{"id":18978,"date":"2018-05-18T06:24:03","date_gmt":"2018-05-17T22:24:03","guid":{"rendered":"\/\/www.gsbet888.com\/?p=18978"},"modified":"2019-08-02T18:51:37","modified_gmt":"2019-08-02T10:51:37","slug":"%e5%8f%af%e9%80%89%e6%8b%a9%e7%8e%af%e5%b0%ba%e5%af%b8%e7%9a%84%e5%8f%8c%e8%83%ba%e5%8c%96","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2018\/05\/%e5%8f%af%e9%80%89%e6%8b%a9%e7%8e%af%e5%b0%ba%e5%af%b8%e7%9a%84%e5%8f%8c%e8%83%ba%e5%8c%96.html","title":{"rendered":"\u53ef\u9009\u62e9\u73af\u5c3a\u5bf8\u7684\u53cc\u80fa\u5316"},"content":{"rendered":"<p>\u672c\u6587\u7ffb\u8bd1\u6295\u7a3f Suming \u6821\u5bf9\u7f16\u8f91 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href=\"https:\/\/i0.wp.com\/assets.chem-station.com\/uploads\/2018\/01\/2018-01-30_22-19-45.png?ssl=1\" data-featherlight=\"image\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-55723 size-full\" src=\"https:\/\/i0.wp.com\/assets.chem-station.com\/uploads\/2018\/01\/2018-01-30_22-19-45.png?resize=1115%2C378&amp;ssl=1\" alt=\"\" width=\"648\" height=\"220\" \/><\/a><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2018-01-30_22-19-45.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-18982\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2018-01-30_22-19-45.png\" alt=\"\" width=\"1115\" height=\"378\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2018-01-30_22-19-45.png 1115w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2018-01-30_22-19-45-300x102.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2018-01-30_22-19-45-768x260.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2018-01-30_22-19-45-680x231.png 680w\" sizes=\"(max-width: 1115px) 100vw, 1115px\" \/><\/a><\/p>\n<p class=\"wp-caption-text\">\u00a0\u56fe1. \u70ef\u70c3\u5206\u5b50\u95f4<span lang=\"EN-US\">\/<\/span>\u5206\u5b50\u5185\u7684\u53cc\u80fa\u5316<\/p>\n<\/div>\n<blockquote><p><strong>\u201c<\/strong><strong>Regiodivergent Iridium(III)-Catalyzed Diamination of Alkenyl Amides with Secondary Amines: Complementary Access to <\/strong><strong>\u03b3<\/strong><strong>\u2013 or <\/strong><strong>\u03b4\u2010<\/strong><strong>Lactams<\/strong><strong>\u201d<\/strong><\/p>\n<p>Conway, J. H. Jr.; Rovis, T. <em>J. Am. Chem. Soc. <\/em><strong>2018<\/strong>, <em>140<\/em>, 135.\u00a0DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/jacs.7b11455\">10.1021\/jacs.7b11455<\/a><\/p><\/blockquote>\n<h4>\u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd<\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2018-01-30_22-34-00.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-18983\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2018-01-30_22-34-00.png\" alt=\"\" width=\"176\" height=\"248\" \/><\/a><\/p>\n<p>\u7814\u7a76\u8005\uff1aTomislav Rovis (URL: <a href=\"https:\/\/rovisresearch.wordpress.com\/\">https:\/\/rovisresearch.wordpress.com<\/a>)<\/p>\n<p>\u7814\u7a76\u8005\u7ecf\u5386\uff1a<\/p>\n<ul>\n<li>1990\u5e74 B.S \u52a0\u62ff\u5927\u5b89\u5927\u7565\u7701\u591a\u4f26\u591a\u5927\u5b66S. S.<\/li>\n<li>1998\u5e74 Ph.D \u5b89\u5927\u7565\u7701\u591a\u4f26\u591a\u5927\u5b66\uff08Mark Lautens\u6559\u6388\uff09<\/li>\n<li>1998\u5e74 Postdoc \u54c8\u4f5b\u5927\u5b66\u7855\u58eb\uff08David A. Evans\u6559\u6388\uff09<\/li>\n<li>2000\u5e74 \u52a9\u7406\u6559\u6388 \u79d1\u7f57\u62c9\u591a\u5dde\u7acb\u5927\u5b66<\/li>\n<li>2005\u5e74 \u526f\u6559\u6388 \u79d1\u7f57\u62c9\u591a\u5dde\u7acb\u5927\u5b66<\/li>\n<li>2008\u5e74 \u6559\u6388 \u79d1\u7f57\u62c9\u591a\u5dde\u7acb\u5927\u5b66<\/li>\n<li>2016\u5e74 \u6559\u6388 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id=\"attachment_55728\" class=\"wp-caption aligncenter\">\n<p><a href=\"https:\/\/i1.wp.com\/assets.chem-station.com\/uploads\/2018\/01\/2018-01-30_22-35-12.png?ssl=1\" data-featherlight=\"image\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-55728 size-full\" src=\"https:\/\/i1.wp.com\/assets.chem-station.com\/uploads\/2018\/01\/2018-01-30_22-35-12.png?resize=1020%2C508&amp;ssl=1\" alt=\"\" width=\"648\" height=\"322\" \/><\/a><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2018-01-30_22-35-12.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-18984\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2018-01-30_22-35-12.png\" alt=\"\" width=\"1020\" height=\"508\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2018-01-30_22-35-12.png 1020w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2018-01-30_22-35-12-300x149.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2018-01-30_22-35-12-768x382.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2018-01-30_22-35-12-680x339.png 680w\" sizes=\"(max-width: 1020px) 100vw, 1020px\" \/><\/a><\/p>\n<p class=\"wp-caption-text\">\u56fe2. A. \u5e95\u7269\u4f7f\u7528\u8303\u56f4\u00a0<span lang=\"EN-US\">B. <\/span>\u53ef\u80fd\u7684\u53cd\u5e94\u673a\u7406<\/p>\n<\/div>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<ol>\n<li>De Jong, S.; Nosal, D. G.; Wardrop, D. J. <em>Tetrahedron<\/em> <strong>2012<\/strong>, <em>68<\/em>, 4067. DOI: <a href=\"http:\/\/dx.doi.org\/10.1016\/j.tet.2012.03.036\">1016\/j.tet.2012.03.036<\/a><\/li>\n<li>Sibbald, P. A.; Michael, F. E. <em>Org.<\/em>\u00a0<em>Lett.<\/em> <strong>2009<\/strong>, <em>11<\/em>, 1147. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/ol9000087\">10.1021\/ol9000087<\/a>(b) Ingalls, E. L.; Sibbald, P. A.; Kaminsky, W.; Michael, F. E.<em> J. Am. Chem. Soc.\u00a0<\/em><strong>2013<\/strong>, <em>135<\/em>, 8854. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/ja4043406\">10.1021\/ja4043406<\/a><\/li>\n<li>Shen, K.; Wang, Q. <em>Chem<\/em>\u00a0<em>Sci.<\/em> <strong>2015<\/strong>, <em>6<\/em>, 4279. DOI: <a href=\"http:\/\/dx.doi.org\/10.1039\/c5sc00897b\">10.1039\/c5sc00897b<\/a><\/li>\n<li>Kong, A.; Blakey, S. B. <em>Synthesis<\/em> <strong>2012<\/strong>, <em>44<\/em>, 1190. DOI: <a href=\"http:\/\/dx.doi.org\/10.1055\/s-0031-1290591\">1055\/s-0031-1290591<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u7ffb\u8bd1\u6295\u7a3f Suming \u6821\u5bf9\u7f16\u8f91 JiaoJiao \u672c\u6587\u62a5\u9053\u4e86\u4f7f\u7528\u5177\u6709\u94f1\u50ac\u5316\u5242\u7684\u4ef2\u80fa\u6765\u8fdb\u884c\u70ef\u57fa\u9170\u80fa\u5728\u5206\u5b50\u95f4\/\u5206\u5b50\u5185\u7684\u53cc\u80fa\u5316\uff0c\u53ef\u4ee5\u901a\u8fc7\u6539\u53d8\u6dfb\u52a0\u5242\u548c\u6eb6\u5242\u6765\u9009\u62e9\u6240\u5f97\u7684\u5185\u9170\u80fa\u7684\u73af\u5927\u5c0f\uff08\u03b3-\u6216\u03b4-\u5185\u9170\u80fa\uff09\u3002\u8fde\u63a5\u5176\u4e2d\u4e00\u4e2a\u80fa\u4e0e\u70ef\u70c3\u7684\u53cc\u80fa\u5316 \u7531\u4e8e\u542b\u6c2e\u5316\u5408\u7269\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5927\u591a\u6570\u836f\u7269\u5206\u5b50\u4e2d\uff0c\u6240\u4ee5\u5f00\u53d1\u51fa\u80fd\u591f\u65b9\u4fbf\u7684\u5c06\u6c2e\u539f\u5b50\u5f15\u5165\u7684\u65b9\u6cd5\u663e\u5f97\u610f\u4e49\u91cd\u5927\u3002\u5728\u8fd9\u4e9b\u65b9\u6cd5\u4e2d\uff0c\u6211\u4eec\u77e5\u9053\u70ef\u70c3\u7684\u53cc\u80fa\u5316\u662f\u4e00\u79cd\u53ef\u4ee5\u4e00\u6b21\u6027\u5f15\u5165\u4e24\u4e2a\u6c2e\u539f\u5b50\uff0c\u88ab\u79f0\u4e3a\u90bb\u4e8c\u80fa\u7684\u6709\u6548\u5408\u6210\u65b9\u6cd5\u3002\u7136\u800c\uff0c\u4e24\u8005\u5f15\u5165\u4e0d\u540c\u7684\u6c28\u57fa\u7684\u65f6\u5019\uff0c\u6709\u5fc5\u8981\u63a7\u5236\u5176\u5404\u81ea\u7684\u53cd\u5e94\u6027\u548c\u533a\u57df\u9009\u62e9\u6027\uff0c\u56e0\u800c\u5b83\u4ecd\u7136\u662f\u4e00\u9879\u5177\u6709\u6311\u6218\u6027\u7684\u7814\u7a76\u3002[1] \u4f5c\u4e3a\u8be5\u95ee\u9898\u7684\u89e3\u51b3\u65b9\u6848\u4e4b\u4e00\uff0c\u6211\u4eec\u5df2\u7ecf\u77e5\u9053\u4e86\u51e0\u4f8b\u5c06\u70ef\u70c3\u4e0e\u80fa\u7684\u5355\u4fa7\u76f8\u8fde\uff0c\u5b9e\u73b0\u5206\u5b50\u5185\/\u5206\u5b50\u95f4\u5185\u8fdb\u884c\u53cc\u80fa\u5316\u53cd\u5e94\u3002 Michael\u7b49\u4eba\u62a5\u9053\u4e86\u4f7f\u7528Pd\u50ac\u5316\u5242\uff0c\u901a\u8fc7\u5206\u5b50\u5185\u7684\u9170\u80fa\u548cNFSI\u5bf9\u70ef\u70c3\u7684\u53cc\u80fa\u5316\uff0c\u5e76\u4e14\u968f\u540e\u53d1\u5c55\u4e3a\u4e0d\u5bf9\u79f0\u53cd\u5e94\uff08\u89c1\u56fe1A\uff09\u3002[2]\u5c3d\u7ba1\u8be5\u65b9\u6cd5\u662f\u5206\u5b50\u95f4\/\u5206\u5b50\u5185\u53cc\u80fa\u5316\u7684\u7b2c\u4e00\u4e2a\u5b9e\u4f8b\uff0c\u4f46\u5206\u5b50\u95f4\u80fa\u5316\u5242\u4ec5\u9650\u4e8e\u4f7f\u7528NFSI\u3002\u4f5c\u4e3a\u53ef\u4ee5\u5f15\u5165\u66f4\u591a\u901a\u7528\u6c28\u57fa\u7684\u4f8b\u5b50\uff0c\u738b\u6559\u6388\u7b49\u4eba\u5df2\u77e5\u4e86\u4e00\u79cd\u5728\u4f7f\u7528\u94dc\u50ac\u5316\u5242\u7684\u60c5\u51b5\u4e0b\u628ao-\u82ef\u7532\u9170\u7f9f\u80fa\u4f5c\u4e3a\u5206\u5b50\u95f4\u80fa\u5316\u5242\u7684\u65b9\u6cd5\u3002\uff08\u56fe1B\uff09[3] \u5c3d\u7ba1\u5728\u4e0a\u9762\u7684\u4f8b\u5b50\u4e2d\u63d0\u4f9b5-exo\u4f53\u7684\u4f8b\u5b50\uff0c\u4f46Blakey\u7b49\u4eba\u6210\u529f\u5730\u4f7f\u7528\u8d85\u4ef7\u7898\u548cTf2NH\u9009\u62e9\u6027\u5730\u83b7\u5f976-endo\u4f53\u3002\uff08\u56fe1c\uff09[4] \u8fd9\u4e00\u6b21\uff0c\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66Rovis\u6559\u6388\u7b49\u4eba\u62a5\u9053\u4e86\u4f7f\u7528\u94f1\u50ac\u5316\u5242\u7684\u70ef\u70c3\u5206\u5b50\u95f4\/\u5206\u5b50\u5185\u7684\u53cc\u80fa\u5316\u53cd\u5e94\u3002\uff08\u56fe1D\uff09\u503c\u5f97\u6ce8\u610f\u7684\u662f\u4ef2\u80fa\u662f\u53ef\u4ee5\u7528\u4f5c\u5206\u5b50\u95f4\u80fa\u7684\u3001\u5e76\u53ef\u4ee5\u901a\u8fc7\u9009\u62e9\u6eb6\u5242\u548c\u6dfb\u52a0\u5242\u6765\u63a7\u52365-exo\u4f53\uff08\u03b3-\u5185\u9170\u80fa\uff09\u548c6-endo\u4f53\uff08\u03b4-\u5185\u9170\u80fa\uff09\u7684\u9009\u62e9\u6027\u3002 \u00a0\u56fe1. \u70ef\u70c3\u5206\u5b50\u95f4\/\u5206\u5b50\u5185\u7684\u53cc\u80fa\u5316 \u201cRegiodivergent Iridium(III)-Catalyzed Diamination of Alkenyl Amides with Secondary Amines: Complementary Access to \u03b3\u2013 or \u03b4\u2010Lactams\u201d Conway, J. H. Jr.; Rovis, T. J. Am. Chem. Soc. 2018, 140, 135.\u00a0DOI: 10.1021\/jacs.7b11455 \u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd \u7814\u7a76\u8005\uff1aTomislav Rovis (URL: https:\/\/rovisresearch.wordpress.com) \u7814\u7a76\u8005\u7ecf\u5386\uff1a 1990\u5e74 B.S \u52a0\u62ff\u5927\u5b89\u5927\u7565\u7701\u591a\u4f26\u591a\u5927\u5b66S. S. 1998\u5e74 Ph.D \u5b89\u5927\u7565\u7701\u591a\u4f26\u591a\u5927\u5b66\uff08Mark Lautens\u6559\u6388\uff09 1998\u5e74 Postdoc \u54c8\u4f5b\u5927\u5b66\u7855\u58eb\uff08David A. 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A. \u5e95\u7269\u4f7f\u7528\u8303\u56f4\u00a0B. \u53ef\u80fd\u7684\u53cd\u5e94\u673a\u7406 \u53c2\u8003\u6587\u732e De Jong, S.; Nosal, D. G.; Wardrop, D. J. Tetrahedron 2012, 68, 4067. DOI: 1016\/j.tet.2012.03.036 Sibbald, P. A.; Michael, F. E. 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