{"id":20627,"date":"2018-10-03T22:14:42","date_gmt":"2018-10-03T14:14:42","guid":{"rendered":"\/\/www.gsbet888.com\/?p=20627"},"modified":"2019-08-02T18:51:13","modified_gmt":"2019-08-02T10:51:13","slug":"frances-h-arnold","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemists\/2018\/10\/frances-h-arnold.html","title":{"rendered":"Frances H. Arnold"},"content":{"rendered":"<p>Frances Hamilton Arnold\u30011956\u5e747\u670825\u65e5-\u3001\u7f8e\u56fd\u7684\u5408\u6210\u751f\u7269\u5b66\u5bb6\u30fb\u751f\u7269\u5316\u5b66\u5bb6\u30fb\u751f\u7269\u5de5\u7a0b\u5b66\u5bb6\u3002\u52a0\u5dde\u7406\u5de5\u5b66\u9662\u6559\u6388\u3002(\u7167\u7247\u6765\u81ea:Twitter)<\/p>\n<p>\u7531\u4e8e\u6307\u5411\u8fdb\u5316\u6cd5\u7684\u5f00\u53d1\u3001\u83b7\u5f97\u4e862018\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u3002<\/p>\n<h4><span id=\"more-53873\"><\/span><br \/>\n\u7ecf\u5386<\/h4>\n<p>1979 \u666e\u6797\u65af\u987f\u5927\u5b66 \u6bd5\u4e1a<br \/>\n1986 \u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821 \u535a\u58eb\u5b66\u4f4d<br \/>\n1986 \u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821 \u535a\u58eb\u540e\u7814\u7a76\u5458<br \/>\n200x \u52a0\u5dde\u7406\u5de5\u5b66\u9662 Dick and Barbara Dickinson Professor<br \/>\n2005 Gevo, Inc. \u5408\u4f19\u4eba<\/p>\n<h4>\u83b7\u5956\u7ecf\u5386<\/h4>\n<p>2011 Charles Stark Draper prize<br \/>\n2013 National Medal of Technology and Innovation<br \/>\n2014 National Inventors Hall of Fame<br \/>\n2016 Millennium Technology Prize<br \/>\n2017 Raymond and Beverly Sackler Prize in Convergence Research<br \/>\n2017 Society of Women Engineers\u2019 2017 Achievement Award<\/p>\n<p>2018 \u8bfa\u8d1d\u5c14\u5316\u5b66\u5956<\/p>\n<h4>\u7814\u7a76\u6982\u8981<\/h4>\n<p>\u5b9a\u5411\u8fdb\u5316\u6cd5\u7684\u5148\u9a71\u4e4b\u4e00\u3002\u7814\u7a76\u65b9\u5411\u4e3a\u4ee5\u86cb\u767d\u8d28\u5de5\u7a0b\u6280\u672f\u4e3a\u57fa\u7840\uff0c\u521b\u9020\u51fa\u7531\u4e8e\u81ea\u7136\u754c\u7684\u529f\u80fd\u6027\u86cb\u767d\u8d28\u30fb\u751f\u7269\u7cfb\u3002\u81ea\u7136\u754c\u4e2d\u5b58\u5728\u7684\u5929\u7136\u7ec6\u80de\u8272\u7d20\u9176\u5177\u6709\u6c27\u5316\u6709\u673a\u7269\u7684\u80fd\u529b\uff0c\u800c\u5f88\u65e9\u4ee5\u524d\u5c31\u5728\u5c1d\u8bd5\u5c06\u8fd9\u4e9b\u5929\u7136\u86cb\u767d\u9176\u7528\u5728\u9009\u62e9\u6027\u6c27\u5316\u53cd\u5e94\u7684\u5f00\u53d1\u4e2d\u3002\u53e6\u5916\uff0c\u5bf9\u4e8e\u78b3-\u78b3\u8fd9\u4e9b\u6bd4\u8f83\u96be\u6c27\u5316\u7684\u5e95\u7269\u6765\u8bf4\uff0c\u5929\u7136\u6c27\u5316\u9176\u7684\u6c27\u5316\u80fd\u529b\u8fd8\u4e0d\u591f\uff0c\u8fd9\u65b9\u9762\u7684\u7814\u7a76\u5e76\u6ca1\u6709\u5f97\u5230\u8fdb\u5c55\u3002<\/p>\n<p>Arnold\u5229\u7528\u6307\u5411\u8fdb\u5316\u6cd5\uff0c\u5f00\u53d1\u51fa\u4e86\u66f4\u52a0\u7a33\u5b9a\uff0c\u5e76\u4e14\u50ac\u5316\u80fd\u529b\u66f4\u5f3a\u7684\u6c27\u5316\u9176[2]\u3001\u901a\u8fc7\u86cb\u767d\u8d28\u4e0a\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\u7684\u6539\u53d8\u6765\u6539\u53d8\u9176\u7684\u7ed3\u6784\uff0c\u4ece\u800c\u5bf9\u5176\u50ac\u5316\u80fd\u8fdb\u884c\u6539\u826f\uff0c\u5728\u8fd9\u65b9\u9762\uff0cArnold\u6559\u6388\u4f5c\u4e86\u5927\u91cf\u7684\u5de5\u4f5c\u4e0e\u8d21\u732e\u3002\u8fd1\u5e74\u6765\uff0c\u901a\u8fc7\u6539\u53d8\u7ec6\u80de\u8272\u7d20\u4e2d\u94c1\u4e2d\u4fe1\u91d1\u5c5e\u9644\u8fd1\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\uff0c\u521b\u9020\u51fa\u4e86\u50ac\u5316\u80fd\u529b\u5927\u5927\u4f18\u4e8e\u5929\u7136\u578b\u9176\u7684\u65b0\u578b\u9176[1-6]\u3002\u5176\u4e2d\u6bd4\u8f83\u8457\u540d\u7684\u662f\u5f00\u53d1\u51fa\u4e86\u6539\u826f\u540e\u7684P450\u9176\uff0c\u5e76\u4e14\u5c06\u5176\u8fd0\u7528\u5230\u4e86\u6709\u673a\u5316\u5408\u7269\u7684\u73af\u6c27\u5316\uff0c\u78b3-\u7845\u952e\u7684\u6784\u7b51\u4e2d[5]\uff0c\u5907\u53d7\u77a9\u76ee\u3002<\/p>\n<div id=\"attachment_53875\" class=\"wp-caption aligncenter\">\n<p><a href=\"https:\/\/i0.wp.com\/assets.chem-station.com\/uploads\/2017\/11\/FH_Arnold_1-e1511005094570.jpg?ssl=1\" data-featherlight=\"image\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-53875\" src=\"https:\/\/i0.wp.com\/assets.chem-station.com\/uploads\/2017\/11\/FH_Arnold_1-e1511005094570.jpg?resize=660%2C340&amp;ssl=1\" alt=\"\" width=\"648\" height=\"334\" \/><\/a><\/p>\n<p class=\"wp-caption-text\">Arnold\u7814\u7a76\u5ba4\u4e3b\u9875<\/p>\n<\/div>\n<h4>\u8865\u5145<\/h4>\n<p>\u4e0e\u5176\u4ed6\u9176\u76f8\u6bd4\uff0c\u4f5c\u4e3a\u6c27\u5316\u9176\u7684\u7ec6\u80de\u8272\u7d20\u57fa\u672c\u4e0a\u4e0d\u7a33\u5b9a\uff0c\u5e76\u4e14\u5176\u50ac\u5316\u80fd\u529b\u901a\u5e38\u8f83\u4f4e\u3002\u56e0\u6b64\uff0c\u5b58\u5728\u50ac\u5316\u5faa\u73af\u6570\uff08TON\uff09\u53d7\u9650\u4e14\u4e0d\u9002\u5408\u6709\u673a\u5316\u5b66\u53cd\u5e94\u7684\u95ee\u9898\u3002Arnold\u6559\u6388\u8fd0\u7528\u6307\u5411\u6027\u8fdb\u5316\u6cd5\u4f7f\u5f97\u539f\u672c\u57fa\u672c\u6ca1\u6709\u6c27\u5316\u6d3b\u6027\u7684\u9176\uff0c\u901a\u8fc7\u6539\u826f\u540e\uff0c\u4ea7\u751f\u4e86TON=1000\uff0c\u5e76\u4e14\u80fd\u591f\u7a33\u5b9a\u5b58\u5728\u7684\u6c27\u5316\u9176\u3002<\/p>\n<p>\u5230\u76ee\u524d\u4e3a\u6b62\u5df2\u77e5\u6709200.000\u79cd\u4ee5\u4e0a\u7684\u7ec6\u80de\u8272\u7d20P450\u3001\u6309\u7167\u6765\u6e90\u4e3b\u8981\u5206\u4e3a4\u4e2a\u5927\u7c7b\uff08\u7ec6\u83cc\u884d\u751f\u7684\uff0c\u7ebf\u7c92\u4f53\u884d\u751f\u7684\uff0c\u5fae\u7c92\u4f53\u884d\u751f\u7684\uff0c\u81ea\u7ed9\u578b\uff09\u3002\u5176\u4e2d\uff0c\u9664\u4e86\u81ea\u7ed9\u578b\u4ee5\u5916\uff0c\u8981\u8fdb\u884c\u7535\u5b50\u8f6c\u79fb\u7684\u8bdd\uff0c\u5176\u4ed6\u9176\u6216\u8f85\u9176\u7684\u53c2\u4e0e\u662f\u5fc5\u4e0d\u53ef\u5c11\u3001\u56e0\u6b64\u4e5f\u9650\u5236\u4e86\u8fd9\u4e9b\u9176\u7684\u5229\u7528\u3002\u56e0\u6b64\uff0cArnold\u6559\u6388\u57fa\u672c\u4e0a\u90fd\u662f\u8fd0\u7528\u7684\u6c27\u5316\u8fd8\u539f\u4e00\u4f53\u578b\u7684BM3\u7b49\u81ea\u7ed9\u578b\u7ec6\u80de\u8272\u7d20P450\u3002<\/p>\n<h4>\u76f8\u5173\u6587\u732e<\/h4>\n<ol>\n<li>Arnold, F. H. <em>Angew. Chem. Int. Ed.<\/em> <strong>2018<\/strong>, <em>57<\/em>, 4143. DOI:<a href=\"http:\/\/doi.wiley.com\/10.1002\/anie.201708408\">10.1002\/anie.201708408<\/a>.<\/li>\n<li>Giver, L.; Gershenson, A.; Freskgard, P.-O.; Arnold, F. H. <em>Proc. Natl. Acad. Sci.<\/em><strong>1998<\/strong>, <em>95<\/em>, 12809. DOI:<a href=\"http:\/\/www.pnas.org\/content\/95\/22\/12809\">10.1073\/pnas.95.22.12809.<\/a><\/li>\n<li>\u00a0Coelho, P. S.; Brustad, E. M.; Kannan, A.; Arnold, F. H. <em>Science<\/em> <strong>2013<\/strong>, <em>339<\/em>, 307. DOI:<a href=\"http:\/\/science.sciencemag.org\/content\/sci\/339\/6117\/307.full.pdf\">10.1126\/science.1231434<\/a>.<\/li>\n<li>\u00a0Chen, K.; Huang, X.; Kan, S. B. J.; Zhang, R. K.; Arnold, F. H. <em>Science<\/em> <strong>2018<\/strong>, <em>360<\/em>, 71. DOI:<a href=\"http:\/\/science.sciencemag.org\/content\/sci\/360\/6384\/71.full.pdf\">10.1126\/science.aar4239<\/a>.\uff08<\/li>\n<li>Kan, S. B. J.; Huang, X.; Gumulya, Y.; Chen, K.; Arnold, F. H. <em>Nature<\/em> <strong>2017<\/strong>, <em>552<\/em>. DOI:<a href=\"https:\/\/www.nature.com\/articles\/nature24996.pdf\">10.1038\/nature24996<\/a>.<\/li>\n<li>Smith, A. M.; Floerke, V. A.; Thomas, A. K. <em>Science<\/em> <strong>2016<\/strong>, <em>354<\/em>, 1046. DOI:<a href=\"http:\/\/science.sciencemag.org\/content\/sci\/354\/6315\/1048.full.pdf\">10.1126\/science.aah6219<\/a>.<\/li>\n<\/ol>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n<p>&nbsp;<\/p>\n<h4>\u5173\u8054\u89c6\u9891<\/h4>\n<p><span class=\"embed-youtube\" style=\"text-align:center; display: block;\"><iframe loading=\"lazy\" class=\"youtube-player\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/es86W2sYl3I?version=3&#038;rel=1&#038;showsearch=0&#038;showinfo=1&#038;iv_load_policy=1&#038;fs=1&#038;hl=en-US&#038;autohide=2&#038;wmode=transparent\" allowfullscreen=\"true\" style=\"border:0;\" sandbox=\"allow-scripts allow-same-origin allow-popups allow-presentation allow-popups-to-escape-sandbox\"><\/iframe><\/span><\/p>\n<p><span class=\"embed-youtube\" style=\"text-align:center; display: block;\"><iframe loading=\"lazy\" class=\"youtube-player\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/Ihb02ptpYTc?version=3&#038;rel=1&#038;showsearch=0&#038;showinfo=1&#038;iv_load_policy=1&#038;fs=1&#038;hl=en-US&#038;autohide=2&#038;wmode=transparent\" allowfullscreen=\"true\" style=\"border:0;\" sandbox=\"allow-scripts allow-same-origin allow-popups allow-presentation allow-popups-to-escape-sandbox\"><\/iframe><\/span><\/p>\n<p><span class=\"embed-youtube\" style=\"text-align:center; display: block;\"><iframe loading=\"lazy\" class=\"youtube-player\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/9zNkbrNMJtI?version=3&#038;rel=1&#038;showsearch=0&#038;showinfo=1&#038;iv_load_policy=1&#038;fs=1&#038;hl=en-US&#038;autohide=2&#038;wmode=transparent\" allowfullscreen=\"true\" style=\"border:0;\" sandbox=\"allow-scripts allow-same-origin allow-popups allow-presentation allow-popups-to-escape-sandbox\"><\/iframe><\/span> <\/p>\n","protected":false},"excerpt":{"rendered":"Frances Hamilton Arnold\u30011956\u5e747\u670825\u65e5-\u3001\u7f8e\u56fd\u7684\u5408\u6210\u751f\u7269\u5b66\u5bb6\u30fb\u751f\u7269\u5316\u5b66\u5bb6\u30fb\u751f\u7269\u5de5\u7a0b\u5b66\u5bb6\u3002\u52a0\u5dde\u7406\u5de5\u5b66\u9662\u6559\u6388\u3002(\u7167\u7247\u6765\u81ea:Twitter) \u7531\u4e8e\u6307\u5411\u8fdb\u5316\u6cd5\u7684\u5f00\u53d1\u3001\u83b7\u5f97\u4e862018\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u3002 \u7ecf\u5386 1979 \u666e\u6797\u65af\u987f\u5927\u5b66 \u6bd5\u4e1a 1986 \u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821 \u535a\u58eb\u5b66\u4f4d 1986 \u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821 \u535a\u58eb\u540e\u7814\u7a76\u5458 200x \u52a0\u5dde\u7406\u5de5\u5b66\u9662 Dick and Barbara Dickinson Professor 2005 Gevo, Inc. \u5408\u4f19\u4eba \u83b7\u5956\u7ecf\u5386 2011 Charles Stark Draper prize 2013 National Medal of Technology and Innovation 2014 National Inventors Hall of Fame 2016 Millennium Technology Prize 2017 Raymond and Beverly Sackler Prize in Convergence Research 2017 Society of Women Engineers\u2019 2017 Achievement Award 2018 \u8bfa\u8d1d\u5c14\u5316\u5b66\u5956 \u7814\u7a76\u6982\u8981 \u5b9a\u5411\u8fdb\u5316\u6cd5\u7684\u5148\u9a71\u4e4b\u4e00\u3002\u7814\u7a76\u65b9\u5411\u4e3a\u4ee5\u86cb\u767d\u8d28\u5de5\u7a0b\u6280\u672f\u4e3a\u57fa\u7840\uff0c\u521b\u9020\u51fa\u7531\u4e8e\u81ea\u7136\u754c\u7684\u529f\u80fd\u6027\u86cb\u767d\u8d28\u30fb\u751f\u7269\u7cfb\u3002\u81ea\u7136\u754c\u4e2d\u5b58\u5728\u7684\u5929\u7136\u7ec6\u80de\u8272\u7d20\u9176\u5177\u6709\u6c27\u5316\u6709\u673a\u7269\u7684\u80fd\u529b\uff0c\u800c\u5f88\u65e9\u4ee5\u524d\u5c31\u5728\u5c1d\u8bd5\u5c06\u8fd9\u4e9b\u5929\u7136\u86cb\u767d\u9176\u7528\u5728\u9009\u62e9\u6027\u6c27\u5316\u53cd\u5e94\u7684\u5f00\u53d1\u4e2d\u3002\u53e6\u5916\uff0c\u5bf9\u4e8e\u78b3-\u78b3\u8fd9\u4e9b\u6bd4\u8f83\u96be\u6c27\u5316\u7684\u5e95\u7269\u6765\u8bf4\uff0c\u5929\u7136\u6c27\u5316\u9176\u7684\u6c27\u5316\u80fd\u529b\u8fd8\u4e0d\u591f\uff0c\u8fd9\u65b9\u9762\u7684\u7814\u7a76\u5e76\u6ca1\u6709\u5f97\u5230\u8fdb\u5c55\u3002 Arnold\u5229\u7528\u6307\u5411\u8fdb\u5316\u6cd5\uff0c\u5f00\u53d1\u51fa\u4e86\u66f4\u52a0\u7a33\u5b9a\uff0c\u5e76\u4e14\u50ac\u5316\u80fd\u529b\u66f4\u5f3a\u7684\u6c27\u5316\u9176[2]\u3001\u901a\u8fc7\u86cb\u767d\u8d28\u4e0a\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\u7684\u6539\u53d8\u6765\u6539\u53d8\u9176\u7684\u7ed3\u6784\uff0c\u4ece\u800c\u5bf9\u5176\u50ac\u5316\u80fd\u8fdb\u884c\u6539\u826f\uff0c\u5728\u8fd9\u65b9\u9762\uff0cArnold\u6559\u6388\u4f5c\u4e86\u5927\u91cf\u7684\u5de5\u4f5c\u4e0e\u8d21\u732e\u3002\u8fd1\u5e74\u6765\uff0c\u901a\u8fc7\u6539\u53d8\u7ec6\u80de\u8272\u7d20\u4e2d\u94c1\u4e2d\u4fe1\u91d1\u5c5e\u9644\u8fd1\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\uff0c\u521b\u9020\u51fa\u4e86\u50ac\u5316\u80fd\u529b\u5927\u5927\u4f18\u4e8e\u5929\u7136\u578b\u9176\u7684\u65b0\u578b\u9176[1-6]\u3002\u5176\u4e2d\u6bd4\u8f83\u8457\u540d\u7684\u662f\u5f00\u53d1\u51fa\u4e86\u6539\u826f\u540e\u7684P450\u9176\uff0c\u5e76\u4e14\u5c06\u5176\u8fd0\u7528\u5230\u4e86\u6709\u673a\u5316\u5408\u7269\u7684\u73af\u6c27\u5316\uff0c\u78b3-\u7845\u952e\u7684\u6784\u7b51\u4e2d[5]\uff0c\u5907\u53d7\u77a9\u76ee\u3002 Arnold\u7814\u7a76\u5ba4\u4e3b\u9875 \u8865\u5145 \u4e0e\u5176\u4ed6\u9176\u76f8\u6bd4\uff0c\u4f5c\u4e3a\u6c27\u5316\u9176\u7684\u7ec6\u80de\u8272\u7d20\u57fa\u672c\u4e0a\u4e0d\u7a33\u5b9a\uff0c\u5e76\u4e14\u5176\u50ac\u5316\u80fd\u529b\u901a\u5e38\u8f83\u4f4e\u3002\u56e0\u6b64\uff0c\u5b58\u5728\u50ac\u5316\u5faa\u73af\u6570\uff08TON\uff09\u53d7\u9650\u4e14\u4e0d\u9002\u5408\u6709\u673a\u5316\u5b66\u53cd\u5e94\u7684\u95ee\u9898\u3002Arnold\u6559\u6388\u8fd0\u7528\u6307\u5411\u6027\u8fdb\u5316\u6cd5\u4f7f\u5f97\u539f\u672c\u57fa\u672c\u6ca1\u6709\u6c27\u5316\u6d3b\u6027\u7684\u9176\uff0c\u901a\u8fc7\u6539\u826f\u540e\uff0c\u4ea7\u751f\u4e86TON=1000\uff0c\u5e76\u4e14\u80fd\u591f\u7a33\u5b9a\u5b58\u5728\u7684\u6c27\u5316\u9176\u3002 \u5230\u76ee\u524d\u4e3a\u6b62\u5df2\u77e5\u6709200.000\u79cd\u4ee5\u4e0a\u7684\u7ec6\u80de\u8272\u7d20P450\u3001\u6309\u7167\u6765\u6e90\u4e3b\u8981\u5206\u4e3a4\u4e2a\u5927\u7c7b\uff08\u7ec6\u83cc\u884d\u751f\u7684\uff0c\u7ebf\u7c92\u4f53\u884d\u751f\u7684\uff0c\u5fae\u7c92\u4f53\u884d\u751f\u7684\uff0c\u81ea\u7ed9\u578b\uff09\u3002\u5176\u4e2d\uff0c\u9664\u4e86\u81ea\u7ed9\u578b\u4ee5\u5916\uff0c\u8981\u8fdb\u884c\u7535\u5b50\u8f6c\u79fb\u7684\u8bdd\uff0c\u5176\u4ed6\u9176\u6216\u8f85\u9176\u7684\u53c2\u4e0e\u662f\u5fc5\u4e0d\u53ef\u5c11\u3001\u56e0\u6b64\u4e5f\u9650\u5236\u4e86\u8fd9\u4e9b\u9176\u7684\u5229\u7528\u3002\u56e0\u6b64\uff0cArnold\u6559\u6388\u57fa\u672c\u4e0a\u90fd\u662f\u8fd0\u7528\u7684\u6c27\u5316\u8fd8\u539f\u4e00\u4f53\u578b\u7684BM3\u7b49\u81ea\u7ed9\u578b\u7ec6\u80de\u8272\u7d20P450\u3002 \u76f8\u5173\u6587\u732e Arnold, F. H. Angew. Chem. Int. Ed. 2018, 57, 4143. DOI:10.1002\/anie.201708408. Giver, L.; Gershenson, A.; Freskgard, P.-O.; Arnold, F. H. Proc. Natl. Acad. Sci.1998, 95, 12809. DOI:10.1073\/pnas.95.22.12809. \u00a0Coelho, P. S.; Brustad, E. 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