{"id":19359,"date":"2018-06-26T10:54:27","date_gmt":"2018-06-26T02:54:27","guid":{"rendered":"\/\/www.gsbet888.com\/?p=19359"},"modified":"2019-08-02T18:51:32","modified_gmt":"2019-08-02T10:51:32","slug":"kuwajima-reich%e9%87%8d%e6%8e%92","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/%e9%87%8d%e6%8e%92%e5%8f%8d%e5%ba%94\/2018\/06\/kuwajima-reich%e9%87%8d%e6%8e%92.html","title":{"rendered":"Kuwajima-Reich\u91cd\u6392"},"content":{"rendered":"<h4><strong>\u6982\u8981<\/strong><\/h4>\n<p>Kuwajima-Reich\u91cd\u6392(Kuwajima-Reichrearrangent)\u662f\u5728\u5f3a\u78b1(\u5982\u70f7\u57fa\u9502)\u8bf1\u5bfc\u4e0b\uff0c1-\u4e09\u7532\u57fa\u7845\u57fa\u7094\u4e19\u9187\u53d1\u751f\u91cd\u6392\uff0c\u751f\u6210\u7845\u6c27\u57fa\u8054\u70ef\u7684\u53cd\u5e94\u3002\u8be5\u53cd\u5e94\u57281980\u5e74\u7531\u65e5\u672c\u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66(Tokyo Institute of Technology)\u7684\u6851\u5c9b\u529f(KuwajimaIsao)\u7814\u7a76\u7ec4\u4e0e\u7f8e\u56fdWisconsin\u5927\u5b66(University of Wisconsin)\u7684H. J.Reich\u7814\u7a76\u7ec4\u72ec\u7acb\u62a5\u9053[1]-[4]\u30022011\u5e74\uff0c\u65e5\u672c\u5e7f\u5c9b\u5927\u5b66(Hiroshima University)\u7684\u6b66\u7530\u656c(Takeda Kei)\u7814\u7a76\u7ec4\u62a5\u9053\u4e86\u9996\u4f8b\u5bf9\u6620\u9009\u62e9\u6027Kuwajima-Reich\u91cd\u6392\u3002<br \/>\n<a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/2-4.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19361 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/2-4-680x165.png\" alt=\"\" width=\"680\" height=\"165\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/2-4-680x165.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/2-4-300x73.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/2-4-768x186.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/2-4.png 1074w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a>\u76ee\u524d\uff0c\u8be5\u53cd\u5e94\u5df2\u7ecf\u6210\u4e3a\u7845\u6c27\u57fa\u8054\u70ef\u5408\u6210\u65f6\u6700\u4e3a\u5e38\u7528\u7684\u65b9\u6cd5[5]\u3002\u540c\u65f6\uff0c\u91c7\u7528\u4e0d\u540c\u7684\u4eb2\u7535\u5e95\u7269\u5c06\u91cd\u6392\u4ea7\u751f\u7684\u8054\u70ef\u57fa\u9502\u6355\u83b7\uff0c\u53ef\u4ee5\u65b9\u4fbf\u5730\u6784\u5efa\u91c7\u7528\u5e38\u89c4\u65b9\u6cd5\u96be\u4ee5\u5408\u6210\u7684\u5404\u7c7b\u6709\u673a\u5206\u5b50[6]-[8]\u3002<br \/>\n<a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/3-3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19362 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/3-3-680x155.png\" alt=\"\" width=\"680\" height=\"155\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/3-3-680x155.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/3-3-300x68.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/3-3.png 715w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/4-3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19363 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/4-3.png\" alt=\"\" width=\"1139\" height=\"176\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/4-3.png 1139w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/4-3-300x46.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/4-3-768x119.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/4-3-680x105.png 680w\" sizes=\"(max-width: 1139px) 100vw, 1139px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u57fa\u672c\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1]I.Kuwajima, M. Kato, TetrahedronLett.1980, 21, 623. doi:10.1016\/S0040-4039(01)85575-1.<\/li>\n<li>[2] H. J.Reich, R. E.Olson, M. C.Clark, J. Am. Chem. Soc. 1980, 102,\u00a01423.doi:10.1021\/ja00524a036.<\/li>\n<li>[3]I. Kuwajima, J. Organomet. Chem. 1985, 285, 137.doi:10.1016\/0022-328X(85)87363-0.<\/li>\n<li>[4] H. J.Reich, E. K.Eisenhart, R. E.Olson,M. J. Kelly, J. Am. Chem. Soc.1986, 108, 7791. doi:10.1021\/ja00284a051.<\/li>\n<li>[5] M.Sasaki, Y.Kondo, M. Kawahata, K.Yamaguchi, K.Takeda, Angew.Chem. Int. Ed. 2011, 123, 6499. doi:10.1002\/ange.201102430.<\/li>\n<li>[6] R.Matsuoka, Y. Horiguchi, I. Kuwajima, Tetrahedron Lett. 1987, 28, 1299.doi:10.1016\/S0040-4039(00)95352-8.<\/li>\n<li>[7] G.R. Boyce, S. Liu, J. S. Johnson, Org.Lett. 2012, 14, 652.doi:10.1021\/ol2033527.<\/li>\n<li>[8]T. E. Reynolds, K. A. Scheidt, Angew.Chem. Int. Ed. Engl. 2007, 46, 7806.doi: 10.1002\/anie.200702818.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h4><strong>\u53cd\u5e94\u673a\u7406<\/strong><\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/5-3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19364 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/5-3.png\" alt=\"\" width=\"1138\" height=\"126\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/5-3.png 1138w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/5-3-300x33.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/5-3-768x85.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/5-3-680x75.png 680w\" sizes=\"(max-width: 1138px) 100vw, 1138px\" \/><\/a><\/p>\n<h4><strong>\u53cd\u5e94\u5b9e\u4f8b<\/strong><\/h4>\n<ul>\n<li>\u916e\u7c7b\u5316\u5408\u7269\u7684\u5408\u6210[1]<\/li>\n<\/ul>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/6-3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19365 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/6-3.png\" alt=\"\" width=\"1111\" height=\"138\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/6-3.png 1111w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/6-3-300x37.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/6-3-768x95.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/6-3-680x84.png 680w\" sizes=\"(max-width: 1111px) 100vw, 1111px\" \/><\/a><\/p>\n<ul>\n<li>\u73af\u620a\u9187\u884d\u751f\u7269\u7684\u5408\u6210[2]\n<a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/7-2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19366 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/7-2.png\" alt=\"\" width=\"1128\" height=\"189\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/7-2.png 1128w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/7-2-300x50.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/7-2-768x129.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/7-2-680x114.png 680w\" sizes=\"(max-width: 1128px) 100vw, 1128px\" \/><\/a><\/li>\n<li>\u53d6\u4ee3Indanone\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210[3]\n<a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/8-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-19367 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/8-1.png\" alt=\"\" width=\"1120\" height=\"149\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/8-1.png 1120w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/8-1-300x40.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/8-1-768x102.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/8-1-680x90.png 680w\" sizes=\"(max-width: 1120px) 100vw, 1120px\" \/><\/a><\/li>\n<\/ul>\n<h4><strong>\u5b9e\u9a8c\u6b65\u9aa4<\/strong><\/h4>\n<p>0\u00b0C\u4e0b\uff0c\u5411\u7094(1.1 eq.)\u7684\u65e0\u6c34\u56db\u6c22\u544b\u5583\u6eb6\u6db2(\u5e95\u7269\u6d53\u5ea6\u4e3a0.64 M)\u4e2d\u52a0\u5165MeLi(1.1 eq., l:l LiBr\u914d\u5408\u7269)\u7684\u4e59\u919a\u6eb6\u6db2(\u6d53\u5ea6\u4e3a1.15 M)\u3002\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u6405\u62cc15min\u540e\uff0c\u5c06\u5f62\u6210\u7684\u6eb6\u6db2\u51b7\u5374\u81f3-78\u00b0C\uff0c\u518d\u5411\u8be5\u6eb6\u6db2\u4e2d\u6ef4\u52a0\u4e09\u7532\u7845\u57fa\u916e(1 eq.)\uff0c\u6b64\u65f6\u4f1a\u5f62\u6210\u767d\u8272\u6c89\u6dc0\u300215 min\u540e\uff0c\u518d\u5411\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u4e2d\u52a0\u5165\u4eb2\u7535\u5e95\u7269(1.3 eq.)\uff0c\u4e4b\u540e\uff0c\u5c06\u4e0a\u8ff0\u53cd\u5e94\u6df7\u5408\u7269\u5347\u6e29\u81f30\u00b0C\uff0c\u7ee7\u7eed\u6405\u62cc\u81f3\u53cd\u5e94\u7ed3\u675f\u3002\u53cd\u5e94\u7ed3\u675f\u540e\uff0c\u91c7\u7528\u51b7\u76847% NaHCO<sub>3<\/sub>\u6eb6\u6db2\u6dec\u706d\u53cd\u5e94\uff0c\u6dec\u706d\u7ed3\u675f\u540e\uff0c\u5c06\u53cd\u5e94\u6db2\u91c7\u7528\u4e59\u919a-\u6b63\u620a\u70f7\u6df7\u5408\u6eb6\u5242(1:l v\/v)\u8fdb\u884c\u8403\u53d6\uff0c\u518d\u4f9d\u6b21\u7528\u9971\u548c\u98df\u76d0\u6c34\u8fdb\u884c\u6d17\u6da4\u3001\u65e0\u6c34Na<sub>2<\/sub>SO<sub>4<\/sub>\u8fdb\u884c\u5e72\u71e5\u3002\u51cf\u538b\u9664\u53bb\u6eb6\u5242\u540e\uff0c\u5c06\u6b8b\u4f59\u7269\u901a\u8fc7Kugelrohr\u84b8\u998f\u88c5\u7f6e(24 mm,\u6d74\u6e2989-91\u00b0C)\u8fdb\u884c\u84b8\u998f\uff0c\u83b7\u5f97\u76f8\u5e94\u76ee\u6807\u4ea7\u7269\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u5b9e\u9a8c\u6280\u5de7<\/strong><\/h4>\n<p>&nbsp;<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h4>\n<ul>\n<li>[1]H. J.Reich, R. E. Olson, M. C.Clark, J. Am. Chem. Soc. 1980, 102,\u00a01423.doi:10.1021\/ja00524a036.<\/li>\n<li>[2]G. R. Boyce, S. Liu, J. S. Johnson, Org.Lett. 2012, 14, 652.doi:10.1021\/ol2033527.<\/li>\n<li>[3]J. A.Brekan, T. E. Reynolds, K. A. Scheidt, J. Am.Chem. Soc. 2010, 132, 1472.doi:10.1021\/ja909669e.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong>\u00a0\u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 Kuwajima-Reich\u91cd\u6392(Kuwajima-Reichrearrangent)\u662f\u5728\u5f3a\u78b1(\u5982\u70f7\u57fa\u9502)\u8bf1\u5bfc\u4e0b\uff0c1-\u4e09\u7532\u57fa\u7845\u57fa\u7094\u4e19\u9187\u53d1\u751f\u91cd\u6392\uff0c\u751f\u6210\u7845\u6c27\u57fa\u8054\u70ef\u7684\u53cd\u5e94\u3002\u8be5\u53cd\u5e94\u57281980\u5e74\u7531\u65e5\u672c\u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66(Tokyo Institute of Technology)\u7684\u6851\u5c9b\u529f(KuwajimaIsao)\u7814\u7a76\u7ec4\u4e0e\u7f8e\u56fdWisconsin\u5927\u5b66(University of Wisconsin)\u7684H. J.Reich\u7814\u7a76\u7ec4\u72ec\u7acb\u62a5\u9053[1]-[4]\u30022011\u5e74\uff0c\u65e5\u672c\u5e7f\u5c9b\u5927\u5b66(Hiroshima University)\u7684\u6b66\u7530\u656c(Takeda Kei)\u7814\u7a76\u7ec4\u62a5\u9053\u4e86\u9996\u4f8b\u5bf9\u6620\u9009\u62e9\u6027Kuwajima-Reich\u91cd\u6392\u3002 \u76ee\u524d\uff0c\u8be5\u53cd\u5e94\u5df2\u7ecf\u6210\u4e3a\u7845\u6c27\u57fa\u8054\u70ef\u5408\u6210\u65f6\u6700\u4e3a\u5e38\u7528\u7684\u65b9\u6cd5[5]\u3002\u540c\u65f6\uff0c\u91c7\u7528\u4e0d\u540c\u7684\u4eb2\u7535\u5e95\u7269\u5c06\u91cd\u6392\u4ea7\u751f\u7684\u8054\u70ef\u57fa\u9502\u6355\u83b7\uff0c\u53ef\u4ee5\u65b9\u4fbf\u5730\u6784\u5efa\u91c7\u7528\u5e38\u89c4\u65b9\u6cd5\u96be\u4ee5\u5408\u6210\u7684\u5404\u7c7b\u6709\u673a\u5206\u5b50[6]-[8]\u3002 &nbsp; \u57fa\u672c\u6587\u732e [1]I.Kuwajima, M. Kato, TetrahedronLett.1980, 21, 623. doi:10.1016\/S0040-4039(01)85575-1. [2] H. J.Reich, R. E.Olson, M. C.Clark, J. Am. Chem. Soc. 1980, 102,\u00a01423.doi:10.1021\/ja00524a036. [3]I. Kuwajima, J. Organomet. Chem. 1985, 285, 137.doi:10.1016\/0022-328X(85)87363-0. [4] H. J.Reich, E. K.Eisenhart, R. E.Olson,M. J. Kelly, J. Am. Chem. Soc.1986, 108, 7791. doi:10.1021\/ja00284a051. [5] M.Sasaki, Y.Kondo, M. Kawahata, K.Yamaguchi, K.Takeda, Angew.Chem. Int. Ed. 2011, 123, 6499. doi:10.1002\/ange.201102430. [6] R.Matsuoka, Y. Horiguchi, I. Kuwajima, Tetrahedron Lett. 1987, 28, 1299.doi:10.1016\/S0040-4039(00)95352-8. [7] G.R. Boyce, S. Liu, J. S. Johnson, Org.Lett. 2012, 14, 652.doi:10.1021\/ol2033527. [8]T. E. Reynolds, K. A. Scheidt, Angew.Chem. Int. Ed. Engl. 2007, 46, 7806.doi: 10.1002\/anie.200702818. &nbsp; \u53cd\u5e94\u673a\u7406 [&hellip;]","protected":false},"author":21,"featured_media":19423,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[12],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/06\/Kuwajima.jpg","jetpack_shortlink":"https:\/\/wp.me\/p96op1-52f","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/19359"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=19359"}],"version-history":[{"count":8,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/19359\/revisions"}],"predecessor-version":[{"id":27074,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/19359\/revisions\/27074"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/19423"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=19359"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=19359"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=19359"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}