{"id":18168,"date":"2018-03-21T09:35:13","date_gmt":"2018-03-21T01:35:13","guid":{"rendered":"\/\/www.gsbet888.com\/?p=18168"},"modified":"2019-08-02T18:51:53","modified_gmt":"2019-08-02T10:51:53","slug":"%e9%92%8c%e5%82%ac%e5%8c%96%e6%b4%bb%e5%8c%96c-c%e9%94%ae%e7%9a%84%e6%b0%a2%e8%bd%ac%e7%a7%bb%e7%8e%af%e5%8a%a0%e6%88%90%e5%9e%8b%e5%81%b6%e8%81%94%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2018\/03\/%e9%92%8c%e5%82%ac%e5%8c%96%e6%b4%bb%e5%8c%96c-c%e9%94%ae%e7%9a%84%e6%b0%a2%e8%bd%ac%e7%a7%bb%e7%8e%af%e5%8a%a0%e6%88%90%e5%9e%8b%e5%81%b6%e8%81%94%e5%8f%8d%e5%ba%94.html","title":{"rendered":"\u948c\u50ac\u5316\u6d3b\u5316C &#8211; C\u952e\u7684\u6c22\u8f6c\u79fb\u73af\u52a0\u6210\u578b\u5076\u8054\u53cd\u5e94"},"content":{"rendered":"<p><strong>2017\u5e74\uff0c\u5fb7\u514b\u8428\u65af\u5927\u5b66\u5965\u65af\u6c40\u5206\u6821\u30fb<a href=\"\/\/www.gsbet888.com\/chemists\/2017\/03\/michael-j-krische.html\">Micharl J. Krische<\/a>\u7b49\u4eba\u3001\u6210\u529f\u5f00\u53d1\u51fa\u4e86\u901a\u8fc7Ru(0)\u50ac\u5316\u5242\u50ac\u5316\u7684\u82ef\u5e76\u4e01\u70ef\u916e\u4e0e\u4e8c\u9187\u7684\u6c22\u8f6c\u79fb\u578b\u73af\u52a0\u6210\u53cd\u5e94\u3002\u7531\u4e8e\u8be5\u53cd\u5e94\u4f18\u5f02\u7684\u4f4d\u7f6e\u30fb\u7acb\u4f53\u9009\u62e9\u6027\uff0c\u56e0\u6b64\u8be5\u53cd\u5e94\u88ab\u8ba4\u4e3a\u6709\u671b\u7528\u4f5c\u9ad8\u6548\u5408\u6210 type II polyketides\u3002<\/strong><\/p>\n<blockquote><p>\u201cRuthenium-catalyzed insertion of adjacent diol carbon atoms into C-C bonds:Entry to type II polyketides\u201d<br \/>\nBender, M.; Turnbull, B. W. H.; Ambler, B. R.; Krische, M. J.* <em>Science<\/em> <strong>2017<\/strong>, <em>357<\/em>, 779-781. DOI: <a href=\"http:\/\/dx.doi.org\/10.1126\/science.aao0453\">10.1126\/science.aao0453<\/a><\/p><\/blockquote>\n<h4><span id=\"more-56336\"><\/span><br \/>\n\u4e0e\u4ee5\u5f80\u7684\u7814\u7a76\u76f8\u6bd4\uff0c\u4f18\u8d8a\u6027\u5728\u4e8e<\/h4>\n<p>\u5bf9\u4e8e\u626d\u66f2\u7684\u78b3\u73af\u4e3a\u5bf9\u8c61\u7684C-C\u952e\u6d3b\u6027\u5316\u53cd\u5e94\u7684\u7814\u7a76\u5176\u5b9e\u4ece\u5f88\u65e9\u5f00\u59cb\u5c31\u5df2\u7ecf\u5728\u8fdb\u884c\u4e86\u3002\u7136\u800c\u6240\u7528\u91d1\u5c5e\u50ac\u5316\u5242\u6bd4\u5982Pt 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\u50ac\u5316\u5242\u5bf9\u03b1-\u7f9f\u57fa\u916f\u548c1,2-\u4e8c\u9187\u7684\u6c27\u5316\u3001\u5f00\u53d1\u51fa\u4e86[4+2]\u578b\u7684\u73af\u5316\u53cd\u5e94\u7b49\u591a\u79cd\u53cd\u5e94\u7c7b\u578b[2]\u3002\u4f8b\u5982\u4e0b\u56fe\u7684\u53cd\u5e94[2b]\u6240\u793a\u3001\u4e8c\u9187\u88abRu(0)\u6c27\u5316\u5f62\u6210\u4e8c\u916e\u540e\u3001\u4e0e\u4e8c\u70ef\u8fdb\u884c\u6c27\u5316\u5076\u8054\u53cd\u5e94\u5f62\u6210\u516d\u5143\u73af\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-18170 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/Krische_Ru_1-e1519393315163.png\" alt=\"\" width=\"458\" height=\"293\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/Krische_Ru_1-e1519393315163.png 458w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/Krische_Ru_1-e1519393315163-300x192.png 300w\" sizes=\"(max-width: 458px) 100vw, 458px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h4>\u4e3b\u5f20\u7684\u6709\u6548\u6027\u9a8c\u8bc1<\/h4>\n<h5>\u2460\u53cd\u5e94\u6761\u4ef6\u7684\u7b5b\u9009\u4f18\u5316<\/h5>\n<p>\u4f5c\u8005\u4f7f\u7528\u4ee5\u4e0b\u5e95\u7269\u548c\u7532\u82ef\u6eb6\u5242\u8fdb\u884c\u521d\u671f\u63a2\u8ba8\u3001\u5728Ru<sub>3<\/sub>(CO)<sub>12<\/sub> (2 mol%), dppp (6 mol%)\u5b58\u5728\u4e0b110 \u00b0C \uff0c\u53cd\u5e9424 h\u540e\u5f97\u5230\u4e86\u76ee\u6807\u73af\u5316\u4ea7\u7269\uff0c\u4ea7\u738722%\u3002\u4e8c\u9187\u90e8\u4f4d\u7684\u7acb\u4f53\u9009\u62e9\u6027\u975e\u5e38\u597d\uff0c\u5f97\u5230\u4e86syn only\u7684\u7acb\u4f53\u9009\u62e9\u6027\u4ea7\u7269\u3002\u7136\u540e\u901a\u8fc7\u8c03\u6574\u53cd\u5e94\u6eb6\u5242\uff0c\u5728\u4f7f\u7528\u4e8c\u7532\u82ef\uff0c150 \u00b0C \u53cd\u5e9424h\u7684\u6761\u4ef6\u4e0b\uff0c\u4ea7\u7387\u63d0\u9ad8\u5230\u4e8688%\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-18171 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/Krische_Ru_2-e1519393408458.png\" alt=\"\" width=\"437\" height=\"128\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/Krische_Ru_2-e1519393408458.png 437w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/Krische_Ru_2-e1519393408458-300x88.png 300w\" sizes=\"(max-width: 437px) 100vw, 437px\" \/><\/p>\n<h5>\u2461\u5e95\u7269\u62d3\u5c55<\/h5>\n<p>\u5bf9\u82ef\u5e76\u73af\u4e01\u70ef\u916e\u5e95\u7269\u4e00\u4fa7\u8fdb\u884cscreening\u3001\u5bf9\u4e8e\u82ef\u73af\u4e0a\u7684\u53d6\u4ee3\u57fa\u867d\u7136\u4ec5\u4ec5\u5c40\u9650\u4e8e\u70f7\u6c27\u57fa\u4e0e\u5364\u7d20\uff0c\u4f46\u662f\u5364\u7d20\u6709\u671b\u53ef\u4ee5\u8fdb\u4e00\u6b65\u901a\u8fc7\u5076\u8054\u7528\u4e8e\u5408\u6210\u591a\u79cd\u884d\u751f\u5e95\u7269\u3002<\/p>\n<p>\u5bf9\u4e8e\u53e6\u4e00\u4e2a\u5e95\u7269\uff0c\u4e8c\u9187\u6765\u8bf4\u30015 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\/><\/p>\n<h5>\u2462\u53cd\u5e94\u673a\u7406\u7684\u8003\u5bdf<\/h5>\n<p>\u5728\u901a\u5e38\u6761\u4ef6\u4e0b\uff0c\u526f\u4ea7\u7269\u4e2d\u6709\u82ef\u5e76\u73af\u4e01\u70ef\u916e\u539f\u6599\u5f00\u73af\u540e\u7684\u526f\u4ea7\u7269\uff082-\u7532\u6c27\u57fa-6-\u7532\u57fa\u82ef\u57fa\uff09-\u7532\u9187\u7684\u5f62\u6210\uff0c\u8fd9\u8868\u660e\u5e95\u7269\u63a5\u53d72\u5f53\u91cf\u7684\u6c22\uff0c\u6c27\u5316\u4e86\u5e95\u7269\u4e8c\u9187\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5f53\u4f7f\u7528\u916e\u9187\u4f5c\u4e3a\u539f\u6599\u65f6\uff0c\u7531\u4e8e\u4f53\u7cfb\u8f6c\u53d8\u4e3aredox-neutral\u578b\uff0c\u56e0\u6b64\u76f8\u5bf9\u4e8e\u82ef\u5e76\u4e01\u70ef\u916e\u6765\u8bf4\uff0c\u916e\u9187\u7684\u7528\u91cf\u9700\u89811\u5f53\u91cf\u3002\u5f53\u4e8c\u916e\u7528\u4f5c\u539f\u6599\u65f6\uff0c\u901a\u8fc7\u52a0\u5165iPrOH\u4f5c\u4e3a\u8fd8\u539f\u5242\u8fdb\u884c\u53cd\u5e94[3]\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-18173 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/Krische_Ru_4-e1519393480925.png\" alt=\"\" width=\"572\" height=\"338\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/Krische_Ru_4-e1519393480925.png 572w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/Krische_Ru_4-e1519393480925-300x177.png 300w\" sizes=\"(max-width: 572px) 100vw, 572px\" \/><\/p>\n<p>\u63a8\u5b9a\u7684\u53cd\u5e94\u673a\u5236\u5982\u4e0b\u3002\u9996\u5148\uff0c\u539f\u6599\u5f7c\u6b64\u53cd\u5e94\u751f\u6210\u4e8c\u916e\u5e95\u7269\u3002\u82ef\u5e76\u73af\u4e01\u70ef\u916e\u7684C &#8211; C\u952e\u88ab\u6c27\u5316\u52a0\u6210\u5230\u948c\u4e0a\u5f62\u6210\u948c\u70ef\u916e\u3002\u4e4b\u540e\uff0c\u901a\u8fc7\u8fde\u7eed\u7684\u4e8c\u916e\u52a0\u6210\u53cd\u5e94\u5f97\u5230\u4e8c\u6c27\u6742\u948c\u73af\u3002\u4e4b\u540e\uff0c\u901a\u8fc7\u539f\u6599\u4f9b\u7ed9\u6c22\uff0c\u518d\u4ece\u6c22\u5316\u948c\u4e2d\u8fd8\u539f\u6d88\u9664\u800c\u751f\u6210\u76ee\u6807\u7269\uff0c\u518d\u751fRu\uff080\uff09\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-18174 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/Krische_Ru_5-e1519393527606.png\" alt=\"\" width=\"509\" height=\"371\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/Krische_Ru_5-e1519393527606.png 509w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/03\/Krische_Ru_5-e1519393527606-300x219.png 300w\" sizes=\"(max-width: 509px) 100vw, 509px\" \/><\/p>\n<h5>\u2463\u624b\u6027\u53cd\u5e94\u7684\u5c55\u5f00<\/h5>\n<p>\u4f5c\u8005\u5229\u7528\u4e0a\u8ff0standard\u7684\u5e95\u7269\uff0c\u901a\u8fc7\u4f7f\u7528(CF<sub>3<\/sub>CO<sub>2<\/sub>)<sub>2<\/sub>Ru(CO)(PPh<sub>3<\/sub>)<sub>2<\/sub>\uff65MeOH\u4e0e\u624b\u6027\u914d\u4f53(<em>R<\/em>)-SEGPHOS\u8fdb\u884c\u53cd\u5e94\u3001\u5f97\u5230\u4e8651%ee\u7684\u4ea7\u7269\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8fd9\u662f\u552f\u4e00\u7684\u4e00\u4e2a\u624b\u6027\u5408\u6210\u7684\u4f8b\u5b50\u3002<\/p>\n<h4>\u63a5\u4e0b\u6765\u9700\u8981\u5173\u6ce8\u7684\u8bba\u6587\u662f\uff1f<\/h4>\n<ul>\n<li>Ru \u50ac\u5316\u7684C-C\u952e\u6d3b\u5316\uff0c\u7279\u522b\u662f\u7528\u4e8e\u624b\u6027\u50ac\u5316\u53cd\u5e94\u9886\u57df\u7684\u8bba\u6587\uff0c\u8fd8\u5f88\u5c11\u89c1\u3002<\/li>\n<\/ul>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<ol>\n<li>Ketcham, J. M.; Shin, I.; Montgomery, T. P.; Krishe, M. J. <em>Angew. Chem. Int. Ed.<\/em><strong>2014<\/strong>,<em> 53<\/em>, 9142. DOI: <a href=\"http:\/\/dx.doi.org\/10.1002\/anie.201403873\">10.1002\/anie.201403873<\/a><\/li>\n<li>For example: (a) Leung, J. C.; Geary, L. M.; Chen, T.-Y.; Zbieg, J. R.; Krische, M. J. <em>J. Am. Chem. Soc.<\/em> <strong>2012<\/strong>, <em>134<\/em>, 15700. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/ja3075049\">10.1021\/ja3075049<\/a> (b) Geary, L. M.; Glasspoole, B. W.; Kim, M. M.; Krische, M. J. <em>J. Am. Chem. Soc.<\/em>\u00a0<strong>2013<\/strong>, <em>135<\/em>, 3796. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/ja400691t\">10.1021\/ja400691t<\/a><\/li>\n<li>Johnson, T. C.; Totty, W. G.; Wills, M.<em> Org. Lett.<\/em> <strong>2012<\/strong>, <em>14<\/em>, 5230. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/ol302354z\">10.1021\/ol302354z<\/a><\/li>\n<\/ol>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong> \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01 <\/p>\n","protected":false},"excerpt":{"rendered":"2017\u5e74\uff0c\u5fb7\u514b\u8428\u65af\u5927\u5b66\u5965\u65af\u6c40\u5206\u6821\u30fbMicharl J. Krische\u7b49\u4eba\u3001\u6210\u529f\u5f00\u53d1\u51fa\u4e86\u901a\u8fc7Ru(0)\u50ac\u5316\u5242\u50ac\u5316\u7684\u82ef\u5e76\u4e01\u70ef\u916e\u4e0e\u4e8c\u9187\u7684\u6c22\u8f6c\u79fb\u578b\u73af\u52a0\u6210\u53cd\u5e94\u3002\u7531\u4e8e\u8be5\u53cd\u5e94\u4f18\u5f02\u7684\u4f4d\u7f6e\u30fb\u7acb\u4f53\u9009\u62e9\u6027\uff0c\u56e0\u6b64\u8be5\u53cd\u5e94\u88ab\u8ba4\u4e3a\u6709\u671b\u7528\u4f5c\u9ad8\u6548\u5408\u6210 type II polyketides\u3002 \u201cRuthenium-catalyzed insertion of adjacent diol carbon atoms into C-C bonds:Entry to type II polyketides\u201d Bender, M.; Turnbull, B. W. H.; Ambler, B. R.; Krische, M. J.* Science 2017, 357, 779-781. DOI: 10.1126\/science.aao0453 \u4e0e\u4ee5\u5f80\u7684\u7814\u7a76\u76f8\u6bd4\uff0c\u4f18\u8d8a\u6027\u5728\u4e8e \u5bf9\u4e8e\u626d\u66f2\u7684\u78b3\u73af\u4e3a\u5bf9\u8c61\u7684C-C\u952e\u6d3b\u6027\u5316\u53cd\u5e94\u7684\u7814\u7a76\u5176\u5b9e\u4ece\u5f88\u65e9\u5f00\u59cb\u5c31\u5df2\u7ecf\u5728\u8fdb\u884c\u4e86\u3002\u7136\u800c\u6240\u7528\u91d1\u5c5e\u50ac\u5316\u5242\u6bd4\u5982Pt \u4e0eNi\u3001Rh\u3001Ru\u751f\u6210\u7684metacycle\u96c6\u4e2d\u5728\u4e0e\u03c0\u952e\u7684\u53cd\u5e94\u4e0a\u3002\u56e0\u6b64\u4ee5\u9971\u548cC-H\u952e\u4e5f\u5c31\u662f\u03c3(C-C)\u952e\u4e3a\u5bf9\u8c61\u7684\u63d2\u5165\u53cd\u5e94\u7684\u4f8b\u5b50\u8fd8\u5f88\u5c11\u3002 \u5728\u4eca\u5929\u6240\u4ecb\u7ecd\u7684\u8bba\u6587\u4e2d\uff0c\u901a\u8fc7\u4f7f\u7528\u6c22\u8f6c\u79fb\u578bC-C\u5076\u8054\u7684\u6982\u5ff5\u6765\u5b9e\u73b0\u7684\u5bf9C-H\u7684\u6d3b\u5316\u53cd\u5e94[1]\u3002\u540c\u65f6\uff0c\u5f97\u5230\u7684\u5f97\u5230\u7684\u7a20\u73af\u5316\u5408\u7269\u5177\u6709\u6865\u5934\u4e8c\u9187\u7ed3\u6784\uff0c\u6709\u671b\u5e94\u7528\u4e8e\u9ad8\u6548\u5408\u6210type II polyketides\u3002 \u6280\u672f\u624b\u6cd5\u7684\u5173\u952e\u70b9 Krische\u8bfe\u9898\u7ec4\u3001\u901a\u8fc7\u4f7f\u7528\u70ef\u70c3\u548c\u7094\u70c3\u4f5c\u4e3a\u6c22\u53d7\u4f53\u6765\u52a0\u901fRu3(CO)12 \u50ac\u5316\u5242\u5bf9\u03b1-\u7f9f\u57fa\u916f\u548c1,2-\u4e8c\u9187\u7684\u6c27\u5316\u3001\u5f00\u53d1\u51fa\u4e86[4+2]\u578b\u7684\u73af\u5316\u53cd\u5e94\u7b49\u591a\u79cd\u53cd\u5e94\u7c7b\u578b[2]\u3002\u4f8b\u5982\u4e0b\u56fe\u7684\u53cd\u5e94[2b]\u6240\u793a\u3001\u4e8c\u9187\u88abRu(0)\u6c27\u5316\u5f62\u6210\u4e8c\u916e\u540e\u3001\u4e0e\u4e8c\u70ef\u8fdb\u884c\u6c27\u5316\u5076\u8054\u53cd\u5e94\u5f62\u6210\u516d\u5143\u73af\u3002 &nbsp; \u4e3b\u5f20\u7684\u6709\u6548\u6027\u9a8c\u8bc1 \u2460\u53cd\u5e94\u6761\u4ef6\u7684\u7b5b\u9009\u4f18\u5316 \u4f5c\u8005\u4f7f\u7528\u4ee5\u4e0b\u5e95\u7269\u548c\u7532\u82ef\u6eb6\u5242\u8fdb\u884c\u521d\u671f\u63a2\u8ba8\u3001\u5728Ru3(CO)12 (2 mol%), dppp (6 mol%)\u5b58\u5728\u4e0b110 \u00b0C \uff0c\u53cd\u5e9424 h\u540e\u5f97\u5230\u4e86\u76ee\u6807\u73af\u5316\u4ea7\u7269\uff0c\u4ea7\u738722%\u3002\u4e8c\u9187\u90e8\u4f4d\u7684\u7acb\u4f53\u9009\u62e9\u6027\u975e\u5e38\u597d\uff0c\u5f97\u5230\u4e86syn only\u7684\u7acb\u4f53\u9009\u62e9\u6027\u4ea7\u7269\u3002\u7136\u540e\u901a\u8fc7\u8c03\u6574\u53cd\u5e94\u6eb6\u5242\uff0c\u5728\u4f7f\u7528\u4e8c\u7532\u82ef\uff0c150 \u00b0C \u53cd\u5e9424h\u7684\u6761\u4ef6\u4e0b\uff0c\u4ea7\u7387\u63d0\u9ad8\u5230\u4e8688%\u3002 \u2461\u5e95\u7269\u62d3\u5c55 \u5bf9\u82ef\u5e76\u73af\u4e01\u70ef\u916e\u5e95\u7269\u4e00\u4fa7\u8fdb\u884cscreening\u3001\u5bf9\u4e8e\u82ef\u73af\u4e0a\u7684\u53d6\u4ee3\u57fa\u867d\u7136\u4ec5\u4ec5\u5c40\u9650\u4e8e\u70f7\u6c27\u57fa\u4e0e\u5364\u7d20\uff0c\u4f46\u662f\u5364\u7d20\u6709\u671b\u53ef\u4ee5\u8fdb\u4e00\u6b65\u901a\u8fc7\u5076\u8054\u7528\u4e8e\u5408\u6210\u591a\u79cd\u884d\u751f\u5e95\u7269\u3002 \u5bf9\u4e8e\u53e6\u4e00\u4e2a\u5e95\u7269\uff0c\u4e8c\u9187\u6765\u8bf4\u30015 \uff5e7\u5143\u9971\u548c\u78b3\u73af\uff0c\u90bb\u4f4d\u6709\u4e8c\u5055\u7532\u57fa\u7684\u5e95\u7269\u90fd\u53ef\u4ee5\u987a\u5229\u8fdb\u884c\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u5bf9\u4e8e\u5728\u03b1-\u4f4d\u5177\u6709\u4e0d\u5bf9\u79f0\u78b3\u7684\u5e95\u7269\uff0c\u53cd\u5e94\u8fdb\u884c\u800c\u4e0d\u4f1a\u635f\u5bb3\u4e0d\u5bf9\u79f0\u6027\u3002 \u2462\u53cd\u5e94\u673a\u7406\u7684\u8003\u5bdf \u5728\u901a\u5e38\u6761\u4ef6\u4e0b\uff0c\u526f\u4ea7\u7269\u4e2d\u6709\u82ef\u5e76\u73af\u4e01\u70ef\u916e\u539f\u6599\u5f00\u73af\u540e\u7684\u526f\u4ea7\u7269\uff082-\u7532\u6c27\u57fa-6-\u7532\u57fa\u82ef\u57fa\uff09-\u7532\u9187\u7684\u5f62\u6210\uff0c\u8fd9\u8868\u660e\u5e95\u7269\u63a5\u53d72\u5f53\u91cf\u7684\u6c22\uff0c\u6c27\u5316\u4e86\u5e95\u7269\u4e8c\u9187\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5f53\u4f7f\u7528\u916e\u9187\u4f5c\u4e3a\u539f\u6599\u65f6\uff0c\u7531\u4e8e\u4f53\u7cfb\u8f6c\u53d8\u4e3aredox-neutral\u578b\uff0c\u56e0\u6b64\u76f8\u5bf9\u4e8e\u82ef\u5e76\u4e01\u70ef\u916e\u6765\u8bf4\uff0c\u916e\u9187\u7684\u7528\u91cf\u9700\u89811\u5f53\u91cf\u3002\u5f53\u4e8c\u916e\u7528\u4f5c\u539f\u6599\u65f6\uff0c\u901a\u8fc7\u52a0\u5165iPrOH\u4f5c\u4e3a\u8fd8\u539f\u5242\u8fdb\u884c\u53cd\u5e94[3]\u3002 \u63a8\u5b9a\u7684\u53cd\u5e94\u673a\u5236\u5982\u4e0b\u3002\u9996\u5148\uff0c\u539f\u6599\u5f7c\u6b64\u53cd\u5e94\u751f\u6210\u4e8c\u916e\u5e95\u7269\u3002\u82ef\u5e76\u73af\u4e01\u70ef\u916e\u7684C &#8211; 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M.; Shin, I.; Montgomery, T. P.; Krishe, M. J. Angew. Chem. Int. Ed.2014, 53, 9142. DOI: 10.1002\/anie.201403873 For example: (a) Leung, J. C.; Geary, L. M.; Chen, T.-Y.; Zbieg, J. 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