<\/p>\n

\u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 Antilla\u70ef\u4e19\u57fa\u787c\u5316(Antilla allylboration)\u662f\u5728\u624b\u6027\u78f7\u9178\u50ac\u5316\u5242(R)-TRIP-PA\u4f5c\u7528\u4e0b\u8fdb\u884c\u7684\u919b\u7684\u4e0d\u5bf9\u79f0\u70ef\u4e19\u57fa\u787c\u5316\uff0c\u751f\u6210\u7684\u787c\u9178\u916f\uff0c\u518d\u7ecf\u624b\u6027\u78f7\u9178\u7684\u8d28\u5b50\u53bb\u787c\u5316\u53cd\u5e94(protodeboronation)\uff0c\u6700\u7ec8\u83b7\u5f97\u624b\u6027\u9ad8\u70ef\u4e19\u9187(homoallylic alcohol)\u4ea7\u7269\u7684\u53cd\u5e94\u3002\u8be5\u53cd\u5e94\u57282010\u5e74\uff0c\u7531\u7f8e\u56fdSouth Florida\u5927\u5b66(University of South Florida)\u5316\u5b66\u7cfb\u7684J. C. Antilla\u7814\u7a76\u7ec4\u9996\u6b21\u62a5\u9053\u3002\u53cd\u5e94\u5177\u6709\u826f\u597d\u7684\u5e95\u7269\u9002\u7528\u6027\uff0c\u9002\u7528\u4e8e\u82b3\u9999\u919b\u3001\u8102\u80aa\u919b\u53ca\u03b1,\u03b2-\u4e0d\u9971\u548c\u919b\u7684\u4e0d\u5bf9\u79f0\u70ef\u4e19\u57fa\u787c\u5316\u53cd\u5e94\u3002\u540c\u65f6\uff0c\u8be5\u53cd\u5e94\u5177\u6709\u4f18\u826f\u7684\u4ea7\u7387\u4e0e\u8f83\u9ad8\u7684\u5bf9\u6620\u9009\u62e9\u6027\u3002\u5e76\u4e14\uff0c(R)-TRIP-PA\u50ac\u5316\u5242\u540c\u6837\u9002\u7528\u4e8e\u919b(\u4e0e\u5df4\u8c46\u57fa\u787c\u9178\u916f)\u7684\u5df4\u8c46\u57fa\u5316\u53cd\u5e94\u30022012\u5e74\uff0cL. R Reddy\u53c8\u5c06\u8be5\u624b\u6027\u78f7\u9178\u50ac\u5316\u5242\u5e94\u7528\u4e8e\u919b\u4e0e\u8054\u70ef\u57fa\u787c\u9178\u916f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u7094\u4e19\u57fa\u5316\u53cd\u5e94\u3002\u540c\u6837\u83b7\u5f97\u8f83\u9ad8\u7684\u4ea7\u7387\u4e0e\u4f18\u826f\u7684\u5bf9\u6620\u9009\u62e9\u6027\u3002 \u57fa\u672c\u6587\u732e [1] P. Jain, J. C. Antilla, J. Am. Chem. Soc. 2010, 132, 11884. doi: 10.1021\/ja104956s. [2] P. Jain, J. C. Antilla, Synfacts, 2010, 1187. doi: 10.1055\/s-0030-1258672. [3] L. R Reddy, Org. Lett. 2012, 14, 1142. doi: 10.1021\/ol300075n.   \u53cd\u5e94\u673a\u7406 \u53cd\u5e94\u5b9e\u4f8b Baulamycin\u4e2dFragment A\u7684\u5408\u6210[1] \u82ef\u7532\u919b\u7684\u4e0d\u5bf9\u79f0\u5df4\u8c46\u57fa\u5316[2] \u9ad8\u7094\u4e19\u9187\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210[3] \u5b9e\u9a8c\u6b65\u9aa4 \u5728\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u5c06(R)-TRIP-PA\u50ac\u5316\u5242 (0.05 eq.)\u3001\u91cd\u65b0\u84b8\u998f\u8fc7\u7684\u919b(1 eq.)\u53ca\u5e72\u71e5\u7684\u7532\u82ef(\u7ef4\u6301\u5e95\u7269\u6d53\u5ea6\u4e3a0.06 M)\u52a0\u5165\u81f3Schlenk\u74f6\u4e2d\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6db2\u51b7\u5374\u81f3-30 \u00b0C\uff0c\u968f\u540e\u7528\u6ce8\u5c04\u6cf5\u7f13\u6162\u52a0\u5165\u70ef\u4e19\u57fa\u787c\u9178\u9891\u90a3\u9187\u916f(1.2 eq.)\u3002\u6ef4\u52a0\u7ed3\u675f\u540e\uff0c\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u5347\u81f3\u5ba4\u6e29\uff0c\u5e76\u5728\u5ba4\u6e29\u4e0b\u6405\u62cc\uff0c\u76f4\u81f3\u53cd\u5e94\u5b8c\u6210\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u53cd\u5e94\u6df7\u5408\u7269\u76f4\u63a5\u91c7\u7528\u7845\u80f6\u67f1\u8272\u8c31\u8fdb\u884c\u5206\u79bb\u7eaf\u5316(\u4e59\u9178\u4e59\u916f\/\u6b63\u5df1\u70f7 1 : 9v\/v \u4f5c\u4e3a\u6d17\u8131\u5242)\uff0c\u83b7\u5f97\u6700\u7ec8\u76ee\u6807\u4ea7\u7269\u3002 \u5b9e\u9a8c\u6280\u5de7 \u53c2\u8003\u6587\u732e [1] J. Wu, P. Lorenzo1, S. Zhong1, M. Ali1, C. P. Butts, E. L. Myers1, V. K. Aggarwal1, Nature, 547, 436. doi: 10.1038\/nature23265. [2] P. Jain, J. C. Antilla, J. Am. Chem. Soc. 2010, 132, 11884. doi: 10.1021\/ja104956s. 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