{"id":18064,"date":"2018-02-22T10:10:57","date_gmt":"2018-02-22T02:10:57","guid":{"rendered":"\/\/www.gsbet888.com\/?p=18064"},"modified":"2019-08-02T18:51:56","modified_gmt":"2019-08-02T10:51:56","slug":"carolyne-r-bertozzi","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemists\/2018\/02\/carolyne-r-bertozzi.html","title":{"rendered":"Carolyne R. Bertozzi"},"content":{"rendered":"

Carolyne R. Bertozzi\u30011966\u5e7410\u670810\u65e5-\u3001\u7f8e\u56fd\u6709\u673a\u5316\u5b66\u5bb6\u3001\u5206\u5b50\u7ec6\u80de\u751f\u7269\u5b66\u5bb6 (\u7167\u7247\uff1aBertozzi Group<\/a>)\u3002\u73b0\u4e3a\u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\u6559\u6388\u3002<\/p>\n

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\u5c65\u5386<\/h4>\n

1988 \u54c8\u4f5b\u5927\u5b66 \u672c\u79d1\u6bd5\u4e1a(Joe Grabowski\u6559\u6388)
\n1993 \u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821 \u535a\u58eb\u5b66\u4f4d\u00a0(Mark Bednarski\u6559\u6388)
\n1993 \u535a\u58eb\u540e\u7814\u7a76\u5458
\n1996 \u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821
\n19xx \u970d\u534e\u5fb7\u533b\u5b66\u7814\u7a76\u6240\uff08HHMI\uff09\u517c\u804c\u7814\u7a76\u5458<\/p>\n

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\u53d7\u8d4f\u7ecf\u5386<\/h4>\n

1987 Danforth Teaching Award
\n1988 New England American Institute of Chemists Award
\n1988 Thomas T. Hoopes Undergraduate Thesis Prize
\n1989, 1990 Outstanding Graduate Student Instructor Awards
\n1992 Bruce Mahan Teaching Award
\n1995 Camille and Henry Dreyfus New Faculty Award
\n1996 Exxon Education Fund Young Investigator Award
\n1996 Pew Scholars Award in the Biomedical Sciences
\n1997 Burroughs Wellcome New Investigator Award in Pharmacology
\n1997 Alfred P. Sloan Research Fellow
\n1997 Horace S. Isbell Award in Carbohydrate Chemistry (ACS)
\n1998 Office of Naval Research Young Investigator Award
\n1998 Research Corporation Research Innovation Award
\n1998 Glaxo Wellcome Scholar
\n1998 Prytanean Faculty Award
\n1998 Beckman Young Investigator Award
\n1999 MacArthur Foundation Award
\n1999 Camille Dreyfus Teacher-Scholar Award
\n1999 ACS Arthur C. Cope Award
\n2000 Presidential Early Career Award in Science and Engineering (PECASE)
\n2000 UC Berkeley Department of Chemistry Teaching Award
\n2000 Merck Academic Development Program Award
\n2001 The Donald Sterling Noyce Prize for Excellence in Undergraduate Teaching
\n2001 Berkeley\u2019s Distinguished Teaching Award
\n2001 ACS Award in Pure Chemistry
\n2002 Irving Sigal Young Investigator Award of the Protein Society
\n2004 Agnes Fay Morgan Research Award
\n2005 Havinga Medal
\n2005 The T.Z. and Irmgard Chu Distinguished Professorship in Chemistry
\n2007 Ernst Schering Prize
\n2008 Willard Gibbs Award
\n2009 W. H. Nichols Award
\n2009 Harrison Howe Award
\n2009 Albert Hofmann Medal, Univ. Zurich
\n2010 Lemelson-MIT Prize
\n2010 Royal Society of Chemistry \u2013 Organic Division, Bioorganic Chemistry Award
\n2011 Tetrahedron Young Investigator Award for Bioorganic and Medicinal Chemistry
\n2012 Heinrich Wieland Prize
\n2013 Elected Fellow of the National Academy of Inventors<\/p>\n

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\u7814\u7a76<\/h4>\n

\u6211\u4eec\u4e13\u6ce8\u4e8e\u7ec6\u80de\u8868\u9762\u7684\u7cd6\u94fe\u7684\u7814\u7a76\uff0c\u8fd9\u4e9b\u7cd6\u94fe\u88ab\u8ba4\u4e3a\u5728\u764c\u75c7\uff0c\u4f20\u67d3\u75c5\uff0c\u708e\u75c7\u6027\u75be\u75c5\u7b49\u65b9\u9762\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u5e76\u4e14\u7740\u91cd\u4ece\u4e8b\u9610\u660e\u8fd9\u4e9b\u7cd6\u94fe\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u7684\u529f\u80fd\u7684\u5316\u5b66\u751f\u7269\u5b66\u7814\u7a76\u3002<\/p>\n

\u7ec6\u80de\u8868\u9762\u4eba\u5de5\u4fee\u9970\u6cd5\u7684\u5f00\u53d1<\/b><\/p>\n

\u4e3b\u8981\u5de5\u4f5c\u4e4b\u4e00\u662f\u5f00\u53d1\u4e86\uff0c\u53e0\u6c2e\u5316\u540e\u7684\u5206\u5b50\u5982\u4e0b\u56fe\u6240\u793a\u4e0e\u78f7\u8bd5\u5242\u53cd\u5e94\uff0c\u5f62\u6210\u7a33\u5b9a\u7684\u9170\u80fa\u952e\uff0c\u5e76\u4e14\u5f15\u5165\u8367\u5149\u663e\u8272\u57fa\u56e2\u7684ligation\u624b\u6cd5(Staudinger-Bertozzi Ligation<\/strong>)[1]<\/sup>\u3002\u8be5\u53cd\u5e94\u4ea7\u7387\u9ad8\u9009\u62e9\u578b\u597d\uff0c\u5e76\u4e14\u80fd\u591f\u5728\u751f\u7269\u6761\u4ef6\u4e0b\u8fdb\u884c\u3002Bertozzi\u53d1\u73b0\u5728\u7ec6\u80de\u8868\u9762\u5b58\u5728\u53e0\u6c2e\u5316\u7684\u7cd6\u7ed3\u6784\uff0c\u56e0\u6b64\u5f00\u53d1\u4e86\u8fd0\u7528\u4ee5\u4e0a\u5316\u5b66\u65b9\u6cd5\u5bf9\u7ec6\u80de\u8868\u9762\u8fdb\u884c\u4eba\u5de5\u4fee\u9970\u7684\u624b\u6cd5\u3002\u8be5\u624b\u6cd5\u4f5c\u4e3a\u5316\u5b66\u751f\u7269\u5b66\u7684\u4e00\u4e2a\u57fa\u7840\u65b9\u6cd5\uff0c\u9002\u7528\u5bf9\u8c61\u5728\u4e0d\u65ad\u5f00\u53d1\u4e2d\u3002<\/p>\n

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Staudinger-Bertozzi Ligation<\/p>\n

\u53e6\u5916\u7684\u4e00\u4e2a\u4e3b\u8981\u7814\u7a76\u96c6\u4e2d\u5728\u8fd0\u7528\u53e0\u6c2e-\u7094\u73af\u52a0\u6210(Huisgen\u73af\u5316)\u7684\u6807\u8bb0\u6cd5\u5f00\u53d1\u3002\u7279\u522b\u662f\u4ee5\u626d\u66f2\u7684\u7f3a\u7535\u5b50\u7094\u70c3\uff08\u4e0b\u56fe\u6240\u793a\u6c1f\u4ee3\u8f9b\u7094\uff09\u4e3a\u5e95\u7269\uff0c\u5728\u65e0\u9700\u94dc\u50ac\u5316\u5242\u50ac\u5316\u4e0b\u6210\u529f\u8fdb\u884c\u53cd\u5e94[2]<\/sup>\u3002\u4e0d\u4f7f\u7528\u6709\u6bd2\u91d1\u5c5e\u662f\u4e00\u5927\u7279\u70b9\u3002<\/p>\n

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    \n
  1. \u76ee\u524d\u8fd8\u53ea\u670940\u591a\u5c81\uff0c\u7136\u800c\u5df2\u7ecf\u662f\u4e16\u754c\u4e0a\u6700\u8457\u540d\u7684\u5973\u6027\u79d1\u5b66\u5bb6\u4e4b\u4e00\u3002\u3002\u662f\u4e16\u754c\u4e0a\u6700\u5e74\u8f7b\uff08\u83b7\u5956\u5f53\u65f633\u5c81\uff09\u7684\u88ab\u6388\u4e88\u5929\u624d\u79d1\u5b66\u5bb6\u30fb\u827a\u672f\u5bb6\u5956\u9879MacArthur Fellowshipd<\/a>\u7684\u79d1\u5b66\u5bb6<\/li>\n
  2. \u7236\u4eb2William Bertozzi(MIT\u7269\u7406\u5b66\u7cfb)\u3001\u59d0\u59d0Andrea Bertozzi<\/a>(UCLA\u6570\u5b66\u7cfb)\u90fd\u662f\u6267\u638c\u7f8e\u56fd\u8457\u540d\u5927\u5b66\u6559\u97ad\u7684\u4eba\u3001\u5b8c\u5b8c\u5168\u5168\u7684\u5b66\u672f\u5bb6\u65cf\u3002<\/li>\n<\/ol>\n

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