{"id":19172,"date":"2018-06-29T06:04:31","date_gmt":"2018-06-28T22:04:31","guid":{"rendered":"\/\/www.gsbet888.com\/?p=19172"},"modified":"2019-08-02T18:51:35","modified_gmt":"2019-08-02T10:51:35","slug":"%e5%8f%af%e4%bb%a5%e6%97%a0%e9%99%90%e7%8e%a9%e8%8a%b1%e7%9a%84aldol%e7%bc%a9%e5%90%88-%e7%ac%ac%e4%b8%89%e9%83%a8%e5%88%86%ef%bc%9a%e4%b8%8d%e5%af%b9%e7%a7%b0%e7%9a%84%e9%85%b0%e8%83%ba%e5%92%8c","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2018\/06\/%e5%8f%af%e4%bb%a5%e6%97%a0%e9%99%90%e7%8e%a9%e8%8a%b1%e7%9a%84aldol%e7%bc%a9%e5%90%88-%e7%ac%ac%e4%b8%89%e9%83%a8%e5%88%86%ef%bc%9a%e4%b8%8d%e5%af%b9%e7%a7%b0%e7%9a%84%e9%85%b0%e8%83%ba%e5%92%8c.html","title":{"rendered":"\u53ef\u4ee5\u65e0\u9650\u73a9\u82b1\u7684Aldol\u7f29\u5408 \u7b2c\u4e09\u90e8\u5206\uff1a\u4e0d\u5bf9\u79f0\u7684\u9170\u80fa\u548c\u916f\u7684\u53cd\u5e94\uff081\uff09"},"content":{"rendered":"

\u672c\u6587\u63a5\u4e0a\u671f\u00a0\u53ef\u4ee5\u65e0\u9650\u73a9\u82b1\u7684Aldol\u7f29\u5408 \u7b2c\u4e8c\u90e8\u5206<\/a><\/p>\n

 <\/p>\n

    \n
  1. Evans\u5f00\u53d1\u7684\u624b\u6027\u52a9\u5242\u7684\u4f7f\u7528\u53c2\u89c1\uff1a<\/li>\n<\/ol>\n

    \u78b3\u78b3\u952e\u6784\u7b51\u7684\u738b\u9053\u53cd\u5e94\uff1a\u7f9f\u919b\u7f29\u5408\u53cd\u5e94(Aldol reaction)\u7b2c\u4e09\u5f39 <\/a><\/p>\n

      \n
    1. Masamune\u5f00\u53d1\u7684\u4e0d\u5bf9\u79f0aldol ref. 1, 2\"\"<\/a><\/li>\n
    2. Crimmins\u5f00\u53d1\u7684\u5641\u5511\u70f7\u786b\u916e\u624b\u6027\u52a9\u5242<\/li>\n<\/ol>\n

      Crimmins\u53d1\u73b0\u4e86\u53ef\u4ee5\u5f97\u5230Evans-syn<\/em>-aldol\u4ea7\u7269\u548c\u975eEvans-syn<\/em>-aldol\u4ea7\u7269\u7684\u53cd\u5e94\u6761\u4ef6\uff0c\u53cd\u5e94\u4e2d\u9700\u8981\u7528\u5230\u949b\u4f5c\u4e3a\u914d\u5408\u8bd5\u5242\uff0c\u8fd9\u4e2a\u65b9\u6cd5\u7684\u53d1\u660e\u5927\u5927\u589e\u52a0\u4e86\u949b\u70ef\u9187\u5728aldol\u53cd\u5e94\u4e2d\u7684\u4f7f\u7528\u8303\u56f4\u3002Ref. 3<\/p>\n

      \uff081\uff09\u4f7f\u75281 equiv.\u949b\u8bd5\u5242<\/p>\n

      \"\"<\/a><\/p>\n

      \uff082\uff09\u4f7f\u75282 equiv.\u949b\u8bd5\u5242<\/p>\n

      \"\"<\/a><\/p>\n

      \u8fd9\u91cc\u662f\u4e00\u4e2a\u03b1-\u70f7\u6c27\u57fa\u7fb0\u57fa\u5316\u5408\u7269\u7684\u4f8b\u5b50\uff1aref. 4<\/p>\n

      \"\"<\/a><\/p>\n

      \u8fd8\u6709\u4e00\u4e9b\u7528\u4e8e\u4e0d\u5bf9\u79f0\u9170\u80fa\u548c\u916faldol\u7684\u624b\u6027\u52a9\u5242<\/p>\n

      1).ref. 5<\/p>\n

      \"\"<\/a><\/p>\n

      2).ref. 6<\/p>\n

      \"\"<\/a><\/p>\n

      \u5176\u4ed6\u4e00\u4e9b\u4f8b\u5b50\uff1a<\/p>\n

      1) ref. 7, 8<\/p>\n

      \"\"<\/a><\/p>\n

      2) ref 9<\/p>\n

      \"\"<\/a><\/p>\n

      3) ref 10<\/p>\n

      \"\"<\/a><\/p>\n

      4) ref 11, 12<\/p>\n

      \"\"<\/a><\/p>\n

      5) ref 13<\/p>\n

      \"\"<\/a><\/p>\n

      6) ref 14<\/p>\n

      \"\"<\/a><\/p>\n

      7) ref 15<\/p>\n

      \"\"<\/a><\/p>\n

        \n
      1. \u70ef\u9187\u7845\u919a\u7684aldol\u53cd\u5e94\uff08Mukaiyama aldol\u7f29\u5408\uff09<\/li>\n<\/ol>\n

        \u5173\u4e8eMukaiyama aldol\u7f29\u5408\u53cd\u5e94\u7684\u57fa\u672c\u5185\u5bb9\uff0c\u5728\u8fd9\u91cc\u6709\u4e00\u4e9b\u76f8\u5173\u7684\u4ecb\u7ecd\uff1a<\/p>\n

        \/\/www.gsbet888.com\/%E5%8C%96%E5%AD%A6%E6%9D%82%E8%AE%B0\/2015\/10\/post-6781.html<\/a>\uff0c\u8fd9\u91cc\u8865\u5145\u7684\u662f\u51e0\u7c7b\u624b\u6027\u50ac\u5316\u5242\u7684\u5f00\u53d1\u548c\u4f7f\u7528\u3002<\/p>\n

          \n
        1. Oppolzer\u7684\u78fa\u5185\u9170\u80fa\u624b\u6027\u52a9\u5242 ref 16\"\"<\/a><\/li>\n
        2. Kobayashi aldol\u7f29\u5408ref 17\"\"<\/a><\/li>\n
        3. Yamamoto\u624b\u6027\u9170\u6c27\u57fa\u787c\u70f7ref 18\"\"<\/a><\/li>\n<\/ol>\n

          \u53c2\u8003\u6587\u732e<\/strong><\/h4>\n
            \n
          1. J. Am. Chem. Soc.<\/em>,\u00a01997<\/strong>,\u00a0119<\/em>(33), pp 7883\u20137884, DOI:\u00a0<\/strong>10.1021\/ja9716721<\/li>\n
          2. Org. Lett.<\/em>,\u00a02002<\/strong>,\u00a04<\/em>(14), pp 2397\u20132400, DOI:\u00a0<\/strong>10.1021\/ol026139r<\/li>\n
          3. J. Am. Chem. Soc.<\/em>,\u00a01997<\/strong>,\u00a0119<\/em>(33), pp 7883\u20137884, DOI:\u00a0<\/strong>10.1021\/ja9716721<\/li>\n
          4. J. Am. Chem. Soc.<\/em>,\u00a02000<\/strong>,\u00a0122<\/em>(23), pp 5473\u20135476, DOI:\u00a0<\/strong>10.1021\/ja0007197<\/li>\n
          5. J. Org. Chem.<\/em>,\u00a01989<\/strong>,\u00a054<\/em>(12), pp 2817\u20132825, DOI:\u00a0<\/strong>10.1021\/jo00273a009<\/li>\n
          6. Tetrahedron Lett.,<\/em> 1993, 1737, DOI:1016\/S0040-4039(00)60765-7<\/a><\/li>\n
          7. J. Am. Chem. Soc.<\/em>,\u00a02001<\/strong>,\u00a0123<\/em>(39), pp 9535\u20139544, DOI:\u00a0<\/strong>10.1021\/ja011211m<\/li>\n
          8. J. Am. Chem. Soc.<\/em>,\u00a01994<\/strong>,\u00a0116<\/em>(25), pp 11287\u201311314, DOI:\u00a0<\/strong>10.1021\/ja00104a010<\/li>\n
          9. Org. Lett.<\/em>,\u00a02002<\/strong>,\u00a04<\/em>(14), pp 2397\u20132400, DOI:\u00a0<\/strong>10.1021\/ol026139r<\/li>\n
          10. J. Am. Chem. Soc.<\/em>,\u00a01982<\/strong>,\u00a0104<\/em>(20), pp 5526\u20135528, DOI:\u00a0<\/strong>10.1021\/ja00384a062<\/li>\n
          11. J. Am. Chem. Soc.<\/em>,\u00a02001<\/strong>,\u00a0123<\/em>(23), pp 5407\u20135413, DOI:\u00a0<\/strong>10.1021\/ja010454b<\/li>\n
          12. Tetrahedron Lett.,<\/em>1996, 9179, DOI:\u00a0<\/strong>1016\/S0040-4039(96)02156-9<\/a><\/li>\n
          13. J. Org. Chem.<\/em>,\u00a02001<\/strong>,\u00a066<\/em>(15), pp 5217\u20135231, DOI:\u00a0<\/strong>10.1021\/jo0104429<\/li>\n
          14. Org. Lett.<\/em>,\u00a02001<\/strong>,\u00a03<\/em>(6), pp 901\u2013904, DOI:\u00a0<\/strong>10.1021\/ol015542f<\/li>\n
          15. J. Am. Chem. Soc.<\/em>,\u00a02001<\/strong>,\u00a0123<\/em>(19), pp 4605\u20134606, DOI:\u00a0<\/strong>10.1021\/ja003507i<\/li>\n
          16. Tetrahedron Lett.<\/em>, 1991, 61,DOI:\u00a0<\/strong>1016\/S0040-4039(00)71218-4<\/a><\/li>\n
          17. Org. Lett.<\/em>,\u00a02012<\/strong>,\u00a014<\/em>(20), pp 5298\u20135301, DOI:\u00a0<\/strong>10.1021\/ol3024677<\/li>\n
          18. J. Am. Chem. Soc.<\/em>,\u00a01991<\/strong>,\u00a0113<\/em>(3), pp 1041\u20131042, DOI:\u00a0<\/strong>10.1021\/ja00003a047<\/li>\n<\/ol>\n

            \u00a0<\/strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6587\u63a5\u4e0a\u671f\u00a0\u53ef\u4ee5\u65e0\u9650\u73a9\u82b1\u7684Aldol\u7f29\u5408 \u7b2c\u4e8c\u90e8\u5206   Evans\u5f00\u53d1\u7684\u624b\u6027\u52a9\u5242\u7684\u4f7f\u7528\u53c2\u89c1\uff1a \u78b3\u78b3\u952e\u6784\u7b51\u7684\u738b\u9053\u53cd\u5e94\uff1a\u7f9f\u919b\u7f29\u5408\u53cd\u5e94(Aldol reaction)\u7b2c\u4e09\u5f39 Masamune\u5f00\u53d1\u7684\u4e0d\u5bf9\u79f0aldol ref. 1, 2 Crimmins\u5f00\u53d1\u7684\u5641\u5511\u70f7\u786b\u916e\u624b\u6027\u52a9\u5242 Crimmins\u53d1\u73b0\u4e86\u53ef\u4ee5\u5f97\u5230Evans-syn-aldol\u4ea7\u7269\u548c\u975eEvans-syn-aldol\u4ea7\u7269\u7684\u53cd\u5e94\u6761\u4ef6\uff0c\u53cd\u5e94\u4e2d\u9700\u8981\u7528\u5230\u949b\u4f5c\u4e3a\u914d\u5408\u8bd5\u5242\uff0c\u8fd9\u4e2a\u65b9\u6cd5\u7684\u53d1\u660e\u5927\u5927\u589e\u52a0\u4e86\u949b\u70ef\u9187\u5728aldol\u53cd\u5e94\u4e2d\u7684\u4f7f\u7528\u8303\u56f4\u3002Ref. 3 \uff081\uff09\u4f7f\u75281 equiv.\u949b\u8bd5\u5242 \uff082\uff09\u4f7f\u75282 equiv.\u949b\u8bd5\u5242 \u8fd9\u91cc\u662f\u4e00\u4e2a\u03b1-\u70f7\u6c27\u57fa\u7fb0\u57fa\u5316\u5408\u7269\u7684\u4f8b\u5b50\uff1aref. 4 \u8fd8\u6709\u4e00\u4e9b\u7528\u4e8e\u4e0d\u5bf9\u79f0\u9170\u80fa\u548c\u916faldol\u7684\u624b\u6027\u52a9\u5242 1).ref. 5 2).ref. 6 \u5176\u4ed6\u4e00\u4e9b\u4f8b\u5b50\uff1a 1) ref. 7, 8 2) ref 9 3) ref 10 4) ref 11, 12 5) ref 13 6) ref 14 7) ref 15 \u70ef\u9187\u7845\u919a\u7684aldol\u53cd\u5e94\uff08Mukaiyama aldol\u7f29\u5408\uff09 \u5173\u4e8eMukaiyama aldol\u7f29\u5408\u53cd\u5e94\u7684\u57fa\u672c\u5185\u5bb9\uff0c\u5728\u8fd9\u91cc\u6709\u4e00\u4e9b\u76f8\u5173\u7684\u4ecb\u7ecd\uff1a \/\/www.gsbet888.com\/%E5%8C%96%E5%AD%A6%E6%9D%82%E8%AE%B0\/2015\/10\/post-6781.html\uff0c\u8fd9\u91cc\u8865\u5145\u7684\u662f\u51e0\u7c7b\u624b\u6027\u50ac\u5316\u5242\u7684\u5f00\u53d1\u548c\u4f7f\u7528\u3002 Oppolzer\u7684\u78fa\u5185\u9170\u80fa\u624b\u6027\u52a9\u5242 ref 16 Kobayashi aldol\u7f29\u5408ref 17 Yamamoto\u624b\u6027\u9170\u6c27\u57fa\u787c\u70f7ref 18 \u53c2\u8003\u6587\u732e J. Am. Chem. Soc.,\u00a01997,\u00a0119(33), pp 7883\u20137884, DOI:\u00a010.1021\/ja9716721 Org. Lett.,\u00a02002,\u00a04(14), pp 2397\u20132400, DOI:\u00a010.1021\/ol026139r J. Am. Chem. Soc.,\u00a01997,\u00a0119(33), pp 7883\u20137884, DOI:\u00a010.1021\/ja9716721 J. Am. Chem. Soc.,\u00a02000,\u00a0122(23), pp 5473\u20135476, DOI:\u00a010.1021\/ja0007197 J. Org. Chem.,\u00a01989,\u00a054(12), pp 2817\u20132825, DOI:\u00a010.1021\/jo00273a009 Tetrahedron Lett., 1993, 1737, DOI:1016\/S0040-4039(00)60765-7 J. Am. Chem. Soc.,\u00a02001,\u00a0123(39), pp 9535\u20139544, DOI:\u00a010.1021\/ja011211m J. Am. Chem. Soc.,\u00a01994,\u00a0116(25), […]","protected":false},"author":8,"featured_media":19148,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[414,1271],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/0cover.gif","jetpack_shortlink":"https:\/\/wp.me\/p96op1-4Ze","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/19172"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=19172"}],"version-history":[{"count":7,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/19172\/revisions"}],"predecessor-version":[{"id":27084,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/19172\/revisions\/27084"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/19148"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=19172"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=19172"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=19172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}