\u591a\u91cd\u836f\u7406\uff08polypharmacology\uff09\u987e\u540d\u601d\u4e49\u5c31\u662f\u4e00\u79cd\u5316\u5408\u7269\u5bf9\u591a\u79cd\u9776\u86cb\u767d\u5177\u6709\u6d3b\u5316\u6216\u8005\u6291\u5236\u4f5c\u7528\uff0c\u4ece\u800c\u5bfc\u81f4\u6709\u591a\u79cd\u836f\u7406\u4f5c\u7528\u3002(\u753b\u50cf\u5f15\u7528\u81ea\uff1aMedical Xpress)<\/p>\n
\u4e00\u822c\u7531\u4e8e\u5bf9\u975e\u6cbb\u7597\u9776\u70b9\u6709\u4f5c\u7528\u7684\u8bdd\uff0c\u53ef\u80fd\u4f1a\u4ea7\u751f\u4e00\u4e9b\u8d1f\u9762\u7684\u6bd2\u6027\uff0c\u526f\u4f5c\u7528\u7b49\uff0c\u6240\u4ee5\u901a\u5e38\u7684\u65b0\u836f\u7814\u53d1\u5e0c\u671b\u8fbe\u5230\u53ea\u5bf9\u4e8e\u4e00\u79cd\u9776\u86cb\u767d\u5177\u6709\u7279\u5f02\u6027\u7684\u4f5c\u7528\u800c\u8fdb\u884c\u7684\u836f\u7269\u5206\u5b50\u8bbe\u8ba1\u5f00\u53d1\u3002<\/p>\n
\u53e6\u4e00\u65b9\u9762\uff0c\u8fd1\u5e74\u6765\uff0c\u7531\u4e8e\u5c0f\u5206\u5b50\u836f\u7269\u7684\u65b0\u836f\u95ee\u4e16\u7387\u4e0d\u65ad\u5730\u4e0b\u6ed1\uff0c\u65b0\u7684\u836f\u7269\u6982\u5ff5\u53d1\u73b0\u4e5f\u8d8a\u6765\u8d8a\u7d27\u8feb\u4e5f\u53d7\u5230\u5173\u6ce8\u3002\u5728\u8fd9\u6837\u7684\u80cc\u666f\u4e0b\uff0c\u591a\u91cd\u836f\u7406\u7684\u6982\u5ff5\u4e0e\u5177\u6709\u9769\u547d\u6027\u7684\u65b0\u836f\u7684\u521b\u51fa\u5c31\u6709\u53ef\u80fd\u7d27\u5bc6\u7684\u8054\u7cfb\u5728\u4e00\u8d77\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u5982\u679c\u53ef\u4ee5\u8bbe\u8ba1\u51fa\u5bf9\u591a\u4e2a\u751f\u7269\u8def\u5f84\u5177\u6709\u5e72\u6d89\u6548\u679c\u7684\u5206\u5b50\u7684\u8bdd\uff0c\u5c31\u6709\u53ef\u80fd\u521b\u9020\u51fa\u9ad8\u6548\u679c\uff0c\u4f4e\u6bd2\u6027\uff0c\u5e76\u4e14\u4e0d\u5bb9\u6613\u4ea7\u751f\u8010\u836f\u6027\u7684\u65b0\u836f\u3002<\/p>\n
\u5230\u76ee\u524d\u4e3a\u6b62\u4e0a\u5e02\u7684\u5c0f\u5206\u5b50\u836f\u7269\u4e2d\uff0c\u4e5f\u4e0d\u4ec5\u4ec5\u90fd\u662f\u9009\u62e9\u6027\u4f5c\u7528\u4e8e\u5355\u4e00\u9776\u70b9\u7684\u836f\u7269\uff0c\u4e5f\u6709\u5f88\u591a\u5177\u6709\u591a\u91cd\u836f\u7406\u6d3b\u6027\u3002\u968f\u7740\u7cfb\u7edf\u751f\u7269\u5b66\u7684\u53d1\u5c55\uff0c\u6709\u4e00\u79cd\u89c2\u70b9\u8ba4\u4e3a\uff0c\u901a\u8fc7\u591a\u79cd\u836f\u7406\u5b66\u8c03\u8282\u751f\u7269\u5316\u5b66\u7f51\u7edc\u53ef\u4ee5\u89e3\u6790\u51fa\u836f\u6548\u53d1\u6325\u7684\u6839\u6e90\u3002<\/p>\n
\u53e6\u5916\u591a\u91cd\u836f\u7406\u836f\u54c1\u53ef\u4ee5\u901a\u8fc7\u5176off-target\u7684\u6548\u679c\uff0c\u53ef\u4ee5\u5728drug-repurposing\u4e0edrug-repositioning\u7684\u5927\u80cc\u666f\u4e0b\u91cd\u590d\u5229\u7528\u3002<\/p>\n
\u5176\u4e2d\u4e00\u4e2a\u5f88\u597d\u7684\u4f8b\u5b50\u662f\u6c99\u5229\u5ea6\u80fa\uff08\u53cd\u5e94\u505c\uff09\uff0c\u8fd9\u662f\u4e00\u6b3e\u5f88\u597d\u7684\u598a\u5a20\u671f\u6b62\u5410\u836f\u7269\uff0c\u7136\u800c\u7531\u4e8e\u5176\u4f1a\u5bfc\u81f4\u80ce\u513f\u7578\u5f62\uff0c\u57281961\u5e74\u88ab\u4e0b\u67b6\u7981\u6b62\u51fa\u552e\u3002\u7136\u800c\uff0c\u8be5\u836f\u7269\u53c8\u5728\u4e4b\u540e\u88ab\u7528\u4e8e\u7ed3\u8282\u6027\u7ea2\u6591\uff08ENL\uff09\uff0c\u591a\u53d1\u6027\u9aa8\u9ad3\u80bf\u7624\u3002\u8fd9\u5c31\u662f\u56e0\u4e3a\u6c99\u5229\u5ea6\u80fa\u7684off-target\u4f5c\u7528\u3002<\/p>\n
\u73b0\u5728\u591a\u91cd\u836f\u7406\u521b\u836f\u6cd5\u8fd8\u505c\u7559\u5728\u5b66\u672f\u7814\u7a76\u9636\u6bb5\uff0c\u836f\u4f01\u8fd8\u5e76\u6ca1\u6709\u91c7\u7528\uff08\u7531\u4e8elead\u4f18\u5316\u7814\u7a76\u592a\u590d\u6742\uff09\u3002\u4f46\u662f\u5728\u764c\u75c7\u4e0e\u4e2d\u67a2\u75be\u75c5\u9886\u57df\uff0c\u5177\u6709\u590d\u6742\u4f5c\u7528\u673a\u5236\u7684\u6cbb\u7597\u836f\u7684\u9700\u6c42\u662f\u663e\u800c\u6613\u89c1\u7684\uff0c\u53ef\u80fd\u5728\u6b64\u9886\u57df\u4f1a\u5927\u5c55\u8eab\u624b\u3002<\/p>\n
\u53c2\u8003\u6587\u732e<\/p>\n
\u201cPolypharmacology \u2013 Foe or Friend?\u201d Peters, J.-U. J. Med. Chem. 2013, 56, 8955\u20138971. DOI: 10.1021\/jm400856t
\n\u201cPolypharmacology: drug discovery for the future\u201d Reddy, A. S.; Zhang, S. Expert Rev. Clin. Pharmacol. 2013, 6, 41-47. doi:10.1586\/ecp.12.74
\n\u201dPolypharmacology: Challenges and Opportunities in Drug Discovery\u201d Anighoro, A.; Bajorath, J.; Rastelli, G. J. Med. Chem. 2014, 57, 7874\u20137887. DOI: 10.1021\/jm5006463
\n\u5916\u90e8\u30ea\u30f3\u30af<\/p>\n
Polypharmacology \u2013 Wikipedia
\nPolypharmacology: An underutilized paradigm in drug discovery<\/p>\n
\u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01 <\/p>\n","protected":false},"excerpt":{"rendered":"\u591a\u91cd\u836f\u7406\uff08polypharmacology\uff09\u987e\u540d\u601d\u4e49\u5c31\u662f\u4e00\u79cd\u5316\u5408\u7269\u5bf9\u591a\u79cd\u9776\u86cb\u767d\u5177\u6709\u6d3b\u5316\u6216\u8005\u6291\u5236\u4f5c\u7528\uff0c\u4ece\u800c\u5bfc\u81f4\u6709\u591a\u79cd\u836f\u7406\u4f5c\u7528\u3002(\u753b\u50cf\u5f15\u7528\u81ea\uff1aMedical Xpress) \u4e00\u822c\u7531\u4e8e\u5bf9\u975e\u6cbb\u7597\u9776\u70b9\u6709\u4f5c\u7528\u7684\u8bdd\uff0c\u53ef\u80fd\u4f1a\u4ea7\u751f\u4e00\u4e9b\u8d1f\u9762\u7684\u6bd2\u6027\uff0c\u526f\u4f5c\u7528\u7b49\uff0c\u6240\u4ee5\u901a\u5e38\u7684\u65b0\u836f\u7814\u53d1\u5e0c\u671b\u8fbe\u5230\u53ea\u5bf9\u4e8e\u4e00\u79cd\u9776\u86cb\u767d\u5177\u6709\u7279\u5f02\u6027\u7684\u4f5c\u7528\u800c\u8fdb\u884c\u7684\u836f\u7269\u5206\u5b50\u8bbe\u8ba1\u5f00\u53d1\u3002 \u53e6\u4e00\u65b9\u9762\uff0c\u8fd1\u5e74\u6765\uff0c\u7531\u4e8e\u5c0f\u5206\u5b50\u836f\u7269\u7684\u65b0\u836f\u95ee\u4e16\u7387\u4e0d\u65ad\u5730\u4e0b\u6ed1\uff0c\u65b0\u7684\u836f\u7269\u6982\u5ff5\u53d1\u73b0\u4e5f\u8d8a\u6765\u8d8a\u7d27\u8feb\u4e5f\u53d7\u5230\u5173\u6ce8\u3002\u5728\u8fd9\u6837\u7684\u80cc\u666f\u4e0b\uff0c\u591a\u91cd\u836f\u7406\u7684\u6982\u5ff5\u4e0e\u5177\u6709\u9769\u547d\u6027\u7684\u65b0\u836f\u7684\u521b\u51fa\u5c31\u6709\u53ef\u80fd\u7d27\u5bc6\u7684\u8054\u7cfb\u5728\u4e00\u8d77\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u5982\u679c\u53ef\u4ee5\u8bbe\u8ba1\u51fa\u5bf9\u591a\u4e2a\u751f\u7269\u8def\u5f84\u5177\u6709\u5e72\u6d89\u6548\u679c\u7684\u5206\u5b50\u7684\u8bdd\uff0c\u5c31\u6709\u53ef\u80fd\u521b\u9020\u51fa\u9ad8\u6548\u679c\uff0c\u4f4e\u6bd2\u6027\uff0c\u5e76\u4e14\u4e0d\u5bb9\u6613\u4ea7\u751f\u8010\u836f\u6027\u7684\u65b0\u836f\u3002 \u5230\u76ee\u524d\u4e3a\u6b62\u4e0a\u5e02\u7684\u5c0f\u5206\u5b50\u836f\u7269\u4e2d\uff0c\u4e5f\u4e0d\u4ec5\u4ec5\u90fd\u662f\u9009\u62e9\u6027\u4f5c\u7528\u4e8e\u5355\u4e00\u9776\u70b9\u7684\u836f\u7269\uff0c\u4e5f\u6709\u5f88\u591a\u5177\u6709\u591a\u91cd\u836f\u7406\u6d3b\u6027\u3002\u968f\u7740\u7cfb\u7edf\u751f\u7269\u5b66\u7684\u53d1\u5c55\uff0c\u6709\u4e00\u79cd\u89c2\u70b9\u8ba4\u4e3a\uff0c\u901a\u8fc7\u591a\u79cd\u836f\u7406\u5b66\u8c03\u8282\u751f\u7269\u5316\u5b66\u7f51\u7edc\u53ef\u4ee5\u89e3\u6790\u51fa\u836f\u6548\u53d1\u6325\u7684\u6839\u6e90\u3002 \u53e6\u5916\u591a\u91cd\u836f\u7406\u836f\u54c1\u53ef\u4ee5\u901a\u8fc7\u5176off-target\u7684\u6548\u679c\uff0c\u53ef\u4ee5\u5728drug-repurposing\u4e0edrug-repositioning\u7684\u5927\u80cc\u666f\u4e0b\u91cd\u590d\u5229\u7528\u3002 \u5176\u4e2d\u4e00\u4e2a\u5f88\u597d\u7684\u4f8b\u5b50\u662f\u6c99\u5229\u5ea6\u80fa\uff08\u53cd\u5e94\u505c\uff09\uff0c\u8fd9\u662f\u4e00\u6b3e\u5f88\u597d\u7684\u598a\u5a20\u671f\u6b62\u5410\u836f\u7269\uff0c\u7136\u800c\u7531\u4e8e\u5176\u4f1a\u5bfc\u81f4\u80ce\u513f\u7578\u5f62\uff0c\u57281961\u5e74\u88ab\u4e0b\u67b6\u7981\u6b62\u51fa\u552e\u3002\u7136\u800c\uff0c\u8be5\u836f\u7269\u53c8\u5728\u4e4b\u540e\u88ab\u7528\u4e8e\u7ed3\u8282\u6027\u7ea2\u6591\uff08ENL\uff09\uff0c\u591a\u53d1\u6027\u9aa8\u9ad3\u80bf\u7624\u3002\u8fd9\u5c31\u662f\u56e0\u4e3a\u6c99\u5229\u5ea6\u80fa\u7684off-target\u4f5c\u7528\u3002 \u73b0\u5728\u591a\u91cd\u836f\u7406\u521b\u836f\u6cd5\u8fd8\u505c\u7559\u5728\u5b66\u672f\u7814\u7a76\u9636\u6bb5\uff0c\u836f\u4f01\u8fd8\u5e76\u6ca1\u6709\u91c7\u7528\uff08\u7531\u4e8elead\u4f18\u5316\u7814\u7a76\u592a\u590d\u6742\uff09\u3002\u4f46\u662f\u5728\u764c\u75c7\u4e0e\u4e2d\u67a2\u75be\u75c5\u9886\u57df\uff0c\u5177\u6709\u590d\u6742\u4f5c\u7528\u673a\u5236\u7684\u6cbb\u7597\u836f\u7684\u9700\u6c42\u662f\u663e\u800c\u6613\u89c1\u7684\uff0c\u53ef\u80fd\u5728\u6b64\u9886\u57df\u4f1a\u5927\u5c55\u8eab\u624b\u3002 \u53c2\u8003\u6587\u732e \u201cPolypharmacology \u2013 Foe or Friend?\u201d Peters, J.-U. J. Med. Chem. 2013, 56, 8955\u20138971. DOI: 10.1021\/jm400856t \u201cPolypharmacology: drug discovery for the future\u201d Reddy, A. S.; Zhang, S. Expert Rev. Clin. Pharmacol. 2013, 6, 41-47. doi:10.1586\/ecp.12.74 \u201dPolypharmacology: Challenges and Opportunities in Drug Discovery\u201d Anighoro, A.; Bajorath, J.; Rastelli, G. J. Med. Chem. 2014, 57, 7874\u20137887. DOI: 10.1021\/jm5006463 \u5916\u90e8\u30ea\u30f3\u30af Polypharmacology \u2013 Wikipedia Polypharmacology: An underutilized paradigm in drug discovery \u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01","protected":false},"author":5,"featured_media":15615,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1274,414],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/08\/polypharmacology.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-43Q","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15614"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=15614"}],"version-history":[{"count":5,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15614\/revisions"}],"predecessor-version":[{"id":27329,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15614\/revisions\/27329"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/15615"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=15614"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=15614"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=15614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}