{"id":18111,"date":"2018-03-12T06:19:45","date_gmt":"2018-03-11T22:19:45","guid":{"rendered":"\/\/www.gsbet888.com\/?p=18111"},"modified":"2019-08-02T18:51:55","modified_gmt":"2019-08-02T10:51:55","slug":"nakata%e7%bc%a9%e7%a1%ab%e9%85%ae%e5%8c%96-%e5%86%85%e9%85%af%e5%8c%96","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/%e5%8f%96%e4%bb%a3%e5%8f%8d%e5%ba%94\/2018\/03\/nakata%e7%bc%a9%e7%a1%ab%e9%85%ae%e5%8c%96-%e5%86%85%e9%85%af%e5%8c%96.html","title":{"rendered":"Nakata\u7f29\u786b\u916e\u5316-\u5185\u916f\u5316"},"content":{"rendered":"<h4><strong>\u6982\u8981<\/strong><\/h4>\n<p>Nakata\u7f29\u786b\u916e\u5316-\u5185\u916f\u5316(Nakata thioketalization-lactonization) \u662f\u901a\u8fc7BF<sub>3<\/sub>\u00b7OEt<sub>2<\/sub>\u4fc3\u8fdb\u7684\u7f29\u916e\u4e0e1,3-\u4e19\u4e8c\u786b\u9187\u4e4b\u95f4\u7684\u4e32\u8054\u786b\u7f29\u916e\u5316\/\u5185\u916f\u5316\u8fc7\u7a0b\u3002\u8be5\u53cd\u5e94\u7531\u65e5\u672c\u7406\u5316\u7814\u7a76\u9662(The Institute of Physical and Chemical Research , Riken)\u7684\u4e2d\u7530\u5fe0(Nakata Tadashi)\u7814\u7a76\u7ec4\u57281983\u5e74\u9996\u6b21\u62a5\u9053\u3002\u76ee\u524d\u8be5\u53cd\u5e94\u5df2\u6210\u529f\u5e94\u7528\u4e8e\u4e00\u4e9b\u751f\u7269\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u7684\u5173\u952e\u6b65\u9aa4\u3002<\/p>\n<h4><strong>\u57fa\u672c\u6587\u732e<\/strong><\/h4>\n[1]T.Nakata, S.Takao, M.Fukui, T.Tanaka, T.Oishi, Tetrahedron Lett. 1983, 24, 3873.doi:<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0040403900942990\">10.1016\/S0040-4039(00)94299-0.<\/a><\/p>\n<h4><strong>\u53cd\u5e94\u673a\u7406<\/strong><\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/2-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-18113 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/2-1.png\" alt=\"\" width=\"1130\" height=\"584\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/2-1.png 1130w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/2-1-300x155.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/2-1-768x397.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/2-1-680x351.png 680w\" sizes=\"(max-width: 1130px) 100vw, 1130px\" \/><\/a><\/p>\n<h4><strong>\u53cd\u5e94\u5b9e\u4f8b<\/strong><\/h4>\n<p>\u5b98\u80fd\u56e2\u5316syn-1,3 ,5,7-\u56db\u9187\u7684\u5408\u6210[1]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/3-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-18114 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/3-1.png\" alt=\"\" width=\"1118\" height=\"178\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/3-1.png 1118w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/3-1-300x48.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/3-1-768x122.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/3-1-680x108.png 680w\" sizes=\"(max-width: 1118px) 100vw, 1118px\" \/><\/a><\/p>\n<p>Bryostatin 11\u5e95\u90e8\u7247\u6bb5(bottom half \u00a0fragment)\u7684\u5408\u6210[2]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/4-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-18115 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/4-1.png\" alt=\"\" width=\"1127\" height=\"565\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/4-1.png 1127w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/4-1-300x150.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/4-1-768x385.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/4-1-680x341.png 680w\" sizes=\"(max-width: 1127px) 100vw, 1127px\" \/><\/a><\/p>\n<h4><strong>\u5b9e\u9a8c\u6b65\u9aa4<\/strong><\/h4>\n<p>\u5c06\u7f29\u916e\u7684(175 mg, 0.46 mmol) MeNO<sub>2<\/sub>-DCM\u6eb6\u6db2(2:1 v\/v\uff0c\u5e95\u7269\u6d53\u5ea6\u4e3a0.15 M)\u51b7\u5374\u81f3-45\u00b0C\uff0c\u4e4b\u540e\u52a0\u51651,3-\u4e19\u4e8c\u786b\u9187(3.3eq.)\u4e0eBF<sub>3<\/sub>\u00b7OEt<sub>2<\/sub>\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u9010\u6e10\u5347\u6e29\u81f30\u00b0C(\u5347\u6e29\u65f6\u95f4\u8d85\u8fc71h)\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6db2\u76f4\u63a5\u91c7\u7528\u7845\u80f6\u67f1\u8272\u8c31\u8fdb\u884c\u5206\u79bb\u7eaf\u5316\uff0c\u83b7\u5f97\u76f8\u5e94\u76ee\u6807\u4ea7\u7269\u3002<\/p>\n<h4><strong>\u5b9e\u9a8c\u6280\u5de7<\/strong><\/h4>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1]T.Nakata, S.Takao, M.Fukui, T.Tanaka, T.Oishi, Tetrahedron Lett. 1983, 24, 3873.doi:<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0040403900942990\">10.1016\/S0040-4039(00)94299-0.<\/a><\/li>\n<li>[2] K. Nakagawa-Goto, M. T. Crimmins, Synlett 2011, 11, 1555.xdoi:<a href=\"https:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0030-1260784\">10.1055\/s-0030-1260784<\/a>.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong> \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01 <\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 Nakata\u7f29\u786b\u916e\u5316-\u5185\u916f\u5316(Nakata thioketalization-lactonization) \u662f\u901a\u8fc7BF3\u00b7OEt2\u4fc3\u8fdb\u7684\u7f29\u916e\u4e0e1,3-\u4e19\u4e8c\u786b\u9187\u4e4b\u95f4\u7684\u4e32\u8054\u786b\u7f29\u916e\u5316\/\u5185\u916f\u5316\u8fc7\u7a0b\u3002\u8be5\u53cd\u5e94\u7531\u65e5\u672c\u7406\u5316\u7814\u7a76\u9662(The Institute of Physical and Chemical Research , Riken)\u7684\u4e2d\u7530\u5fe0(Nakata Tadashi)\u7814\u7a76\u7ec4\u57281983\u5e74\u9996\u6b21\u62a5\u9053\u3002\u76ee\u524d\u8be5\u53cd\u5e94\u5df2\u6210\u529f\u5e94\u7528\u4e8e\u4e00\u4e9b\u751f\u7269\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u7684\u5173\u952e\u6b65\u9aa4\u3002 \u57fa\u672c\u6587\u732e [1]T.Nakata, S.Takao, M.Fukui, T.Tanaka, T.Oishi, Tetrahedron Lett. 1983, 24, 3873.doi:10.1016\/S0040-4039(00)94299-0. \u53cd\u5e94\u673a\u7406 \u53cd\u5e94\u5b9e\u4f8b \u5b98\u80fd\u56e2\u5316syn-1,3 ,5,7-\u56db\u9187\u7684\u5408\u6210[1] Bryostatin 11\u5e95\u90e8\u7247\u6bb5(bottom half \u00a0fragment)\u7684\u5408\u6210[2] \u5b9e\u9a8c\u6b65\u9aa4 \u5c06\u7f29\u916e\u7684(175 mg, 0.46 mmol) MeNO2-DCM\u6eb6\u6db2(2:1 v\/v\uff0c\u5e95\u7269\u6d53\u5ea6\u4e3a0.15 M)\u51b7\u5374\u81f3-45\u00b0C\uff0c\u4e4b\u540e\u52a0\u51651,3-\u4e19\u4e8c\u786b\u9187(3.3eq.)\u4e0eBF3\u00b7OEt2\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u9010\u6e10\u5347\u6e29\u81f30\u00b0C(\u5347\u6e29\u65f6\u95f4\u8d85\u8fc71h)\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6db2\u76f4\u63a5\u91c7\u7528\u7845\u80f6\u67f1\u8272\u8c31\u8fdb\u884c\u5206\u79bb\u7eaf\u5316\uff0c\u83b7\u5f97\u76f8\u5e94\u76ee\u6807\u4ea7\u7269\u3002 \u5b9e\u9a8c\u6280\u5de7 \u53c2\u8003\u6587\u732e [1]T.Nakata, S.Takao, M.Fukui, T.Tanaka, T.Oishi, Tetrahedron Lett. 1983, 24, 3873.doi:10.1016\/S0040-4039(00)94299-0. [2] K. Nakagawa-Goto, M. T. Crimmins, Synlett 2011, 11, 1555.xdoi:10.1055\/s-0030-1260784. &nbsp; \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01","protected":false},"author":21,"featured_media":18154,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[16],"tags":[171,2217,2216],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/nakata.jpg","jetpack_shortlink":"https:\/\/wp.me\/p96op1-4I7","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/18111"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=18111"}],"version-history":[{"count":4,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/18111\/revisions"}],"predecessor-version":[{"id":27157,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/18111\/revisions\/27157"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/18154"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=18111"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=18111"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=18111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}