{"id":15358,"date":"2017-08-29T06:52:08","date_gmt":"2017-08-28T22:52:08","guid":{"rendered":"\/\/www.gsbet888.com\/?p=15358"},"modified":"2019-08-02T18:52:49","modified_gmt":"2019-08-02T10:52:49","slug":"%e5%8a%9f%e8%83%bd%e6%8c%87%e5%90%91%e6%80%a7%e5%90%88%e6%88%90-function-oriented-synthesis","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemnews\/2017\/08\/%e5%8a%9f%e8%83%bd%e6%8c%87%e5%90%91%e6%80%a7%e5%90%88%e6%88%90-function-oriented-synthesis.html","title":{"rendered":"\u529f\u80fd\u6307\u5411\u6027\u5408\u6210 Function-Oriented Synthesis"},"content":{"rendered":"<p>\u4e0d\u62d8\u6ce5\u4e8e\u4e00\u5b9a\u5316\u5408\u7269\u7684\u7ed3\u6784\uff0c\u4e3b\u8981\u6ce8\u91cd\u4e8e\u529f\u80fd\u7684\u518d\u73b0\u6216\u8005\u4f18\u5316\u4e3a\u76ee\u7684\u7684\u5408\u6210\u6cd5\uff0c\u88ab\u79f0\u4e3a<b>\u529f\u80fd\u6307\u5411\u6027\u5408\u6210\uff08Function-Oriented Synthesis, FOS\uff09<\/b>\u3002\u65af\u5766\u798f\u5927\u5b66\u7684<a href=\"http:\/\/www.chem-station.com\/chemist-db\/archives\/2009\/04\/-paul-a-wender.php\">Paul A. Wender<\/a><br \/>\n\uff08\u6807\u9898\u56fe\u5f15\u7528\u4e8e\u6587\u732e[1]\uff09<\/p>\n<p>\u529f\u80fd\u6307\u5411\u6027\u5408\u6210\uff08FOS\uff09\u6240\u5e26\u6765\u7684\u300c\u4ece\u91cd\u89c6\u7ed3\u6784\u5230\u6ce8\u91cd\u529f\u80fd\u7684SHIFT\u300d\uff0c\u76f4\u63a5\u5f71\u54cd\u4e86\u5408\u6210\u7b56\u7565\u7684\u5236\u5b9a\u3002\u7b80\u5355\u5730\u8bf4FOS\u7684\u7406\u5ff5\u5c31\u662f\uff0c\u4e3a\u4e86\u5f97\u5230\u76f8\u540c\u7684\u6216\u8005\u66f4\u597d\u7684\u7ed3\u679c\uff08\u5206\u5b50\u6d3b\u6027\uff0c\u6210\u836f\u6027\u7b49\uff09\uff0c\u8bbe\u8ba1\u5408\u6210\u51fa\u66f4\u52a0simple\u7684target\u5206\u5b50\u3002<\/p>\n<p>\u4ee5phorbol ester\u4e3a\u4f8b\u3001\u901a\u8fc7\u8ba1\u7b97\u673a\u5efa\u6a21\u8fdb\u884c\u7684\u7ed3\u6784\u2015\u529f\u80fd\u76f8\u5173\u7814\u7a76\uff0c\u5e76\u4e14\u53c2\u8003\u73b0\u6709\u7684\u6d3b\u6027\u5316\u5408\u7269\u638c\u63e1PKC\u6d3b\u6027\u63a7\u5236\u4e0a\u6240\u5fc5\u987b\u7684\u51e0\u4e2a\u4e3b\u8981\u7684\u70b9\u540e\uff0c\u518d\u8fdb\u884c\u65b0\u4e00\u8f6e\u7684\u5316\u5408\u7269\u8bbe\u8ba1\uff0c\u5f97\u5230\u65b0\u7684\u5177\u6709\u66f4\u52a0simple\u7ed3\u6784\u7684PKC\u8c03\u63a7\u5242<b>1<\/b>\uff08\u5177\u4f53\u5982\u4e0b\u56fe\u6240\u793a\uff09\u3002<\/p>\n<div id=\"attachment_51232\" class=\"wp-caption alignnone\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u5f15\u7528\u4e8e\u6587\u732e3<br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-15360\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/FOS_2-e1502292156578-224x300.png\" alt=\"\" width=\"224\" height=\"300\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/FOS_2-e1502292156578-224x300.png 224w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/FOS_2-e1502292156578.png 300w\" sizes=\"(max-width: 224px) 100vw, 224px\" \/><\/div>\n<div><\/div>\n<div><\/div>\n<div>\n<h4><b>\u53c2\u8003\u6587\u732e<\/b><\/h4>\n<ol>\n<li>\u201cFunction Oriented Synthesis, Step Economy, and Drug Design\u201d Wender, P. A.; Verma, V. A.; Paxton, T. J.; Pillow, T. H. <i>Acc. Chem. Res.<\/i> <b>2008<\/b>, <i>41<\/i>, 40-49. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/ar700155p\">10.1021\/ar700155p<\/a><\/li>\n<li>\u201cToward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis\u201d Wender, P. A. \u00a0<i>Tetrahedron<\/i> <b>2013<\/b>, <i>69<\/i>, 7529-7550. doi:<a href=\"http:\/\/dx.doi.org\/10.1016\/j.tet.2013.06.004\">10.1016\/j.tet.2013.06.004<\/a><\/li>\n<li>\u201cFunction Through Synthesis-Informed Design\u201d Wender, P. A.; Quiroz, R.; Stevens, M. <i>\u00a0Acc. Chem. Res.<\/i> <b>2015<\/b>, <i>48<\/i>, 752-760. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/acs.accounts.5b00004\">10.1021\/acs.accounts.5b00004<\/a><\/li>\n<\/ol>\n<h4><b>\u5916\u90e8\u94fe\u63a5<\/b><\/h4>\n<ul>\n<li><a href=\"http:\/\/web.stanford.edu\/group\/pawender\/index.html\">Paul Wender Group<\/a><\/li>\n<\/ul>\n<\/div>\n","protected":false},"excerpt":{"rendered":"\u4e0d\u62d8\u6ce5\u4e8e\u4e00\u5b9a\u5316\u5408\u7269\u7684\u7ed3\u6784\uff0c\u4e3b\u8981\u6ce8\u91cd\u4e8e\u529f\u80fd\u7684\u518d\u73b0\u6216\u8005\u4f18\u5316\u4e3a\u76ee\u7684\u7684\u5408\u6210\u6cd5\uff0c\u88ab\u79f0\u4e3a\u529f\u80fd\u6307\u5411\u6027\u5408\u6210\uff08Function-Oriented Synthesis, FOS\uff09\u3002\u65af\u5766\u798f\u5927\u5b66\u7684Paul A. Wender \uff08\u6807\u9898\u56fe\u5f15\u7528\u4e8e\u6587\u732e[1]\uff09 \u529f\u80fd\u6307\u5411\u6027\u5408\u6210\uff08FOS\uff09\u6240\u5e26\u6765\u7684\u300c\u4ece\u91cd\u89c6\u7ed3\u6784\u5230\u6ce8\u91cd\u529f\u80fd\u7684SHIFT\u300d\uff0c\u76f4\u63a5\u5f71\u54cd\u4e86\u5408\u6210\u7b56\u7565\u7684\u5236\u5b9a\u3002\u7b80\u5355\u5730\u8bf4FOS\u7684\u7406\u5ff5\u5c31\u662f\uff0c\u4e3a\u4e86\u5f97\u5230\u76f8\u540c\u7684\u6216\u8005\u66f4\u597d\u7684\u7ed3\u679c\uff08\u5206\u5b50\u6d3b\u6027\uff0c\u6210\u836f\u6027\u7b49\uff09\uff0c\u8bbe\u8ba1\u5408\u6210\u51fa\u66f4\u52a0simple\u7684target\u5206\u5b50\u3002 \u4ee5phorbol ester\u4e3a\u4f8b\u3001\u901a\u8fc7\u8ba1\u7b97\u673a\u5efa\u6a21\u8fdb\u884c\u7684\u7ed3\u6784\u2015\u529f\u80fd\u76f8\u5173\u7814\u7a76\uff0c\u5e76\u4e14\u53c2\u8003\u73b0\u6709\u7684\u6d3b\u6027\u5316\u5408\u7269\u638c\u63e1PKC\u6d3b\u6027\u63a7\u5236\u4e0a\u6240\u5fc5\u987b\u7684\u51e0\u4e2a\u4e3b\u8981\u7684\u70b9\u540e\uff0c\u518d\u8fdb\u884c\u65b0\u4e00\u8f6e\u7684\u5316\u5408\u7269\u8bbe\u8ba1\uff0c\u5f97\u5230\u65b0\u7684\u5177\u6709\u66f4\u52a0simple\u7ed3\u6784\u7684PKC\u8c03\u63a7\u52421\uff08\u5177\u4f53\u5982\u4e0b\u56fe\u6240\u793a\uff09\u3002 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u5f15\u7528\u4e8e\u6587\u732e3 \u53c2\u8003\u6587\u732e \u201cFunction Oriented Synthesis, Step Economy, and Drug Design\u201d Wender, P. A.; Verma, V. A.; Paxton, T. J.; Pillow, T. H. Acc. Chem. Res. 2008, 41, 40-49. DOI: 10.1021\/ar700155p \u201cToward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis\u201d Wender, P. A. \u00a0Tetrahedron 2013, 69, 7529-7550. doi:10.1016\/j.tet.2013.06.004 [&hellip;]","protected":false},"author":5,"featured_media":15359,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[868],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/FOS_1.gif","jetpack_shortlink":"https:\/\/wp.me\/p96op1-3ZI","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15358"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=15358"}],"version-history":[{"count":4,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15358\/revisions"}],"predecessor-version":[{"id":27346,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15358\/revisions\/27346"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/15359"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=15358"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=15358"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=15358"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}