{"id":2118,"date":"2014-07-10T01:49:40","date_gmt":"2014-07-09T17:49:40","guid":{"rendered":"\/\/www.gsbet888.com\/?p=2118"},"modified":"2019-08-02T18:56:32","modified_gmt":"2019-08-02T10:56:32","slug":"%e5%a4%8f%e7%9a%ae%e7%bd%97%e5%8f%8d%e5%ba%94-shapiro-reaction","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/reactions\/%e9%87%8d%e6%8e%92%e5%8f%8d%e5%ba%94\/2014\/07\/%e5%a4%8f%e7%9a%ae%e7%bd%97%e5%8f%8d%e5%ba%94-shapiro-reaction.html","title":{"rendered":"\u590f\u76ae\u7f57\u53cd\u5e94 Shapiro Reaction"},"content":{"rendered":"<ul>\n<li>\u6982\u8981<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>\u916e\u53d8\u6210\u5bf9\u7532\u82ef\u78fa\u9170\u8159\u4e4b\u540e\uff0c\u52a0\u5165\u4e24\u6469\u5c14\u5f53\u91cf\u7684\u4e01\u57fa\u9502\uff0c\u4f34\u968f\u7740\u82ef\u78fa\u9170\u57fa\u548c\u6c2e\u6c14\u7684\u8131\u53bb\uff0c\u5f97\u5230\u70ef\u57fa\u9502\u3002\u5b83\u63a5\u4e0b\u6765\u548c\u5176\u4ed6\u4eb2\u7535\u8bd5\u5242\u53cd\u5e94\u5f97\u5230\u4e09\u7f6e\u6362\u7684\u70ef\u3002<br \/>\n\u4e0d\u5bf9\u79f0\u916e\u7684\u60c5\u51b5\uff0c\u53cc\u952e\u5728\u53d6\u4ee3\u57fa\u8f83\u5c11\u7684\u4e00\u4fa7\u751f\u6210<strong><span style=\"color: #ff6600\">\uff08\u901f\u5ea6\u8ad6\u7684\u5f71\u54cd\uff09<\/span><\/strong>\u3002\u56e0\u6b64\uff0c\u80fd\u591f\u4f4d\u7f6e\u9009\u62e9\u6027\u7684\u751f\u6210\u78b3\u78b3\u53cc\u952e\u662f\u8fd9\u4e00\u53cd\u5e94\u7684\u4e00\u5927\u7279\u5f81\u3002<\/p>\n<p>\u7528NaOMe\u505a\u78b1\u7684\u60c5\u51b5\uff0c\u7279\u79f0\u4e3a<strong><span style=\"color: #ff6600\">Bamford-Stevens\u53cd\u5e94<\/span><\/strong>\uff0c\u90e8\u5206\u53cd\u5e94\u673a\u7406\u6709\u4e9b\u533a\u522b\u3002\u5b83\u5728\u70ed\u529b\u5b66\u4e0a\u7684\u7279\u5f81\u5c31\u662f\u751f\u6210\u4e86\u70ef\u9187\u3002<\/p>\n<ul>\n<li>\u57fa\u672c\u6587\u732e<\/li>\n<\/ul>\n<p>\u30fbBamford, W. R.; Stevens, T. S. <em>J. Chem. Soc.<\/em> <strong><span style=\"color: #ff6600\">1952<\/span><\/strong>, 4735.<br \/>\n\u30fbShapiro, R. H.; Heath, M. J. <em>J. Am. Chem. Soc.<\/em> <strong><span style=\"color: #ff6600\">1967<\/span><\/strong>, <em>89<\/em>, 5734. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/ja00998a601\"><span style=\"color: #336600\">10.1021\/ja00998a601<\/span><\/a><br \/>\n\u30fbShapiro, R.H.; Lipton, M.F.; Kolonko, K.J.; Buswell, R.L.; Capuano, L.A. <em>Tetrahedron Lett<\/em>, <strong><span style=\"color: #ff6600\">1975<\/span><\/strong>, <em>22<\/em>, 1811. doi:<a href=\"http:\/\/dx.doi.org\/10.1016\/S0040-4039%2800%2975263-4\"><span style=\"color: #336600\">10.1016\/S0040-4039(00)75263-4<\/span><\/a><br \/>\n\u30fbShapiro, R. H., <em>Org. React.<\/em> <strong><span style=\"color: #ff6600\">1976<\/span><\/strong>, <em>23<\/em>, 405.<br \/>\n\u30fbAdlington, R. M.; Barrett, A. G. M. <em>Acc. Chem. Res.<\/em> <strong><span style=\"color: #ff6600\">1983<\/span><\/strong>, <em>16<\/em>, 55. DOI: <a href=\"http:\/\/dx.doi.org\/10.1021\/ar00086a004\"><span style=\"color: #336600\">10.1021\/ar00086a004<\/span><\/a><br \/>\n\u30fbChamberin, A. R.; Bloom, S. H. <em>Org. React.<\/em> <strong><span style=\"color: #ff6600\">1990<\/span><\/strong>, <em>39<\/em>, 1.<br \/>\n\u30fbMaruka, K.; Yamamoto, H. <em>Comp. Org. Syn.<\/em> <strong><span style=\"color: #ff6600\">1991<\/span><\/strong>, <em>6<\/em>, 776.<br \/>\n\u30fbChamberlin, A. R.; Sall, D. J. <em>Comp. Org. Syn. <\/em><strong><span style=\"color: #ff6600\">1991<\/span><\/strong>, <em> 8<\/em>, 944.<\/p>\n<ul>\n<li>\u53cd\u5e94\u673a\u7406<\/li>\n<\/ul>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/06\/29.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2120\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/06\/29.gif\" alt=\"2\" width=\"417\" height=\"144\" \/><\/a><\/p>\n<ul>\n<li>\u53cd\u5e94\u5b9e\u4f8b<\/li>\n<\/ul>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/06\/37.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2121\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/06\/37.gif\" alt=\"3\" width=\"406\" height=\"59\" \/><\/a><\/p>\n<p>Taxol\u7684\u5408\u6210[1]\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/06\/44.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2122\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/06\/44.gif\" alt=\"4\" width=\"496\" height=\"180\" \/><\/a><\/p>\n<ul>\n<li>\u5b9e\u9a8c\u6b65\u9aa4<\/li>\n<\/ul>\n<ul>\n<li>\u5b9e\u9a8c\u6280\u5de7<\/li>\n<\/ul>\n<ul>\n<li>\u53c2\u8003\u6587\u732e<\/li>\n<\/ul>\n[1] Nicolaou, K. C. et al. <em>Nature<\/em> <strong><span style=\"color: #ff6600\">1994<\/span><\/strong>, <em>367<\/em>, 630. doi:<a href=\"http:\/\/dx.doi.org\/10.1038\/367630a0\"><span style=\"color: #336600\">10.1038\/367630a0<\/span><\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"\u6982\u8981 &nbsp; \u916e\u53d8\u6210\u5bf9\u7532\u82ef\u78fa\u9170\u8159\u4e4b\u540e\uff0c\u52a0\u5165\u4e24\u6469\u5c14\u5f53\u91cf\u7684\u4e01\u57fa\u9502\uff0c\u4f34\u968f\u7740\u82ef\u78fa\u9170\u57fa\u548c\u6c2e\u6c14\u7684\u8131\u53bb\uff0c\u5f97\u5230\u70ef\u57fa\u9502\u3002\u5b83\u63a5\u4e0b\u6765\u548c\u5176\u4ed6\u4eb2\u7535\u8bd5\u5242\u53cd\u5e94\u5f97\u5230\u4e09\u7f6e\u6362\u7684\u70ef\u3002 \u4e0d\u5bf9\u79f0\u916e\u7684\u60c5\u51b5\uff0c\u53cc\u952e\u5728\u53d6\u4ee3\u57fa\u8f83\u5c11\u7684\u4e00\u4fa7\u751f\u6210\uff08\u901f\u5ea6\u8ad6\u7684\u5f71\u54cd\uff09\u3002\u56e0\u6b64\uff0c\u80fd\u591f\u4f4d\u7f6e\u9009\u62e9\u6027\u7684\u751f\u6210\u78b3\u78b3\u53cc\u952e\u662f\u8fd9\u4e00\u53cd\u5e94\u7684\u4e00\u5927\u7279\u5f81\u3002 \u7528NaOMe\u505a\u78b1\u7684\u60c5\u51b5\uff0c\u7279\u79f0\u4e3aBamford-Stevens\u53cd\u5e94\uff0c\u90e8\u5206\u53cd\u5e94\u673a\u7406\u6709\u4e9b\u533a\u522b\u3002\u5b83\u5728\u70ed\u529b\u5b66\u4e0a\u7684\u7279\u5f81\u5c31\u662f\u751f\u6210\u4e86\u70ef\u9187\u3002 \u57fa\u672c\u6587\u732e \u30fbBamford, W. R.; Stevens, T. S. J. Chem. Soc. 1952, 4735. \u30fbShapiro, R. H.; Heath, M. J. J. Am. Chem. Soc. 1967, 89, 5734. DOI: 10.1021\/ja00998a601 \u30fbShapiro, R.H.; Lipton, M.F.; Kolonko, K.J.; Buswell, R.L.; Capuano, L.A. Tetrahedron Lett, 1975, 22, 1811. doi:10.1016\/S0040-4039(00)75263-4 \u30fbShapiro, R. H., Org. React. 1976, 23, 405. \u30fbAdlington, R. M.; Barrett, A. G. M. Acc. Chem. Res. 1983, 16, 55. DOI: 10.1021\/ar00086a004 \u30fbChamberin, A. R.; Bloom, S. H. Org. React. 1990, 39, 1. \u30fbMaruka, K.; Yamamoto, H. Comp. Org. Syn. 1991, 6, 776. \u30fbChamberlin, A. R.; Sall, D. J. Comp. Org. Syn. 1991, 8, 944. \u53cd\u5e94\u673a\u7406 \u53cd\u5e94\u5b9e\u4f8b Taxol\u7684\u5408\u6210[1] \u5b9e\u9a8c\u6b65\u9aa4 \u5b9e\u9a8c\u6280\u5de7 \u53c2\u8003\u6587\u732e [&hellip;]","protected":false},"author":4,"featured_media":2119,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[12],"tags":[313],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2014\/06\/112.gif","jetpack_shortlink":"https:\/\/wp.me\/p96op1-ya","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/2118"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=2118"}],"version-history":[{"count":2,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/2118\/revisions"}],"predecessor-version":[{"id":28136,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/2118\/revisions\/28136"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/2119"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=2118"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=2118"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=2118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}