{"id":16883,"date":"2017-11-24T08:40:36","date_gmt":"2017-11-24T00:40:36","guid":{"rendered":"\/\/www.gsbet888.com\/?p=16883"},"modified":"2019-08-02T18:52:19","modified_gmt":"2019-08-02T10:52:19","slug":"%e7%94%a8%e6%b7%bb%e5%8a%a0%e5%89%82%e6%8e%a7%e5%88%b6%e8%8b%af%e8%83%ba%e7%9a%84%e4%bd%8d%e7%bd%ae%e9%80%89%e6%8b%a9%e6%80%a7c-h%e7%83%b7%e5%9f%ba%e5%8c%96%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2017\/11\/%e7%94%a8%e6%b7%bb%e5%8a%a0%e5%89%82%e6%8e%a7%e5%88%b6%e8%8b%af%e8%83%ba%e7%9a%84%e4%bd%8d%e7%bd%ae%e9%80%89%e6%8b%a9%e6%80%a7c-h%e7%83%b7%e5%9f%ba%e5%8c%96%e5%8f%8d%e5%ba%94.html","title":{"rendered":"\u7528\u6dfb\u52a0\u5242\u63a7\u5236\u82ef\u80fa\u7684\u4f4d\u7f6e\u9009\u62e9\u6027C-H\u70f7\u57fa\u5316\u53cd\u5e94"},"content":{"rendered":"<p><strong>\u672c\u8bb0\u4e8b\u4ecb\u7ecd\u4e0b\u6700\u65b0\u7684\u4e00\u7bc7Ru\u50ac\u5316\u7684\u82ef\u80fa\u884d\u751f\u7269\u7684\u5bf9\u4f4d\u70f7\u57fa\u5316\u53cd\u5e94\u7684\u8bba\u6587\u3002\u4f4d\u7f6e\u9009\u62e9\u6027\u6781\u597d\uff0c\u5e76\u4e14\u53ef\u4ee5\u901a\u8fc7\u6dfb\u52a0\u5242\u5207\u6362\u6210\u95f4\u4f4d\u9009\u62e9\u6027\u3002<\/strong><\/p>\n<p>&nbsp;<\/p>\n<h4>\u82ef\u80fa\u7684\u4f4d\u7f6e\u9009\u62e9\u6027\u70f7\u57fa\u5316\u53cd\u5e94<\/h4>\n<p>\u4ee5\u82b3\u9999\u65cf\u5316\u5408\u7269\u4e3a\u5e95\u7269\uff0c\u8fdb\u884c\u4f4d\u7f6e\u9009\u62e9\u6027\u7684\u76f4\u63a5\u5b98\u80fd\u56e2\u5bfc\u5165\u7684\u5408\u6210\u624b\u6cd5\uff0c\u5373\u300c<strong>\u4f4d\u7f6e\u9009\u62e9\u6027C-H\u5b98\u80fd\u56e2\u5316\u53cd\u5e94<\/strong>\u300d\u662f\u76ee\u524d\u6574\u4e2a\u6709\u673a\u5408\u6210\u9886\u57df\u7684\u4e00\u5927\u70ed\u95e8\u8bfe\u9898\u3002<\/p>\n<p>\u4e3a\u4e86\u5bf9\u7279\u5b9a\u4f4d\u7f6e\u7684C-H\u8fdb\u884c\u6d3b\u5316\uff0c\u88ab\u7528\u7684\u6700\u591a\u7684\u4e00\u79cd\u624b\u6cd5\u662f\u901a\u8fc7\u4e8b\u5148\u5f15\u5165<strong>\u5bfc\u5411\u57fa\u56e2<\/strong>\uff0c\u4e0e\u8fc7\u6e21\u91d1\u5c5e\u8fdb\u884c\u914d\u4f4d\uff0c\u7136\u540e\u91d1\u5c5e\u5bf9\u6700\u63a5\u8fd1\u7684\u82b3\u9999\u73af\u4e0a\u7684C-H\u8fdb\u884c\u6d3b\u5316\uff0c\u4e5f\u5c31\u662f\u53ef\u4ee5\u4fc3\u8fdb\u82b3\u9999\u73af\u7684\u73af\u91d1\u5c5e\u5316\u53cd\u5e94(\u56fe 1A)<sup>(1)<\/sup>\uff0c\u4ece\u800c\u8fbe\u5230\u9009\u62e9\u6027C-H\u6d3b\u5316\u7684\u76ee\u7684\u3002\u901a\u8fc7\u5bfc\u5411\u57fa\u56e2\u7684\u5f00\u53d1\uff0c\u8fd1\u5e74\u6765\u62a5\u9053\u4e86\u4e00\u7cfb\u5217\u7684\u95f4\u4f4d\u30fb\u5bf9\u4f4dC\u2013H\u6d3b\u5316\u53cd\u5e94<sup>(2)<\/sup>\u3002<\/p>\n<p>\u7136\u800c\uff0c\u9700\u8981\u660e\u767d\u7684\u662f\uff0c\u5373\u4f7f\u6709\u5bfc\u5411\u57fa\u7684\u52a0\u5165\uff0c\u5e76\u4e14\u53ef\u4ee5\u8fbe\u6210\u4e0e\u82b3\u9999\u73af\u7684\u73af\u91d1\u5c5e\u5316\u53cd\u5e94\uff0c\u4e5f\u5e76\u4e0d\u662f\u8bf4\u53ef\u4ee5\u5b9e\u73b0\u5728\u7279\u5b9a\u4f4d\u7f6e\u53d1\u751f\u9009\u62e9\u6027\u7684C-H\u6d3b\u5316\u3002<\/p>\n<p>\u63a5\u4e0b\u6765\uff0c\u5c0f\u7f16\u4ecb\u7ecd\u4e0b\u5177\u6709\u4ee3\u8868\u6027\u7684\u82b3\u9999\u65cf\u5316\u5408\u7269-\u82ef\u80fa\u7684\u50ac\u5316C-H\u70f7\u57fa\u5316\u53cd\u5e94\u3002<\/p>\n<p>Ackermann\u7b49\u4eba\u4ee5\u5627\u5576\u4f5c\u4e3a\u5bfc\u5411\u57fa\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u82ef\u80fa\u7684Ru\u50ac\u5316\u7684\u95f4\u4f4d\u9009\u62e9\u6027\u70f7\u57fa\u5316\u53cd\u5e94(\u56fe 1C)<sup>(3)<\/sup>\u3002\u901a\u8fc7\u5bfc\u5411\u57fa\u7684\u4f5c\u7528\uff0cRu\u50ac\u5316\u5242\u5728\u90bb\u4f4d\u53d1\u751f\u73af\u91d1\u5c5e\u5316\u5f62\u6210\u7684\u914d\u5408\u7269<strong>a<\/strong>\uff0c\u4e0d\u4f1a\u4e0e\u9ad8\u7ea7\u5364\u4ee3\u70f7\u70c3\u53cd\u5e94\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u87af\u5408\u7269<strong>a<\/strong>\u80fd\u591f\u4f5c\u4e3a\u03c3-\u82b3\u57fa\u91d1\u5c5e\u7edc\u5408\u7269\u8fdb\u884c\u53cd\u5e94\uff0c\u5f15\u8d77\u95f4\u4f4d\u7684\u4eb2\u7535\u53d6\u4ee3\u53cd\u5e94<sup>(4)<\/sup>\u3002\u53e6\u5916Weng\u4e0eLu\u7b49\u4eba\u62a5\u9053\u4e86\u4ee5\u7532\u57fa\u5421\u5576\u9170\u80fa\u4e3a\u5bfc\u5411\u57fa\u56e2\uff0c\u94dc\u50ac\u5316\u5242\u50ac\u5316\u7684\u6c28\u57fa\u8418\u7684\u5bf9\u4f4dC &#8211; H\u5b98\u80fd\u5316\u53cd\u5e94(\u56fe 1C)<sup>(5)<\/sup>\u3002\u94dc\u50ac\u5316\u5242\u4e0e\u7532\u57fa\u5421\u5576\u9170\u80fa\u90e8\u4f4d\u5f62\u6210\u4e8c\u9f7f\u914d\u4f4d\uff08\u7edc\u5408\u7269<strong>b<\/strong>\uff09\uff0c\u4e0d\u4f1a\u8fdb\u884c\u82b3\u9999\u73af\u7684\u73af\u91d1\u5c5e\u5316\u3002<\/p>\n<p>\u8fd9\u4e00\u6b21\uff0c\u5df4\u65af\u5927\u5b66\u7684Frost\u6559\u6388\uff0c\u5f00\u53d1\u51fa\u4e86Ru\u50ac\u5316\u7684\u5bf9\u4f4d\u9009\u62e9\u6027\u7684\u82ef\u80fa\u7684C-H\u70f7\u57fa\u5316\u53cd\u5e94(\u56fe 1D)\u3002\u8be5\u6587\u7ae0\u4e2d\u4f7f\u7528\u7684\u6761\u4ef6\u51e0\u4e4e\u4e0eAckerman\u7b49\u4eba\u7684\u6761\u4ef6\u76f8\u540c\uff0c\u800cRu\u50ac\u5316\u5242\u4e0d\u4f1a\u4e0e\u82b3\u9999\u73af\u53d1\u751f\u73af\u91d1\u5c5e\u5316\u53cd\u5e94\uff0c\u800c\u662f\u4e0e\u82ef\u80fa\u5f62\u6210\u4e8c\u9f7f\u914d\u4f4d\uff0c\u5f62\u6210\u9ad8\u4f4d\u963b\u7684\u82ef\u80fa\u884d\u751f\u7269<strong>c<\/strong>\uff0c\u6700\u7ec8\u53d1\u73b0\u4e86\u5bf9\u4f4d\u9009\u62e9\u6027C-H\u70f7\u57fa\u5316\u53cd\u5e94\u3002<\/p>\n<div id=\"attachment_53968\" class=\"wp-caption aligncenter\">\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-16885 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/2017-11-21_20-52-20.png\" alt=\"\" width=\"919\" height=\"367\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/2017-11-21_20-52-20.png 919w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/2017-11-21_20-52-20-300x120.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/2017-11-21_20-52-20-768x307.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/2017-11-21_20-52-20-680x272.png 680w\" sizes=\"(max-width: 919px) 100vw, 919px\" \/><\/p>\n<p class=\"wp-caption-text\">\u56fe1. (A) \u82b3\u9999\u65cf\u5316\u5408\u7269\u7684\u73af\u91d1\u5c5e\u5316\u53cd\u5e94 (B) \u82ef\u80fa\u7684\u95f4\u4f4d\u70f7\u57fa\u5316\u53cd\u5e94 (C) \u8418\u80fa\u7684\u5bf9\u4f4d\u70f7\u57fa\u5316\u53cd\u5e94 (D) \u672c\u6587\u7ae0\u4ecb\u7ecd\u7684\u53cd\u5e94<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<blockquote><p><strong>\u201cRuthenium-Catalyzed para-Selective C\u2013H Alkylation of Aniline Derivatives\u201d<\/strong><\/p>\n<p>Leitch, J. A.; McMullin, C. L.; Paterson, A. J.; Mahon, M. F.; Bhonoah, Y.; Frost, C. G. <em>Angew. Chem., Int. Ed.<\/em> <strong>2017<\/strong>, <em>56<\/em>, 15131.\u00a0DOI: <a href=\"http:\/\/dx.doi.org\/10.1002\/anie.201708961\">10.1002\/anie.201708961<\/a><\/p><\/blockquote>\n<h4>\u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd<\/h4>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-16886 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/2017-11-21_20-54-10.png\" alt=\"\" width=\"123\" height=\"181\" \/><\/p>\n<p>\u7814\u7a76\u8005\uff1a<a href=\"https:\/\/frostgroupblog.wordpress.com\/\">Christopher G. Frost<\/a><\/p>\n<p>\u7814\u7a76\u8005\u7ecf\u5386\uff1a<br \/>\n-1991 B.S., University of Loughborough<br \/>\n1991-1994 Ph.D., University of Loughborough<br \/>\n1994-1996 Posdoc, University of Texas (Prof. Philip D. Magnus)<br \/>\n1996-2011 Lecturer, Senior Ledcturer, University of Bath<br \/>\n2011- Professor, University of Bath<br \/>\n\u7814\u7a76\u5185\u5bb9\uff1a\u4f4d\u7f6e\u9009\u62e9\u6027\u7684C-H\u5b98\u80fd\u56e2\u5316\u3001\u4e32\u8054\u50ac\u5316\u5242\u4f53\u7cfb\u7684\u5f00\u53d1\u3001\u751f\u7269\u63a2\u9488\u7684\u53d1\u5c55\u53ca\u5176\u5bfc\u5165\u6cd5\u7684\u5f00\u53d1<\/p>\n<h4>\u8bba\u6587\u6982\u8981<\/h4>\n<p>\u672c\u53cd\u5e94\uff0c\u4ee5TBME\u4e3a\u6eb6\u5242\uff0c\u5728Ru\u50ac\u5316\u5242\u4e0eK<sub>2<\/sub>CO<sub>3<\/sub>\u5b58\u5728\u4e0b\uff0c\u4ee5\u4f5c\u4e3a\u5bfc\u5411\u57fa\u56e2\u76845-\u6c2f\u5627\u5576\u53d6\u4ee3\u7684\u82ef\u80fa\u884d\u751f\u7269<strong>1<\/strong>\u4e3a\u5e95\u7269\uff0c\u4e0e<em>tert<\/em>-\u6eb4\u4ee3\u70f7\u57fa\u916f<strong>2<\/strong>\u53cd\u5e94\uff0c\u5f97\u5230\u4e86\u5bf9\u4f4d\u9009\u62e9\u6027\u70f7\u57fa\u5316\u4ea7\u7387<strong>3<\/strong>(\u56fe 2A)\u3002\u4f5c\u8005\u5c1d\u8bd5\u4e86\u591a\u79cd\u82ef\u80fa\u884d\u751f\u7269\u4e0e<em>tert<\/em>-\u6eb4\u4ee3\u70f7\u57fa\u916f\uff0c\u90fd\u5f97\u5230\u4e86\u5b8c\u7f8e\u5bf9\u4f4d\u9009\u62e9\u6027\u7684\u4ea7\u7269\u3002\u53e6\u59165-\u4f4d\u6c2f\u4ee3\u5627\u5576\u53ef\u4ee5\u9632\u6b62\u6c2f\u4e5f\u88ab\u70f7\u57fa\u5316\uff0c\u6709\u5229\u4e8e\u4ea7\u7387\u7684\u63d0\u9ad8\u3002<\/p>\n<p>\u63a8\u5b9a\u7684\u53cd\u5e94\u673a\u7406\u5982\u4e0b\u56fe 2B\u6240\u793a(\u53c2\u7167\u8bba\u6587SI)\u3002<\/p>\n<p>\u9996\u5148\u3001Ru\u50ac\u5316\u5242\u7684\u6c2f\u79bb\u5b50\u88ab\u78b3\u9178\u79bb\u5b50\u7f6e\u6362\u5f62\u6210\u91d1\u5c5e\u87af\u5408\u7269<strong>A<\/strong>\uff0c\u518d\u4e0e1\u53cd\u5e94\u5f62\u6210\u87af\u5408\u7269<strong>B<\/strong>\u3002<strong>B<\/strong>\u7684\u91d1\u5c5e-\u5bfc\u5411\u57fa\u90e8\u4f4d\u4f5c\u4e3a\u9ad8\u4f4d\u963b\u7684\u53d6\u4ee3\u57fa\u8d77\u4f5c\u7528\u3002Ru\u87af\u5408\u7269\u540c\u65f6\u4e0e<em>tert<\/em>-\u6eb4\u4ee3\u70f7\u57fa\u916f<strong>2<\/strong>\u53d1\u751f\u5355\u7535\u5b50\u8fd8\u539f\u751f\u6210\u70f7\u57fa\u81ea\u7531\u57fa\uff0c\u4e0e<strong>B<\/strong>\u53cd\u5e94\u751f\u6210\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53<strong>C<\/strong>\u3002<strong>C<\/strong>\u88ab\u5728\u751f\u6210\u70f7\u57fa\u81ea\u7531\u57fa\u65f6\u5f62\u6210\u7684\u4e09\u4ef7Ru\u50ac\u5316\u5242\u8fdb\u884c\u5355\u7535\u5b50\u6c27\u5316\uff0c\u5f97\u5230\u87af\u5408\u7269<strong>D<\/strong>\uff0c\u6700\u7ec8\u5bfc\u5411\u57fa\u4ece\u91d1\u5c5e\u89e3\u79bb\uff0c\u5f62\u6210\u5bf9\u4f4d\u9009\u62e9\u6027\u4ea7\u7269<strong>3<\/strong>\u3002<\/p>\n<p>\u4f5c\u8005\u7b49\u4eba\uff0c\u8fd8\u901a\u8fc7\u628a\u6dfb\u52a0\u5242K<sub>2<\/sub>CO<sub>3<\/sub>\u6539\u6210KOAc\/AcOH\uff0c\u6210\u529f\u628a\u5bf9\u4f4d\u9009\u62e9\u6027\u5207\u6362\u6210\u95f4\u4f4d\u9009\u62e9\u6027(\u56fe 2C)\u3002\u3002<\/p>\n<p>\u901a\u8fc7DFT\u8ba1\u7b97\u7b97\u6210\u4e86\u5728\u78b3\u9178\u76d0\u4e0e\u918b\u9178\u76d0\u5b58\u5728\u4e0b\uff0cRu\u87af\u5408\u7269\u5f62\u6210\u65f6\u7684\u5409\u5e03\u65af\u81ea\u7531\u80fd\u53d8\u5316\u3002\u4f5c\u8005\u53d1\u73b0\uff0c\u5728\u78b3\u9178\u76d0\u5b58\u5728\u4e0b\uff0c\u4f18\u5148\u6d3b\u5316\u82ef\u80fa\u90e8\u4f4d\u7684N-H\u952e\uff08\u5f62\u6210\u87af\u5408\u7269<strong>B<\/strong>\uff09\uff0c\u4ece\u800c\u53d1\u751f\u5bf9\u4f4d\u9009\u62e9\u6027\u3002\u800c\u5728\u918b\u9178\u76d0\u5b58\u5728\u4e0b\u82ef\u80fa\u7684\u90bb\u4f4d\u7684C-H\u952e\u66f4\u5bb9\u6613\u88ab\u6d3b\u5316\uff08\u82b3\u9999\u73af\u73af\u91d1\u5c5e\u5316\u4f53\uff1a\u4e0a\u8ff0\u87af\u5408\u7269<strong>a<\/strong>\uff09\uff0c\u4ece\u800c\u5f97\u5230\u95f4\u4f4d\u9009\u62e9\u6027\u4ea7\u7269\u3002<\/p>\n<div id=\"attachment_53970\" class=\"wp-caption aligncenter\">\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-16887 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/2017-11-21_20-58-22.png\" alt=\"\" width=\"810\" height=\"407\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/2017-11-21_20-58-22.png 810w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/2017-11-21_20-58-22-300x151.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/2017-11-21_20-58-22-768x386.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/2017-11-21_20-58-22-680x342.png 680w\" sizes=\"(max-width: 810px) 100vw, 810px\" \/><\/p>\n<p class=\"wp-caption-text\">\u56fe2. (A) \u82ef\u80fa\u7684\u50ac\u5316\u5bf9\u4f4d\u9009\u62e9\u6027\u70f7\u57fa\u5316\u53cd\u5e94 (B) \u63a8\u5b9a\u7684\u53cd\u5e94\u673a\u7406 (C) \u901a\u8fc7\u6539\u53d8\u53cd\u5e94\u6761\u4ef6\u5b9e\u73b0\u9009\u62e9\u6027\u7684\u5207\u6362<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<ol>\n<li>Ackermann, L. <em>Chem.<\/em>\u00a0<em>Rev<\/em>. <strong>2011<\/strong>, <em>111<\/em>, 1315. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/cr100412j\">10.1021\/cr100412j<\/a><\/li>\n<li>Ma, W.; Gandeepan, P.; Li, J.; Ackermann, L. <em>Chem. Front.<\/em> <strong>2017<\/strong>, <em>4<\/em>, 1435. DOI: <a href=\"http:\/\/dx.doi.org\/10.1039\/C7QO00134G\">10.1039\/C7QO00134G<\/a><\/li>\n<li>Li, J.; Warratz, S.; Zell, D.; Sarkar, S. D.; Ishikawa, E. E.; Ackermann, L. <em>J.\u00a0Am. Chem. Soc.<\/em> <strong>2015<\/strong>, <em>137<\/em>, 13894. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/jacs.5b08435\">10.1021\/jacs.5b08435<\/a><\/li>\n<li>Gagliardo, M.; Snelders, D. J. M.; Chase, P. A.; Gebbink, R. J. M. K.;van Klink, G. P. M.; van Koten, G. <em>Angew.\u00a0Chem., Int. Ed<\/em>. <strong>2007<\/strong>, <em>46<\/em>, 8558. DOI: <a href=\"http:\/\/dx.doi.org\/10.1002\/anie.200604290\">10.1002\/anie.200604290<\/a><\/li>\n<li>Li, J.-M.; Wang, Y.-H.; Yu, Y.; Wu, R.-B.; Weng, J.; Lu, G. <em>ACS Catal<\/em>. <strong>2017<\/strong>, <em>7<\/em>, 2661. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/acscatal.6b03671\">10.1021\/acscatal.6b03671<\/a><\/li>\n<\/ol>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u8bb0\u4e8b\u4ecb\u7ecd\u4e0b\u6700\u65b0\u7684\u4e00\u7bc7Ru\u50ac\u5316\u7684\u82ef\u80fa\u884d\u751f\u7269\u7684\u5bf9\u4f4d\u70f7\u57fa\u5316\u53cd\u5e94\u7684\u8bba\u6587\u3002\u4f4d\u7f6e\u9009\u62e9\u6027\u6781\u597d\uff0c\u5e76\u4e14\u53ef\u4ee5\u901a\u8fc7\u6dfb\u52a0\u5242\u5207\u6362\u6210\u95f4\u4f4d\u9009\u62e9\u6027\u3002 &nbsp; \u82ef\u80fa\u7684\u4f4d\u7f6e\u9009\u62e9\u6027\u70f7\u57fa\u5316\u53cd\u5e94 \u4ee5\u82b3\u9999\u65cf\u5316\u5408\u7269\u4e3a\u5e95\u7269\uff0c\u8fdb\u884c\u4f4d\u7f6e\u9009\u62e9\u6027\u7684\u76f4\u63a5\u5b98\u80fd\u56e2\u5bfc\u5165\u7684\u5408\u6210\u624b\u6cd5\uff0c\u5373\u300c\u4f4d\u7f6e\u9009\u62e9\u6027C-H\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u300d\u662f\u76ee\u524d\u6574\u4e2a\u6709\u673a\u5408\u6210\u9886\u57df\u7684\u4e00\u5927\u70ed\u95e8\u8bfe\u9898\u3002 \u4e3a\u4e86\u5bf9\u7279\u5b9a\u4f4d\u7f6e\u7684C-H\u8fdb\u884c\u6d3b\u5316\uff0c\u88ab\u7528\u7684\u6700\u591a\u7684\u4e00\u79cd\u624b\u6cd5\u662f\u901a\u8fc7\u4e8b\u5148\u5f15\u5165\u5bfc\u5411\u57fa\u56e2\uff0c\u4e0e\u8fc7\u6e21\u91d1\u5c5e\u8fdb\u884c\u914d\u4f4d\uff0c\u7136\u540e\u91d1\u5c5e\u5bf9\u6700\u63a5\u8fd1\u7684\u82b3\u9999\u73af\u4e0a\u7684C-H\u8fdb\u884c\u6d3b\u5316\uff0c\u4e5f\u5c31\u662f\u53ef\u4ee5\u4fc3\u8fdb\u82b3\u9999\u73af\u7684\u73af\u91d1\u5c5e\u5316\u53cd\u5e94(\u56fe 1A)(1)\uff0c\u4ece\u800c\u8fbe\u5230\u9009\u62e9\u6027C-H\u6d3b\u5316\u7684\u76ee\u7684\u3002\u901a\u8fc7\u5bfc\u5411\u57fa\u56e2\u7684\u5f00\u53d1\uff0c\u8fd1\u5e74\u6765\u62a5\u9053\u4e86\u4e00\u7cfb\u5217\u7684\u95f4\u4f4d\u30fb\u5bf9\u4f4dC\u2013H\u6d3b\u5316\u53cd\u5e94(2)\u3002 \u7136\u800c\uff0c\u9700\u8981\u660e\u767d\u7684\u662f\uff0c\u5373\u4f7f\u6709\u5bfc\u5411\u57fa\u7684\u52a0\u5165\uff0c\u5e76\u4e14\u53ef\u4ee5\u8fbe\u6210\u4e0e\u82b3\u9999\u73af\u7684\u73af\u91d1\u5c5e\u5316\u53cd\u5e94\uff0c\u4e5f\u5e76\u4e0d\u662f\u8bf4\u53ef\u4ee5\u5b9e\u73b0\u5728\u7279\u5b9a\u4f4d\u7f6e\u53d1\u751f\u9009\u62e9\u6027\u7684C-H\u6d3b\u5316\u3002 \u63a5\u4e0b\u6765\uff0c\u5c0f\u7f16\u4ecb\u7ecd\u4e0b\u5177\u6709\u4ee3\u8868\u6027\u7684\u82b3\u9999\u65cf\u5316\u5408\u7269-\u82ef\u80fa\u7684\u50ac\u5316C-H\u70f7\u57fa\u5316\u53cd\u5e94\u3002 Ackermann\u7b49\u4eba\u4ee5\u5627\u5576\u4f5c\u4e3a\u5bfc\u5411\u57fa\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u82ef\u80fa\u7684Ru\u50ac\u5316\u7684\u95f4\u4f4d\u9009\u62e9\u6027\u70f7\u57fa\u5316\u53cd\u5e94(\u56fe 1C)(3)\u3002\u901a\u8fc7\u5bfc\u5411\u57fa\u7684\u4f5c\u7528\uff0cRu\u50ac\u5316\u5242\u5728\u90bb\u4f4d\u53d1\u751f\u73af\u91d1\u5c5e\u5316\u5f62\u6210\u7684\u914d\u5408\u7269a\uff0c\u4e0d\u4f1a\u4e0e\u9ad8\u7ea7\u5364\u4ee3\u70f7\u70c3\u53cd\u5e94\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u87af\u5408\u7269a\u80fd\u591f\u4f5c\u4e3a\u03c3-\u82b3\u57fa\u91d1\u5c5e\u7edc\u5408\u7269\u8fdb\u884c\u53cd\u5e94\uff0c\u5f15\u8d77\u95f4\u4f4d\u7684\u4eb2\u7535\u53d6\u4ee3\u53cd\u5e94(4)\u3002\u53e6\u5916Weng\u4e0eLu\u7b49\u4eba\u62a5\u9053\u4e86\u4ee5\u7532\u57fa\u5421\u5576\u9170\u80fa\u4e3a\u5bfc\u5411\u57fa\u56e2\uff0c\u94dc\u50ac\u5316\u5242\u50ac\u5316\u7684\u6c28\u57fa\u8418\u7684\u5bf9\u4f4dC &#8211; H\u5b98\u80fd\u5316\u53cd\u5e94(\u56fe 1C)(5)\u3002\u94dc\u50ac\u5316\u5242\u4e0e\u7532\u57fa\u5421\u5576\u9170\u80fa\u90e8\u4f4d\u5f62\u6210\u4e8c\u9f7f\u914d\u4f4d\uff08\u7edc\u5408\u7269b\uff09\uff0c\u4e0d\u4f1a\u8fdb\u884c\u82b3\u9999\u73af\u7684\u73af\u91d1\u5c5e\u5316\u3002 \u8fd9\u4e00\u6b21\uff0c\u5df4\u65af\u5927\u5b66\u7684Frost\u6559\u6388\uff0c\u5f00\u53d1\u51fa\u4e86Ru\u50ac\u5316\u7684\u5bf9\u4f4d\u9009\u62e9\u6027\u7684\u82ef\u80fa\u7684C-H\u70f7\u57fa\u5316\u53cd\u5e94(\u56fe 1D)\u3002\u8be5\u6587\u7ae0\u4e2d\u4f7f\u7528\u7684\u6761\u4ef6\u51e0\u4e4e\u4e0eAckerman\u7b49\u4eba\u7684\u6761\u4ef6\u76f8\u540c\uff0c\u800cRu\u50ac\u5316\u5242\u4e0d\u4f1a\u4e0e\u82b3\u9999\u73af\u53d1\u751f\u73af\u91d1\u5c5e\u5316\u53cd\u5e94\uff0c\u800c\u662f\u4e0e\u82ef\u80fa\u5f62\u6210\u4e8c\u9f7f\u914d\u4f4d\uff0c\u5f62\u6210\u9ad8\u4f4d\u963b\u7684\u82ef\u80fa\u884d\u751f\u7269c\uff0c\u6700\u7ec8\u53d1\u73b0\u4e86\u5bf9\u4f4d\u9009\u62e9\u6027C-H\u70f7\u57fa\u5316\u53cd\u5e94\u3002 \u56fe1. (A) \u82b3\u9999\u65cf\u5316\u5408\u7269\u7684\u73af\u91d1\u5c5e\u5316\u53cd\u5e94 (B) \u82ef\u80fa\u7684\u95f4\u4f4d\u70f7\u57fa\u5316\u53cd\u5e94 (C) \u8418\u80fa\u7684\u5bf9\u4f4d\u70f7\u57fa\u5316\u53cd\u5e94 (D) \u672c\u6587\u7ae0\u4ecb\u7ecd\u7684\u53cd\u5e94 &nbsp; \u201cRuthenium-Catalyzed para-Selective C\u2013H Alkylation of Aniline Derivatives\u201d Leitch, J. A.; McMullin, C. L.; Paterson, A. J.; Mahon, M. F.; Bhonoah, Y.; Frost, C. G. Angew. Chem., Int. Ed. 2017, 56, 15131.\u00a0DOI: 10.1002\/anie.201708961 \u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd \u7814\u7a76\u8005\uff1aChristopher G. Frost \u7814\u7a76\u8005\u7ecf\u5386\uff1a -1991 B.S., University of Loughborough 1991-1994 Ph.D., University of Loughborough 1994-1996 Posdoc, University of Texas (Prof. Philip D. 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