{"id":16932,"date":"2017-11-30T06:13:00","date_gmt":"2017-11-29T22:13:00","guid":{"rendered":"\/\/www.gsbet888.com\/?p=16932"},"modified":"2019-08-02T18:52:19","modified_gmt":"2019-08-02T10:52:19","slug":"trimethyl-lock","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/2017\/11\/trimethyl-lock.html","title":{"rendered":"Trimethyl Lock"},"content":{"rendered":"<p><strong>trimethyl lock, TML<\/strong>\u3001\u7b80\u5355\u5730\u8bf4\u5b83\u662f\u4fdd\u62a4\u57fa\u7684\u4e00\u79cd\uff0c\u4f5c\u7528\u662f\u53ef\u4ee5\u5bf9\u5e94\u7279\u5b9a\u7684\u914d\u4f53\uff0c\u6216\u8005\u9776\u70b9\u91ca\u653e\u5206\u5b50\u3002\u5b83\u7ecf\u5e38\u51fa\u73b0\u5728\u5316\u5b66\u751f\u7269\u5b66\u6216\u8005\u524d\u836f\u7684\u5e94\u7528\u8bba\u6587\u4e2d\u3002<\/p>\n<h4>\u539f\u7406<\/h4>\n<p>2-hydroxybenzenepropionic acids\u7684lactone\u5316\uff08\u5185\u916f\u5316\uff09\u8fdb\u7a0b\u4e2d\u3001\u82ef\u915a\u9644\u8fd1\u7684\u4e09\u4e2amethyl\u57fa\u7684\u5055\u4e8c\u7532\u57fa\u6548\u5e94\uff08Thorpe-Ingold effect\uff09\u3001\u5bf9\u73af\u5316\u5177\u6709\u5de8\u5927\u7684\u52a0\u901f\u4f5c\u7528\u3002\u7279\u522b\u662f\u6700\u540e\u7aef\u7684\u5316\u5408\u7269\uff0clactone\u5316\u7279\u522b\u5feb\uff0c\u5373\u4f7f\u7fa7\u9178\u90e8\u4f4d\u662f\u9170\u80fa\u57fa\u56e2\uff0c\u4e5f\u4f1a\u88ab\u5207\u65ad\u8fdb\u884clactone\u5316\u3002<\/p>\n<div id=\"attachment_54102\" class=\"wp-caption aligncenter\">\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-16934\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/trimethyl_lock_1-e1511703774875-300x93.png\" alt=\"\" width=\"300\" height=\"93\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/trimethyl_lock_1-e1511703774875-300x93.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/trimethyl_lock_1-e1511703774875.png 341w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p class=\"wp-caption-text\">lactone\u5f62\u6210\u901f\u5ea6\u7684\u76f8\u5bf9\u503c<\/p>\n<\/div>\n<p>\u82ef\u915a\u90e8\u4f4d\u88ab\u4fdd\u62a4\u540e\u7684\u82ef\u915a\u4e09\u7532\u57fa\u53d6\u4ee3lock\u7684\u7ed3\u6784\uff0c\u53ef\u4ee5\u63a9\u76d6\u81ea\u5df1\u4f5c\u4e3a\u9776\u70b9\u5316\u5408\u7269\u7684\u529f\u80fd\uff0c\u5148\u4e0d\u4e0e\u9776\u70b9\u86cb\u767d\u4f5c\u7528\uff0c\u5728\u82ef\u915a\u8131\u4fdd\u62a4\u540e\uff0c\u529f\u80fd\u5f97\u5230\u89e6\u53d1\uff0c\u77ac\u95f4\u53d8\u6210\u524d\u836f\u5316\u5408\u7269\uff0c\u53d1\u6325\u4f5c\u7528\uff08\u53c2\u7167\u4e0b\u56fe\u6240\u793a\uff09\u3002<\/p>\n<p>\u4f8b\u5982\uff0c\u9170\u57fa\u4fdd\u62a4\u7684\u5316\u5408\u7269\u5728\u916f\u9176\u4f5c\u7528\u4e0b\u6c34\u89e3\uff0c\u6c27\u5316\u6210\u918c\u540e\u53ef\u4ee5\u9a71\u52a8\u8fd8\u539f\u9176\uff0c\u5728\u80dc\u5229\u6761\u4ef6\u4e0b\u5f62\u6210lactone\u540e\u518d\u91ca\u653e\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-16935 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/trimethyl_lock_2-e1511704059418.png\" alt=\"\" width=\"570\" height=\"142\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/trimethyl_lock_2-e1511704059418.png 570w, https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/trimethyl_lock_2-e1511704059418-300x75.png 300w\" sizes=\"(max-width: 570px) 100vw, 570px\" \/><\/p>\n<h4>\u5173\u8054\u6587\u732e<\/h4>\n<ol>\n<li>\u201cRate Acceleration by Stereopopulation Control: Models for Enzyme Action\u201d Milstien, S.; Cohen, L. A. <em>Proc. Natl. Acad. Sci. USA<\/em> <strong>1970<\/strong>, <em>67<\/em>, 1143.<\/li>\n<li>\u201cTrimethyl lock: a trigger for molecular release in chemistry, biology, and pharmacology\u201d Levine, M. N.; Raines, R. T. <em>Chem. Sci.<\/em> <strong>2012<\/strong>, <em>3<\/em>, 2412. doi:<a href=\"http:\/\/dx.doi.org\/10.1039\/C2SC20536J\">10.1039\/C2SC20536J<\/a><\/li>\n<li>\u201c\u523a\u6fc0\u5fdc\u7b54\u578b\u30a2\u30df\u30ce\u9178\u306e\u958b\u767a\u3068\u30b1\u30df\u30ab\u30eb\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u5206\u91ce\u3078\u306e\u5c55\u958b\u201d <em>\u85ac\u5b66\u96d1\u8a8c<\/em>, <strong>2012<\/strong>,<em> 132<\/em>, 1075.<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/132\/9\/132_132.1075\/_pdf\"> [PDF]<\/a><\/li>\n<\/ol>\n<h4>\u5316\u5b66\u7a7a\u95f4\u76f8\u5173\u8bb0\u4e8b<\/h4>\n<ul>\n<li><a href=\"\/\/www.gsbet888.com\/reactions\/2017\/04\/\u5055\u4e8c\u7532\u57fa\u6548\u5e94-thorpe-ingold-effect.html\">\u5055\u4e8c\u7532\u57fa\u6548\u5e94<\/a>\uff08ODOS\uff09<\/li>\n<\/ul>\n<h4>\u5916\u90e8\u94fe\u63a5<\/h4>\n<ul>\n<li><a href=\"https:\/\/amphoteros.com\/2016\/09\/02\/trimethyl-lock\/\">Trimethyl Lock<\/a> (amphoterous)<\/li>\n<li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Thorpe%E2%80%93Ingold_effect\">Thorpe-Ingold Effect \u2013 Wikipedia<\/a><\/li>\n<\/ul>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"trimethyl lock, TML\u3001\u7b80\u5355\u5730\u8bf4\u5b83\u662f\u4fdd\u62a4\u57fa\u7684\u4e00\u79cd\uff0c\u4f5c\u7528\u662f\u53ef\u4ee5\u5bf9\u5e94\u7279\u5b9a\u7684\u914d\u4f53\uff0c\u6216\u8005\u9776\u70b9\u91ca\u653e\u5206\u5b50\u3002\u5b83\u7ecf\u5e38\u51fa\u73b0\u5728\u5316\u5b66\u751f\u7269\u5b66\u6216\u8005\u524d\u836f\u7684\u5e94\u7528\u8bba\u6587\u4e2d\u3002 \u539f\u7406 2-hydroxybenzenepropionic acids\u7684lactone\u5316\uff08\u5185\u916f\u5316\uff09\u8fdb\u7a0b\u4e2d\u3001\u82ef\u915a\u9644\u8fd1\u7684\u4e09\u4e2amethyl\u57fa\u7684\u5055\u4e8c\u7532\u57fa\u6548\u5e94\uff08Thorpe-Ingold effect\uff09\u3001\u5bf9\u73af\u5316\u5177\u6709\u5de8\u5927\u7684\u52a0\u901f\u4f5c\u7528\u3002\u7279\u522b\u662f\u6700\u540e\u7aef\u7684\u5316\u5408\u7269\uff0clactone\u5316\u7279\u522b\u5feb\uff0c\u5373\u4f7f\u7fa7\u9178\u90e8\u4f4d\u662f\u9170\u80fa\u57fa\u56e2\uff0c\u4e5f\u4f1a\u88ab\u5207\u65ad\u8fdb\u884clactone\u5316\u3002 lactone\u5f62\u6210\u901f\u5ea6\u7684\u76f8\u5bf9\u503c \u82ef\u915a\u90e8\u4f4d\u88ab\u4fdd\u62a4\u540e\u7684\u82ef\u915a\u4e09\u7532\u57fa\u53d6\u4ee3lock\u7684\u7ed3\u6784\uff0c\u53ef\u4ee5\u63a9\u76d6\u81ea\u5df1\u4f5c\u4e3a\u9776\u70b9\u5316\u5408\u7269\u7684\u529f\u80fd\uff0c\u5148\u4e0d\u4e0e\u9776\u70b9\u86cb\u767d\u4f5c\u7528\uff0c\u5728\u82ef\u915a\u8131\u4fdd\u62a4\u540e\uff0c\u529f\u80fd\u5f97\u5230\u89e6\u53d1\uff0c\u77ac\u95f4\u53d8\u6210\u524d\u836f\u5316\u5408\u7269\uff0c\u53d1\u6325\u4f5c\u7528\uff08\u53c2\u7167\u4e0b\u56fe\u6240\u793a\uff09\u3002 \u4f8b\u5982\uff0c\u9170\u57fa\u4fdd\u62a4\u7684\u5316\u5408\u7269\u5728\u916f\u9176\u4f5c\u7528\u4e0b\u6c34\u89e3\uff0c\u6c27\u5316\u6210\u918c\u540e\u53ef\u4ee5\u9a71\u52a8\u8fd8\u539f\u9176\uff0c\u5728\u80dc\u5229\u6761\u4ef6\u4e0b\u5f62\u6210lactone\u540e\u518d\u91ca\u653e\u3002 \u5173\u8054\u6587\u732e \u201cRate Acceleration by Stereopopulation Control: Models for Enzyme Action\u201d Milstien, S.; Cohen, L. A. Proc. Natl. Acad. Sci. USA 1970, 67, 1143. \u201cTrimethyl lock: a trigger for molecular release in chemistry, biology, and pharmacology\u201d Levine, M. N.; Raines, R. T. Chem. Sci. 2012, 3, 2412. doi:10.1039\/C2SC20536J \u201c\u523a\u6fc0\u5fdc\u7b54\u578b\u30a2\u30df\u30ce\u9178\u306e\u958b\u767a\u3068\u30b1\u30df\u30ab\u30eb\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u5206\u91ce\u3078\u306e\u5c55\u958b\u201d \u85ac\u5b66\u96d1\u8a8c, 2012, 132, 1075. [PDF] \u5316\u5b66\u7a7a\u95f4\u76f8\u5173\u8bb0\u4e8b \u5055\u4e8c\u7532\u57fa\u6548\u5e94\uff08ODOS\uff09 \u5916\u90e8\u94fe\u63a5 Trimethyl Lock (amphoterous) Thorpe-Ingold Effect \u2013 Wikipedia \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01","protected":false},"author":5,"featured_media":16933,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2],"tags":[2125,1113],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/11\/trimethyl_lock_0.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-4p6","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/16932"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=16932"}],"version-history":[{"count":7,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/16932\/revisions"}],"predecessor-version":[{"id":27242,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/16932\/revisions\/27242"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/16933"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=16932"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=16932"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=16932"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}