{"id":20797,"date":"2018-11-02T22:45:55","date_gmt":"2018-11-02T14:45:55","guid":{"rendered":"\/\/www.gsbet888.com\/?p=20797"},"modified":"2019-08-02T18:51:07","modified_gmt":"2019-08-02T10:51:07","slug":"j-am-chem-soc-%e9%80%9a%e8%bf%87%e6%89%8b%e6%80%a7%e8%b7%af%e6%98%93%e6%96%af%e9%85%b8%e5%82%ac%e5%8c%96%e5%89%82%e7%bb%8f%e7%94%b13%e5%85%83%e7%8e%af%e5%90%88%e6%88%904%e5%85%83%e7%8e%af","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2018\/11\/j-am-chem-soc-%e9%80%9a%e8%bf%87%e6%89%8b%e6%80%a7%e8%b7%af%e6%98%93%e6%96%af%e9%85%b8%e5%82%ac%e5%8c%96%e5%89%82%e7%bb%8f%e7%94%b13%e5%85%83%e7%8e%af%e5%90%88%e6%88%904%e5%85%83%e7%8e%af.html","title":{"rendered":"J. Am. Chem. Soc. \u901a\u8fc7\u624b\u6027\u8def\u6613\u65af\u9178\u50ac\u5316\u5242\u201c\u7ecf\u75313\u5143\u73af\u5408\u62104\u5143\u73af\u201d"},"content":{"rendered":"<p class=\"a\"><strong>\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u4f7f\u7528\u624b\u6027\u8def\u6613\u65af\u9178\u50ac\u5316\u5242\u7684\u65b0\u578b\u73af\u4e01\u916e\u4e0d\u5bf9\u79f0\u5408\u6210\u65b9\u6cd5\u3002\u5b9e\u73b0\u4e86\u9ad8\u975e\u5bf9\u6620\u4f53\/\u5bf9\u6620\u4f53\u9009\u62e9\u7684\u591a\u7c73\u8bfa\u578b\u7684\u73af\u4e19\u70f7\u5316\u2192\u534a\u9891\u54ea\u9187\u91cd\u6392\u5f62\u6210\u624b\u6027\u591a\u53d6\u4ee3\u73af\u4e01\u916e\u3002<\/strong><\/p>\n<h4 class=\"1\">\u50ac\u5316\u4e0d\u5bf9\u79f0\u73af\u4e01\u916e\u5408\u6210<\/h4>\n<p class=\"a\">\u73af\u4e01\u70f7\u884d\u751f\u7269\u662f\u836f\u7269\u548c\u5929\u7136\u4ea7\u7269\u4e2d\u5e38\u89c1\u7684\u9aa8\u67b6\u3002\u7279\u522b\u662f\uff0c\u73af\u4e01\u916e\u662f\u4e00\u79cd\u975e\u5e38\u6709\u7528\u7684\u7ed3\u6784\u5355\u5143\uff0c\u53ef\u4ee5\u901a\u8fc7\u5229\u7528\u73af\u5e94\u53d8\u7684\u5f00\u73af\u548c\u73af\u81a8\u80c0\u53cd\u5e94\u5408\u6210\u4e3a\u5404\u79cd\u5316\u5408\u7269\uff0c\u6700\u8fd1\u5df2\u7ecf\u6709\u51e0\u7bc7\u9488\u5bf9\u8be5\u9aa8\u67b6\u7684\u50ac\u5316\u4e0d\u5bf9\u79f0\u5408\u6210\u65b9\u6cd5\u7684\u62a5\u9053\u3002\u4f8b\u5982\u3001\u6700\u8fd1<a href=\"\/\/www.gsbet888.com\/chemists\/2015\/06\/vy-m-dong.html\"><span lang=\"EN-US\">Dong<\/span><\/a>\u7b49\u4eba\u62a5\u9053\u4e86\u4f7f\u7528\u94b4\u50ac\u5316\u7684\u5206\u5b50\u5185\u4e0d\u5bf9\u79f0\u52a0\u6c22\u9170\u5316\u5408\u6210\u73af\u4e01\u916e\uff08\u56fe1A\uff09<span lang=\"EN-US\"><sup>[1]<\/sup><\/span>\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u901a\u8fc7\u50ac\u5316\u534a\u73af\u9187\u91cd\u6392\u73af\u4e19\u9187\u884d\u751f\u7269\u5408\u6210\u73af\u4e01\u916e\u7684\u65b9\u6cd5\u4e5f\u5df2\u7ecf\u88ab\u62a5\u9053\u3002Alexakis\u7b49\u4eba\u5728\u624b\u6027\u78f7\u9178\uff08CPA\uff09\u50ac\u5316\u5242\u5b58\u5728\u4e0b\u901a\u8fc7\u94fe\u70ef\u57fa\u73af\u4e19\u9187\u7684\u534a\u5fae\u91cf\u9187\u91cd\u6392\u5f00\u53d1\u51fa\u4e86\u03b2-\u5364\u4ee3\u87ba\u73af\u4e01\u916e\u5408\u6210\u6cd5\uff08\u56fe1B\uff09<span lang=\"EN-US\"><sup>[2]<\/sup><\/span>\u3002\u4f5c\u4e3a\u4f7f\u7528\u4e0d\u5bf9\u79f0\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u5242\u7684\u5b9e\u4f8b\uff0cToste\u4e0eTrost\u7b49\u4eba\u5206\u522b\u62a5\u9053\u4e86\u4f7f\u7528\u91d1\u6216\u94af\u4f5c\u4e3a\u50ac\u5316\u5242\u7684\u94fe\u70ef\u57fa\u73af\u4e19\u9187\u7684\u534a\u9891\u54ea\u9187\u91cd\u6392<span lang=\"EN-US\">(\u56fe<\/span><span lang=\"EN-US\">1C)<sup>[3]<\/sup><\/span>\u3002\u6b64\u5916\uff0c\u8fd8\u62a5\u9053\u4e86\u901a\u8fc7\u9178\uff0c\u78b1\u548c\u70ed\u5c06\u534a\u4e73\u7cd6\u9187\u91cd\u6392\u6210\u7fb0\u57fa\u90e8\u5206\u5408\u6210\u73af\u4e01\u916e\uff0c\u4f46\u6ca1\u6709\u5bf9\u6620\u9009\u62e9\u6027\u5b9e\u4f8b\uff08\u56fe1D\uff09<span lang=\"EN-US\"><sup>[4]<\/sup><\/span>\u3002<\/p>\n<p class=\"a\">\u3000\u6700\u8fd1\uff0cRyu\u6559\u6388\u53ca\u5176\u540c\u4e8b\u4f7f\u7528\u624b\u6027\u6c27\u6742\u787c\u6742\u73af\u9393\u79bb\u5b50\uff08COBI\uff09\u4f5c\u4e3a\u8def\u6613\u65af\u9178\u50ac\u5316\u5242\uff0c\u901a\u8fc7\u03b1-\u7532\u7845\u70f7\u6c27\u57fa\u4e19\u70ef\u919b\u548c\u91cd\u6c2e\u916f\u7684\u53cd\u5e94\u8fdb\u884c\u8fde\u7eed\u73af\u4e19\u70f7\u5316\/\u534a\u9891\u54ea\u9187\u91cd\u6392\uff0c \u6210\u529f\u5730\u5408\u6210\u4e86\u5177\u6709\u7acb\u4f53\/\u5bf9\u6620\u9009\u62e9\u6027\u90bb\u8fd1\u624b\u6027\u4e2d\u5fc3\u7684\u73af\u4e01\u916e<span lang=\"EN-US\">(\u56fe<\/span><span lang=\"EN-US\">1E)<\/span>\uff0c\u4eca\u5929\u5c0f\u7f16\u5c31\u5e26\u5927\u5bb6\u6765\u770b\u4e00\u4e0b\u8fd9\u4e2a\u53cd\u5e94\u3002<\/p>\n<div id=\"attachment_60681\" class=\"wp-caption aligncenter\">\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-20799 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/10\/2018-10-05_00-09-40-680x289.png\" alt=\"\" width=\"680\" height=\"289\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/10\/2018-10-05_00-09-40-680x289.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/10\/2018-10-05_00-09-40-300x128.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/10\/2018-10-05_00-09-40-768x326.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/10\/2018-10-05_00-09-40.png 880w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/p>\n<p class=\"wp-caption-text\">\u56fe1.\u50ac\u5316\u4e0d\u5bf9\u79f0\u73af\u4e01\u916e\u7684\u5408\u6210<\/p>\n<\/div>\n<blockquote><p><strong>\u201c<\/strong><strong>Asymmetric Synthesis of Cyclobutanone via Lewis Acid Catalyzed Tandem Cyclopropanation\/Semipinacol Rearrangement<\/strong><strong>\u201d<\/strong><\/p>\n<p>Shim, S. Y.; Choi, Y.; Ryu, D. H. <em>J. Am. Chem. Soc.<\/em><strong>2018<\/strong>, <em>140<\/em>, 11184\u221211188.\u3000DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/jacs.8b06835\">10.1021\/jacs.8b06835<\/a><\/p><\/blockquote>\n<h4>\u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd<\/h4>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-20800\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/10\/2018-10-05_00-11-19.png\" alt=\"\" width=\"200\" height=\"279\" \/><\/p>\n<p>\u7814\u7a76\u8005\uff1a<a href=\"http:\/\/chemistry.skku.edu\/dhryu\/index.html\"><strong>Do Hyun Ryu<\/strong><\/a><\/p>\n<p>\u7ecf\u5386\uff1a<\/p>\n<p>1993-1997 Ph. D., Department of Chemistry, KAIST (Prof. Sung Ho Kang)<br \/>\n1997-2001 Associate Research Scientist, SK Chemicals, Life Science Institute<br \/>\n2000-2002 Postdoc Fellow, Harvard Medical School (Prof. Robert R. Rando)<br \/>\n2002-2005 Postdoc Fellow, Harvard University\u00a0(Prof. <a href=\"https:\/\/www.chem-station.com\/chemist-db\/archives\/2008\/09\/ejcorey.php\">E. J. Corey<\/a>)<br \/>\n2005-2009Assistant Professor, Sungkyunkwan University<br \/>\n2009-2015Associate Professor, Sungkyunkwan University<br \/>\n2015- Professor, Sungkyunkwan University<\/p>\n<p>\u7814\u7a76\u5185\u5bb9\uff1a\u50ac\u5316\u5242\u5f00\u53d1\u3001\u4e0d\u5bf9\u79f0\u53cd\u5e94\u5f00\u53d1\u3001\u5168\u5408\u6210\u7814\u7a76\u3001\u5316\u5b66\u751f\u7269\u5b66<\/p>\n<h4 class=\"1\">\u8bba\u6587\u6982\u8981<\/h4>\n<p class=\"a\">\u4f5c\u8005\u5728\u5148\u524d\u7684\u7814\u7a76\u4e2d\u62a5\u9053\u4e86\u4f7f\u7528COBI\u50ac\u5316\u5242\u5bf9\u4e0d\u9971\u548c\u919b\u548c\u91cd\u6c2e\u916f\u8fdb\u884c\u4e0d\u5bf9\u79f0\u73af\u4e19\u70f7\u5316<sup><span lang=\"EN-US\">[5]<\/span><\/sup>\u3002\u5728\u8fd9\u6b21\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u4f7f\u7528\u03b1-\u7845\u6c27\u57fa\u4e19\u70ef\u919b\uff0c\u5e76\u4e14\u5229\u7528\u540c\u6837\u7684\u624b\u6cd5\u5982\u679c\u80fd\u5148\u751f\u62101-\u7532\u9170\u57fa-1-\u7532\u7845\u70f7\u6c27\u57fa\u73af\u4e19\u70f7<strong>1<\/strong>\u3001\u7136\u540e\u53d1\u751f\u534a\u9891\u54ea\u9187\u91cd\u6392\uff0c\u6700\u540e\u5f62\u6210\u73af\u4e01\u916e<strong>2<\/strong>\u3002\u53cd\u5e94\u5b9e\u9645\u4e0a\u6309\u9884\u671f\u8fdb\u884c\uff0c\u5e76\u4e14\u53ef\u4ee5\u5e94\u7528\u4e8e\u5404\u79cd\u91cd\u6c2e\u916f\uff08\u56fe2A\uff09\u3002\u5373\u4f7f\u4f7f\u7528\u5177\u6709\u5364\u7d20\u6216\u6c30\u57fa\u7b49\u5b98\u80fd\u56e2\u7684\u82b3\u57fa\uff0c\u70f7\u57fa\u6216\u5177\u6709\u5927\u4f53\u79ef\u916f\u7684\u91cd\u6c2e\u916f\uff0c\u53cd\u5e94\u4e5f\u4ee5\u9ad8\u6536\u7387\uff0c\u9ad8\u975e\u5bf9\u6620\u4f53\/\u5bf9\u6620\u4f53\u9009\u62e9\u6027\u8fdb\u884c\u3002<\/p>\n<p class=\"a\">\u3000\u6839\u636e\u5404\u79cd\u5bf9\u7167\u5b9e\u9a8c\u7684\u7ed3\u679c\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u901a\u8fc7\u8fc7\u6e21\u6001<strong>4<\/strong>\u4ea7\u751f\u73af\u4e01\u916e<strong>2<\/strong>\u7684\u673a\u7406<span lang=\"EN-US\">(\u56fe<\/span><span lang=\"EN-US\">2B)<\/span>\u3002\u9996\u5148\uff0cCOBI\u50ac\u5316\u5242\u4e0e\u4e0d\u9971\u548c\u919b\u7684\u7fb0\u57fa\u90e8\u5206\u914d\u4f4d\uff0c\u91cd\u6c2e\u916f\u76841,4-\u52a0\u6210\u5e73\u9762\u9009\u62e9\u6027\u5730\u53d1\u751f\uff0c\u5e76\u4e14\u901a\u8fc7\u968f\u540e\u7684\u73af\u4e19\u70f7\u5316\u5f62\u6210<strong>4<\/strong>\u3002\u6b64\u5916\uff0c\u5bf9\u7531COBI\u50ac\u5316\u5242\u6d3b\u5316\u7684\u7fb0\u57fa\u90e8\u5206\u53d1\u751f\u534a\u9891\u54ea\u9187\u91cd\u6392\uff0c\u5e76\u4e14\u901a\u8fc7\u7532\u7845\u70f7\u57fa\u8f6c\u79fb\u83b7\u5f97\u76ee\u6807\u73af\u4e01\u916e<strong>2<\/strong>\u3002<\/p>\n<p class=\"a\">\u3000\u56e0\u6b64\uff0c\u8fd9\u7bc7\u6587\u7ae0\u62a5\u9053\u4e86\u4e00\u79cd\u5408\u6210\u5177\u6709\u8fde\u7eed\u4e0d\u5bf9\u79f0\u4e2d\u5fc3\u7684\u73af\u4e01\u916e\u7684\u65b0\u65b9\u6cd5\u3002 \u5c06\u6765\uff0c\u53ef\u4ee5\u9884\u671f\u8be5\u65b9\u6cd5\u53ef\u7528\u4f5c\u5404\u79cd\u6709\u7528\u590d\u6742\u5316\u5408\u7269\u4e2d\u95f4\u4f53\u5408\u6210\u3002<\/p>\n<div id=\"attachment_60683\" class=\"wp-caption aligncenter\">\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-20801 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/10\/2018-10-05_00-12-51-680x352.png\" alt=\"\" width=\"680\" height=\"352\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/10\/2018-10-05_00-12-51-680x352.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/10\/2018-10-05_00-12-51-300x155.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/10\/2018-10-05_00-12-51-768x397.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2018\/10\/2018-10-05_00-12-51.png 988w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/p>\n<p class=\"wp-caption-text\">\u56fe2. (A)\u5e95\u7269\u9002\u7528\u8303\u56f4\u3001(B)\u8fc7\u6e21\u6001\u6a21\u578b<\/p>\n<\/div>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<ol>\n<li>Kim, D. K.; Riedel, J.; Kim, R. S.; Dong, V. M. <em>J.<\/em>\u00a0<em>Am. Chem. Soc<\/em>. <strong>2017<\/strong>, <em>139<\/em>, 10208. DOI:<a href=\"http:\/\/dx.doi.org\/10.1021\/jacs.7b05327\">10.1021\/jacs.7b05327<\/a><\/li>\n<li>Romanov-Michailidis,F.;Gue\u0144e\u00e9,L.;Alexakis, <em>Angew. Chem., Int. Ed<\/em>. <strong>2013<\/strong>, <em>52<\/em>, 9266. DOI: <a href=\"http:\/\/dx.doi.org\/10.1002\/anie.201303527\">10.1002\/anie.201303527 <\/a><\/li>\n<li>[a]Kleinbeck, F.; Toste, F. D. <em>J.<\/em>\u00a0<em>Am. Chem. Soc<\/em>. <strong>2009<\/strong>, <em>131<\/em>, 9178. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/ja904055z\">10.1021\/ja904055z<\/a>[b] Trost, B. M.; Yasukata, T.<em>J. Am. Chem. Soc<\/em>.<strong>2001<\/strong>, <em>123<\/em>, 7162. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/ja010504c\">10.1021\/ja010504c<\/a><\/li>\n<li>[a]Paukstelis, J. V.; Kao, J. L.<em> J<\/em>.\u00a0<em>Am. Chem. Soc<\/em>. <strong>1972<\/strong>, <em>94<\/em>, 4783. <a href=\"http:\/\/dx.doi.org\/10.1021\/ja00768a086\">10.1021\/ja00768a086<\/a>[b] Appendino, G.; Bertolino, A.; Minassi, A.; Annunziata, R.; Szallasi, A.; de Petrocellis, L.; Di Marzo, V. Eur.<em>J. Org. Chem<\/em>. <strong>2004<\/strong>, <em>2004<\/em>, 3413. DOI: <a href=\"http:\/\/dx.doi.org\/10.1002\/ejoc.200400122\">10.1002\/ejoc.200400122 <\/a><\/li>\n<li>Gao, L.; Hwang, G.-S.; Ryu, D. H. <em>J.<\/em>\u00a0<em>Am. Chem. Soc<\/em>. <strong>2011<\/strong>,<em>133<\/em>, 20708. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/ja209270e\">10.1021\/ja209270e<\/a><\/li>\n<\/ol>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u4f7f\u7528\u624b\u6027\u8def\u6613\u65af\u9178\u50ac\u5316\u5242\u7684\u65b0\u578b\u73af\u4e01\u916e\u4e0d\u5bf9\u79f0\u5408\u6210\u65b9\u6cd5\u3002\u5b9e\u73b0\u4e86\u9ad8\u975e\u5bf9\u6620\u4f53\/\u5bf9\u6620\u4f53\u9009\u62e9\u7684\u591a\u7c73\u8bfa\u578b\u7684\u73af\u4e19\u70f7\u5316\u2192\u534a\u9891\u54ea\u9187\u91cd\u6392\u5f62\u6210\u624b\u6027\u591a\u53d6\u4ee3\u73af\u4e01\u916e\u3002 \u50ac\u5316\u4e0d\u5bf9\u79f0\u73af\u4e01\u916e\u5408\u6210 \u73af\u4e01\u70f7\u884d\u751f\u7269\u662f\u836f\u7269\u548c\u5929\u7136\u4ea7\u7269\u4e2d\u5e38\u89c1\u7684\u9aa8\u67b6\u3002\u7279\u522b\u662f\uff0c\u73af\u4e01\u916e\u662f\u4e00\u79cd\u975e\u5e38\u6709\u7528\u7684\u7ed3\u6784\u5355\u5143\uff0c\u53ef\u4ee5\u901a\u8fc7\u5229\u7528\u73af\u5e94\u53d8\u7684\u5f00\u73af\u548c\u73af\u81a8\u80c0\u53cd\u5e94\u5408\u6210\u4e3a\u5404\u79cd\u5316\u5408\u7269\uff0c\u6700\u8fd1\u5df2\u7ecf\u6709\u51e0\u7bc7\u9488\u5bf9\u8be5\u9aa8\u67b6\u7684\u50ac\u5316\u4e0d\u5bf9\u79f0\u5408\u6210\u65b9\u6cd5\u7684\u62a5\u9053\u3002\u4f8b\u5982\u3001\u6700\u8fd1Dong\u7b49\u4eba\u62a5\u9053\u4e86\u4f7f\u7528\u94b4\u50ac\u5316\u7684\u5206\u5b50\u5185\u4e0d\u5bf9\u79f0\u52a0\u6c22\u9170\u5316\u5408\u6210\u73af\u4e01\u916e\uff08\u56fe1A\uff09[1]\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u901a\u8fc7\u50ac\u5316\u534a\u73af\u9187\u91cd\u6392\u73af\u4e19\u9187\u884d\u751f\u7269\u5408\u6210\u73af\u4e01\u916e\u7684\u65b9\u6cd5\u4e5f\u5df2\u7ecf\u88ab\u62a5\u9053\u3002Alexakis\u7b49\u4eba\u5728\u624b\u6027\u78f7\u9178\uff08CPA\uff09\u50ac\u5316\u5242\u5b58\u5728\u4e0b\u901a\u8fc7\u94fe\u70ef\u57fa\u73af\u4e19\u9187\u7684\u534a\u5fae\u91cf\u9187\u91cd\u6392\u5f00\u53d1\u51fa\u4e86\u03b2-\u5364\u4ee3\u87ba\u73af\u4e01\u916e\u5408\u6210\u6cd5\uff08\u56fe1B\uff09[2]\u3002\u4f5c\u4e3a\u4f7f\u7528\u4e0d\u5bf9\u79f0\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u5242\u7684\u5b9e\u4f8b\uff0cToste\u4e0eTrost\u7b49\u4eba\u5206\u522b\u62a5\u9053\u4e86\u4f7f\u7528\u91d1\u6216\u94af\u4f5c\u4e3a\u50ac\u5316\u5242\u7684\u94fe\u70ef\u57fa\u73af\u4e19\u9187\u7684\u534a\u9891\u54ea\u9187\u91cd\u6392(\u56fe1C)[3]\u3002\u6b64\u5916\uff0c\u8fd8\u62a5\u9053\u4e86\u901a\u8fc7\u9178\uff0c\u78b1\u548c\u70ed\u5c06\u534a\u4e73\u7cd6\u9187\u91cd\u6392\u6210\u7fb0\u57fa\u90e8\u5206\u5408\u6210\u73af\u4e01\u916e\uff0c\u4f46\u6ca1\u6709\u5bf9\u6620\u9009\u62e9\u6027\u5b9e\u4f8b\uff08\u56fe1D\uff09[4]\u3002 \u3000\u6700\u8fd1\uff0cRyu\u6559\u6388\u53ca\u5176\u540c\u4e8b\u4f7f\u7528\u624b\u6027\u6c27\u6742\u787c\u6742\u73af\u9393\u79bb\u5b50\uff08COBI\uff09\u4f5c\u4e3a\u8def\u6613\u65af\u9178\u50ac\u5316\u5242\uff0c\u901a\u8fc7\u03b1-\u7532\u7845\u70f7\u6c27\u57fa\u4e19\u70ef\u919b\u548c\u91cd\u6c2e\u916f\u7684\u53cd\u5e94\u8fdb\u884c\u8fde\u7eed\u73af\u4e19\u70f7\u5316\/\u534a\u9891\u54ea\u9187\u91cd\u6392\uff0c \u6210\u529f\u5730\u5408\u6210\u4e86\u5177\u6709\u7acb\u4f53\/\u5bf9\u6620\u9009\u62e9\u6027\u90bb\u8fd1\u624b\u6027\u4e2d\u5fc3\u7684\u73af\u4e01\u916e(\u56fe1E)\uff0c\u4eca\u5929\u5c0f\u7f16\u5c31\u5e26\u5927\u5bb6\u6765\u770b\u4e00\u4e0b\u8fd9\u4e2a\u53cd\u5e94\u3002 \u56fe1.\u50ac\u5316\u4e0d\u5bf9\u79f0\u73af\u4e01\u916e\u7684\u5408\u6210 \u201cAsymmetric Synthesis of Cyclobutanone via Lewis Acid Catalyzed Tandem Cyclopropanation\/Semipinacol Rearrangement\u201d Shim, S. Y.; Choi, Y.; Ryu, D. H. J. Am. Chem. Soc.2018, 140, 11184\u221211188.\u3000DOI: 10.1021\/jacs.8b06835 \u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd \u7814\u7a76\u8005\uff1aDo Hyun Ryu \u7ecf\u5386\uff1a 1993-1997 Ph. D., Department of Chemistry, KAIST (Prof. Sung Ho Kang) 1997-2001 Associate Research Scientist, SK Chemicals, Life Science Institute 2000-2002 Postdoc Fellow, Harvard Medical School (Prof. Robert R. Rando) 2002-2005 Postdoc Fellow, Harvard University\u00a0(Prof. E. J. Corey) 2005-2009Assistant Professor, Sungkyunkwan University 2009-2015Associate Professor, Sungkyunkwan University 2015- Professor, Sungkyunkwan University \u7814\u7a76\u5185\u5bb9\uff1a\u50ac\u5316\u5242\u5f00\u53d1\u3001\u4e0d\u5bf9\u79f0\u53cd\u5e94\u5f00\u53d1\u3001\u5168\u5408\u6210\u7814\u7a76\u3001\u5316\u5b66\u751f\u7269\u5b66 \u8bba\u6587\u6982\u8981 \u4f5c\u8005\u5728\u5148\u524d\u7684\u7814\u7a76\u4e2d\u62a5\u9053\u4e86\u4f7f\u7528COBI\u50ac\u5316\u5242\u5bf9\u4e0d\u9971\u548c\u919b\u548c\u91cd\u6c2e\u916f\u8fdb\u884c\u4e0d\u5bf9\u79f0\u73af\u4e19\u70f7\u5316[5]\u3002\u5728\u8fd9\u6b21\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u4f7f\u7528\u03b1-\u7845\u6c27\u57fa\u4e19\u70ef\u919b\uff0c\u5e76\u4e14\u5229\u7528\u540c\u6837\u7684\u624b\u6cd5\u5982\u679c\u80fd\u5148\u751f\u62101-\u7532\u9170\u57fa-1-\u7532\u7845\u70f7\u6c27\u57fa\u73af\u4e19\u70f71\u3001\u7136\u540e\u53d1\u751f\u534a\u9891\u54ea\u9187\u91cd\u6392\uff0c\u6700\u540e\u5f62\u6210\u73af\u4e01\u916e2\u3002\u53cd\u5e94\u5b9e\u9645\u4e0a\u6309\u9884\u671f\u8fdb\u884c\uff0c\u5e76\u4e14\u53ef\u4ee5\u5e94\u7528\u4e8e\u5404\u79cd\u91cd\u6c2e\u916f\uff08\u56fe2A\uff09\u3002\u5373\u4f7f\u4f7f\u7528\u5177\u6709\u5364\u7d20\u6216\u6c30\u57fa\u7b49\u5b98\u80fd\u56e2\u7684\u82b3\u57fa\uff0c\u70f7\u57fa\u6216\u5177\u6709\u5927\u4f53\u79ef\u916f\u7684\u91cd\u6c2e\u916f\uff0c\u53cd\u5e94\u4e5f\u4ee5\u9ad8\u6536\u7387\uff0c\u9ad8\u975e\u5bf9\u6620\u4f53\/\u5bf9\u6620\u4f53\u9009\u62e9\u6027\u8fdb\u884c\u3002 \u3000\u6839\u636e\u5404\u79cd\u5bf9\u7167\u5b9e\u9a8c\u7684\u7ed3\u679c\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u901a\u8fc7\u8fc7\u6e21\u60014\u4ea7\u751f\u73af\u4e01\u916e2\u7684\u673a\u7406(\u56fe2B)\u3002\u9996\u5148\uff0cCOBI\u50ac\u5316\u5242\u4e0e\u4e0d\u9971\u548c\u919b\u7684\u7fb0\u57fa\u90e8\u5206\u914d\u4f4d\uff0c\u91cd\u6c2e\u916f\u76841,4-\u52a0\u6210\u5e73\u9762\u9009\u62e9\u6027\u5730\u53d1\u751f\uff0c\u5e76\u4e14\u901a\u8fc7\u968f\u540e\u7684\u73af\u4e19\u70f7\u5316\u5f62\u62104\u3002\u6b64\u5916\uff0c\u5bf9\u7531COBI\u50ac\u5316\u5242\u6d3b\u5316\u7684\u7fb0\u57fa\u90e8\u5206\u53d1\u751f\u534a\u9891\u54ea\u9187\u91cd\u6392\uff0c\u5e76\u4e14\u901a\u8fc7\u7532\u7845\u70f7\u57fa\u8f6c\u79fb\u83b7\u5f97\u76ee\u6807\u73af\u4e01\u916e2\u3002 \u3000\u56e0\u6b64\uff0c\u8fd9\u7bc7\u6587\u7ae0\u62a5\u9053\u4e86\u4e00\u79cd\u5408\u6210\u5177\u6709\u8fde\u7eed\u4e0d\u5bf9\u79f0\u4e2d\u5fc3\u7684\u73af\u4e01\u916e\u7684\u65b0\u65b9\u6cd5\u3002 \u5c06\u6765\uff0c\u53ef\u4ee5\u9884\u671f\u8be5\u65b9\u6cd5\u53ef\u7528\u4f5c\u5404\u79cd\u6709\u7528\u590d\u6742\u5316\u5408\u7269\u4e2d\u95f4\u4f53\u5408\u6210\u3002 \u56fe2. 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