{"id":21226,"date":"2018-12-03T06:18:48","date_gmt":"2018-12-02T22:18:48","guid":{"rendered":"\/\/www.gsbet888.com\/?p=21226"},"modified":"2019-08-02T18:51:02","modified_gmt":"2019-08-02T10:51:02","slug":"angew-chem-int-ed-%e9%87%8d%e6%b0%ae%e7%9b%90%e5%90%8c%e6%97%b6%e7%94%a8%e4%bd%9c%e5%bc%95%e5%8f%91%e5%89%82%e5%92%8c%e6%b8%85%e9%99%a4%e5%89%82","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2018\/12\/angew-chem-int-ed-%e9%87%8d%e6%b0%ae%e7%9b%90%e5%90%8c%e6%97%b6%e7%94%a8%e4%bd%9c%e5%bc%95%e5%8f%91%e5%89%82%e5%92%8c%e6%b8%85%e9%99%a4%e5%89%82.html","title":{"rendered":"Angew. Chem., Int. Ed.\u00a0\u91cd\u6c2e\u76d0\u201c\u540c\u65f6\u201d\u7528\u4f5c\u5f15\u53d1\u5242\u548c\u6e05\u9664\u5242"},"content":{"rendered":"

\u672c\u6b21\u4ecb\u7ecd\u7684\u6587\u7ae0\u62a5\u9053\u4e86\u6c28\u57fa\u7532\u9178\u5f02\u620a\u916f\/\u8132\u4e0e\u82b3\u57fa\u91cd\u6c2e\u76d0\u7684\u73af\u6c28\u57fa\u91cd\u6c2e\u5316\u53cd\u5e94\u3002\u672c\u53cd\u5e94\u4e2d\u4f7f\u7528\u6613\u4e8e\u83b7\u5f97\u5e76\u4e14\u53ef\u4ee5\u957f\u671f\u50a8\u5b58\u7684\u91cd\u6c2e\u76d0\u7528\u4f5c\u53cd\u5e94\u5f15\u53d1\u5242\u548c\u81ea\u7531\u57fa\u6e05\u9664\u5242\u3002<\/strong><\/p>\n

\u6c28\u57fa\u7532\u9178\u916f\/\u8132<\/strong>\u7684\u73af\u5316\u53cd\u5e94<\/h4>\n

\u542b\u6709\u70ef\u4e19\u9187\u6216\u70ef\u4e19\u80fa\u7684\u70ef\u70c3\u7684\u80fa\u57fa\u5316\uff0c\u4ece\u539f\u6599\u6613\u5f97\u4e14\u5927\u91cf\u5b58\u5728\u7684\u89c2\u70b9\u51fa\u53d1\u3001\u662f\u4e00\u79cd\u5e7f\u6cdb\u7528\u4e8e\u5408\u6210\u591a\u5b98\u80fd\u8102\u65cf\u5316\u5408\u7269\u7684\u65b9\u6cd5\u3002\u5176\u4e2d\uff0c\u5df2\u7ecf\u6709\u8bb8\u591a\u5173\u4e8e\u542b\u6709\u70ef\u4e19\u57fa\u7684\u6c28\u57fa\u7532\u9178\u916f\u6216\u8132\u7684\u5206\u5b50\u5185\u73af\u5316\u5f62\u6210C-N\u952e\u7684\u53cd\u5e94\u7684\u62a5\u9053\u3002\u4f8b\u5982\uff0c\u5f88\u65e9\u4ee5\u524d\u5bf9\u4e8eC-N\u952e\u5f62\u6210\uff0c\u5c31\u6709\u8bf8\u5982\u901a\u8fc7\u5364\u9393\u4e2d\u95f4\u4f53\u7684\u6c28\u57fa\u5364\u5316\u548c\u4f7f\u7528\u94af\u50ac\u5316\u5242\u7684\u6c28\u57fa\u7532\u9170\u5316\u7b49\u5b9e\u4f8b\u62a5\u9053[1]<\/span><\/sup>\u3002\u8fd1\u5e74\u6765\uff0c\u901a\u8fc7\u6539\u53d8\u81ea\u7531\u57fa\u6e05\u9664\u5242\u53ef\u4ee5\u81ea\u5728\u7684\u5bfc\u5165\u5b98\u80fd\u56e2\uff0c\u800c\u901a\u8fc7\u6c28\u57fa\u7532\u9178\u916f\/\u8132\u5f62\u6210\u7684\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53\u8fdb\u884c\u7684\u53cd\u5e94\u65b9\u6cd5\u5b66\u5f00\u53d1\u53d7\u5230\u5173\u6ce8\u00a0(\u56fe<\/span>1A)<\/span>\u3002<\/p>\n

2000<\/span>\u5e74\uff0cNicolaou<\/span><\/a>\u7b49\u4eba\u3001\u4f7f\u75282-\u7898\u4ee3\u82ef\u7532\u9178\uff08IBX\uff09\u62a5\u544a\u4e86\u52a0\u6c22\u80fa\u5316\u53cd\u5e94[2]<\/span><\/sup>\u3002\u63a5\u7740\u57282013<\/span>\u5e74\uff0cLi\u7b49\u4eba<\/span>\u3001\u4f7f\u7528\u94f6\u50ac\u5316\u5242\u4e0eSelectfluor\u00ae<\/span><\/sup>\u5f00\u53d1\u51fa\u4e86\u73af\u6c28\u57fa\u6c1f\u5316\u53cd\u5e94[3]<\/span><\/sup>\u3002\u7136\u800c\uff0c\u4f7f\u7528\u8fd9\u4e9b\u9170\u80fa\u81ea\u7531\u57fa\u4f5c\u4e3a\u9a71\u52a8\u529b\u7684\u73af\u5316\u53cd\u5e94\u4e2d\u4f7f\u7528\u7684\u6240\u6709\u8bd5\u5242\u90fd\u662f\u975e\u5e38\u6602\u8d35\u7684\uff0c\u800c\u4e14\uff0c\u53cd\u5e94\u65f6\u95f4\u957f\u4e5f\u662f\u4e00\u4e2a\u9700\u8981\u6539\u5584\u7684\u5730\u65b9\u3002\u4f5c\u4e3a\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\u7684\u65b9\u6cd5\uff0cKnowles\u7b49\u4eba\u57282015\u5e74\u4f7f\u7528\u53ef\u89c1\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u5242\u548c\u5f31\u78b1\u901a\u8fc7\u8d28\u5b50\u5171\u8f6d\u7535\u5b50\u8f6c\u79fb\uff08PCET\uff09\u751f\u6210\u9170\u80fa\u81ea\u7531\u57fa\uff0c\u6210\u529f\u8fdb\u884c\u4e86\u73af\u5316\u53cd\u5e94\u6784\u5efaC-N\u952e[4]<\/span><\/sup>\u3002<\/p>\n

\u3000\u8fd9\u4e00\u6b21\uff0c\u5e03\u91cc\u65af\u6258\u5c14\u5927\u5b66\u7684Clayden<\/span>\u6559\u6388\u548c\u7b49\u4eba\uff0c\u6210\u529f\u5f00\u53d1\u4e86\u4ee5\u5f02\u620a\u70ef\u6c28\u57fa\u7532\u9178\u916f\/\u8132\u4e3a\u5e95\u7269\uff0c\u901a\u8fc7\u4f7f\u7528\u82b3\u57fa\u91cd\u6c2e\u76d0\u4f5c\u4e3a\u81ea\u7531\u57fa\u6e05\u9664\u5242\uff0c\u901a\u8fc7\u9170\u80fa\u57fa\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53\u8fdb\u884c\u7684\u73af\u6c28\u57fa\u91cd\u6c2e\u5316\u53cd\u5e94\uff08\u56fe1B\uff09\u3002\u8be5\u53cd\u5e94\u4f7f\u7528\u5bcc\u7535\u5b50\u7684\u5f02\u620a\u70ef\u6c28\u57fa\u7532\u9178\u916f\/\u8132\u4e0e\u7f3a\u7535\u5b50\u7684\u91cd\u6c2e\u76d0\u7684\u7ec4\u5408\u8fdb\u884c\u7684\uff0c\u65e0\u9700\u5149\u50ac\u5316\u5242\u53c2\u4e0e\u3002<\/p>\n

\n

\"\"<\/p>\n

\u56fe1. \u6c28\u57fa\u7532\u9178\u916f\u6216\u8132\u7684\u5206\u5b50\u5185\u73af\u5316\u53cd\u5e94<\/p>\n<\/div>\n

 <\/p>\n

\u201c<\/strong>Transition Metal-Free Cycloamination of Prenyl Carbamates and Ureas Promoted by Aryldiazonium Salts<\/strong>\u201d<\/strong><\/p>\n

Abrams, R.; Lefebvre, Q.; Clayden, J. Angew. Chem., Int. Ed.\u00a0<\/em>2018<\/strong>,57<\/em>, 13587.<\/p>\n

DOI: 10.1002\/anie.201809323<\/a><\/p><\/blockquote>\n

\u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd<\/h4>\n

\"\"<\/p>\n

\u7814\u7a76\u8005\uff1aJonathan Clayden<\/a><\/p>\n

\u7ecf\u5386\uff1a
\n1986-1989 B.A., Churchill College, University of Cambridge
\n1989-1992 Ph.D., University of Cambridge (Prof. Stuart Warren)
\n1992-1994 Posdoc, \u00c9cole Normale Sup\u00e9rieure (Prof. Marc Julia)
\n1994-2000 Lecturer in Chemistry, University of Manchester
\n2000-2001 Reader in Chemistry, University of Manchester
\n2001-2015 Professor in Organic Chemistry, University of Manchester
\n2015- Professor of Chemistry, University of Bristol<\/p>\n

\u7814\u7a76\u5185\u5bb9\uff1a\u65b0\u578b\u963b\u8f6c\u5f02\u6784\u4f53\u7684\u5408\u6210\u3001\u53cd\u5e94\u5f00\u53d1\u3001\u751f\u7269\u6d3b\u6027\u7269\u8d28\u7684\u5408\u6210<\/p>\n

\u8bba\u6587\u6982\u8981<\/h4>\n

\u672c\u53cd\u5e94\u3001\u4ee5DMSO\u4e3a\u6eb6\u5242\uff0c\u5728<\/span>NaPO2<\/sub>(OBu)2<\/sub><\/span>\u5b58\u5728\u4e0b\u3001O-\u5f02\u620a\u70ef\u57fa\u6c28\u57fa\u7532\u9178\u916f\u6216N-\u5f02\u620a\u70ef\u57fa\u8132(1<\/strong>)\u4e0ep<\/span><\/i>\u2013\u4e09\u6c1f\u7532\u57fa\u82ef\u57fa\u91cd\u6c2e\u76d0<\/span>(2<\/b>)\u5728\u5ba4\u6e29\u4e0b\u53cd\u5e9430\u5206\u949f<\/span>\u3001\u4ee5\u9ad8\u4ea7\u7387\u5f97\u5230\u4e86\u73af\u5316\u4f53\u3002\u672c\u53cd\u5e94\u5bf9\u8132\u7684\u6c2e\u539f\u5b50\u4e0a\u542b\u6709\u70f7\u57fa\u6216\u8005\u542b\u6709\u82ef\u73af\u7684\u5e95\u7269\u90fd\u9002\u7528(\u56fe<\/span>2Aa)<\/span>\u3002<\/p>\n

\u53e6\u5916\uff0c\u5bf9\u4e8e\u5728\u5f02\u620a\u70ef\u57fa\u90e8\u5206\u5177\u6709\u5404\u79cd\u70f7\u57fa\u7684\u5e95\u7269\uff0c\u53cd\u5e94\u4e5f\u80fd\u8fdb\u884c(\u56fe<\/span>2Ab)<\/span>\u3002\u901a\u8fc7\u4f7f\u7528\u5faa\u73af\u4f0f\u5b89\u6cd5\u7684\u5404\u79cd\u5bf9\u7167\u5b9e\u9a8c\u548c\u673a\u7406\u9610\u660e\u7814\u7a76\u7684\u7ed3\u679c\uff0c\u4e86\u89e3\u5230\u91cd\u6c2e\u76d0\u5728\u78b1NaPO2<\/sub>(OBu)2<\/sub><\/span>\u5b58\u5728\u4e0b\uff0c\u77ed\u65f6\u95f4\u4ece2<\/span><\/b>\u5206\u89e3\u4e3a2*<\/span><\/b>\u662f\u53cd\u5e94\u7684\u5f15\u53d1\u9636\u6bb5\u3002\u672c\u53cd\u5e94\u63a8\u6d4b\u7684\u673a\u7406\u5982\u4e0b\u00a01) 2<\/b><\/span>\u7684\u5206\u89e3\u5f62\u6210\u82ef\u57fa\u81ea\u7531\u57fa2*<\/span><\/b>\u30012) \u78b1\u5b58\u5728\u4e0b<\/span>\u3001\u6c28\u57fa\u7532\u9178\u916f\/\u8132<\/span>1<\/span><\/b>\u5f62\u6210\u9170\u80fa\u81ea\u7531\u57fa4<\/span><\/b>\u30013) \u5bf9\u70ef\u70c3\u8fdb\u884c\u81ea\u7531\u57fa\u73af\u5316\u52a0\u6210<\/span>\u30014) \u81ea\u7531\u57fa\u88ab2<\/b><\/span>\u6355\u6349\u30015) \u78b1\u5b58\u5728\u4e0b\uff0c5<\/strong>\u4e0e\u53e6\u5916\u4e00\u5206\u5b50\u7684<\/span>1<\/span><\/b>\u5f62\u62103<\/span><\/b>\u7684\u540c\u65f6\u4f7f\u5f974<\/span><\/b>\u518d\u751f(\u56fe<\/span>2B)<\/span>\u3002<\/p>\n

\u3000\u7efc\u4e0a\uff0c\u4f5c\u8005\u4f7f\u7528\u91cd\u6c2e\u76d0\uff0c\u5f00\u53d1\u51fa\u4e86\u5f02\u620a\u70ef\u6c28\u57fa\u7532\u9178\u916f\/\u8132\u7684\u73af\u6c28\u57fa\u91cd\u6c2e\u5316\u53cd\u5e94\u3002\u672c\u53cd\u5e94\u7684\u7279\u70b9\u662f\u6709\u8da3\u7684\u662f\uff0c\u4e0d\u4f7f\u7528\u91d1\u5c5e\u50ac\u5316\u5242\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u7684\u201dredox-neutral\u201d<\/span>\u53cd\u5e94\u3002<\/p>\n

\n

\"\"<\/p>\n

\u56fe2. (A) \u5e95\u7269\u9002\u7528\u8303\u56f4 (B) \u63a8\u5b9a\u7684\u53cd\u5e94\u673a\u7406<\/p>\n<\/div>\n

 <\/p>\n

\u53c2\u8003\u6587\u732e<\/h4>\n
    \n
  1. (a)Balko, T. W.; Brinkmeyer, R. S.; Terando, N. H. Tetrahedron Lett.<\/em>1989<\/strong>, 30,<\/em> DOI: 10.1016\/S0040-4039(01)93707-4<\/a> (b) Tamaru, Y.; Hojo, M.; Higashimura, H.; Yoshida, Z.-I. J. Am. Chem. Soc. <\/em>1988<\/strong>,110<\/em>, 3994. DOI: 10.1021\/ja00220a044<\/a><\/li>\n
  2. Nicolaou, K. C.; Zhong, Y.-L.; Baran, P. S. Angew.<\/em>\u00a0Chem., Int. Ed. <\/em>2000<\/strong>, 39<\/em>, 625. DOI: 10.1002\/(SICI)1521-3773(20000204)39:3<625::AID-ANIE625>3.0.CO;2-#<\/a><\/li>\n
  3. Li, Z.; Song, L.; Li, C. J.\u00a0Am. Chem. Soc.<\/em>2013<\/strong>, 135, 4640. DOI: 10.1021\/ja400124t<\/a><\/li>\n
  4. Choi, G. J.; Knowles, R. R. J.<\/em>\u00a0Am. Chem. Soc. <\/em>2015<\/strong>, 137<\/em>, 9226. DOI: 10.1021\/jacs.5b05377<\/a><\/li>\n<\/ol>\n

    \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":"\u672c\u6b21\u4ecb\u7ecd\u7684\u6587\u7ae0\u62a5\u9053\u4e86\u6c28\u57fa\u7532\u9178\u5f02\u620a\u916f\/\u8132\u4e0e\u82b3\u57fa\u91cd\u6c2e\u76d0\u7684\u73af\u6c28\u57fa\u91cd\u6c2e\u5316\u53cd\u5e94\u3002\u672c\u53cd\u5e94\u4e2d\u4f7f\u7528\u6613\u4e8e\u83b7\u5f97\u5e76\u4e14\u53ef\u4ee5\u957f\u671f\u50a8\u5b58\u7684\u91cd\u6c2e\u76d0\u7528\u4f5c\u53cd\u5e94\u5f15\u53d1\u5242\u548c\u81ea\u7531\u57fa\u6e05\u9664\u5242\u3002 \u6c28\u57fa\u7532\u9178\u916f\/\u8132\u7684\u73af\u5316\u53cd\u5e94 \u542b\u6709\u70ef\u4e19\u9187\u6216\u70ef\u4e19\u80fa\u7684\u70ef\u70c3\u7684\u80fa\u57fa\u5316\uff0c\u4ece\u539f\u6599\u6613\u5f97\u4e14\u5927\u91cf\u5b58\u5728\u7684\u89c2\u70b9\u51fa\u53d1\u3001\u662f\u4e00\u79cd\u5e7f\u6cdb\u7528\u4e8e\u5408\u6210\u591a\u5b98\u80fd\u8102\u65cf\u5316\u5408\u7269\u7684\u65b9\u6cd5\u3002\u5176\u4e2d\uff0c\u5df2\u7ecf\u6709\u8bb8\u591a\u5173\u4e8e\u542b\u6709\u70ef\u4e19\u57fa\u7684\u6c28\u57fa\u7532\u9178\u916f\u6216\u8132\u7684\u5206\u5b50\u5185\u73af\u5316\u5f62\u6210C-N\u952e\u7684\u53cd\u5e94\u7684\u62a5\u9053\u3002\u4f8b\u5982\uff0c\u5f88\u65e9\u4ee5\u524d\u5bf9\u4e8eC-N\u952e\u5f62\u6210\uff0c\u5c31\u6709\u8bf8\u5982\u901a\u8fc7\u5364\u9393\u4e2d\u95f4\u4f53\u7684\u6c28\u57fa\u5364\u5316\u548c\u4f7f\u7528\u94af\u50ac\u5316\u5242\u7684\u6c28\u57fa\u7532\u9170\u5316\u7b49\u5b9e\u4f8b\u62a5\u9053[1]\u3002\u8fd1\u5e74\u6765\uff0c\u901a\u8fc7\u6539\u53d8\u81ea\u7531\u57fa\u6e05\u9664\u5242\u53ef\u4ee5\u81ea\u5728\u7684\u5bfc\u5165\u5b98\u80fd\u56e2\uff0c\u800c\u901a\u8fc7\u6c28\u57fa\u7532\u9178\u916f\/\u8132\u5f62\u6210\u7684\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53\u8fdb\u884c\u7684\u53cd\u5e94\u65b9\u6cd5\u5b66\u5f00\u53d1\u53d7\u5230\u5173\u6ce8\u00a0(\u56fe1A)\u3002 2000\u5e74\uff0cNicolaou\u7b49\u4eba\u3001\u4f7f\u75282-\u7898\u4ee3\u82ef\u7532\u9178\uff08IBX\uff09\u62a5\u544a\u4e86\u52a0\u6c22\u80fa\u5316\u53cd\u5e94[2]\u3002\u63a5\u7740\u57282013\u5e74\uff0cLi\u7b49\u4eba\u3001\u4f7f\u7528\u94f6\u50ac\u5316\u5242\u4e0eSelectfluor\u00ae\u5f00\u53d1\u51fa\u4e86\u73af\u6c28\u57fa\u6c1f\u5316\u53cd\u5e94[3]\u3002\u7136\u800c\uff0c\u4f7f\u7528\u8fd9\u4e9b\u9170\u80fa\u81ea\u7531\u57fa\u4f5c\u4e3a\u9a71\u52a8\u529b\u7684\u73af\u5316\u53cd\u5e94\u4e2d\u4f7f\u7528\u7684\u6240\u6709\u8bd5\u5242\u90fd\u662f\u975e\u5e38\u6602\u8d35\u7684\uff0c\u800c\u4e14\uff0c\u53cd\u5e94\u65f6\u95f4\u957f\u4e5f\u662f\u4e00\u4e2a\u9700\u8981\u6539\u5584\u7684\u5730\u65b9\u3002\u4f5c\u4e3a\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\u7684\u65b9\u6cd5\uff0cKnowles\u7b49\u4eba\u57282015\u5e74\u4f7f\u7528\u53ef\u89c1\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u5242\u548c\u5f31\u78b1\u901a\u8fc7\u8d28\u5b50\u5171\u8f6d\u7535\u5b50\u8f6c\u79fb\uff08PCET\uff09\u751f\u6210\u9170\u80fa\u81ea\u7531\u57fa\uff0c\u6210\u529f\u8fdb\u884c\u4e86\u73af\u5316\u53cd\u5e94\u6784\u5efaC-N\u952e[4]\u3002 \u3000\u8fd9\u4e00\u6b21\uff0c\u5e03\u91cc\u65af\u6258\u5c14\u5927\u5b66\u7684Clayden\u6559\u6388\u548c\u7b49\u4eba\uff0c\u6210\u529f\u5f00\u53d1\u4e86\u4ee5\u5f02\u620a\u70ef\u6c28\u57fa\u7532\u9178\u916f\/\u8132\u4e3a\u5e95\u7269\uff0c\u901a\u8fc7\u4f7f\u7528\u82b3\u57fa\u91cd\u6c2e\u76d0\u4f5c\u4e3a\u81ea\u7531\u57fa\u6e05\u9664\u5242\uff0c\u901a\u8fc7\u9170\u80fa\u57fa\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53\u8fdb\u884c\u7684\u73af\u6c28\u57fa\u91cd\u6c2e\u5316\u53cd\u5e94\uff08\u56fe1B\uff09\u3002\u8be5\u53cd\u5e94\u4f7f\u7528\u5bcc\u7535\u5b50\u7684\u5f02\u620a\u70ef\u6c28\u57fa\u7532\u9178\u916f\/\u8132\u4e0e\u7f3a\u7535\u5b50\u7684\u91cd\u6c2e\u76d0\u7684\u7ec4\u5408\u8fdb\u884c\u7684\uff0c\u65e0\u9700\u5149\u50ac\u5316\u5242\u53c2\u4e0e\u3002 \u56fe1. \u6c28\u57fa\u7532\u9178\u916f\u6216\u8132\u7684\u5206\u5b50\u5185\u73af\u5316\u53cd\u5e94   \u201cTransition Metal-Free Cycloamination of Prenyl Carbamates and Ureas Promoted by Aryldiazonium Salts\u201d Abrams, R.; Lefebvre, Q.; Clayden, J. Angew. Chem., Int. Ed.\u00a02018,57, 13587. DOI: 10.1002\/anie.201809323 \u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd \u7814\u7a76\u8005\uff1aJonathan Clayden \u7ecf\u5386\uff1a 1986-1989 B.A., Churchill College, University of Cambridge 1989-1992 Ph.D., University of Cambridge (Prof. Stuart Warren) 1992-1994 Posdoc, \u00c9cole Normale Sup\u00e9rieure (Prof. Marc Julia) 1994-2000 Lecturer in Chemistry, University of Manchester 2000-2001 Reader in Chemistry, University of Manchester 2001-2015 Professor in Organic Chemistry, University of Manchester 2015- Professor of Chemistry, University of Bristol \u7814\u7a76\u5185\u5bb9\uff1a\u65b0\u578b\u963b\u8f6c\u5f02\u6784\u4f53\u7684\u5408\u6210\u3001\u53cd\u5e94\u5f00\u53d1\u3001\u751f\u7269\u6d3b\u6027\u7269\u8d28\u7684\u5408\u6210 \u8bba\u6587\u6982\u8981 \u672c\u53cd\u5e94\u3001\u4ee5DMSO\u4e3a\u6eb6\u5242\uff0c\u5728NaPO2(OBu)2\u5b58\u5728\u4e0b\u3001O-\u5f02\u620a\u70ef\u57fa\u6c28\u57fa\u7532\u9178\u916f\u6216N-\u5f02\u620a\u70ef\u57fa\u8132(1)\u4e0ep\u2013\u4e09\u6c1f\u7532\u57fa\u82ef\u57fa\u91cd\u6c2e\u76d0(2)\u5728\u5ba4\u6e29\u4e0b\u53cd\u5e9430\u5206\u949f\u3001\u4ee5\u9ad8\u4ea7\u7387\u5f97\u5230\u4e86\u73af\u5316\u4f53\u3002\u672c\u53cd\u5e94\u5bf9\u8132\u7684\u6c2e\u539f\u5b50\u4e0a\u542b\u6709\u70f7\u57fa\u6216\u8005\u542b\u6709\u82ef\u73af\u7684\u5e95\u7269\u90fd\u9002\u7528(\u56fe2Aa)\u3002 \u53e6\u5916\uff0c\u5bf9\u4e8e\u5728\u5f02\u620a\u70ef\u57fa\u90e8\u5206\u5177\u6709\u5404\u79cd\u70f7\u57fa\u7684\u5e95\u7269\uff0c\u53cd\u5e94\u4e5f\u80fd\u8fdb\u884c(\u56fe2Ab)\u3002\u901a\u8fc7\u4f7f\u7528\u5faa\u73af\u4f0f\u5b89\u6cd5\u7684\u5404\u79cd\u5bf9\u7167\u5b9e\u9a8c\u548c\u673a\u7406\u9610\u660e\u7814\u7a76\u7684\u7ed3\u679c\uff0c\u4e86\u89e3\u5230\u91cd\u6c2e\u76d0\u5728\u78b1NaPO2(OBu)2\u5b58\u5728\u4e0b\uff0c\u77ed\u65f6\u95f4\u4ece2\u5206\u89e3\u4e3a2*\u662f\u53cd\u5e94\u7684\u5f15\u53d1\u9636\u6bb5\u3002\u672c\u53cd\u5e94\u63a8\u6d4b\u7684\u673a\u7406\u5982\u4e0b\u00a01) 2\u7684\u5206\u89e3\u5f62\u6210\u82ef\u57fa\u81ea\u7531\u57fa2*\u30012) \u78b1\u5b58\u5728\u4e0b\u3001\u6c28\u57fa\u7532\u9178\u916f\/\u81321\u5f62\u6210\u9170\u80fa\u81ea\u7531\u57fa4\u30013) \u5bf9\u70ef\u70c3\u8fdb\u884c\u81ea\u7531\u57fa\u73af\u5316\u52a0\u6210\u30014) \u81ea\u7531\u57fa\u88ab2\u6355\u6349\u30015) \u78b1\u5b58\u5728\u4e0b\uff0c5\u4e0e\u53e6\u5916\u4e00\u5206\u5b50\u76841\u5f62\u62103\u7684\u540c\u65f6\u4f7f\u5f974\u518d\u751f(\u56fe2B)\u3002 \u3000\u7efc\u4e0a\uff0c\u4f5c\u8005\u4f7f\u7528\u91cd\u6c2e\u76d0\uff0c\u5f00\u53d1\u51fa\u4e86\u5f02\u620a\u70ef\u6c28\u57fa\u7532\u9178\u916f\/\u8132\u7684\u73af\u6c28\u57fa\u91cd\u6c2e\u5316\u53cd\u5e94\u3002\u672c\u53cd\u5e94\u7684\u7279\u70b9\u662f\u6709\u8da3\u7684\u662f\uff0c\u4e0d\u4f7f\u7528\u91d1\u5c5e\u50ac\u5316\u5242\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u7684\u201dredox-neutral\u201d\u53cd\u5e94\u3002 \u56fe2. (A) \u5e95\u7269\u9002\u7528\u8303\u56f4 (B) \u63a8\u5b9a\u7684\u53cd\u5e94\u673a\u7406   \u53c2\u8003\u6587\u732e (a)Balko, T. W.; Brinkmeyer, […]","protected":false},"author":5,"featured_media":21227,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[414,1271],"tags":[672,59,100],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2018\/11\/2018-11-14_23-48-04.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-5wm","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/21226"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=21226"}],"version-history":[{"count":12,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/21226\/revisions"}],"predecessor-version":[{"id":26967,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/21226\/revisions\/26967"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/21227"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=21226"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=21226"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=21226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}