240\u30fbPhil S. Baran\u7b49\u4eba\uff0c\u53d7\u5230\u751f\u7269\u4f53\u4e2d\u7684\u4e9a\u80fa\u5f15\u53d1\u7684\u73af\u5316\u53cd\u5e94\u7684\u542f\u53d1\uff0c\u5f00\u53d1\u51fa\u4e86\u5927\u73af\u591a\u80bd\u7684\u5408\u6210\u65b9\u6cd5\uff0c\u5408\u6210\u4e86\u591a\u79cd\u6784\u9020\u591a\u6837\u7684\u5927\u73af\u591a\u80bd\u3002\u53cd\u5e94\u7684\u4eae\u70b9\u662f\u5728\u6c34\u4e2d\u8fdb\u884c\u800c\u4e14\u6c28\u57fa\u9178\u4fa7\u94fe\u65e0\u9700\u4fdd\u62a4\u3002\u751f\u6210\u7684\u4e9a\u80fa\u53ef\u4ee5\u8fdb\u4e00\u6b65\u8fdb\u884c\u5b98\u80fd\u56e2\u4fee\u9970\uff0c\u5f97\u5230\u66f4\u591a\u529f\u80fd\u4e30\u5bcc\u7684\u4ea7\u7269\u3002 Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products Malins, L. E.; deGruyiter, J. N.; Robbins, K. J.; Scola, P. M.; Eastgate, M.\u3000D.; Ghadiri, M. R.; Baran, P. S.* J. Am. Chem. Soc. 2017, 139, 5233. DOI: 10.1021\/jacs.7b01624 \uff08\u5c01\u9762\u56fe\u7247\u6765\u81ea\u8bba\u6587\uff09 \u95ee\u9898\u8bbe\u5b9a\u4e0e\u89e3\u51b3\u65b9\u6cd5 \u5206\u5b50\u91cf\u5728500~2000\u5de6\u53f3\u7684\u4e2d\u5206\u5b50\uff0c\u5177\u6709\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7684\u963b\u65ad\u529f\u80fd\uff0c\u8fd1\u5e74\u6765\u4f5c\u4e3a\u65b0\u836f\u7814\u53d1\u7684\u76ee\u6807\u5316\u5408\u7269\uff0c\u9700\u6c42\u9010\u6e10\u589e\u5927\u3002\u5176\u4e2d\u4ee5\u5177\u6709\u86cb\u767d\u9176\u8010\u53d7\u6027\uff0c\u819c\u900f\u8fc7\u6027\u4e0e\u836f\u7269\u7279\u6027\u7684\u5927\u73af\u72b6\u591a\u80bd\u4e3a\u4ee3\u8868\uff0c\u5907\u53d7\u77a9\u76ee\u3002 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\u8fd9\u4e2a\u8bfe\u9898\u662f\u4e0e\u7f8e\u56fd\u5236\u836f\u754c\u5de8\u5934\u65bd\u8d35\u5b9d\uff08\uff22\uff2d\uff33\uff09\u7684\u4e00\u9879\u5171\u540c\u7814\u7a76\u3002\u987a\u5e26\u8bf4\u4e00\u4e0b\uff0c\u65bd\u8d35\u5b9d\u57282010\u5e74\u5c31\u5f00\u59cb\u4e0e\u80bd\u96f7\u59c6\u516c\u53f8\u4e00\u8d77\uff0c\u7814\u7a76\u7279\u6b8a\u73af\u72b6\u7684\u591a\u80bd\u836f\u7269\uff0c\u5e76\u4e14\u5728\u53bb\u5e74\u5df2\u7ecf\u8fdb\u884c\u5230\u4e34\u5e8a\u8bd5\u9a8c\u4e86\u3002 \u53c2\u8003\u6587\u732e Schwarzer, D.; Finking, R.; Marahie, M. Nat. Prod. Rep. 2003, 20, 275. 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