{"id":15199,"date":"2017-08-10T06:57:40","date_gmt":"2017-08-09T22:57:40","guid":{"rendered":"\/\/www.gsbet888.com\/?p=15199"},"modified":"2019-08-02T18:52:53","modified_gmt":"2019-08-02T10:52:53","slug":"jeffrey-w-bode","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemists\/2017\/08\/jeffrey-w-bode.html","title":{"rendered":"Jeffrey W. Bode"},"content":{"rendered":"<p><strong>\u672c\u6587\u7ffb\u8bd1\u6295\u7a3f\u4f5c\u8005 alberto-caeiro<\/strong><\/p>\n<p>Jeffrey W. Bode\u6559\u6388\u3002\u745e\u58eb\u6709\u673a\u5316\u5b66\u5bb6\uff0c\u5e08\u627f\u745e\u58eb\u8054\u90a6\u7406\u5de5\u5b66\u9662E. M. Carreira\u6559\u6388 (\u54c8\u4f5b\u5927\u5b66David A. Evans\u6559\u6388 PhD)\uff0c\u73b0\u4e3a\u745e\u58eb\u8054\u90a6\u7406\u5de5\u5b66\u9662\u6559\u6388\uff0c\u540c\u65f6\u540d\u53e4\u5c4b\u5927\u5b66Institute of Transformative Bio-Molecules\u7684\u5ba2\u5ea7\u6559\u6388\u3002\uff08\u7167\u7247\uff1a<a href=\"http:\/\/www.itbm.nagoya-u.ac.jp\/ja\/members\/j-bode\/\">\u540d\u5927ITbM<\/a>\uff09<a href=\"http:\/\/www.bode.ethz.ch\/\">\u5b9e\u9a8c\u5ba4\u4e3b\u9875<\/a><\/p>\n<p>&nbsp;<\/p>\n<h4 style=\"text-align: left\"><strong>\u7ecf\u5386<\/strong><\/h4>\n<ul>\n<li>1996 Trinity University B. S.\uff08M. P. Doyle\u6559\u6388\uff09<\/li>\n<li>2001 \u745e\u58eb\u8054\u90a6\u7406\u5de5\u5b66\u9662 \u535a\u58eb\uff08E.M.Carreira\u6559\u6388\uff09<\/li>\n<li>2001-2003 \u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66 \u535a\u58eb\u7814\u7a76\u54e1\uff08<a href=\"http:\/\/www.chem-station.com\/chemist-db\/archives\/2012\/09\/-keisuke-suzuki.php\">\u9234\u6728\u5553\u4ecb<\/a> \u6559\u6388\uff09<\/li>\n<li>2003-2007 University of California, Santa Barbara \u52a9\u6559<\/li>\n<li>2007-2009 University of Pennsylvania\u526f\u6559\u6388<\/li>\n<li>2009 University of Pennsylvania \u6559\u6388<\/li>\n<li>2010-\u73b0\u5728 \u745e\u58eb\u8054\u90a6\u7406\u5de5\u5b66\u9662 \u6559\u6388<\/li>\n<li>2013-\u73b0\u5728 \u540d\u53e4\u5c4b\u5927\u5b66 Institute of Transformative Bio-Molecules \uff08ITbM\uff09\u5ba2\u5ea7\u6559\u6388<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h4><strong>\u83b7\u5956\u7ecf\u5386<\/strong><\/h4>\n<ul>\n<li>2013 Fellow of the Royal Society of Chemistry, UK<\/li>\n<li>2012 ERC Starting Grant<\/li>\n<li>2011 E. J. Corey Award (ACS)<\/li>\n<li>2010 \u5e73\u7530\u91d1\u5956<\/li>\n<li>2008 Arthur C. Cope Scholar Award (ACS)<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h4><strong>\u7814\u7a76\u6982\u8981<\/strong><\/h4>\n<ol>\n<li><strong>\u80bd\u952e\u7684\u65b0\u578b\u5408\u6210\u65b9\u6cd5[1-3]<\/strong><\/li>\n<\/ol>\n<p>\u901a\u8fc7\u5c06\u03b1-\u916e\u9178\u4e0e\u7f9f\u80fa\u6df7\u5408\u53cd\u5e94\uff0c\u5f00\u53d1\u4e86\u4e0d\u9700\u8981\u4fa7\u94fe\u4fdd\u62a4\uff0c\u5728\u6e29\u548c\u6761\u4ef6\u4e0b\u5373\u53ef\u53cd\u5e94\u7684\u65b0\u578b\u80bd\u952e\u5408\u6210\u65b9\u6cd5\uff0c\u4e5f\u79f0KAHA ligation\uff08\u03b1-Ketoacid-Hydroxylamine (KAHA) Ligation\uff09\u3002\u8be6\u89c1<a href=\"http:\/\/www.chem-station.com\/odos\/2009\/07\/bode-bode-peptide-synthesis.html\">Bode Peptide Synthesis<\/a>\uff08\u65e5\u6587\u7248\uff09<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/topic_peptide_4.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-15207\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/topic_peptide_4.gif\" alt=\"\" width=\"371\" height=\"190\" \/><\/a><\/p>\n<ol start=\"2\">\n<li><strong>\u7ecf\u9170\u57fa\u4e09\u6c1f\u787c\u9178\u94be\u7684\u80bd\u952e\u5408\u6210\u65b9\u6cd5\u7684\u5f00\u53d1[4, 5]<\/strong><\/li>\n<\/ol>\n<p>\u7531\u4e0a\u8ff0KAHA ligation \u53d1\u5c55\u51fa\u6765\u7684\uff0c\u5c06\u4e0b\u9762\u4e24\u79cd\u5e95\u7269\u6df7\u5408\u540e\uff0c\u6c34\u4e2d\u5373\u53ef\u5b9e\u73b0\u5f53\u91cf\u53cd\u5e94\u7684\u9170\u80fa\u952e\u5408\u6210\u65b9\u6cd5\uff0c\u5177\u6709\u826f\u597d\u7684\u5316\u5b66\u9009\u62e9\u6027\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/2-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15201 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/2-1.jpg\" alt=\"\" width=\"608\" height=\"212\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/2-1.jpg 608w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/2-1-300x105.jpg 300w\" sizes=\"(max-width: 608px) 100vw, 608px\" \/><\/a><\/p>\n<ol start=\"3\">\n<li><strong>\u7b80\u5355\u5b9e\u73b0\u542b\u6c2e\u5076\u6570\u73af\u5316\u5408\u7269\u6784\u5efa\u7684\u8bd5\u5242 (SnAP\u8bd5\u5242)\u7684\u5f00\u53d1[6-8]<\/strong><\/li>\n<\/ol>\n<p>\u901a\u8fc7\u5c06SnAP (Sn(tin) Amine Protocol)\u8bd5\u5242\u548c\u7fb0\u57fa\u5316\u5408\u7269\u6df7\u5408\u540e\u7ecf\u9178\u5316\u5904\u7406\uff0c\u53ef\u8f7b\u677e\u5f97\u5230\u542b\u6709\u9971\u548c\u7684\u5076\u6570\u73af\uff0c\u87ba\u73af\u7b49\u7ed3\u6784\u7684\u6c28\u57fa\u5316\u5408\u7269\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/3-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15202 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/3-1.jpg\" alt=\"\" width=\"668\" height=\"123\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/3-1.jpg 668w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/3-1-300x55.jpg 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/3-1-660x123.jpg 660w\" sizes=\"(max-width: 668px) 100vw, 668px\" \/><\/a><\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ol>\n<li>Pattabiraman, V.; Bode, J. W. Nature 2011, 480, 471. <a href=\"https:\/\/www.nature.com\/nature\/journal\/v480\/n7378\/full\/nature10702.html\">DOI:10.1038\/nature10702<\/a>;<\/li>\n<li>Harmand, T. J.; Murar, C. E.; Bode, J. W. Nat. Protoc. 2016, 11, 1130-1147. <a href=\"https:\/\/www.nature.com\/nprot\/journal\/v11\/n6\/full\/nprot.2016.052.html\">DOI:10.1038\/nprot.2016.052<\/a>;<\/li>\n<li>armand, T. J. R.; Murar, C. E.; Bode, J. W. Curr. Opin. Chem. Biol. 2014, 22, 115. <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1367593114001392?via%3Dihub\">DOI: 10.1016\/j.cbpa.2014.09.032<\/a>;<\/li>\n<li>Dumas, A. M.; Molander, G. A.; Bode, J. W. Angew. Chem. Int. Ed. 2012, 51, 5683\u20135686. <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201201077\/abstract\">DOI: 10.1002\/anie.201201077<\/a>;<\/li>\n<li>Noda, H; Eros, G; Bode, J. W. J. Am. Chem. Soc. 2014, 136, 5611\u20135614. <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja5018442\">DOI: 10.1021\/ja5018442<\/a><\/li>\n<li>Vo, C.-V.; Mikutis, G.; Bode, J. W. Angew. Chem. Int. Ed. 2013, 52, 1705\u20131708. <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201208064\/abstract\">DOI: 10.1002\/anie.201208064<\/a>;<\/li>\n<li>Vo, C.-V.; Luescher, M. U.; Bode, J. W. Nat. Chem. 2014, 6, 310\u2013314. <a href=\"https:\/\/www.nature.com\/nchem\/journal\/v6\/n4\/full\/nchem.1878.html\">DOI:10.1038\/nchem.1878<\/a>;<\/li>\n<li>Review: (a) Vo, C.-V.; Bode, J. W. J. Org. Chem. 2014, 79, 2809\u20132815. <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jo5001252\">DOI: 10.1021\/jo5001252<\/a>; (b) Luescher, M. U.; Geoghegan, K.; Nichols, P. L.; Bode, J. W. Aldrichim. Acta 2015, 48, 43\u201348. [<a href=\"http:\/\/www.sigmaaldrich.com\/content\/dam\/sigma-aldrich\/docs\/Aldrich\/Brochure\/1\/acta-48-2.pdf\">PDF<\/a>]<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01 <\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u7ffb\u8bd1\u6295\u7a3f\u4f5c\u8005 alberto-caeiro Jeffrey W. Bode\u6559\u6388\u3002\u745e\u58eb\u6709\u673a\u5316\u5b66\u5bb6\uff0c\u5e08\u627f\u745e\u58eb\u8054\u90a6\u7406\u5de5\u5b66\u9662E. M. Carreira\u6559\u6388 (\u54c8\u4f5b\u5927\u5b66David A. Evans\u6559\u6388 PhD)\uff0c\u73b0\u4e3a\u745e\u58eb\u8054\u90a6\u7406\u5de5\u5b66\u9662\u6559\u6388\uff0c\u540c\u65f6\u540d\u53e4\u5c4b\u5927\u5b66Institute of Transformative Bio-Molecules\u7684\u5ba2\u5ea7\u6559\u6388\u3002\uff08\u7167\u7247\uff1a\u540d\u5927ITbM\uff09\u5b9e\u9a8c\u5ba4\u4e3b\u9875 &nbsp; \u7ecf\u5386 1996 Trinity University B. S.\uff08M. P. Doyle\u6559\u6388\uff09 2001 \u745e\u58eb\u8054\u90a6\u7406\u5de5\u5b66\u9662 \u535a\u58eb\uff08E.M.Carreira\u6559\u6388\uff09 2001-2003 \u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66 \u535a\u58eb\u7814\u7a76\u54e1\uff08\u9234\u6728\u5553\u4ecb \u6559\u6388\uff09 2003-2007 University of California, Santa Barbara \u52a9\u6559 2007-2009 University of Pennsylvania\u526f\u6559\u6388 2009 University of Pennsylvania \u6559\u6388 2010-\u73b0\u5728 \u745e\u58eb\u8054\u90a6\u7406\u5de5\u5b66\u9662 \u6559\u6388 2013-\u73b0\u5728 \u540d\u53e4\u5c4b\u5927\u5b66 Institute of Transformative Bio-Molecules \uff08ITbM\uff09\u5ba2\u5ea7\u6559\u6388 &nbsp; \u83b7\u5956\u7ecf\u5386 2013 Fellow of the Royal Society of Chemistry, UK 2012 ERC Starting Grant 2011 E. J. Corey Award (ACS) 2010 \u5e73\u7530\u91d1\u5956 2008 Arthur C. Cope Scholar Award (ACS) &nbsp; \u7814\u7a76\u6982\u8981 \u80bd\u952e\u7684\u65b0\u578b\u5408\u6210\u65b9\u6cd5[1-3] \u901a\u8fc7\u5c06\u03b1-\u916e\u9178\u4e0e\u7f9f\u80fa\u6df7\u5408\u53cd\u5e94\uff0c\u5f00\u53d1\u4e86\u4e0d\u9700\u8981\u4fa7\u94fe\u4fdd\u62a4\uff0c\u5728\u6e29\u548c\u6761\u4ef6\u4e0b\u5373\u53ef\u53cd\u5e94\u7684\u65b0\u578b\u80bd\u952e\u5408\u6210\u65b9\u6cd5\uff0c\u4e5f\u79f0KAHA ligation\uff08\u03b1-Ketoacid-Hydroxylamine (KAHA) Ligation\uff09\u3002\u8be6\u89c1Bode Peptide Synthesis\uff08\u65e5\u6587\u7248\uff09 \u7ecf\u9170\u57fa\u4e09\u6c1f\u787c\u9178\u94be\u7684\u80bd\u952e\u5408\u6210\u65b9\u6cd5\u7684\u5f00\u53d1[4, 5] \u7531\u4e0a\u8ff0KAHA ligation \u53d1\u5c55\u51fa\u6765\u7684\uff0c\u5c06\u4e0b\u9762\u4e24\u79cd\u5e95\u7269\u6df7\u5408\u540e\uff0c\u6c34\u4e2d\u5373\u53ef\u5b9e\u73b0\u5f53\u91cf\u53cd\u5e94\u7684\u9170\u80fa\u952e\u5408\u6210\u65b9\u6cd5\uff0c\u5177\u6709\u826f\u597d\u7684\u5316\u5b66\u9009\u62e9\u6027\u3002 \u7b80\u5355\u5b9e\u73b0\u542b\u6c2e\u5076\u6570\u73af\u5316\u5408\u7269\u6784\u5efa\u7684\u8bd5\u5242 (SnAP\u8bd5\u5242)\u7684\u5f00\u53d1[6-8] \u901a\u8fc7\u5c06SnAP (Sn(tin) Amine Protocol)\u8bd5\u5242\u548c\u7fb0\u57fa\u5316\u5408\u7269\u6df7\u5408\u540e\u7ecf\u9178\u5316\u5904\u7406\uff0c\u53ef\u8f7b\u677e\u5f97\u5230\u542b\u6709\u9971\u548c\u7684\u5076\u6570\u73af\uff0c\u87ba\u73af\u7b49\u7ed3\u6784\u7684\u6c28\u57fa\u5316\u5408\u7269\u3002 \u53c2\u8003\u6587\u732e Pattabiraman, V.; Bode, [&hellip;]","protected":false},"author":8,"featured_media":15208,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[212],"tags":[1941],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/JW_Bode_0.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-3X9","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15199"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=15199"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15199\/revisions"}],"predecessor-version":[{"id":27357,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15199\/revisions\/27357"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/15208"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=15199"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=15199"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=15199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}