{"id":19130,"date":"2018-06-14T05:45:07","date_gmt":"2018-06-13T21:45:07","guid":{"rendered":"\/\/www.gsbet888.com\/?p=19130"},"modified":"2019-08-02T18:51:35","modified_gmt":"2019-08-02T10:51:35","slug":"%e5%8f%af%e4%bb%a5%e6%97%a0%e9%99%90%e7%8e%a9%e8%8a%b1%e7%9a%84aldol%e7%bc%a9%e5%90%88%ef%bc%88%e4%b8%80%ef%bc%89%e7%ae%80%e4%bb%8b","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2018\/06\/%e5%8f%af%e4%bb%a5%e6%97%a0%e9%99%90%e7%8e%a9%e8%8a%b1%e7%9a%84aldol%e7%bc%a9%e5%90%88%ef%bc%88%e4%b8%80%ef%bc%89%e7%ae%80%e4%bb%8b.html","title":{"rendered":"\u53ef\u4ee5\u65e0\u9650\u73a9\u82b1\u7684Aldol\u7f29\u5408\uff08\u4e00\uff09\u7b80\u4ecb"},"content":{"rendered":"<p>\u5c0f\u7f16 \u5b59\u82cf\u8d5f<\/p>\n<p>\u7f9f\u919b\u7f29\u5408\uff0c\u53c8\u53eb<a href=\"\/\/www.gsbet888.com\/reactions\/2014\/02\/%e7%bb%8f%e5%85%b8%e7%9a%84%e7%be%9f%e9%86%9b%e5%8f%8d%e5%ba%94classical-aldol-reaction.html\">aldol<\/a>\u53cd\u5e94\uff0c\u5e94\u8be5\u7b97\u662f\u6709\u673a\u5316\u5b66\u4e2d\u5f88\u91cd\u8981\u7684\u4e00\u4e2a\u5f62\u6210C-C\u5355\u952e\u7684\u65b9\u6cd5\uff0c\u5173\u4e8e\u5b83\u7684\u4e00\u4e9b\u57fa\u672c\u5185\u5bb9\u4e4b\u524d\u5728\u6b64\u524dchemstation\u5df2\u7ecf\u6709\u4e86\u4e00\u4e9b\u5f88\u597d\u7684\u4ecb\u7ecd\u3002\u89c1\u00a0<strong>\u78b3\u78b3\u952e\u6784\u7b51\u7684\u738b\u9053\u53cd\u5e94\uff1a\u7f9f\u919b\u7f29\u5408\u53cd\u5e94(Aldol reaction) \u7cfb\u5217<\/strong><\/p>\n<ul>\n<li><a href=\"\/\/www.gsbet888.com\/\u5316\u5b66\u6742\u8bb0\/2015\/10\/post-6728.html\">\u7b2c\u4e00\u5f39 <\/a><\/li>\n<li><a href=\"\/\/www.gsbet888.com\/\u5316\u5b66\u6742\u8bb0\/2015\/10\/post-6781.html\">\u7b2c\u4e8c\u5f39<\/a><\/li>\n<li><a href=\"\/\/www.gsbet888.com\/\u5316\u5b66\u6742\u8bb0\/2015\/10\/post-6854.html\"> 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https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/1-9-300x43.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/1-9-768x110.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/1-9-680x97.png 680w\" sizes=\"(max-width: 980px) 100vw, 980px\" \/><\/a><\/p>\n<h4>1.\u9178\u6216\u78b1\u50ac\u5316\u7684\u4ea4\u53c9aldol\u7f29\u5408<\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2-8.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19132 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2-8.png\" alt=\"\" width=\"1075\" height=\"579\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2-8.png 1075w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2-8-300x162.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2-8-768x414.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2-8-680x366.png 680w\" sizes=\"(max-width: 1075px) 100vw, 1075px\" \/><\/a><\/p>\n<p>\u5173\u4e8ealdol\u4ea4\u53c9\u7f29\u5408\u53cd\u5e94\u7684\u7ecf\u5178\u6761\u4ef6\u4e0e\u5176\u96be\u70b9\uff0c\u8bf7\u53c2\u89c1<strong>\u7f9f\u919b\u7f29\u5408\u53cd\u5e94(Aldol reaction) \u7cfb\u5217\u00a0<a href=\"\/\/www.gsbet888.com\/\u5316\u5b66\u6742\u8bb0\/2015\/10\/post-6728.html\">\u7b2c\u4e00\u5f39<\/a><\/strong><\/p>\n<h4>2.\u624b\u6027\u9009\u62e9\u5bfc\u5411\u7684aldol\u7f29\u5408\u53cd\u5e94<\/h4>\n<p>\u5728<a href=\"\/\/www.gsbet888.com\/reactions\/\u52a0\u6210\u53cd\u5e94\/2014\/05\/\u4ea4\u53c9\u7f9f\u919b\u7f29\u5408\u53cd\u5e94cross-aldol-reaction.html\">\u4ea4\u53c9aldol\u7f29\u5408<\/a>\u4e2d\u4f1a\u4ea7\u751f\u4e24\u79cd\u5177\u6709\u53cd\u5e94\u6d3b\u6027\u7684\u70ef\u9187\u4e2d\u95f4\u4f53\uff0c\u5bf9\u4e8e\u8fd9\u4e24\u79cd\u70ef\u9187\u4e2d\u95f4\u4f53\u7684\u63a7\u5236\u53ef\u4ee5\u76f4\u63a5\u5f71\u54cdaldol\u7684\u53d7\u4f53\u548c\u4f9b\u4f53\uff0c\u8fd9\u5c31\u53eb\u505a\u5bfc\u5411\u7684aldol\u7f29\u5408\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u53cd\u5e94\u7684\u7acb\u4f53\u9009\u62e9\u6027\u4e5f\u662f\u53ef\u63a7\u7684\uff0c\u8fd9\u4f7f\u5f97aldol\u53cd\u5e94\u5728\u6709\u673a\u5408\u6210\u4e2d\u5177\u6709\u66f4\u52a0\u5e7f\u6cdb\u7684\u5e94\u7528\uff0c\u4f8b\u5982\u5728(+)-discodermolide\u7684\u7ed3\u6784\u4e2d\u5c31\u6709\u4e09\u4e2a\u53ef\u4ee5\u8003\u8651\u7528aldol\u53cd\u5e94\u8fdb\u884c\u7684\u7ed3\u6784\u7247\u6bb5\uff1a<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/3-9.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19133 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/3-9.png\" alt=\"\" width=\"625\" height=\"279\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/3-9.png 625w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/3-9-300x134.png 300w\" sizes=\"(max-width: 625px) 100vw, 625px\" \/><\/a><\/p>\n<p><strong>i.\u00a0 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src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/4-7.png\" alt=\"\" width=\"1119\" height=\"190\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/4-7.png 1119w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/4-7-300x51.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/4-7-768x130.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/4-7-680x115.png 680w\" sizes=\"(max-width: 1119px) 100vw, 1119px\" \/><\/a><\/p>\n<p>\u5176\u4e2d\uff0caldol\u4ea7\u7269\u7684<em>syn\/anit<\/em>-\u9009\u62e9\u6027\u662f\u548c\u70ef\u9187\u7684\u6784\u5f62\u5bc6\u5207\u76f8\u5173\u7684\uff0c\u800c\u5728\u52a8\u529b\u5b66\u6761\u4ef6\u4e0b\uff0c\u70ef\u9187\u7684\u6784\u5f62\u548c\u53cd\u5e94\u5e95\u7269\u7684\u7ed3\u6784\u7531\u5f88\u5927\u7684\u5173\u7cfb\uff1a<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/5-6.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19135 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/5-6.png\" alt=\"\" width=\"1118\" height=\"314\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/5-6.png 1118w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/5-6-300x84.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/5-6-768x216.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/5-6-680x191.png 680w\" sizes=\"(max-width: 1118px) 100vw, 1118px\" \/><\/a><\/p>\n<p>\u4e00\u822c\u6765\u8bb2\uff0c\u5728\u70ed\u529b\u5b66\u7684\u6761\u4ef6\u4e0b\uff0c<em>Z<\/em>-\u70ef\u9187\u503e\u5411\u4e8e\u5f97\u5230<em>syn<\/em>-aldol\u4ea7\u7269\uff0c\u800c<em>E<\/em>-\u70ef\u9187\u503e\u5411\u4e8e\u5f97\u5230<em>anti<\/em>-aldol\u4ea7\u7269\u3002<\/p>\n<p>\u6eb6\u5242\u4e5f\u4f1a\u5f71\u54cd\u70ef\u9187\u7684\u6784\u5f62\uff1a<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/6-6.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19136 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/6-6-680x231.png\" alt=\"\" width=\"680\" height=\"231\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/6-6-680x231.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/6-6-300x102.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/6-6-768x261.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/6-6.png 808w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>HMPA\u53ef\u4ee5\u51cf\u5c0fLi<sup>+<\/sup>\u7684\u914d\u4f4d\u4f5c\u7528\u800c\u5f97\u5230<em>Z<\/em>-\u70ef\u9187\uff0c\u800c\u5728THF\u4e2d\u4ed6\u4eec\u7684\u4f5c\u7528\u5374\u5f88\u5f3a\u70c8\uff0c\u503e\u5411\u4e8e\u5f97\u5230<em>E<\/em>-\u70ef\u9187\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u70ef\u9187\u5316\u7684\u8fc7\u7a0b\u662f\u901a\u8fc7\u516d\u5143\u73af\u7684\u8fc7\u6e21\u6001\u8fdb\u884c\u7684\uff0c\u5176\u8be6\u7ec6\u7684\u673a\u7406\u548c\u7acb\u4f53\u9009\u62e9\u6027\u53c2\u89c1<strong>\u7f9f\u919b\u7f29\u5408\u53cd\u5e94(Aldol reaction) \u7cfb\u5217<\/strong><\/p>\n<p><a href=\"\/\/www.gsbet888.com\/\u5316\u5b66\u6742\u8bb0\/2015\/10\/post-6781.html\">\u7b2c\u4e8c\u5f39<\/a><\/p>\n<p>\u8fd9\u91cc\u8865\u5145\u4e00\u4e0b<em>Z<\/em>\/<em>E<\/em>-\u9502\u70ef\u9187\u7684aldol\u7f29\u5408\u7684\u7acb\u4f53\u9009\u62e9\u6027\u7684\u5dee\u5f02\uff1a<\/p>\n<p>(1) <em>E<\/em>-\u9502\u70ef\u9187<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/7-7.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19137 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/7-7-680x450.png\" alt=\"\" width=\"680\" height=\"450\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/7-7-680x450.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/7-7-300x198.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/7-7-768x508.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/7-7.png 898w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p><em>E<\/em>-\u70ef\u9187\u7684\u53cd\u5e94\u901a\u5e38\u4f1a\u7ecf\u8fc7\u4e00\u4e2a\u626d\u8239\u5f62\u7684\u8fc7\u6e21\u6001\uff0c\u8fd9\u6837\u7684\u80fd\u91cf\u8f83\u6905\u5f0f\u8fc7\u6e21\u6001\u66f4\u4f4e\uff0c\u56e0\u6b64<em>E<\/em>-\u70ef\u9187\u53cd\u5e94\u7684\u9009\u62e9\u6027\u4e0d\u5982\u5bf9\u5e94\u7684<em>Z<\/em>-\u70ef\u9187\u5176\uff0c\u4f8b\u5982\uff1a<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/8-5.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19138 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/8-5.png\" alt=\"\" width=\"1021\" height=\"235\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/8-5.png 1021w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/8-5-300x69.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/8-5-768x177.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/8-5-680x157.png 680w\" sizes=\"(max-width: 1021px) 100vw, 1021px\" \/><\/a><\/p>\n<p>(2) <em>Z<\/em>-\u9502\u70ef\u9187\uff1a<em>Z<\/em>-\u70ef\u9187\u5728\u5b9e\u9645\u4e0a\u66f4\u52a0\u5bb9\u6613\u5f97\u5230\uff0c\u53cd\u5e94\u7684\u9009\u62e9\u6027\u4e5f\u66f4\u597d\u4e00\u4e9b(\u503e\u5411\u4e8e\u751f\u6210syn-aldol)<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/9-5.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19139 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/9-5-680x442.png\" alt=\"\" width=\"680\" height=\"442\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/9-5-680x442.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/9-5-300x195.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/9-5-768x500.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/9-5-260x170.png 260w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/9-5.png 904w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p><strong>ii.\u00a0 \u787c\u70ef\u9187\u53cd\u5e94\u7684\u7acb\u4f53\u9009\u62e9\u6027<\/strong><\/p>\n<p><em>a.\u00a0 Z<\/em>-\u787c\u70ef\u9187<\/p>\n<p>\u5728\u70ef\u9187\u5316\u7684\u8fc7\u7a0b\u4e2d\uff0c\u6709\u787c\u7684\u53c2\u4e0e\u66f4\u52a0\u503e\u5411\u4e8e\u751f\u6210Z-\u70ef\u9187\uff0c\u6b64\u5916\uff0c\u56e0\u4e3aB-O\u952e\u8f83Li-O\u952e\u66f4\u52a0\u77ed\uff0c\u4f4d\u963b\u6548\u5e94\u5c31\u88ab\u653e\u5927\u4e86\uff0c\u56e0\u6b64\u4ea7\u7269\u7684syn\/anti\u6bd4\u4f8b\u5c31\u66f4\u5927\u4e86\uff0c\u4e5f\u5c31\u662f\u8bf4\u53cd\u5e94\u7684\u7acb\u4f53\u9009\u62e9\u6027\u6bd4\u9502\u70ef\u9187\u66f4\u597d\uff0c\u4f8b\u5982\uff1a<\/p>\n<p>\u53cd\u5e94\u673a\u7406\u548c\u8fc7\u6e21\u6001\uff1a<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/00.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19141 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/00.png\" alt=\"\" width=\"1140\" height=\"411\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/00.png 1140w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/00-300x108.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/00-768x277.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/00-680x245.png 680w\" sizes=\"(max-width: 1140px) 100vw, 1140px\" \/><\/a><\/p>\n<p>\u4e00\u822c\u6765\u8bf4\uff0c\u867d\u7136\u70ef\u9187\u7684\u6784\u5f62\u662f\u57fa\u672c\u786e\u5b9a\u7684\uff0c\u4f46\u662f\u53cd\u5e94\u8fc7\u7a0b\u8fd8\u6709\u4ee5\u4e0b\u4e09\u4e2a\u56e0\u7d20\u9700\u8981\u8003\u8651\uff1a<\/p>\n<ul>\n<li>1.\u4f4d\u963b\u6548\u5e94\uff0c\u8b6c\u5982\u70ef\u4e19\u57fa\u4f53\u7cfb\u4e2d\u7684\u91cd\u53e0\u6548\u5e94<\/li>\n<li>2.\u7535\u5b50\u6548\u5e94\uff0c\u4f8b\u5982\u5076\u6781\u5f31\u5316\u7b49<\/li>\n<li>3.\u7acb\u4f53\u7535\u5b50\u6548\u5e94\uff0c\u8d85\u5171\u8f6d\u6548\u5e94\u7b49<\/li>\n<\/ul>\n<p>\u53cd\u5e94\u7684\u5b9e\u4f8b<sup>[1]<\/sup>\uff1a<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/13-2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19143 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/13-2.png\" alt=\"\" width=\"1129\" height=\"192\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/13-2.png 1129w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/13-2-300x51.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/13-2-768x131.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/13-2-680x116.png 680w\" sizes=\"(max-width: 1129px) 100vw, 1129px\" \/><\/a><\/p>\n<p><em>a.\u00a0 E<\/em>-\u787c\u70ef\u9187<\/p>\n<p>\u5728\u8fd9\u4e9b\u5b9e\u4f8b\u4e2d\uff0cZimmerman-Traxler\u63d0\u51fa\u7684\u6a21\u578b\u53ef\u4ee5\u89e3\u91ca\u53cd\u5e94\u7684\u7acb\u4f53\u82b1\u96ea\uff0c\u53cd\u5e94\u4e2d\u6700\u91cd\u8981\u7684\u662f\u7532\u57fa\uff0c\u540c\u65f6\u4e5f\u548c\u53c2\u4e0e\u53cd\u5e94\u7684\u91d1\u5c5e\u79bb\u5b50\u6709\u5173\u3002[2]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/14-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19144 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/14-1-680x408.png\" alt=\"\" width=\"680\" height=\"408\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/14-1-680x408.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/14-1-300x180.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/14-1.png 751w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>\u70ef\u9187\u5316\u8fc7\u7a0b\u4e2d\u4f7f\u7528\u7684\u662fBu<sub>2<\/sub>OTf\/DIEPA\uff0c\u90a3\u4e48\u751f\u6210\u7684\u70ef\u9187\u7684\u6784\u5f62\u662f\u76f8\u53cd\u7684\u3002\u4f46\u662f\u8fd9\u4e2a\u53cd\u5e94\u7684\u540e\u534a\u90e8\u5206\u7684\u7ed3\u679c\u4e5f\u662f\u6709\u4e9b\u51fa\u4e4e\u610f\u6599\u7684\uff0c\u4f46\u662f\u5229\u7528Houk\u7684\u6a21\u578b\u6765\u89e3\u91ca\u53cd\u5e94\u7684\u9762\u9009\u62e9\u6027\u662f\u5f88\u597d\u7684\uff1a<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/15-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19145 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/15-1.png\" alt=\"\" width=\"263\" height=\"205\" \/><\/a><\/p>\n<p>\u901a\u8fc7\u8ba1\u7b97\u4e4b\u540e\u7684\u7ed3\u8bba\u662f\u66f4\u52a0\u53ef\u9760\u7684\u60c5\u5f62\u662f\u53cd\u5e94\u7ecf\u8fc7\u8239\u5f62\u8fc7\u6e21\u6001\uff0c\u5982\u679cBu<sub>2<\/sub>BOTf\u4f5c\u4e3a\u787c\u8bd5\u5242\uff0c\u90a3\u4e48\u53ef\u4ee5\u6709\u5229\u7684\u652f\u6301\u8fd9\u4e2a\u89c2\u70b9\uff1a<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/16-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19146 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/16-1.png\" alt=\"\" width=\"680\" height=\"202\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/16-1.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/16-1-300x89.png 300w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ol>\n<li><em>Angew. Chem. Int. Engl. Ed.<\/em>, <strong>1980<\/strong>, 19, 557, DOI; 10.1002\/anie.198005571<\/li>\n<li><em>J. Am. Chem. Soc.<\/em>,\u00a0<strong>1990<\/strong>,\u00a0<em>112<\/em>(2), pp 866\u2013868, DOI:\u00a010.1021\/ja00158a056<\/li>\n<\/ol>\n<p><strong>\u00a0<\/strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u5c0f\u7f16 \u5b59\u82cf\u8d5f \u7f9f\u919b\u7f29\u5408\uff0c\u53c8\u53ebaldol\u53cd\u5e94\uff0c\u5e94\u8be5\u7b97\u662f\u6709\u673a\u5316\u5b66\u4e2d\u5f88\u91cd\u8981\u7684\u4e00\u4e2a\u5f62\u6210C-C\u5355\u952e\u7684\u65b9\u6cd5\uff0c\u5173\u4e8e\u5b83\u7684\u4e00\u4e9b\u57fa\u672c\u5185\u5bb9\u4e4b\u524d\u5728\u6b64\u524dchemstation\u5df2\u7ecf\u6709\u4e86\u4e00\u4e9b\u5f88\u597d\u7684\u4ecb\u7ecd\u3002\u89c1\u00a0\u78b3\u78b3\u952e\u6784\u7b51\u7684\u738b\u9053\u53cd\u5e94\uff1a\u7f9f\u919b\u7f29\u5408\u53cd\u5e94(Aldol reaction) \u7cfb\u5217 \u7b2c\u4e00\u5f39 \u7b2c\u4e8c\u5f39 \u7b2c\u4e09\u5f39 \u7b2c\u56db\u5f39 \u4eca\u5929\u5728\u8fd9\u91cc\u7ed9\u5927\u5bb6\u4ecb\u7ecd\u4e00\u4e9b\u4e4b\u524d\u6ca1\u6709\u63d0\u5230\u7684\u4e00\u4e9b\u5df2\u6709\u5185\u5bb9\u7684\u6269\u5145\u3002\u672c\u6587\u662f\u8fd9\u4e2a\u7cfb\u5217\u7684\u7b2c\u4e00\u90e8\u5206\uff0c\u4e3a\u5927\u5bb6\u7b80\u8981\u4ecb\u7ecd\u9502\u70ef\u9187\u548c\u4e24\u79cd\u787c\u70ef\u9187\u5728Aldol\u53cd\u5e94\u4e2d\u7684\u7acb\u4f53\u9009\u62e9\u6027\u3002 1.\u9178\u6216\u78b1\u50ac\u5316\u7684\u4ea4\u53c9aldol\u7f29\u5408 \u5173\u4e8ealdol\u4ea4\u53c9\u7f29\u5408\u53cd\u5e94\u7684\u7ecf\u5178\u6761\u4ef6\u4e0e\u5176\u96be\u70b9\uff0c\u8bf7\u53c2\u89c1\u7f9f\u919b\u7f29\u5408\u53cd\u5e94(Aldol reaction) \u7cfb\u5217\u00a0\u7b2c\u4e00\u5f39 2.\u624b\u6027\u9009\u62e9\u5bfc\u5411\u7684aldol\u7f29\u5408\u53cd\u5e94 \u5728\u4ea4\u53c9aldol\u7f29\u5408\u4e2d\u4f1a\u4ea7\u751f\u4e24\u79cd\u5177\u6709\u53cd\u5e94\u6d3b\u6027\u7684\u70ef\u9187\u4e2d\u95f4\u4f53\uff0c\u5bf9\u4e8e\u8fd9\u4e24\u79cd\u70ef\u9187\u4e2d\u95f4\u4f53\u7684\u63a7\u5236\u53ef\u4ee5\u76f4\u63a5\u5f71\u54cdaldol\u7684\u53d7\u4f53\u548c\u4f9b\u4f53\uff0c\u8fd9\u5c31\u53eb\u505a\u5bfc\u5411\u7684aldol\u7f29\u5408\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u53cd\u5e94\u7684\u7acb\u4f53\u9009\u62e9\u6027\u4e5f\u662f\u53ef\u63a7\u7684\uff0c\u8fd9\u4f7f\u5f97aldol\u53cd\u5e94\u5728\u6709\u673a\u5408\u6210\u4e2d\u5177\u6709\u66f4\u52a0\u5e7f\u6cdb\u7684\u5e94\u7528\uff0c\u4f8b\u5982\u5728(+)-discodermolide\u7684\u7ed3\u6784\u4e2d\u5c31\u6709\u4e09\u4e2a\u53ef\u4ee5\u8003\u8651\u7528aldol\u53cd\u5e94\u8fdb\u884c\u7684\u7ed3\u6784\u7247\u6bb5\uff1a i.\u00a0 \u5229\u7528\u9502\u70ef\u9187\u8fdb\u884c\u53cd\u5e94\u9009\u62e9\u6027 \u5728\u4f4e\u6e29\uff0c\u7fb0\u57fa\u5316\u5408\u7269\u503e\u5411\u4e8e\u548c\u78b1\u751f\u6210\u52a8\u529b\u5b66\u63a7\u5236\u7684\u70ef\u9187\u4ea7\u7269\uff0c\u8fd9\u65f6\u5019\u53e6\u5916\u4e00\u4e2a\u7fb0\u57fa\u5316\u5408\u7269\u518d\u52a0\u5165\u5230\u53cd\u5e94\u4f53\u7cfb\u4e2d\uff0c\u518d\u5c06\u6e29\u5ea6\u9010\u6e10\u5347\u9ad8\uff0c\u5c31\u53ef\u4ee5\u5f97\u5230aldol\u7f29\u5408\u4ea7\u7269\u3002\u901a\u5e38\u6765\u8bf4\uff0c\u70ef\u9187\u5316\u7684\u8fc7\u7a0b\u662f\u8981\u6bd4\u4eb2\u6838\u52a0\u6210\u8981\u5feb\u7684\uff0c\u56e0\u6b64\u53ef\u4ee5\u63a7\u5236\u53cd\u5e94\u7684\u7acb\u4f53\u9009\u62e9\u6027\u3002 \u4e00\u822c\u7684\u7b56\u7565\u662f\uff1a \u5176\u4e2d\uff0caldol\u4ea7\u7269\u7684syn\/anit-\u9009\u62e9\u6027\u662f\u548c\u70ef\u9187\u7684\u6784\u5f62\u5bc6\u5207\u76f8\u5173\u7684\uff0c\u800c\u5728\u52a8\u529b\u5b66\u6761\u4ef6\u4e0b\uff0c\u70ef\u9187\u7684\u6784\u5f62\u548c\u53cd\u5e94\u5e95\u7269\u7684\u7ed3\u6784\u7531\u5f88\u5927\u7684\u5173\u7cfb\uff1a \u4e00\u822c\u6765\u8bb2\uff0c\u5728\u70ed\u529b\u5b66\u7684\u6761\u4ef6\u4e0b\uff0cZ-\u70ef\u9187\u503e\u5411\u4e8e\u5f97\u5230syn-aldol\u4ea7\u7269\uff0c\u800cE-\u70ef\u9187\u503e\u5411\u4e8e\u5f97\u5230anti-aldol\u4ea7\u7269\u3002 \u6eb6\u5242\u4e5f\u4f1a\u5f71\u54cd\u70ef\u9187\u7684\u6784\u5f62\uff1a HMPA\u53ef\u4ee5\u51cf\u5c0fLi+\u7684\u914d\u4f4d\u4f5c\u7528\u800c\u5f97\u5230Z-\u70ef\u9187\uff0c\u800c\u5728THF\u4e2d\u4ed6\u4eec\u7684\u4f5c\u7528\u5374\u5f88\u5f3a\u70c8\uff0c\u503e\u5411\u4e8e\u5f97\u5230E-\u70ef\u9187\u3002 \u6b64\u5916\uff0c\u70ef\u9187\u5316\u7684\u8fc7\u7a0b\u662f\u901a\u8fc7\u516d\u5143\u73af\u7684\u8fc7\u6e21\u6001\u8fdb\u884c\u7684\uff0c\u5176\u8be6\u7ec6\u7684\u673a\u7406\u548c\u7acb\u4f53\u9009\u62e9\u6027\u53c2\u89c1\u7f9f\u919b\u7f29\u5408\u53cd\u5e94(Aldol reaction) \u7cfb\u5217 \u7b2c\u4e8c\u5f39 \u8fd9\u91cc\u8865\u5145\u4e00\u4e0bZ\/E-\u9502\u70ef\u9187\u7684aldol\u7f29\u5408\u7684\u7acb\u4f53\u9009\u62e9\u6027\u7684\u5dee\u5f02\uff1a (1) 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Chem. Int. Engl. Ed., 1980, 19, 557, DOI; 10.1002\/anie.198005571 J. Am. Chem. 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