{"id":15837,"date":"2017-10-19T06:08:11","date_gmt":"2017-10-18T22:08:11","guid":{"rendered":"\/\/www.gsbet888.com\/?p=15837"},"modified":"2019-08-02T18:52:41","modified_gmt":"2019-08-02T10:52:41","slug":"zweifel-%e7%83%af%e5%9f%ba%e5%8c%96","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2017\/10\/zweifel-%e7%83%af%e5%9f%ba%e5%8c%96.html","title":{"rendered":"Zweifel \u70ef\u57fa\u5316"},"content":{"rendered":"<h4><strong>\u6982\u8981<\/strong><\/h4>\n<p>Zweifel \u70ef\u57fa\u5316\u662f\u5728\u78b1\u6027\u6761\u4ef6\u4e0b\uff0c\u70ef\u57fa\u787c\u9178\u916f\u6216\u70ef\u57fa\u787c\u70f7\u4e0e\u7898\u4f5c\u7528\u5f62\u6210\u70ef\u70c3\u7684\u53cd\u5e94\u3002\u8be5\u53cd\u5e94\u57281967\u5e74\u7531\u7f8e\u56fdCalifornia\u5927\u5b66(Unicersity of California)\u7684G. Zweifel\u8bfe\u9898\u7ec4\u9996\u6b21\u62a5\u9053\uff0c\u53cd\u5e94\u5177\u6709\u9ad8\u5ea6\u7684\u7acb\u4f53\u9009\u62e9\u6027\uff0c\u4e3b\u8981\u751f\u6210(Z)-\u70ef\u70c3<sup>[1]<\/sup>\u3002\uff08\u5c01\u9762\u56fe\uff09<\/p>\n<p>&nbsp;<\/p>\n<p>\u4e4b\u540e\uff0c\u8be5\u8bfe\u9898\u7ec4\u5728\u65e0\u78b1\u5b58\u5728\u7684\u6761\u4ef6\u4e0b\uff0c\u91c7\u7528\u6eb4\u5316\u6c30\u8fdb\u884c\u53cd\u5e94\uff0c\u4ee5\u9ad8\u5ea6\u7acb\u4f53\u9009\u62e9\u6027\u7684\u65b9\u5f0f\u83b7\u5f97(E)-\u70ef\u70c3<sup>[2]<\/sup>\u3002\u540c\u65f6\uff0c\u7814\u7a76\u53d1\u73b0\u91c7\u7528\u624b\u6027\u787c\u70f7\u65f6\uff0c\u8be5\u53cd\u5e94\u540c\u6837\u5177\u6709\u9ad8\u5ea6\u7684\u7acb\u4f53\u4e13\u4e00\u6027<sup>[3]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/2-4.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15839 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/2-4.png\" alt=\"\" width=\"438\" height=\"120\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/2-4.png 438w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/2-4-300x82.png 300w\" sizes=\"(max-width: 438px) 100vw, 438px\" \/><\/a><\/p>\n<p>1973\u5e74\uff0cH. C. Brown\u5c06\u8be5\u53cd\u5e94\u6761\u4ef6\u5e94\u7528\u4e8e\u7094\u70c3\u7684\u5408\u6210<sup>[4]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/3-4.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15840 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/3-4-680x109.png\" alt=\"\" width=\"680\" height=\"109\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/3-4-680x109.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/3-4-300x48.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/3-4.png 733w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>\u7136\u800c\uff0c\u5728\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u70ef\u57fa\u787c\u70f7\u7684\u4e24\u4e2a\u70f7\u57fa\u4e2d\uff0c\u53ea\u6709\u4e00\u4e2a\u70f7\u57fa\u80fd\u591f\u8fdb\u5165\u70ef\u70c3\u4ea7\u7269\u4e2d\uff0c\u7531\u6b64\u9020\u6210\u787c\u70f7\u7684\u6d6a\u8d39(\u5c24\u5176\u5bf9\u4e8e\u4e00\u4e9b\u96be\u4ee5\u5408\u6210\u4e14\u4ef7\u683c\u6602\u8d35\u7684\u787c\u70f7)\uff0c\u6709\u65f6\u8fd8\u5b58\u5728\u4e0d\u540c\u70f7\u57fa\u95f4\u7684\u7ade\u4e89\u6027\u8fc1\u79fb\u95ee\u9898\uff0c\u4ece\u800c\u964d\u4f4e\u70ef\u70c3\u7684\u4ea7\u7387\u4e0e\u53cd\u5e94\u7684\u533a\u57df\u9009\u62e9\u6027\u3002\u4e3a\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\uff0cZweifel\u91c7\u7528\u4e09\u7532\u80fa\u6c27\u5316\u7269\u5c06\u800c\u4e59\u70ef\u57fa\u787c\u70f7\u6c27\u5316\u4e3a\u787c\u9178\u916f(\u5728\u7a7a\u6c14\u4e2d\u8f83\u4e3a\u7a33\u5b9a)\uff0c\u968f\u540e\u8fdb\u884c\u4e0b\u4e00\u6b65\u7684\u70ef\u57fa\u5316\u53cd\u5e94\uff0c\u6210\u529f\u5730\u89e3\u51b3\u4e86\u4e4b\u524d\u91c7\u7528\u5177\u6709\u4f4e\u8fc1\u79fb\u6027\u80fd\u7684\u70f7\u57fa\u53d6\u4ee3\u7684\u70ef\u57fa\u787c\u70f7\u65f6\u51fa\u73b0\u7684\u7ade\u4e89\u6027\u8fc1\u79fb(\u70f7\u6c27\u57fa\u7684\u8fc1\u79fb\u80fd\u529b\u8f83\u4f4e)\u53ca\u787c\u70f7\u5229\u7528\u7387\u4f4e\u7684\u95ee\u9898<sup>[5]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/4-4.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15841 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/4-4-680x115.png\" alt=\"\" width=\"680\" height=\"115\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/4-4-680x115.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/4-4-300x51.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/4-4.png 735w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>1976\u5e74\uff0cEvans\u4e0eMattesson \u91c7\u7528\u6709\u673a\u9502\u8bd5\u5242\u4e0e\u787c\u9178\u916f\u5f62\u6210\u7684\u9178\u6839\u914d\u5408\u7269\uff0c\u5c06\u787c\u9178\u916f\u7684\u5e95\u7269\u8303\u56f4\u6269\u5c55\u81f3\u70ef\u57fa\u787c\u9178\u916f\u4e0e\u4e8c\u7ea7\u70f7\u57fa\u787c\u9178\u916f<sup>[6]-[8]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/5-4.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15842 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/5-4-680x220.png\" alt=\"\" width=\"680\" height=\"220\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/5-4-680x220.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/5-4-300x97.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/5-4.png 729w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/6-3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15843 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/6-3.png\" alt=\"\" width=\"534\" height=\"127\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/6-3.png 534w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/6-3-300x71.png 300w\" sizes=\"(max-width: 534px) 100vw, 534px\" \/><\/a><\/p>\n<p>2016\u5e74\uff0cAggarwal\u7814\u7a76\u7ec4\u91c7\u7528\u7c7b\u4f3c\u6761\u4ef6\uff0c\u5c06\u787c\u9178\u916f\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u4e00\u6b65\u6269\u5c55\u81f3\u5177\u6709\u6742\u539f\u5b50\u7684\u70ef\u57fa\u787c\u9178\u916f\uff0c\u540c\u65f6\uff0c\u4f7f\u8be5\u53cd\u5e94\u5177\u6709\u9ad8\u5ea6\u7684\u5bf9\u6620\u4e13\u4e00\u6027<sup>[9]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/7-2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15844 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/7-2-680x123.png\" alt=\"\" width=\"680\" height=\"123\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/7-2-680x123.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/7-2-300x54.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/7-2.png 753w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/8-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15845 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/8-1.png\" alt=\"\" width=\"668\" height=\"158\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/8-1.png 668w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/8-1-300x71.png 300w\" sizes=\"(max-width: 668px) 100vw, 668px\" \/><\/a><\/p>\n<p>2017\u5e74\uff0cAggarwal\u91c7\u7528\u787c\u9178\u916f\u4e0eGrignard\u8bd5\u5242\u5f62\u6210\u7684\u9178\u6839\u914d\u5408\u7269\uff0c\u5c06\u787c\u9178\u916f\u7684\u5e94\u7528\u8303\u56f4\u6709\u6548\u5730\u6269\u5c55\u81f3\u4e00\u7ea7\u3001\u4e8c\u7ea7\u3001\u4e09\u7ea7\u70f7\u57fa\u787c\u9178\u916f\u53ca\u82b3\u57fa\u787c\u9178\u916f\uff0c\u540c\u65f6\uff0c\u5c06\u8be5\u53cd\u5e94\u6210\u529f\u5e94\u7528\u4e8e\u5927\u4f4d\u963b\u70ef\u70c3\u7684\u5408\u6210<sup>[10]- [13]<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/9.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15846 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/9-680x143.png\" alt=\"\" width=\"680\" height=\"143\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/9-680x143.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/9-300x63.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/9.png 732w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>Zweifel \u70ef\u57fa\u5316\u53cd\u5e94\u4e3aSuzuki-Miyaura\u53cd\u5e94\u7684\u5f3a\u6709\u529b\u7684\u8865\u5145<sup>[14]<\/sup>\uff0c\u53cd\u5e94\u65e0\u9700\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u5242\u53c2\u4e0e\uff0c\u80fd\u591f\u4ee5\u9ad8\u5ea6\u5bf9\u6620\u4e13\u4e00\u6027\u7684\u65b9\u5f0f\u5b9e\u73b0\u5149\u5b66\u7eaf\u5ea6\u7684\u4e8c\u7ea7\u3001\u4e09\u7ea7\u70f7\u57fa\u787c\u9178\u916f\u4e0e\u70ef\u57fa\u91d1\u5c5e\u5316\u5408\u7269\u4e4b\u95f4\u7684\u5076\u8054\u53cd\u5e94\u3002<\/p>\n<h4><strong>\u57fa\u672c\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] G. Zweifel, H. Arzoumanian, C. C. Whitney, J. Am. Chem. Soc.1967, 89, 3652. doi: <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja00990a061\">10.1021\/ja00990a061.<\/a><\/li>\n<li>[2] G. Zweifel, R. P. Fisher, J. T. Snow, C. C.Whitney, J. Am. Chem.\u00a0Soc. 1971, 93, 6309. doi:<a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja00752a075\"> 10.1021\/ja00752a075.<\/a><\/li>\n<li>[3] G. Zweifel, R. P. Fisher, J. T. Snow, C. C. Whitney, J. Am. Chem.\u00a0Soc. 1972, 94, 6560. doi: <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja00773a059\">10.1021\/ja00773a059.<\/a><\/li>\n<li>[4] A. Suzuki, N. Miyaura, S. Abiko, M. Itoh, H. C. Brown, J. A. Sinclair,\u00a0<span style=\"line-height: normal\">M.M. Midland, J. Am. Chem. Soc. 1973, 95, 3080. doi: <\/span><a style=\"line-height: normal\" href=\"http:\/\/pubs.acs.org\/doi\/10.1021\/ja00790a092\">10.1021\/ja00790a092.<\/a><\/li>\n<li>[5] G. Zweifel, N. L. Polston, C. C. Whitney, J. Am. Chem. Soc. 1968, 90, 6243. doi: <a href=\"http:\/\/pubs.acs.org\/doi\/10.1021\/ja01024a068\">10.1021\/ja01024a068.<\/a><\/li>\n<li>[6] D. S. Matteson, P. K. Jesthi, J. Organomet. Chem. 1976, 110,\u00a0<span style=\"line-height: normal\">25.doi: <\/span><a style=\"line-height: normal\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022328X00901554\">10.1016\/S0022-328X(00)90155-4.\u00a0<\/a><\/li>\n<li>[7 D. A. Evans, R. C.Thomas, J. A. Walker, Tetrahedron Lett. 1976, 17, 1427. doi: <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0040403900712743\">10.1016\/S0040-4039(00)71274-3.<\/a><\/li>\n<li>[8] D. A. Evans, T. C. Crawford, R. C. Thomas, J. A. Walker, J. Org. Chem. 1976, 41, 3947. doi: <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jo00887a003\">10.1021\/jo00887a003.<\/a><\/li>\n<li>[9] Y. Wang, A. Noble, E. L. Myers, V. K. Aggarwal, Angew. Chem.\u00a0Int. Ed. 2016, 55, 4270. doi:\u00a0<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201600599\/pdf\">10.1002\/anie.201600599.<\/a><\/li>\n<li>[10] R. P. Sonawane, V. Jheengut, C. Rabalakos, R. Larouche-Gauthier, H. K. Scott, V. K. Aggarwal, Angew. Chem. Int. Ed. 2011, 50, 3760. doi: <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201008067\/abstract\">10.1002\/anie.201008067.<\/a><\/li>\n<li>[11] M. Shimizu, Angew. Chem. Int. Ed. 2011, 50, 5998. doi: <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201407013\/references\">10.1002\/anie.201407013.<\/a><\/li>\n<li>[12] A. B. Levy, S. J. Schwartz, N. Wilson, B. Christie, J. Organomet. Chem. 1978,\u00a0156, 123. doi: <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022328X00848706\">10.1016\/S0022-328X(00)84870-6.<\/a><\/li>\n<li>[13] R. J. Armstrong, W. Niwetmarin, V. K. Aggarwal, Org. Lett. 2017, 19, 2762. doi: <a href=\"http:\/\/pubs.acs.org\/doi\/10.1021\/acs.orglett.7b01124\">10.1021\/acs.orglett.7b01124.<\/a><\/li>\n<li>[14] R. J. Armstrong, V. K. Aggarwal, Synthesis 2017, 49, 3323. doi: <a href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/pdf\/10.1055\/s-0036-1589046.pdf\">10.1055\/s-0036-1589046.<\/a><\/li>\n<\/ul>\n<h4><strong>\u53cd\u5e94\u673a\u7406<\/strong><\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/10.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15847 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/10-680x261.png\" alt=\"\" width=\"680\" height=\"261\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/10-680x261.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/10-300x115.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/10.png 728w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/11.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15848 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/11-680x231.png\" alt=\"\" width=\"680\" height=\"231\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/11-680x231.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/11-300x102.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/11.png 721w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/12.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15849 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/12-680x255.png\" alt=\"\" width=\"680\" height=\"255\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/12-680x255.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/12-300x112.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/12.png 740w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<h4><strong>\u53cd\u5e94\u5b9e\u4f8b<\/strong><\/h4>\n<p>(+)-faranal\u7684\u5168\u5408\u6210[1]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/13.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15850 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/13-680x275.png\" alt=\"\" width=\"680\" height=\"275\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/13-680x275.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/13-300x121.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/13.png 722w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>(-)-stemaphylline\u7684\u5168\u5408\u6210[2]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/14.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15851 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/14-680x270.png\" alt=\"\" width=\"680\" height=\"270\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/14-680x270.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/14-300x119.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/14.png 737w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n[5]-ladderanoic acid\u7684\u5168\u5408\u6210[3]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/15.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-15852 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/15-680x277.png\" alt=\"\" width=\"680\" height=\"277\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/15-680x277.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/15-300x122.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/15.png 723w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<h4><strong>\u5b9e\u9a8c\u6b65\u9aa4<\/strong><\/h4>\n<p><strong>(<em>Z<\/em>)-<\/strong><strong>\u70ef\u70c3\u7684\u5408\u6210<\/strong><strong>:<\/strong> \u5728-10<sup>o<\/sup>C\u4e0b\uff0c\u5411\u539f\u4f4d\u5236\u5907\u7684\u70ef\u57fa\u787c\u70f7(1 eq.)\u4e2d\u52a0\u51656 M NaOH(3.6 eq.)\u6eb6\u6db2\uff0c\u968f\u540e\u7528\u6052\u538b\u6ef4\u6db2\u6f0f\u6597\u5411\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u4e2d\u7f13\u6162\u6ef4\u52a0\u7898(1.3 eq.)\u7684\u56db\u6c22\u544b\u5583\u6eb6\u6db2(2.5 M, \u8d85\u8fc715 min\u6ef4\u52a0\u5b8c\u6bd5)\u3002\u518d\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6db2\u5347\u81f3\u5ba4\u6e29\uff0c\u76f4\u81f3\u53cd\u5e94\u5b8c\u6210\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u7528\u786b\u4ee3\u786b\u9178\u94a0\u6eb6\u6db2\u9664\u53bb\u8fc7\u91cf\u7684\u7898\uff0c\u518d\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u7528\u620a\u70f7\u8fdb\u884c\u8403\u53d6\uff0c\u5408\u5e76\u7684\u6709\u673a\u76f8\u91c7\u7528\u65e0\u6c34\u786b\u9178\u94a0\u8fdb\u884c\u5e72\u71e5\u3002\u84b8\u998f\u7eaf\u5316\u540e\uff0c\u83b7\u5f97\u76f8\u5e94\u76ee\u6807\u4ea7\u7269\u3002<\/p>\n<p><strong>(<em>E<\/em>)-<\/strong><strong>\u70ef\u70c3\u7684\u5408\u6210<\/strong><strong>: <\/strong><strong>\u2460 \u70ef\u57fa\u787c\u70f7\u7684\u539f\u4f4d\u5408\u6210:<\/strong>\u5728THF\u4e2d\u52a0\u5165\u70ef\u70c3(2 eq.)\u4e0eBH<sub>3<\/sub> (1.1 eq.)\uff0c\u518d\u5c06\u4e0a\u8ff0\u6eb6\u6db2\u4e2d\u52a0\u5165\u7094\u70c3(1 eq.)\u7684THF\u6eb6\u6db2(2.5 M), \u5e76\u7ef4\u6301\u53cd\u5e94\u6db2\u6e29\u5ea6\u57280-5<sup>o<\/sup>C\u4e4b\u95f4\u3002\u4e4b\u540e\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u5347\u81f3\u5ba4\u6e29\uff0c\u5e76\u5728\u5ba4\u6e29\u4e0b\u6405\u62cc30min\u3002<strong>\u2461\u70ef\u57fa\u5316:<\/strong>\u57280<sup>o<\/sup>C\u4e0b\u51cf\u538b\u9664\u53bb\u70ef\u57fa\u787c\u70f7\u4e2d\u7684THF\u6eb6\u5242\uff0c\u5e76\u7ef4\u63010<sup>o<\/sup>C\uff0c\u540c\u65f6\u52a0\u5165\u4e8c\u6c2f\u7532\u70f7\u53ca\u6eb4\u5316\u6c30(1.3 eq.)\u7684\u4e8c\u6c2f\u7532\u70f7(0.83 M)\u6eb6\u6db2\uff0c\u4e4b\u540e\u7ee7\u7eed\u7ef4\u63010<sup>o<\/sup>C\uff0c\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6db2\u6405\u62cc2 h\uff0c2 h\u540e\uff0c\u52a0\u51656M NaOH\u6eb6\u6db2\uff0c\u5c06\u53cd\u5e94\u6df7\u5408\u7269\u8fdb\u884c\u7a00\u91ca\u3002\u70ef\u70c3\u4ea7\u7269\u91c7\u7528\u620a\u70f7\u8fdb\u884c\u8403\u53d6\uff0c\u7c97\u4ea7\u7269\u901a\u8fc7\u77edVigreux\u5206\u998f\u67f1\u8fdb\u884c\u5206\u998f\u7eaf\u5316\uff0c\u83b7\u5f97\u76f8\u5e94\u76ee\u6807\u4ea7\u7269\u3002<\/p>\n<p><span style=\"color: #ff0000\"><strong>\u5b9e\u9a8c\u5b9e\u9a8c\u5b89\u5168\u987b\u77e5<\/strong><\/span><\/p>\n<p>\u5c0f\u7f16\u90d1\u91cd\u63d0\u793a\uff1a<strong>\u6eb4\u5316\u6c30\u6709\u5267\u6bd2\uff0c\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u52a0\u78b1\u7a00\u91ca\u83b7\u5f97<\/strong><strong>(E)-<\/strong><strong>\u70ef\u70c3\u7684\u8fc7\u7a0b\u4e2d\uff0c\u4f1a\u4ea7\u751f\u5267\u6bd2\u7684\u6c30\u5316\u7269\u3002\u53cd\u5e94\u9700\u8981\u5728\u901a\u98ce\u6548\u679c\u6781\u4e3a\u4f18\u826f\u7684\u901a\u98ce\u6a71\u5185\u5c0f\u5fc3\u64cd\u4f5c\u3002\u53cd\u5e94\u540e\u5904\u7406\u8fc7\u7a0b\u4ea7\u751f\u7684\u5e9f\u6db2\u53ca\u4f7f\u7528\u8fc7\u7684\u73bb\u7483\u5668\u76bf\u5747\u9700\u8981\u91c7\u7528\u9971\u548c\u6b21\u6c2f\u9178\u94a0\u6eb6\u6db2\u8fdb\u884c\u65e0\u5bb3\u5316\u5904\u7406<\/strong><strong>(<\/strong><strong>\u52a0\u5165\u78b1\u5c06<\/strong><strong>pH<\/strong><strong>\u8c03\u81f3<\/strong><strong>11<\/strong><strong>\uff0c\u52a0\u5165\u6b21\u6c2f\u9178\u94a0\u9971\u548c\u5f7b\u5e95\u6405\u62cc\u540e\uff0c\u9759\u7f6e\u8fc7\u591c\u3002<\/strong><strong>1mol<\/strong><strong>\u7684\u6c30\u5316\u7269\u9700\u8981\u52a0\u5165<\/strong><strong>500mL NaOCl<\/strong><strong>\u9971\u548c\u6eb6\u6db2<\/strong><strong>)<\/strong><strong>\uff0c\u5e76\u7528\u6c30\u6839\u8bd5\u7eb8\u68c0\u6d4b\u81f3\u6c30\u79bb\u5b50\u542b\u91cf<\/strong><strong>(<\/strong><strong>\u5c0f\u4e8e<\/strong><strong>10<sup>-4<\/sup> M)<\/strong><strong>\u5408\u683c\u540e\uff0c\u624d\u53ef\u5012\u5165\u6307\u5b9a\u5e9f\u6db2\u7f38\u3002\u6c30\u5316\u7269\u7684\u5904\u7406\u8fc7\u7a0b\u540c\u6837\u9700\u8981\u5728\u901a\u98ce\u6548\u679c\u6781\u4e3a\u4f18\u826f\u7684\u901a\u98ce\u6a71\u5185\u4ed4\u7ec6\u64cd\u4f5c\u3002<\/strong><\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] G. Dutheuil, M. P. Webster, P. A. Worthington, V. K. Aggarwal, Angew. Chem. Int. Ed. 2009, 48, 6317. doi: <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.200901194\/abstract\">10.1002\/anie.200901194.<\/a><\/li>\n<li>[2] A. Varela, L. K. B. Garve, D. Leonori, V. K. Aggarwal, Angew.\u00a0Chem. Int. Ed. 2017, 56, 2127. doi:<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201611273\/abstract\"> 10.1002\/anie.201611273.<\/a><\/li>\n<li>[3] J. A. M. Mercer, C. M. Cohen, S. R. Shuken, A. M. Wagner, M. W. Smith, F. R. Moss, M. D. Smith, R. Vahala, A. Gonzalez-Martinez, S. G. Boxer, N. Z. Burns, J. Am. Chem. Soc. 2016, 138, 15845.doi: <a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jacs.6b10706?src=recsys\">10.1021\/jacs.6b10706.<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01 <\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 Zweifel \u70ef\u57fa\u5316\u662f\u5728\u78b1\u6027\u6761\u4ef6\u4e0b\uff0c\u70ef\u57fa\u787c\u9178\u916f\u6216\u70ef\u57fa\u787c\u70f7\u4e0e\u7898\u4f5c\u7528\u5f62\u6210\u70ef\u70c3\u7684\u53cd\u5e94\u3002\u8be5\u53cd\u5e94\u57281967\u5e74\u7531\u7f8e\u56fdCalifornia\u5927\u5b66(Unicersity of California)\u7684G. Zweifel\u8bfe\u9898\u7ec4\u9996\u6b21\u62a5\u9053\uff0c\u53cd\u5e94\u5177\u6709\u9ad8\u5ea6\u7684\u7acb\u4f53\u9009\u62e9\u6027\uff0c\u4e3b\u8981\u751f\u6210(Z)-\u70ef\u70c3[1]\u3002\uff08\u5c01\u9762\u56fe\uff09 &nbsp; \u4e4b\u540e\uff0c\u8be5\u8bfe\u9898\u7ec4\u5728\u65e0\u78b1\u5b58\u5728\u7684\u6761\u4ef6\u4e0b\uff0c\u91c7\u7528\u6eb4\u5316\u6c30\u8fdb\u884c\u53cd\u5e94\uff0c\u4ee5\u9ad8\u5ea6\u7acb\u4f53\u9009\u62e9\u6027\u7684\u65b9\u5f0f\u83b7\u5f97(E)-\u70ef\u70c3[2]\u3002\u540c\u65f6\uff0c\u7814\u7a76\u53d1\u73b0\u91c7\u7528\u624b\u6027\u787c\u70f7\u65f6\uff0c\u8be5\u53cd\u5e94\u540c\u6837\u5177\u6709\u9ad8\u5ea6\u7684\u7acb\u4f53\u4e13\u4e00\u6027[3]\u3002 1973\u5e74\uff0cH. C. Brown\u5c06\u8be5\u53cd\u5e94\u6761\u4ef6\u5e94\u7528\u4e8e\u7094\u70c3\u7684\u5408\u6210[4]\u3002 \u7136\u800c\uff0c\u5728\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u70ef\u57fa\u787c\u70f7\u7684\u4e24\u4e2a\u70f7\u57fa\u4e2d\uff0c\u53ea\u6709\u4e00\u4e2a\u70f7\u57fa\u80fd\u591f\u8fdb\u5165\u70ef\u70c3\u4ea7\u7269\u4e2d\uff0c\u7531\u6b64\u9020\u6210\u787c\u70f7\u7684\u6d6a\u8d39(\u5c24\u5176\u5bf9\u4e8e\u4e00\u4e9b\u96be\u4ee5\u5408\u6210\u4e14\u4ef7\u683c\u6602\u8d35\u7684\u787c\u70f7)\uff0c\u6709\u65f6\u8fd8\u5b58\u5728\u4e0d\u540c\u70f7\u57fa\u95f4\u7684\u7ade\u4e89\u6027\u8fc1\u79fb\u95ee\u9898\uff0c\u4ece\u800c\u964d\u4f4e\u70ef\u70c3\u7684\u4ea7\u7387\u4e0e\u53cd\u5e94\u7684\u533a\u57df\u9009\u62e9\u6027\u3002\u4e3a\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\uff0cZweifel\u91c7\u7528\u4e09\u7532\u80fa\u6c27\u5316\u7269\u5c06\u800c\u4e59\u70ef\u57fa\u787c\u70f7\u6c27\u5316\u4e3a\u787c\u9178\u916f(\u5728\u7a7a\u6c14\u4e2d\u8f83\u4e3a\u7a33\u5b9a)\uff0c\u968f\u540e\u8fdb\u884c\u4e0b\u4e00\u6b65\u7684\u70ef\u57fa\u5316\u53cd\u5e94\uff0c\u6210\u529f\u5730\u89e3\u51b3\u4e86\u4e4b\u524d\u91c7\u7528\u5177\u6709\u4f4e\u8fc1\u79fb\u6027\u80fd\u7684\u70f7\u57fa\u53d6\u4ee3\u7684\u70ef\u57fa\u787c\u70f7\u65f6\u51fa\u73b0\u7684\u7ade\u4e89\u6027\u8fc1\u79fb(\u70f7\u6c27\u57fa\u7684\u8fc1\u79fb\u80fd\u529b\u8f83\u4f4e)\u53ca\u787c\u70f7\u5229\u7528\u7387\u4f4e\u7684\u95ee\u9898[5]\u3002 1976\u5e74\uff0cEvans\u4e0eMattesson \u91c7\u7528\u6709\u673a\u9502\u8bd5\u5242\u4e0e\u787c\u9178\u916f\u5f62\u6210\u7684\u9178\u6839\u914d\u5408\u7269\uff0c\u5c06\u787c\u9178\u916f\u7684\u5e95\u7269\u8303\u56f4\u6269\u5c55\u81f3\u70ef\u57fa\u787c\u9178\u916f\u4e0e\u4e8c\u7ea7\u70f7\u57fa\u787c\u9178\u916f[6]-[8]\u3002 &nbsp; 2016\u5e74\uff0cAggarwal\u7814\u7a76\u7ec4\u91c7\u7528\u7c7b\u4f3c\u6761\u4ef6\uff0c\u5c06\u787c\u9178\u916f\u7684\u5e94\u7528\u8303\u56f4\u8fdb\u4e00\u6b65\u6269\u5c55\u81f3\u5177\u6709\u6742\u539f\u5b50\u7684\u70ef\u57fa\u787c\u9178\u916f\uff0c\u540c\u65f6\uff0c\u4f7f\u8be5\u53cd\u5e94\u5177\u6709\u9ad8\u5ea6\u7684\u5bf9\u6620\u4e13\u4e00\u6027[9]\u3002 2017\u5e74\uff0cAggarwal\u91c7\u7528\u787c\u9178\u916f\u4e0eGrignard\u8bd5\u5242\u5f62\u6210\u7684\u9178\u6839\u914d\u5408\u7269\uff0c\u5c06\u787c\u9178\u916f\u7684\u5e94\u7528\u8303\u56f4\u6709\u6548\u5730\u6269\u5c55\u81f3\u4e00\u7ea7\u3001\u4e8c\u7ea7\u3001\u4e09\u7ea7\u70f7\u57fa\u787c\u9178\u916f\u53ca\u82b3\u57fa\u787c\u9178\u916f\uff0c\u540c\u65f6\uff0c\u5c06\u8be5\u53cd\u5e94\u6210\u529f\u5e94\u7528\u4e8e\u5927\u4f4d\u963b\u70ef\u70c3\u7684\u5408\u6210[10]- [13]\u3002 Zweifel \u70ef\u57fa\u5316\u53cd\u5e94\u4e3aSuzuki-Miyaura\u53cd\u5e94\u7684\u5f3a\u6709\u529b\u7684\u8865\u5145[14]\uff0c\u53cd\u5e94\u65e0\u9700\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u5242\u53c2\u4e0e\uff0c\u80fd\u591f\u4ee5\u9ad8\u5ea6\u5bf9\u6620\u4e13\u4e00\u6027\u7684\u65b9\u5f0f\u5b9e\u73b0\u5149\u5b66\u7eaf\u5ea6\u7684\u4e8c\u7ea7\u3001\u4e09\u7ea7\u70f7\u57fa\u787c\u9178\u916f\u4e0e\u70ef\u57fa\u91d1\u5c5e\u5316\u5408\u7269\u4e4b\u95f4\u7684\u5076\u8054\u53cd\u5e94\u3002 \u57fa\u672c\u6587\u732e [1] G. Zweifel, H. Arzoumanian, C. C. Whitney, J. Am. Chem. Soc.1967, 89, 3652. doi: 10.1021\/ja00990a061. [2] G. Zweifel, R. P. Fisher, J. T. Snow, C. C.Whitney, J. Am. Chem.\u00a0Soc. 1971, 93, 6309. doi: 10.1021\/ja00752a075. [3] G. Zweifel, R. P. Fisher, J. T. Snow, C. C. Whitney, J. Am. Chem.\u00a0Soc. 1972, 94, 6560. doi: 10.1021\/ja00773a059. [4] A. Suzuki, N. Miyaura, S. Abiko, M. Itoh, H. C. Brown, J. A. Sinclair,\u00a0M.M. Midland, J. Am. Chem. Soc. 1973, 95, 3080. doi: 10.1021\/ja00790a092. [5] G. Zweifel, N. L. Polston, C. C. Whitney, [&hellip;]","protected":false},"author":21,"featured_media":15838,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2],"tags":[2016,2015,74],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/09\/1-4.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-47r","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15837"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=15837"}],"version-history":[{"count":7,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15837\/revisions"}],"predecessor-version":[{"id":27317,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/15837\/revisions\/27317"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/15838"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=15837"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=15837"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=15837"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}