{"id":15345,"date":"2017-08-11T11:24:16","date_gmt":"2017-08-11T03:24:16","guid":{"rendered":"\/\/www.gsbet888.com\/?p=15345"},"modified":"2019-08-02T18:52:50","modified_gmt":"2019-08-02T10:52:50","slug":"%e8%90%83%e5%8f%96%e5%8f%af%e4%bb%a5%e9%99%a4%e5%8e%bb%e9%86%9b%ef%bc%81","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2017\/08\/%e8%90%83%e5%8f%96%e5%8f%af%e4%bb%a5%e9%99%a4%e5%8e%bb%e9%86%9b%ef%bc%81.html","title":{"rendered":"\u8403\u53d6\u53ef\u4ee5\u9664\u53bb\u919b\uff01"},"content":{"rendered":"<p>\u919b\u662f\u4e00\u79cd\u5165\u624b\u7b80\u4fbf\uff0c\u8f83\u7a33\u5b9a\uff0c\u5e76\u4e14\u5177\u6709\u5f88\u9ad8\u7684\u53cd\u5e94\u6027\u7684\uff0c\u5e38\u7528\u4e8e\u6784\u7b51C-C\u952e\u7684\u5316\u5408\u7269\u3002\u7279\u522b\u662f\u5728\u591a\u6b65\u5408\u6210\u4e2d\uff0c\u662f\u4e00\u79cd\u5341\u5206\u6709\u7528\u7684\u4e2d\u95f4\u4f53\uff0c\u7136\u800c\u53cd\u5e94\u540e\u7684\u9664\u53bb\u5e38\u5e38\u662f\u4e00\u4e2a\u6bd4\u8f83\u9ebb\u70e6\u7684\u95ee\u9898\u3002<\/p>\n<p>\u5728\u8fd9\u91cc\uff0c\u5c0f\u7f16\u5c31\u6765\u4e3a\u5927\u5bb6\u4ecb\u7ecd\u4e0bOPRD\u6742\u5fd7\u4e0a\u521a\u62a5\u9053\u7684\u4e00\u79cd\u65b0\u7684\u9664\u53bb\u919b\u7684\u624b\u6cd5\uff0c<strong>\u53ea\u9700\u8981\u901a\u8fc7\u8403\u53d6\u5206\u6db2\u5c31\u80fd\u9664\u53bb\u919b\uff01<\/strong><\/p>\n<blockquote><p>\u201cLiquid\u2013Liquid Extraction Protocol for the Removal of Aldehydes and Highly Reactive Ketones from Mixtures\u201d<br \/>\nBoucher, M. M.; Furigay, M. H.; Quach, P.; K.; Brindle, C. S.*\u00a0<i>Org. Process Res. Dev.<\/i> <b>2017<\/b>, Article ASAP. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/acs.oprd.7b00231\">10.1021\/acs.oprd.7b00231<\/a><\/p><\/blockquote>\n<p>\u539f\u7406\u4e0a\u4e0e<strong>\u919b\u7eaf\u5316\u6cd5<\/strong>\u6b65\u9aa4\u7c7b\u4f3c[1,2]\u3002\u4e5f\u5c31\u662f\u8bf4\u3001\u919b\u4e0e\u4e9a\u786b\u9178\u6c22\u94a0\u53cd\u5e94\u5f62\u6210bisulfite adduct\u3001\u7136\u540e\u518d\u901a\u8fc7\u91cd\u7ed3\u6676\u56de\u6536\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15347 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/aldehyde_extract_1-e1501340801681.png\" alt=\"\" width=\"473\" height=\"94\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/aldehyde_extract_1-e1501340801681.png 473w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/aldehyde_extract_1-e1501340801681-300x60.png 300w\" sizes=\"(max-width: 473px) 100vw, 473px\" \/><\/p>\n<p>\u8fd9\u6b21\u4ecb\u7ecd\u7684OPRD\u8bba\u6587\u4e0a\uff0c\u7740\u773c\u4e8ebisulfite adduct\u7684\u6c34\u6eb6\u6027\u6027\u8d28\uff0c\u7a0d\u5fae\u6539\u53d8\u4e86\u4e0b\u64cd\u4f5c\u987a\u5e8f\uff0c\u4e3b\u8981\u662f\u5728\u6700\u521d\u7684bisulfite adduct\u5f62\u6210\u8fc7\u7a0b\u4e0a\u7b5b\u9009\u4e86\u5f88\u591a\u6761\u4ef6\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15348 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/aldehyde_extract_2-e1501340847777.png\" alt=\"\" width=\"500\" height=\"121\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/aldehyde_extract_2-e1501340847777.png 500w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/aldehyde_extract_2-e1501340847777-300x73.png 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/p>\n<ol>\n<li><strong>\u5316\u5408\u7269\u6eb6\u89e3\u4e8e\u7532\u9187\u4e2d\uff0c\u7136\u540e\u52a0\u5165\u9971\u548cNaHSO<sub>3<\/sub>\u3001\u644730\u79d2<\/strong><\/li>\n<li><strong>\u6709\u673a\u6eb6\u5242\uff08hexane \u6216\u8005\u662f 10%EtOAc\/Hexane\uff09\u5206\u6db2\u8403\u53d6<\/strong><\/li>\n<\/ol>\n<p>\u4e3b\u8981\u7684Scope &amp; Limitation\u5982\u4e0b\u6240\u793a<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15349 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/aldehyde_extract_3-e1501340918868.png\" alt=\"\" width=\"495\" height=\"295\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/aldehyde_extract_3-e1501340918868.png 495w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/aldehyde_extract_3-e1501340918868-300x179.png 300w\" sizes=\"(max-width: 495px) 100vw, 495px\" \/><\/p>\n<ul>\n<li>\u9664\u53bb\u8102\u80aa\u65cf\u919b\u7684\u65f6\u5019\uff0c\u9700\u8981\u7528<strong>\u51e0\u500d\u91cf\u7684DM<\/strong>F\u6eb6\u5242\u66ff\u4ee3MeOH\uff0c30\u5206\u949f\u6405\u62cc\uff08\u7531\u4e8ebisulfite adduct\u7684\u5f62\u6210\u6bd4\u8f83\u56f0\u96be\uff09\u3002\u53cd\u5e94\u6027\u916e\u4e5f\u80fd\u9664\u53bb\u3002<\/li>\n<li>\u5229\u7528bisulfite\u5f62\u6210\u7684\u6548\u7387\u5dee\u5f02\uff0c\u4e5f\u53ef\u4ee5\u7528\u6765\u5206\u79bb\u919b\u4e0e\u4f4e\u53cd\u5e94\u6027\u7684\u916e\u3002<\/li>\n<li>\u542b\u6709\u5bcc\u7535\u5b50\u7684\u70ef\u70c3\u53d6\u4ee3\u57fa\u7684\u5316\u5408\u7269\u6709\u53ef\u80fd\u4f1a\u4e0eSO<sub>2<\/sub>\u53cd\u5e94\uff0c\u751f\u6210\u526f\u4ea7\u7269\uff08\u8be5\u95ee\u9898\u53ef\u4ee5\u5229\u7528SO<sub>2<\/sub>\u6eb6\u89e3\u5ea6\u4f4e\u7684\u8403\u53d6\u6eb6\u5242hexane\u89e3\u51b3\uff09\u3002<\/li>\n<li>\u80fa\u57fa\u5316\u5408\u7269\u53ef\u4ee5\u4e0eNaHSO<sub>3<\/sub>\u6210\u76d0\u5bfc\u81f4\u56de\u6536\u4ea7\u7387\u3002<\/li>\n<\/ul>\n<p>\u8be5\u65b9\u6cd5\u5bf9large scale\u7684\u53cd\u5e94\uff0c\u6709\u633a\u597d\u7684\u5e94\u7528\u4ef7\u503c\u3002<\/p>\n<h4><b>\u76f8\u5173\u6587\u732e<\/b><\/h4>\n<ol>\n<li>\u201cA Novel, Nonaqueous Method for Regeneration of Aldehydes from Bisulfite Adducts\u201d Kjel, D. P.; Slattery, B. J.; Semo, M. J. <i>J. Org. Chem.<\/i> <b>1999<\/b>, <i>64<\/i>, 5722. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/jo990543v\">10.1021\/jo990543v<\/a><\/li>\n<li>\u201c2-Methyl-3-phenylpropanal\u201d Buntin, S. A.; \u00a0Heck, R. F. <i>Org. Synth.<\/i> <b>1983<\/b>, <i>61<\/i>, 82. DOI: <a href=\"http:\/\/dx.doi.org\/10.15227\/orgsyn.061.0082\">10.15227\/orgsyn.061.0082<\/a><\/li>\n<\/ol>\n<h4><b>\u5916\u90e8\u94fe\u63a5<\/b><\/h4>\n<ul>\n<li><a href=\"https:\/\/amphoteros.com\/2015\/04\/16\/on-bisulfite-adducts-of-aldehydes\/\">On bisulfite adducts of aldehydes<\/a> (amphoterous)<\/li>\n<li><a href=\"https:\/\/zh.wikipedia.org\/wiki\/\u4e9a\u786b\u9178\u6c22\u94a0\">\u4e9a\u786b\u9178\u6c22\u94a0\u00a0\u2013 Wikipedia<\/a><\/li>\n<\/ul>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"\u919b\u662f\u4e00\u79cd\u5165\u624b\u7b80\u4fbf\uff0c\u8f83\u7a33\u5b9a\uff0c\u5e76\u4e14\u5177\u6709\u5f88\u9ad8\u7684\u53cd\u5e94\u6027\u7684\uff0c\u5e38\u7528\u4e8e\u6784\u7b51C-C\u952e\u7684\u5316\u5408\u7269\u3002\u7279\u522b\u662f\u5728\u591a\u6b65\u5408\u6210\u4e2d\uff0c\u662f\u4e00\u79cd\u5341\u5206\u6709\u7528\u7684\u4e2d\u95f4\u4f53\uff0c\u7136\u800c\u53cd\u5e94\u540e\u7684\u9664\u53bb\u5e38\u5e38\u662f\u4e00\u4e2a\u6bd4\u8f83\u9ebb\u70e6\u7684\u95ee\u9898\u3002 \u5728\u8fd9\u91cc\uff0c\u5c0f\u7f16\u5c31\u6765\u4e3a\u5927\u5bb6\u4ecb\u7ecd\u4e0bOPRD\u6742\u5fd7\u4e0a\u521a\u62a5\u9053\u7684\u4e00\u79cd\u65b0\u7684\u9664\u53bb\u919b\u7684\u624b\u6cd5\uff0c\u53ea\u9700\u8981\u901a\u8fc7\u8403\u53d6\u5206\u6db2\u5c31\u80fd\u9664\u53bb\u919b\uff01 \u201cLiquid\u2013Liquid Extraction Protocol for the Removal of Aldehydes and Highly Reactive Ketones from Mixtures\u201d Boucher, M. M.; Furigay, M. H.; Quach, P.; K.; Brindle, C. S.*\u00a0Org. Process Res. Dev. 2017, Article ASAP. DOI: 10.1021\/acs.oprd.7b00231 \u539f\u7406\u4e0a\u4e0e\u919b\u7eaf\u5316\u6cd5\u6b65\u9aa4\u7c7b\u4f3c[1,2]\u3002\u4e5f\u5c31\u662f\u8bf4\u3001\u919b\u4e0e\u4e9a\u786b\u9178\u6c22\u94a0\u53cd\u5e94\u5f62\u6210bisulfite adduct\u3001\u7136\u540e\u518d\u901a\u8fc7\u91cd\u7ed3\u6676\u56de\u6536\u3002 \u8fd9\u6b21\u4ecb\u7ecd\u7684OPRD\u8bba\u6587\u4e0a\uff0c\u7740\u773c\u4e8ebisulfite adduct\u7684\u6c34\u6eb6\u6027\u6027\u8d28\uff0c\u7a0d\u5fae\u6539\u53d8\u4e86\u4e0b\u64cd\u4f5c\u987a\u5e8f\uff0c\u4e3b\u8981\u662f\u5728\u6700\u521d\u7684bisulfite adduct\u5f62\u6210\u8fc7\u7a0b\u4e0a\u7b5b\u9009\u4e86\u5f88\u591a\u6761\u4ef6\u3002 \u5316\u5408\u7269\u6eb6\u89e3\u4e8e\u7532\u9187\u4e2d\uff0c\u7136\u540e\u52a0\u5165\u9971\u548cNaHSO3\u3001\u644730\u79d2 \u6709\u673a\u6eb6\u5242\uff08hexane \u6216\u8005\u662f 10%EtOAc\/Hexane\uff09\u5206\u6db2\u8403\u53d6 \u4e3b\u8981\u7684Scope &amp; Limitation\u5982\u4e0b\u6240\u793a \u9664\u53bb\u8102\u80aa\u65cf\u919b\u7684\u65f6\u5019\uff0c\u9700\u8981\u7528\u51e0\u500d\u91cf\u7684DMF\u6eb6\u5242\u66ff\u4ee3MeOH\uff0c30\u5206\u949f\u6405\u62cc\uff08\u7531\u4e8ebisulfite adduct\u7684\u5f62\u6210\u6bd4\u8f83\u56f0\u96be\uff09\u3002\u53cd\u5e94\u6027\u916e\u4e5f\u80fd\u9664\u53bb\u3002 \u5229\u7528bisulfite\u5f62\u6210\u7684\u6548\u7387\u5dee\u5f02\uff0c\u4e5f\u53ef\u4ee5\u7528\u6765\u5206\u79bb\u919b\u4e0e\u4f4e\u53cd\u5e94\u6027\u7684\u916e\u3002 \u542b\u6709\u5bcc\u7535\u5b50\u7684\u70ef\u70c3\u53d6\u4ee3\u57fa\u7684\u5316\u5408\u7269\u6709\u53ef\u80fd\u4f1a\u4e0eSO2\u53cd\u5e94\uff0c\u751f\u6210\u526f\u4ea7\u7269\uff08\u8be5\u95ee\u9898\u53ef\u4ee5\u5229\u7528SO2\u6eb6\u89e3\u5ea6\u4f4e\u7684\u8403\u53d6\u6eb6\u5242hexane\u89e3\u51b3\uff09\u3002 \u80fa\u57fa\u5316\u5408\u7269\u53ef\u4ee5\u4e0eNaHSO3\u6210\u76d0\u5bfc\u81f4\u56de\u6536\u4ea7\u7387\u3002 \u8be5\u65b9\u6cd5\u5bf9large scale\u7684\u53cd\u5e94\uff0c\u6709\u633a\u597d\u7684\u5e94\u7528\u4ef7\u503c\u3002 \u76f8\u5173\u6587\u732e \u201cA Novel, Nonaqueous Method for Regeneration of Aldehydes from Bisulfite Adducts\u201d Kjel, D. P.; Slattery, B. J.; Semo, M. J. J. Org. Chem. 1999, 64, 5722. DOI: 10.1021\/jo990543v \u201c2-Methyl-3-phenylpropanal\u201d Buntin, S. A.; \u00a0Heck, R. F. Org. Synth. 1983, 61, 82. DOI: 10.15227\/orgsyn.061.0082 \u5916\u90e8\u94fe\u63a5 On bisulfite adducts of aldehydes (amphoterous) \u4e9a\u786b\u9178\u6c22\u94a0\u00a0\u2013 Wikipedia \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01","protected":false},"author":5,"featured_media":15366,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[414,1271],"tags":[1962,1161,58],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/aldehyde_extract_0.jpg","jetpack_shortlink":"https:\/\/wp.me\/p96op1-3Zv","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15345"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=15345"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15345\/revisions"}],"predecessor-version":[{"id":27347,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15345\/revisions\/27347"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/15366"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=15345"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=15345"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=15345"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}