{"id":15005,"date":"2017-07-25T07:50:50","date_gmt":"2017-07-24T23:50:50","guid":{"rendered":"\/\/www.gsbet888.com\/?p=15005"},"modified":"2019-08-02T18:52:56","modified_gmt":"2019-08-02T10:52:56","slug":"craig-m-crews","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemists\/2017\/07\/craig-m-crews.html","title":{"rendered":"Craig M. Crews"},"content":{"rendered":"<p>Craig Martin Crews\u30011964\u5e746\u67081\u65e5(\u7ebd\u65af\u6ce2\u7279\u65af\u3001\u5f17\u5409\u5c3c\u4e9a\u51fa\u751f)\u3001\u7f8e\u56fd\u6709\u673a\u5316\u5b66\u5bb6\u30fb\u751f\u7269\u5316\u5b66\u5bb6\u30fb\u751f\u7269\u5b66\u5bb6\uff0c\u8036\u9c81\u5927\u5b66\u6559\u6388\u3002(\u7167\u7247:<a href=\"https:\/\/medicine.yale.edu\/news\/article.aspx?id=11339\">Yale School of Medicine<\/a>)<\/p>\n<h4>\u7ecf\u5386<\/h4>\n<ul>\n<li>1986 \u5f17\u5409\u5c3c\u4e9a\u5927\u5b66 \u6bd5\u4e1a<\/li>\n<li>1986-87 \u5fb7\u56fd\u8482\u5bbe\u6839\u5927\u5b66\u00a0DAAD Fellow<\/li>\n<li>1993 \u54c8\u4f5b\u5927\u5b66 \u535a\u58eb\u5b66\u4f4d\uff08Raymond Erikson\u6559\u6388\uff09<\/li>\n<li>1993-95 \u54c8\u4f5b\u5927\u5b66 \u535a\u58eb\u7814\u7a76\u5458\uff08<a href=\"\/\/www.gsbet888.com\/chemists\/2014\/07\/post-2034.html\">Stuart L. Schreiber<\/a>\u6559\u6388\uff09<\/li>\n<li>1995-2000 \u8036\u9c81\u5927\u5b66 \u5206\u5b50\u30fb\u7ec6\u80de\u30fb\u53d1\u80b2\u751f\u7269\u5b66\u90e8 \u52a9\u7406\u6559\u6388<\/li>\n<li>1998-2000 \u8036\u9c81\u5927\u5b66 \u533b\u5b66\u90e8\u836f\u5b66\u79d1 \u52a9\u7406\u6559\u6388<\/li>\n<li>2000-2007 \u8036\u9c81\u5927\u5b66 \u5206\u5b50\u30fb\u7ec6\u80de\u30fb\u53d1\u80b2\u751f\u7269\u5b66\u90e8 \u526f\u6559\u6388<\/li>\n<li>2000-2007 \u8036\u9c81\u5927\u5b66 \u533b\u5b66\u90e8\u836f\u5b66\u79d1 \u526f\u6559\u6388<\/li>\n<li>2007-2010 \u8036\u9c81\u5927\u5b66 \u5206\u5b50\u30fb\u7ec6\u80de\u30fb\u53d1\u80b2\u751f\u7269\u5b66\u90e8 \u6559\u6388<\/li>\n<li>2010- \u8036\u9c81\u5927\u5b66 \u5206\u5b50\u30fb\u7ec6\u80de\u30fb\u53d1\u80b2\u751f\u7269\u5b66\u90e8 Lewis B. Cullman Professor<br \/>\n&lt;\u517c\u4efb&gt;<\/li>\n<li>2003 Proteolix, Inc \u5408\u4f19\u4eba<\/li>\n<li>2003 Yale Center for Molecular Discovery, Exective Director<\/li>\n<li>2013 Arvinas, LLC \u521b\u4e1a\u8005<\/li>\n<li>2015 Progam for Innovative Therapeutics for CT\u2019s Health, Co-Director<\/li>\n<\/ul>\n<h4>\u83b7\u5956\u7ecf\u5386<\/h4>\n<ul>\n<li>1999 Arthur Greer Memorial Prize for Outstanding Junior Faculty Member in the Social or Natural Sciences<\/li>\n<li>2005- Bessel Research Award, Alexander von Humboldt Foundation, Germany<\/li>\n<li>2011 Senior Scholar Award, Ellison Medical Foundation<\/li>\n<li>2013 Entrepreneur of the Year, Connecticut United for Research Excellence (CURE)<\/li>\n<li>2014 UCB-Ehrlich Award for Excellence in Medicinal Chemistry (European<\/li>\n<li>Federation of Medicinal Chemistry)<\/li>\n<li>2015 NIH R35 Outstanding Investigator Award (National Cancer Institute)<\/li>\n<li>2015 Translational Research Prize, Yale Cancer Center<\/li>\n<li>2017 AACR Award for Outstanding Achievement in Chemistry in Cancer Research<\/li>\n<\/ul>\n<h4><b>\u7814\u7a76\u6982\u8981<\/b><\/h4>\n<ul>\n<li><b>PROTAC\u6cd5\u7684\u5f00\u53d1<\/b><\/li>\n<\/ul>\n<p>PROTAC\u662f<b>Proteolysis Targeting Chimera<\/b>\u7684\u7b80\u79f0\u3001\u76ee\u7684\u5728\u4e8e\u878d\u5408\u9776\u86cb\u767d\u7684\u914d\u4f53\u548cE3\u6cdb\u7d20\u8fde\u63a5\u9176\u8bc6\u522b\u4f4d\u70b9\u7684\u5206\u5b50<\/p>\n<p>\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\u53ef\u4ee5\u4f7f\u5f97\u6cdb\u7d20\u8fde\u63a5\u9176\u671d\u7740\u7279\u5b9a\u7684\u86cb\u767d\u8d28\u9760\u8fd1\uff0c\u4f18\u5148\u5bf9\u5176\u8fdb\u884c\u6cdb\u7d20\u5316\uff0c\u7ee7\u800c\u7531\u86cb\u767d\u9176\u4f53\u7cfb\u8fdb\u884c\u5206\u89e3\u3002\u4e5f\u5c31\u662f\u5bf9\u7279\u5b9a\u7684\u86cb\u767d\u8d28\u8fdb\u884c\u5316\u5b66\u9009\u62e9\u6027\u7684knock down\u6280\u672f[1]\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15007 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/PROTAC.jpg\" alt=\"\" width=\"500\" height=\"292\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/PROTAC.jpg 500w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/PROTAC-300x175.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/p>\n<ul>\n<li><b>\u6297\u764c\u836fCarfizomib\uff08Kyprolis\u00ae\uff09\u7684\u5f00\u53d1<\/b><\/li>\n<\/ul>\n<p>Craig M. Crews\u5408\u6210\u5f00\u53d1\u4e86\u5929\u7136\u4ea7\u7269\u73af\u6c27\u9176\u7d20[2]\u7684\u884d\u751f\u7269\uff0c\u5982\u4e0b\u56fe\u6240\u793a\uff0c\u8fd9\u662f\u4e00\u4e2a\u542b\u6709\u73af\u6c27\u57fa\u56e2\u7684\u56db\u80bd\u5316\u5408\u7269\u3002\u8be5\u5316\u5408\u7269\u5bf920S\u86cb\u767d\u9176\u5177\u6709\u963b\u65ad\u6548\u679c\uff0c\u9002\u7528\u4e8e\u591a\u53d1\u6027\u7684\u9aa8\u9ad3\u764c\uff0c\u57282012\u5e74\u88abFDA\u6279\u51c6\u4e0a\u5e02[3]\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15008 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/carfilzomib-e1494344977848.png\" alt=\"\" width=\"515\" height=\"126\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/carfilzomib-e1494344977848.png 515w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/carfilzomib-e1494344977848-300x73.png 300w\" sizes=\"(max-width: 515px) 100vw, 515px\" \/><\/p>\n<h4>\u76f8\u5173\u89c6\u9891<\/h4>\n<p><span class=\"embed-youtube\" style=\"text-align:center; display: block;\"><iframe loading=\"lazy\" class=\"youtube-player\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/p63PDNluP0I?version=3&#038;rel=1&#038;showsearch=0&#038;showinfo=1&#038;iv_load_policy=1&#038;fs=1&#038;hl=en-US&#038;autohide=2&#038;wmode=transparent\" allowfullscreen=\"true\" style=\"border:0;\" sandbox=\"allow-scripts allow-same-origin allow-popups allow-presentation allow-popups-to-escape-sandbox\"><\/iframe><\/span><\/p>\n<h4>\u76f8\u5173\u6587\u732e<\/h4>\n<ol>\n<li>\u201cProtacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation\u201d Sakamoto, K. M.; Kim, K. B.; Kumagai, A.; Mercurio, F.; Crews, C. M.; Deshaies, R. J. <i>Proc. Natl. Acad. Sci. USA<\/i> <b>2001<\/b>, <i>98<\/i>, 8554. doi:<a href=\"http:\/\/dx.doi.org\/10.1073\/pnas.141230798\">10.1073\/pnas.141230798<\/a><\/li>\n<li>\u201cEpoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity\u201d Meng, L; Mohan, R.; Kwok, B.H.; Elofsson, M.; Sin, N.; Crews, C. M. <i>Proc. Natl. Acad. Sci. USA<\/i> <b>1999<\/b>\uff0c<i>96<\/i>, 10403. doi:<a href=\"http:\/\/dx.doi.org\/10.1073\/pnas.96.18.10403\">10.1073\/pnas.96.18.10403<\/a><\/li>\n<li>\u201cCarfilzomib: From Discovery To Drug\u201d <i>C&amp;EN<\/i> <b>2012<\/b>, <i>90<\/i>, 34. <a href=\"http:\/\/cen.acs.org\/articles\/90\/i35\/Carfilzomib-Discovery-Drug.html\">[link]<\/a><\/li>\n<\/ol>\n<h4>\u76f8\u5173\u94fe\u63a5<\/h4>\n<ul>\n<li><a href=\"http:\/\/crewslab.yale.edu\/\">Crews Laboratory<\/a><\/li>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Craig_M._Crews\">Craig M. Crews \u2013 Wikipedia<\/a><\/li>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Carfilzomib\">Carfilzomib \u2013 Wikipedia<\/a><\/li>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Proteolysis_targeting_chimera\">Proteolysis Targeting Chimera \u2013 Wikipedia<\/a><\/li>\n<\/ul>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"Craig Martin Crews\u30011964\u5e746\u67081\u65e5(\u7ebd\u65af\u6ce2\u7279\u65af\u3001\u5f17\u5409\u5c3c\u4e9a\u51fa\u751f)\u3001\u7f8e\u56fd\u6709\u673a\u5316\u5b66\u5bb6\u30fb\u751f\u7269\u5316\u5b66\u5bb6\u30fb\u751f\u7269\u5b66\u5bb6\uff0c\u8036\u9c81\u5927\u5b66\u6559\u6388\u3002(\u7167\u7247:Yale School of Medicine) \u7ecf\u5386 1986 \u5f17\u5409\u5c3c\u4e9a\u5927\u5b66 \u6bd5\u4e1a 1986-87 \u5fb7\u56fd\u8482\u5bbe\u6839\u5927\u5b66\u00a0DAAD Fellow 1993 \u54c8\u4f5b\u5927\u5b66 \u535a\u58eb\u5b66\u4f4d\uff08Raymond Erikson\u6559\u6388\uff09 1993-95 \u54c8\u4f5b\u5927\u5b66 \u535a\u58eb\u7814\u7a76\u5458\uff08Stuart L. Schreiber\u6559\u6388\uff09 1995-2000 \u8036\u9c81\u5927\u5b66 \u5206\u5b50\u30fb\u7ec6\u80de\u30fb\u53d1\u80b2\u751f\u7269\u5b66\u90e8 \u52a9\u7406\u6559\u6388 1998-2000 \u8036\u9c81\u5927\u5b66 \u533b\u5b66\u90e8\u836f\u5b66\u79d1 \u52a9\u7406\u6559\u6388 2000-2007 \u8036\u9c81\u5927\u5b66 \u5206\u5b50\u30fb\u7ec6\u80de\u30fb\u53d1\u80b2\u751f\u7269\u5b66\u90e8 \u526f\u6559\u6388 2000-2007 \u8036\u9c81\u5927\u5b66 \u533b\u5b66\u90e8\u836f\u5b66\u79d1 \u526f\u6559\u6388 2007-2010 \u8036\u9c81\u5927\u5b66 \u5206\u5b50\u30fb\u7ec6\u80de\u30fb\u53d1\u80b2\u751f\u7269\u5b66\u90e8 \u6559\u6388 2010- \u8036\u9c81\u5927\u5b66 \u5206\u5b50\u30fb\u7ec6\u80de\u30fb\u53d1\u80b2\u751f\u7269\u5b66\u90e8 Lewis B. Cullman Professor &lt;\u517c\u4efb&gt; 2003 Proteolix, Inc \u5408\u4f19\u4eba 2003 Yale Center for Molecular Discovery, Exective Director 2013 Arvinas, LLC \u521b\u4e1a\u8005 2015 Progam for Innovative Therapeutics for CT\u2019s Health, Co-Director \u83b7\u5956\u7ecf\u5386 1999 Arthur Greer Memorial Prize for Outstanding Junior Faculty Member in the Social or Natural Sciences 2005- Bessel Research Award, Alexander von Humboldt Foundation, Germany 2011 Senior Scholar Award, Ellison Medical Foundation 2013 Entrepreneur [&hellip;]","protected":false},"author":5,"featured_media":15006,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[212],"tags":[1199,1920],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/07\/Craig_Crews_0.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-3U1","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15005"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=15005"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15005\/revisions"}],"predecessor-version":[{"id":27372,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15005\/revisions\/27372"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/15006"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=15005"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=15005"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=15005"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}