{"id":19247,"date":"2018-08-04T11:33:45","date_gmt":"2018-08-04T03:33:45","guid":{"rendered":"\/\/www.gsbet888.com\/?p=19247"},"modified":"2019-08-02T18:51:33","modified_gmt":"2019-08-02T10:51:33","slug":"paterson-%e7%a1%bc%e7%be%9f%e9%86%9b%e7%bc%a9%e5%90%88%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/%e7%bc%a9%e5%90%88%e5%8f%8d%e5%ba%94\/2018\/08\/paterson-%e7%a1%bc%e7%be%9f%e9%86%9b%e7%bc%a9%e5%90%88%e5%8f%8d%e5%ba%94.html","title":{"rendered":"Paterson \u787c\u7f9f\u919b\u7f29\u5408\u53cd\u5e94"},"content":{"rendered":"<h4><strong>\u6982\u8981<\/strong><\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/1-15.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19248 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/1-15.png\" alt=\"\" width=\"1120\" height=\"467\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/1-15.png 1120w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/1-15-300x125.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/1-15-768x320.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/1-15-680x284.png 680w\" sizes=\"(max-width: 1120px) 100vw, 1120px\" \/><\/a><\/p>\n<p>Paterson \u787c\u7f9f\u919b\u7f29\u5408\u53cd\u5e94(Paterson boron adol condensation)\u662f\u5728(+)-(lpc)<sub>2<\/sub>BOTf\u6216(-)-(lpc)<sub>2<\/sub>BOTf(Brown Ipc\u787c\u70f7)\u4e0eH\u00fcnig\u78b1\u4f5c\u7528\u4e0b\uff0c\u916e\u7c7b\u5316\u5408\u7269\u4e0e\u5404\u7c7b\u8102\u80aa\u919b\u53ca\u82b3\u9999\u919b\u4e4b\u95f4\u8fdb\u884c\u7684\u5bf9\u6620\u7acb\u4f53\u9009\u62e9\u6027\u4e0esyn-\u7acb\u4f53\u9009\u62e9\u6027\u7f9f\u919b\u7f29\u5408\u53cd\u5e94\u3002\u8be5\u53cd\u5e94\u57281986\u5e74\u7531\u82f1\u56fdCambridge\u5927\u5b66\u5316\u5b66\u5b9e\u9a8c\u5ba4(Universiry Chemical Laboratory,Cambridge)\u7684I. Paterson\u7814\u7a76\u7ec4\u9996\u6b21\u62a5\u9053<sup>[1]<\/sup>\u3002\u968f\u540e\uff0c\u8be5\u7814\u7a76\u7ec4\u5c06\u5e95\u7269\u8303\u56f4\u7531\u6700\u521d\u7684\u4e8c\u4e59\u57fa\u916e<sup>[1]<\/sup>\u6269\u5c55\u81f3\u624b\u6027\u4e59\u57fa\u916e<sup>[2]-[3]<\/sup>\uff0c\u5e76\u6210\u529f\u5e94\u7528\u4e8emacrolide\u7684\u5408\u6210<sup>[2]<\/sup>\u30021989\u5e74-1990\u5e74\uff0cI. Paterson\u53c8\u5c06\u5e95\u7269\u8303\u56f4\u8fdb\u4e00\u6b65\u6269\u5c55\u81f3\u7532\u57fa\u916e\u53ca\u624b\u6027\u7532\u57fa\u916e<sup>[4]-[6]<\/sup>\u3002\u540c\u65f6\uff0c\u7814\u7a76\u53d1\u73b0\u91c7\u7528(-)-(Ipc)<sub>2<\/sub>BCl\uff0c\u53ef\u4ee5\u5b9e\u73b0anti-\u9009\u62e9\u6027\u7f9f\u919b\u7f29\u5408\u53cd\u5e94<sup>[7]<\/sup>\u3002\u76ee\u524d\uff0c\u8be5\u53cd\u5e94\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5404\u7c7b\u751f\u7406\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u6784\u5efa\u65f6\u7684\u5173\u952e\u6b65\u9aa4<sup>[8]-[11]<\/sup>\u3002<\/p>\n<h4><strong>\u57fa\u672c\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] I. Paterson, M.A. Lister, C. K McClure, Tetrahedron Lett. 1986, 27, 4787.doi: <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0040403900850650\">10.1016\/S0040-4039(00)85065-0.<\/a><\/li>\n<li>[2] I.Paterson, C. K. McClure, Tetrahedron Lett. 1987, 28, 1229.doi:<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0040403900953334\">10.1016\/S0040-4039(00)95333-4.<\/a><\/li>\n<li>[3] I.Paterson, M. A.Lister, Tetrahedron Lett. 1988, 29, 585.doi:<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0040403900801574\">10.1016\/S0040-4039(00)80157-4.<\/a><\/li>\n<li>[4] I. Paterson,Goodman, J. M. Tetrahedron Lett. 1989, 30, 997.doi:<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0040403900953000\">10.1016\/S0040-4039(00)95300-0.<\/a><\/li>\n<li>[5] I.Paterson, Goodman, J. M.Isaka, M. Tetrahedron Lett. 1989, 30, 7121.doi:<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0040403901934409\">10.1016\/S0040-4039(01)93440-9.<\/a><\/li>\n<li>[6] I. Paterson, J. M. Goodman, M. A. Lister, R. C. Schumann, C. K. McClure, R. D. Norcross, Tetrahedron1990, 46, 4663.doi:<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0040402001855885\">10.1016\/S0040-4020(01)85588-5.<\/a><\/li>\n<li>[7] I. Paterson,Pure Appl. Chem. 1992, 64,1821.doi:<a href=\"https:\/\/www.iupac.org\/publications\/pac\/64\/12\/1821\/index.html\">10.1351\/pac199264121821.<\/a><\/li>\n<li>[8] C. J.Cowden,I. Paterson,Org. React. 1997, 51, 1.doi:<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/0471264180.or051.01\/abstract\">10.1002\/0471264180.or051.01<\/a>.<\/li>\n<li>[9] I.Paterson, S. A.Osborne,\u00a0Tetrahedron Lett.\u00a01990,\u00a031, 2213.doi:<a href=\"https:\/\/doi.org\/10.1016\/0040-4039(90)80112-Y\">10.1016\/0040-4039(90)80112-Y<\/a>.<\/li>\n<li>[10]\u00a0<a href=\"http:\/\/pubs.acs.org\/author\/Mickel%2C+Stuart+J\">S. J. Mickel<\/a>,<a href=\"http:\/\/pubs.acs.org\/author\/Daeffler%2C+Robert\">R. Daeffler<\/a>, <a href=\"http:\/\/pubs.acs.org\/author\/Prikoszovich%2C+Walter\">W. Prikoszovich<\/a>, Org. Process Res. Dev.,\u00a02005,\u00a09, 113.doi:<a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/op049800a\">10.1021\/op049800a.<\/a><\/li>\n<li>[11] I.Paterson, C. K.McClure, R. C.Schumann,\u00a0Tetrahedron Lett.\u00a01989,\u00a030, 1293.doi:<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0040403900727407\">10.1016\/S0040-4039(00)72740-7.<\/a><\/li>\n<\/ul>\n<h4><strong>\u53cd\u5e94\u673a\u7406<\/strong><\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2-14.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-19249 size-full aligncenter\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2-14.png\" alt=\"\" width=\"574\" height=\"276\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2-14.png 574w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/2-14-300x144.png 300w\" sizes=\"(max-width: 574px) 100vw, 574px\" \/><\/a> <a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/3-15.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19250 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/3-15.png\" alt=\"\" width=\"596\" height=\"249\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/3-15.png 596w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/3-15-300x125.png 300w\" sizes=\"(max-width: 596px) 100vw, 596px\" \/><\/a> <a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/4-13.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19251 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/4-13.png\" alt=\"\" width=\"569\" height=\"216\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/4-13.png 569w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/4-13-300x114.png 300w\" sizes=\"(max-width: 569px) 100vw, 569px\" \/><\/a><\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1] J. M.Goodman, I.Paterson, S. D.Kahn, Tetrahedron Lett. 1987,28, 5209. doi:<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0040403900956314\">10.1016\/S0040-4039(00)95631-4.<\/a><\/li>\n<li>[2] J. M.Goodman,S. D.Kahn, I.Paterson,\u00a0J. Org. Chem.\u00a01990,\u00a055, 3295. doi:<a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jo00297a058\">10.1021\/jo00297a058.<\/a><\/li>\n<li>[3] A.Bernardi, A. M.Capelli, C.Gennari, J. M.Goodman, I.Paterson,\u00a0J. Org. Chem.\u00a01990,\u00a055, 3576. doi:<a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jo00298a038\">10.1021\/jo00298a038.<\/a><\/li>\n<li>[4] A.Bernardi, A. M.Capelli, A.Comotti, C.Gennari,M.Gardner, J. M.Goodman, I.Paterson,\u00a0Tetrahedron1991,47, 3471. doi:<a href=\"https:\/\/doi.org\/10.1016\/S0040-4020(01)86409-7\">10.1016\/S0040-4020(01)86409-7<\/a>.<\/li>\n<li>[5] A.Bernardi, A. M.Capelli, A. Comotti, C.Gennari, J. M.Goodman,I.Paterson,\u00a0Tetrahedron1992,\u00a048, 4183. doi:<a href=\"https:\/\/doi.org\/10.1016\/S0040-4020(01)92196-9\">10.1016\/S0040-4020(01)92196-9<\/a>.<\/li>\n<li>[6] C.Gennari,C. T.Hewkin, F.Molinari, A. M.Capelli, A. Comotti,J. M.Goodman,I.Paterson,\u00a0J. Org. Chem.\u00a01992,\u00a057, 5173. doi:<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jo00045a033\">10.1021\/jo00045a033.<\/a><\/li>\n<li>[7] A.Bernardi,C.Gennari,J. M.Goodman,V.Leue,I.Paterson,\u00a0Tetrahedron\u00a01995,\u00a051, 4853. doi:<a href=\"https:\/\/doi.org\/10.1016\/0040-4020(95)00170-D\">10.1016\/0040-4020(95)00170-D<\/a>.<\/li>\n<\/ul>\n<h4><strong>\u53cd\u5e94\u5b9e\u4f8b<\/strong><\/h4>\n<p>ebelactone A\u7684\u5168\u5408\u6210[1]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/5-12.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19252 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/5-12.png\" alt=\"\" width=\"1113\" height=\"139\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/5-12.png 1113w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/5-12-300x37.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/5-12-768x96.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/5-12-680x85.png 680w\" sizes=\"(max-width: 1113px) 100vw, 1113px\" \/><\/a><\/p>\n<p>\u6297\u764c\u6d3b\u6027\u6d77\u6d0b\u5929\u7136\u4ea7\u7269(+)-discodermolide\u7684\u5168\u5408\u6210[2]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/6-11.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19253 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/6-11.png\" alt=\"\" width=\"1118\" height=\"556\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/6-11.png 1118w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/6-11-300x149.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/6-11-768x382.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/6-11-680x338.png 680w\" sizes=\"(max-width: 1118px) 100vw, 1118px\" \/><\/a><\/p>\n<p>dihydmpyrone\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210[3]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/7-12.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19254 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/7-12.png\" alt=\"\" width=\"1116\" height=\"147\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/7-12.png 1116w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/7-12-300x40.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/7-12-768x101.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/05\/7-12-680x90.png 680w\" sizes=\"(max-width: 1116px) 100vw, 1116px\" \/><\/a><\/p>\n<h4><\/h4>\n<h4><strong>\u5b9e\u9a8c\u6b65\u9aa4<\/strong><\/h4>\n<p>0\u00b0C\uff0c\u6c29\u6c14\u6c14\u6c1b\u4e0b\uff0c\u5c06\u5e72\u71e5\u7684DCM(25 ml)\u52a0\u5165\u5230 (-)-(-)-(lpc)<sub>2<\/sub>BH (1.3 eq.)\u4e2d\uff0c\u5f00\u542f\u6405\u62cc\uff0c\u518d\u5411\u4e0a\u8ff0\u60ac\u6d4a\u6db2\u4e2d\u6ef4\u52a0TfOH(1.4 eq., \u8d85\u8fc75 min\u6ef4\u52a0\u7ed3\u675f)\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u57280\u00b0C\u4e0b\u7ee7\u7eed\u6405\u62cc0.5 h\u3002\u5c06\u4ea7\u751f\u7684\u6a59\u7ea2\u8272\u6eb6\u6db2\u51b7\u5374\u81f3-78\u00b0C\uff0c\u968f\u540e\u4f9d\u6b21\u52a0\u5165Hunig\u78b1(2eq.)\u53ca\u4e8c\u4e59\u57fa\u916e(1 eq.)\uff0c\u52a0\u6599\u7ed3\u675f\u540e\uff0c\u518d\u5c06\u53cd\u5e94\u6df7\u5408\u7269\u5347\u6e29\u81f30\u00b0C\u3002\u8fdb\u4e00\u6b65\u6405\u62cc5 h\u540e\uff0c\u518d\u6b21\u5c06\u6eb6\u6db2\u51b7\u5374\u81f3-78\u00b0C\u540e\uff0c\u52a0\u5165\u65b0\u9c9c\u84b8\u998f\u7684\u4e59\u919b (3 eq.)\u7684DCM\u6eb6\u6db2(\u919b\u6d53\u5ea6\u4e3a1M) \u52a0\u6599\u7ed3\u675f\u540e\uff0c\u518d\u6b21\u5c06\u53cd\u5e94\u6df7\u5408\u7269\u5347\u6e29\u81f30\u00b0C\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u5012\u5165pH=7\u7684\u7f13\u51b2\u6eb6\u6db2\u4e2d\uff0c\u52a0\u5165\u4e59\u919a\u8fdb\u884c\u8403\u53d6\u3002\u5c06\u5408\u5e76\u7684\u6709\u673a\u76f8\u5728\u51cf\u538b\u6d53\u7f29\u540e\uff0c\u57280\u00b0C \u4e0b\uff0c\u5411\u6b8b\u4f59\u7269\u4e2d\u52a0\u5165\u9002\u91cfMeOH-pH=7\u7684\u7f13\u51b2\u6eb6\u6db2(5:1v\/v)\uff0c\u6405\u62cc\u6eb6\u89e3\u540e\uff0c\u52a0\u5165\u9002\u91cf30%\u8fc7\u6c27\u5316\u6c22\u6eb6\u6db2\uff0c\u5ba4\u6e29\u4e0b\u6405\u62cc1h\u3002\u540e\u5c06\u4e0a\u8ff0\u6df7\u5408\u7269\u52a0\u6c34\u7a00\u91ca\uff0c\u518d\u52a0\u5165DCM\u8fdb\u884c\u8403\u53d6\uff0c\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u540e\uff0c\u83b7\u5f97\u7c97\u4ea7\u7269\u3002\u5c06\u7c97\u4ea7\u7269\u91c7\u7528\u5feb\u901f\u7845\u80f6\u67f1\u8272\u8c31(EtOAc\/\u6b63\u5df1\u70f7 2\uff1a3 v\/v)\u5206\u79bb\u7eaf\u5316\u540e\uff0c\u83b7\u5f97\u76f8\u5e94\u76ee\u6807\u4ea7\u7269\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u5b9e\u9a8c\u6280\u5de7<\/strong><\/h4>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1]I. Paterson,Pure Appl. Chem. 1992, 64,1821.doi:<a href=\"https:\/\/www.iupac.org\/publications\/pac\/64\/12\/1821\/index.html\">10.1351\/pac199264121821.<\/a><\/li>\n<li>[2]<a href=\"http:\/\/pubs.acs.org\/author\/Mickel%2C+Stuart+J\">S. J. Mickel<\/a>,<a href=\"http:\/\/pubs.acs.org\/author\/Daeffler%2C+Robert\">R. Daeffler<\/a>, <a href=\"http:\/\/pubs.acs.org\/author\/Prikoszovich%2C+Walter\">W. Prikoszovich<\/a>, Org. Process Res. Dev.,\u00a02005,\u00a09, 113.doi:<a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/op049800a\">10.1021\/op049800a.<\/a><\/li>\n<li>[3]I.Paterson, S. A.Osborne,\u00a0Tetrahedron Lett.\u00a01990,\u00a031, 2213.doi:<a href=\"https:\/\/doi.org\/10.1016\/0040-4039(90)80112-Y\">10.1016\/0040-4039(90)80112-Y<\/a>.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 Paterson \u787c\u7f9f\u919b\u7f29\u5408\u53cd\u5e94(Paterson boron adol condensation)\u662f\u5728(+)-(lpc)2BOTf\u6216(-)-(lpc)2BOTf(Brown Ipc\u787c\u70f7)\u4e0eH\u00fcnig\u78b1\u4f5c\u7528\u4e0b\uff0c\u916e\u7c7b\u5316\u5408\u7269\u4e0e\u5404\u7c7b\u8102\u80aa\u919b\u53ca\u82b3\u9999\u919b\u4e4b\u95f4\u8fdb\u884c\u7684\u5bf9\u6620\u7acb\u4f53\u9009\u62e9\u6027\u4e0esyn-\u7acb\u4f53\u9009\u62e9\u6027\u7f9f\u919b\u7f29\u5408\u53cd\u5e94\u3002\u8be5\u53cd\u5e94\u57281986\u5e74\u7531\u82f1\u56fdCambridge\u5927\u5b66\u5316\u5b66\u5b9e\u9a8c\u5ba4(Universiry Chemical Laboratory,Cambridge)\u7684I. Paterson\u7814\u7a76\u7ec4\u9996\u6b21\u62a5\u9053[1]\u3002\u968f\u540e\uff0c\u8be5\u7814\u7a76\u7ec4\u5c06\u5e95\u7269\u8303\u56f4\u7531\u6700\u521d\u7684\u4e8c\u4e59\u57fa\u916e[1]\u6269\u5c55\u81f3\u624b\u6027\u4e59\u57fa\u916e[2]-[3]\uff0c\u5e76\u6210\u529f\u5e94\u7528\u4e8emacrolide\u7684\u5408\u6210[2]\u30021989\u5e74-1990\u5e74\uff0cI. Paterson\u53c8\u5c06\u5e95\u7269\u8303\u56f4\u8fdb\u4e00\u6b65\u6269\u5c55\u81f3\u7532\u57fa\u916e\u53ca\u624b\u6027\u7532\u57fa\u916e[4]-[6]\u3002\u540c\u65f6\uff0c\u7814\u7a76\u53d1\u73b0\u91c7\u7528(-)-(Ipc)2BCl\uff0c\u53ef\u4ee5\u5b9e\u73b0anti-\u9009\u62e9\u6027\u7f9f\u919b\u7f29\u5408\u53cd\u5e94[7]\u3002\u76ee\u524d\uff0c\u8be5\u53cd\u5e94\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5404\u7c7b\u751f\u7406\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u6784\u5efa\u65f6\u7684\u5173\u952e\u6b65\u9aa4[8]-[11]\u3002 \u57fa\u672c\u6587\u732e [1] I. Paterson, M.A. Lister, C. K McClure, Tetrahedron Lett. 1986, 27, 4787.doi: 10.1016\/S0040-4039(00)85065-0. [2] I.Paterson, C. K. McClure, Tetrahedron Lett. 1987, 28, 1229.doi:10.1016\/S0040-4039(00)95333-4. [3] I.Paterson, M. A.Lister, Tetrahedron Lett. 1988, 29, 585.doi:10.1016\/S0040-4039(00)80157-4. [4] I. Paterson,Goodman, J. M. Tetrahedron Lett. 1989, 30, 997.doi:10.1016\/S0040-4039(00)95300-0. [5] I.Paterson, Goodman, J. M.Isaka, M. Tetrahedron Lett. 1989, 30, 7121.doi:10.1016\/S0040-4039(01)93440-9. [6] I. Paterson, J. M. Goodman, M. A. Lister, R. C. Schumann, C. K. McClure, R. D. Norcross, Tetrahedron1990, 46, 4663.doi:10.1016\/S0040-4020(01)85588-5. [7] I. Paterson,Pure Appl. Chem. 1992, 64,1821.doi:10.1351\/pac199264121821. [8] C. J.Cowden,I. Paterson,Org. React. 1997, 51, 1.doi:10.1002\/0471264180.or051.01. [9] I.Paterson, S. A.Osborne,\u00a0Tetrahedron Lett.\u00a01990,\u00a031, 2213.doi:10.1016\/0040-4039(90)80112-Y. [10]\u00a0S. J. 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