\n
$\"\"$ <\/p>\n
\u56fe1. \u8fd0\u7528host-guest\u5316\u5b66\u8fdb\u884cDiels\u2013Alder\u53cd\u5e94<\/p>\n<\/div>\n
<\/p>\n
\u201c<\/strong>Cucurbit[7]uril as a Supramolecular Artificial Enzyme for Diels\u2013Alder Reactions<\/strong>\u201d<\/strong><\/p>\n
Palma, A.; Artelsmair, M.; Wu, G.; Lu, X.; Barrow, S. J.; Uddin, N.; Rosta, E.; Masson, E.; Scherman, O. A.Angew. Chem., Int. Ed.<\/em> 2017<\/strong>, 56<\/em>, 15688.<\/p>\n
DOI: 10.1002\/anie.201706487<\/a><\/p><\/blockquote>\n
\u8bba\u6587\u4f5c\u8005\u7b80\u4ecb<\/h4>\n
$\"\"$ <\/p>\n
\u7814\u7a76\u8005\uff1a Oren A. Scherman<\/a><\/p>\n
\u7814\u7a76\u8005\u7ecf\u5386\uff1a
\n-1999 B.A., Cornell University (Prof. Dotsevi Y. Sogah)
\n2004 Ph.D., California Institute of Technology (Prof. Robert H. Grubbs)
\n2004-2006 Posdoc, Eindhoven University of Technology (Prof. E.W. (Bert) Meijer)
\n2006- Lecturer and Next Generation Fellow of the Melville Laboratory, University of Cambridge
\n2011- Reader in Supramolecular and Polymer Chemistry, University of Cambridge
\n2013- Director of the Melville Laboratory, University of Cambridge
\n2015- Professor, University of Cambridge
\n\u7814\u7a76\u5185\u5bb9\uff1a\u8d85\u5206\u5b50\u3001\u9ad8\u5206\u5b50\u5316\u5b66<\/p>\n
<\/p>\n
$\"\"$ <\/p>\n
\u7814\u7a76\u8005\uff1a Eric Masson<\/a><\/p>\n
\u7814\u7a76\u8005\u7ecf\u5386\uff1a
\n-2001 M.S., University of Lausanne
\n2005 Ph.D., Swiss Federal Institute of Technology Lausanne (Prof. Manfred Schlosser)
\n2005-2007 Posdoc, Yale University (Prof. Andrew D. Hamilton)
\n2007-2013 Assistant Professor, Ohio University
\n2013- Associate Professor, Ohio University
\n\u7814\u7a76\u5185\u5bb9\uff1a\u8d85\u5206\u5b50\u3001\u5206\u5b50\u8bc6\u522b\u5316\u5b66<\/p>\n
\u8bba\u6587\u6982\u8981<\/h4>\n
CB[7]\u81ea\u8eab\u662f\u5177\u6709\u9ad8\u6c34\u6eb6\u6027\u7684\u5206\u5b50\uff0c\u800c\u73af\u5185\u90e8\u786e\u662f\u758f\u6c34\u6027\u7684\u3002\u56e0\u6b64\uff0c\u5728\u6c34\u4e2d\u7684\u758f\u6c34\u6027\u5316\u5408\u7269\u5c31\u4f1a\u66f4\u5bb9\u6613\u8fdb\u5165CB\u5185\u90e8\u3002\u672c\u7814\u7a76\u5c31\u662f\u901a\u8fc7\u5229\u7528\u5357\u74dc\u73af\u8fd9\u4e2a\u7279\u6b8a\u6027\u8d28\uff0c\u901a\u8fc7\u5c06\u758f\u6c34\u6027\u5e95\u7269N<\/em>-\u70ef\u4e19\u57fa-2-\u7ce0\u80fa\u884d\u751f\u72691<\/strong>\u5f15\u5165CB\u5185\u90e8\uff0c\u6210\u529f\u4fc3\u8fdb\u4e86\u5176\u5206\u5b50\u5185DA\u53cd\u5e94\u7684\u8fdb\u884c(\u56fe1A)\u3002\u53cd\u5e94\u673a\u7406\u5982\u4e0b\u56fe\u4e2dB<\/strong>\u6240\u793a\u3002\u8d28\u5b50\u5316\u7684\u5e95\u72691<\/strong>\u4e0e\u5b58\u5728\u4e8eCB[7]\u5f00\u53e3\u90e8\u7684\u7fb0\u57fa\u4e4b\u95f4\u53d1\u751fion-dipole\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u4f7f\u758f\u6c34\u6b8b\u57fa\uff08\u544b\u5583\uff0c\u4e19\u70ef\u57fa\uff09\u63ba\u5165\u5230\u5185\u90e8\uff0c\u5f62\u6210\u5e95\u7269\u7684\u53d1\u5939\u8bf1\u5bfc\u6784\u8c61\uff08HIC\uff09(\u56fe1B)\u3002\u901a\u8fc7HIC\u7684\u5f62\u6210\u5c06\u53cc\u70ef\u4e0e\u4eb2\u53cc\u70ef\u4f53\u4ee5\u6700\u5408\u9002\u7684\u4f4d\u7f6e\u5173\u7cfb\u914d\u7f6e\u4ee5\u4fc3\u8fdbDA\u53cd\u5e94\u8fdb\u884c\u3002\u544b\u5583\u4e0e\u70ef\u70c3\u4e4b\u95f4\u7684\u03c0 – \u03c0\u76f8\u4e92\u4f5c\u7528\u53c2\u4e0e\u4e86HIC\u7684\u5f62\u6210\uff0c\u5982\u679c\u70ef\u70c3\u90e8\u4f4d\u6362\u6210\u9971\u548c\u70f7\u70c3\u94fe\u7684\u8bdd\uff0c\u70f7\u70c3\u94fe\u5c31\u65e0\u6cd5\u6e17\u5165\u5230CB\u5185\u90e8\uff0c\u4e5f\u5c31\u65e0\u6cd5\u5f62\u6210HIC(\u56fe1C)\u3002<\/p>\n
\u672c\u624b\u6cd5\uff0cDA\u4ea7\u7269\u6bd4\u539f\u6599\u66f4\u5bb9\u6613\u8fdb\u5165CB\u5185\u90e8\uff0c\u56e0\u6b64\u4e0d\u4f1a\u4ea7\u751f\u663e\u8457\u5730\u751f\u6210\u7269\u963b\u5bb3\u4f5c\u7528\uff0c\u751a\u81f3\u5f53\u4f7f\u7528\u50ac\u5316\u91cf\u7684CB\u65f6\uff0c\u53cd\u5e94\u4ecd\u4ee5\u9ad8\u6536\u7387\u8fdb\u884c[7]\u3002\u901a\u8fc7\u5404\u79cd\u901f\u5ea6\u8bba\u5b9e\u9a8c\u53d1\u73b0\uff0c\u751f\u6210\u7269\u7684CB[7]\u7684\u7ed3\u5408\u5e38\u6570\u6bd4\u662f\u539f\u6599\u7684\u51e0\u5341\u500d\uff0c\u56e0\u6b64\u5373\u4f7f\u5728\u50ac\u5316\u6761\u4ef6\u4e0b\uff0c\u4e5f\u4e0d\u4f1a\u4ea7\u751f\u963b\u788d\u751f\u6210\u7269\u751f\u6210\u8fd9\u4e00\u4e2a\u666e\u904d\u95ee\u9898\u3002<\/p>\n
\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\u83b7\u5f97\u7684\u53d1\u73b0\u4e0d\u4ec5\u5728\u4e8e\u5357\u74dc\u73af\u53ef\u4ee5\u4f5c\u4e3ahost-guest\u5316\u5b66\u7684\u65b0\u50ac\u5316\u5242\uff0c\u800c\u4e14\u8be5\u9879\u7814\u7a76\u6709\u5229\u4e8e\u5bf9Diels-Alderase\u7684\u66f4\u6df1\u5c42\u4f5c\u7528\u673a\u5236\u7684\u7406\u89e3\u3002<\/p>\n
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$\"\"$ <\/p>\n
\u56fe2. (A) \u5e95\u7269\u9002\u7528\u8303\u56f4\u4e0e\u534a\u8870\u671f (B) \u672c\u53cd\u5e94\u7684\u50ac\u5316\u5faa\u73af (C) \u53d1\u5939\u8bf1\u5bfc\u6784\u8c61\uff08HIC\uff09<\/p>\n<\/div>\n
\u53c2\u8003\u6587\u732e<\/h4>\n
\n
Review: (a) Klas, K.; Tsukamoto, S.; Sherman, D. H.; Williams, R. M. J.\u00a0Org. Chem<\/em>. 2015<\/strong>, 80<\/em>, 11672. DOI: 10.1021\/acs.joc.5b01951<\/a> A representative report, see: (b) Ose, T.; Watanabe, K.; Mie, T.; Honma, M.; Watanabe, H.; Yao, M.; Oikawa, H.; Tanaka, I. Nature.<\/em> 2003<\/strong>, 422<\/em>, 185. DOI: 10.1038\/nature01454<\/a><\/li>\n
(a) Kang, J.; Rebek, Jr., J. Nature<\/em>, 1997<\/strong>, 385<\/em>, 50. DOI: 1038\/385050a0<\/a> (b) Marty, M.; Watson, C-. Z.; Twyman, L. J.; Nakash, M.; Sanders, J. K. M. Chem. Commun.<\/em>1998<\/strong>, 2265. DOI: 10.1039\/A806070C<\/a><\/li>\n
(a) Yoshizawa, M.; Tamura, M.; Fujita, M. Science,<\/em>\u00a02006<\/strong>, 312<\/em>, 251. DOI: 10.1126\/science.1124985<\/a> Another example: (b) Howlader, P.; Das, P.; Zangrando, E.; Mukherjee, P. S. J. Am. Chem. Soc.<\/em> 2016<\/strong>, 138<\/em>, 1668. DOI: 10.1021\/jacs.5b12237<\/a><\/li>\n<\/ol>\n
\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong> \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01 <\/p>\n","protected":false},"excerpt":{"rendered":"\u5c06\u73af\u72b6\u6c34\u6eb6\u6027\u5206\u5b50-cucurbit[7]uril\u6a21\u62df\u751f\u7269\u4f53\u5185\u7684Diels\u2013Alderase\uff0c\u5b9e\u73b0\u5206\u5b50\u5185Diels\u2013Alder\u53cd\u5e94\u3002 \u5229\u7528Host-Guest\u5316\u5b66\u8fdb\u884c\u4eba\u5de5Diels\u2013Alderase\u7684\u8bbe\u8ba1 \u4e8c\u70ef\u548c\u4eb2\u53cc\u70ef\u4f53\u7684Diels\u2013Alder(DA)\u53cd\u5e94\u3001\u53ef\u4ee5\u7528\u4e8e\u6784\u5efa\u5177\u6709\u7acb\u4f53\u7279\u5f02\u6027\u7684\u516d\u5143\u73af\u73af\u72b6\u9aa8\u67b6\u3002\u5728\u5929\u7136\u4ea7\u7269\u4e0e\u533b\u836f\u54c1\u7684\u5408\u6210\u4e2d\u5177\u6709\u91cd\u8981\u5730\u4f4d\u3002 \u540c\u65f6\uff0c\u5728\u751f\u7269\u4f53\u5185DA\u53cd\u5e94\u4e5f\u4f5c\u4e3a\u5f88\u591a\u5929\u7136\u6709\u673a\u5316\u5408\u7269\u7684\u751f\u7269\u5408\u6210\u9014\u5f84\u88ab\u5e7f\u4e3a\u6240\u77e5[1]\u3002\u8be5\u7c7b\u751f\u7269\u4f53\u5185\u7684\u53cd\u5e94\u4e2d\u8d77\u5230\u50ac\u5316\u4f5c\u7528\u7684\u9176-Diels\u2013Alderase\uff0c\u53ef\u4ee5\u4e0e\u5e95\u7269\u7279\u5f02\u6027\u7684\u7ed3\u5408\u4ee5\u9694\u65ad\u56f4\u7ed5\u5728\u5e95\u7269\u5468\u56f4\u7684\u6c34\u5206\u5b50\uff0c\u4fc3\u8fdbDiels\u2013Alder\u53cd\u5e94\u9ad8\u6548\u7387\u7684\u8fdb\u884c\u3002\u800c\u6a21\u4effDiels\u2013Alderase\u7684\u4eba\u5de5\u5206\u5b50\u7cfb\u7edf\u7684\u6784\u5efa\uff0c\u662f\u76ee\u524dhost-guest\u5316\u5b66\u7684\u6d3b\u7528\u65b9\u9762\u6bd4\u8f83\u53d7\u5173\u6ce8\u7684\u7814\u7a76\u65b9\u5411\u3002 \u5230\u76ee\u524d\u4e3a\u6b62Julius Rebek Jr.\u7b49\u4eba\u901a\u8fc7\u4f7f\u7528\u81ea\u7ec4\u88c5\u6709\u673a\u5316\u5408\u7269\u4f5c\u4e3ahost\u5206\u5b50\u50ac\u5316\u5242\u5b9e\u73b0\u4e86DA\u53cd\u5e94\u7684200\u500d\u52a0\u901f(\u56fe1A)[2a]\u3002\u4f46\u662f\uff0c\u65e0\u8bba\u662f\u5929\u7136\u7684Diels\u2013Alderase\u8fd8\u662fRebek\u7b49\u4eba\u7684\u62a5\u9053\u4e2d\uff0c\u7531\u4e8e\u4f7f\u7528\u7684\u53cd\u5e94\u7269\u4e0e\u5f97\u5230\u7684\u751f\u6210\u7269\u7ed3\u6784\u7c7b\u4f3c\uff0c\u6240\u4ee5\u751f\u6210\u7269\u4e5f\u80fd\u4f5c\u4e3aguest\u5206\u5b50\uff0c\u963b\u788d\u8fdb\u4e00\u6b65\u53cd\u5e94\u751f\u6210\u7269\u7684\u751f\u6210\uff0c\u4e5f\u5c31\u662f\u5f71\u54cd\u4e86\u53cd\u5e94\u7684\u6548\u7387[2]\u3002 2006\u5e74\uff0c\u85e4\u7530\u7b49\u4eba\u901a\u8fc7\u81ea\u7ec4\u88c5\u87af\u5408\u7269\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u65e0\u751f\u6210\u7269\u963b\u788d\u7684\u50ac\u5316DA\u53cd\u5e94[3]\uff0c\u7136\u800c\u5230\u76ee\u524d\u4e3a\u6b62\u4e5f\u4ec5\u4ec5\u5c40\u9650\u4e8e\u8fd9\u4e00\u4e2a\u4f8b\u5b50(\u56fe1B)\u3002 \u4eca\u5929\u4ecb\u7ecd\u7684\u8fd9\u7bc7\u6587\u7ae0\u4e2d\uff0c\u4f5c\u8005\u7740\u773c\u4e8e\u73af\u72b6\u6c34\u6eb6\u6027host\u5206\u5b50\u4e4b\u4e00\u7684cucurbit[7]uril\uff08CB[7]\uff09\u3002\u901a\u8fc7\u4f7f\u7528CB[7]\uff0c\u5e76\u4e14\u6a21\u4eff\u751f\u7269\u4f53\u4e2d\u7684\u6e29\u548c\u6761\u4ef6\u4e0b\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u65e0\u4fdd\u62a4\u7684N-\u70ef\u4e19\u57fa-2-\u7ce0\u80fa\u884d\u751f\u7269\u7684\u5206\u5b50\u5185DA\u53cd\u5e94(\u56fe1C)\u3002\u672c\u65b9\u6cd5\u7684\u7279\u70b9\u662f\uff0c\u5728\u7ade\u4e89\u6027\u751f\u6210\u7269\u963b\u788d\u4e0b\u4e5f\u80fd\u9ad8\u6548\u7387\u7684\u8fdb\u884c\u53cd\u5e94\u3002 \u56fe1. \u8fd0\u7528host-guest\u5316\u5b66\u8fdb\u884cDiels\u2013Alder\u53cd\u5e94 \u201cCucurbit[7]uril as a Supramolecular Artificial Enzyme for Diels\u2013Alder Reactions\u201d Palma, A.; Artelsmair, M.; Wu, G.; Lu, X.; Barrow, S. J.; Uddin, N.; Rosta, E.; Masson, E.; Scherman, O. A.Angew. Chem., Int. Ed. 2017, 56, 15688. DOI: 10.1002\/anie.201706487 \u8bba\u6587\u4f5c\u8005\u7b80\u4ecb \u7814\u7a76\u8005\uff1aOren A. Scherman \u7814\u7a76\u8005\u7ecf\u5386\uff1a -1999 B.A., Cornell University (Prof. Dotsevi Y. Sogah) 2004 Ph.D., California Institute of Technology (Prof. Robert H. Grubbs) 2004-2006 Posdoc, Eindhoven University of Technology (Prof. E.W. (Bert) Meijer) 2006- Lecturer and Next Generation Fellow of the Melville Laboratory, University of Cambridge 2011- Reader in Supramolecular and Polymer Chemistry, University of Cambridge 2013- Director of the Melville […]","protected":false},"author":5,"featured_media":17211,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[414,1271],"tags":[2150,2148,2149],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2017\/12\/2017-12-06_21-04-13.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-4tA","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/17210"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=17210"}],"version-history":[{"count":16,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/17210\/revisions"}],"predecessor-version":[{"id":27218,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/17210\/revisions\/27218"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/17211"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=17210"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=17210"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=17210"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}