{"id":24165,"date":"2019-01-23T06:15:34","date_gmt":"2019-01-22T22:15:34","guid":{"rendered":"\/\/www.gsbet888.com\/?p=24165"},"modified":"2019-01-23T06:15:34","modified_gmt":"2019-01-22T22:15:34","slug":"angew-chem-int-ed-3%e6%ac%a1%e5%88%86%e5%ad%90%e5%86%85%e5%85%b1%e8%bd%ad%e5%8a%a0%e6%88%90%e5%ae%9e%e7%8e%b0brasilicardin%e7%9a%84%e5%85%a8%e5%90%88%e6%88%90","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2019\/01\/angew-chem-int-ed-3%e6%ac%a1%e5%88%86%e5%ad%90%e5%86%85%e5%85%b1%e8%bd%ad%e5%8a%a0%e6%88%90%e5%ae%9e%e7%8e%b0brasilicardin%e7%9a%84%e5%85%a8%e5%90%88%e6%88%90.html","title":{"rendered":"Angew. Chem., Int. Ed. 3\u6b21\u5206\u5b50\u5185\u5171\u8f6d\u52a0\u6210\u5b9e\u73b0Brasilicardin\u7684\u5168\u5408\u6210"},"content":{"rendered":"<p><b>\u5317\u6d77\u9053\u5927\u5b66\u7684\u8c37\u91ce\u8bfe\u9898\u7ec4\u5b9e\u73b0\u4e86\u5177\u6709\u72ec\u7279\u7a20\u73af\u7ed3\u6784\u7684BrasilicardinA-D\u7684\u7f51\u7f57\u5168\u5408\u6210\u3002\u901a\u8fc7\u4e09\u6b21\u5206\u5b50\u5185\u5171\u8f6d\u52a0\u6210\u5b9e\u73b0\u4e86\u9ad8\u7acb\u4f53\u9009\u62e9\u6027\u7684\u4e09\u7f29\u73af\u5171\u901a\u4e2d\u95f4\u4f53\u662f\u672c\u5168\u5408\u6210\u7684\u5173\u952e\u3002<\/b><\/p>\n<h4 class=\"1\"><span lang=\"EN-US\">Brasilicardin A-D<\/span><\/h4>\n<p class=\"a\"><span lang=\"EN-US\">Brasilicardin A-D(<b>1<\/b>)<\/span>\u3001\u662f\u4ece\u653e\u5c04\u6027\u75c5\u539f\u83cc<i><span lang=\"EN-CA\">Nocardia brasiliensis<\/span><\/i>\u7684\u57f9\u517b\u6db2\u4e2d\u5206\u79bb\u3001\u7ed3\u6784\u5df2\u7ecf\u88ab\u786e\u5b9a\u7684\u4e8c\u5e16\u7c7b\u5316\u5408\u7269<span lang=\"EN-CA\">(\u56fe<\/span><span lang=\"EN-US\">1A)<sup>[1]<\/sup><\/span>\u3002<span lang=\"EN-US\">Brasilicardin <\/span><span lang=\"EN-US\">A(<b>1a<\/b>)\u5177\u6709\u5f88\u5f3a\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u7531\u4e8e\u4f5c\u7528\u673a\u7406\u4e0e\u73b0\u6709\u7684\u514d\u75ab\u6291\u5236\u5242\u4e0d\u540c\uff0c\u56e0\u6b64\u4f5c\u4e3a\u65b0\u578b\u514d\u75ab\u6291\u5236\u5242\u7684lead compound\uff0c\u4e00\u76f4\u53d7\u5230\u9ad8\u5ea6\u5173\u6ce8\u3002 \u4f46\u662f\uff0c\u8ddf\u5929\u7136\u4ea7\u7269\u4e00\u6837\uff0c\u4ece\u81ea\u7136\u4e2d\u83b7\u53d6\u7684\u91cf\u975e\u5e38\u6709\u9650\uff0c\u56e0\u6b64\u5bfc\u81f4\u5176\u836f\u7406\u65b9\u9762\u7684\u7814\u7a76\u5f88\u8fdf\u7f13\u3002\u53e6\u5916\uff0c<\/span><b><span lang=\"EN-US\">1<\/span><\/b>\u5177\u6709<i><span lang=\"EN-US\">anti-syn-anti\u7a20\u73af<\/span><\/i><span lang=\"EN-US\">\u5168\u6c22\u83f2<\/span>\u9aa8\u67b6<span lang=\"EN-US\">(ABC\u73af<\/span><span lang=\"EN-US\">)\uff0c\u53ef\u4ee5\u4e0e\u6c28\u57fa\u9178\u4e0e\u7cd6\u7ed3\u5408\uff0c\u56e0\u6b64\u4e0d\u4ec5\u4ec5\u662f\u751f\u7269\u6d3b\u6027\uff0c\u4ece\u5316\u5b66\u7ed3\u6784\u4e0a\u4e5f\u662f\u975e\u5e38unique\u7684<\/span>\u3002<\/p>\n<p class=\"a\">\u5230\u76ee\u524d\u4e3a\u6b62\u5df2\u7ecf\u62a5\u9053\u4e86\u51e0\u79cd\u90e8\u5206\u5408\u6210\u7684\u5b9e\u4f8b<sup><span lang=\"EN-US\">[2]<\/span><\/sup>\u3001\u800c\u5168\u5408\u6210\u4ec5\u4ec5\u53ea\u67092017\u5e74\u7a74\u7530\u8bfe\u9898\u7ec4\u62a5\u9053\u7684\u4e00\u4e2a\u4f8b\u5b50<sup><span lang=\"EN-US\">[3]<\/span><\/sup>\u3002\u4ed6\u4eec\u5c06\u4ece<span lang=\"EN-US\">Wieland-Miescher\u916e\u8f6c\u6362\u7684\u4eb2\u53cc\u70ef\u901a\u8fc7<\/span><a href=\"\/\/www.gsbet888.com\/reactions\/%e7%8e%af%e5%8c%96%e5%8f%8d%e5%ba%94\/2014\/02\/post-515.html\"><span lang=\"EN-US\">Diels-Alder\u53cd\u5e94<\/span><\/a>\u6784\u5efa\u4e86\u590d\u6742\u7684<span lang=\"EN-US\">ABC\u73af<\/span><span lang=\"EN-US\">(\u56fe<\/span><span lang=\"EN-US\">1B)<\/span>\u3002\u7136\u540e\uff0c\u5bf9\u4e8e\u5728\u5408\u6210\u7ec8\u76d8\u7684\u7cd6\u57fa\u5316\u90a3\u6b65\uff0c\u7531\u4e8e\u9009\u62e9\u6027\u8131\u4fdd\u62a4\u6bd4\u8f83\u56f0\u96be\u3001\u56e0\u6b64C2\u4f4d\u7684\u7f9f\u57fa\u5728\u65e9\u671f\u5c31\u4e8b\u5148\u5bfc\u5165\uff0c\u6700\u7ec8\u5b9e\u73b0<b><span lang=\"EN-US\">1a<\/span><\/b><span lang=\"EN-US\">, <b>1c<\/b>\u7684\u5168\u5408\u6210\u3002<\/span><\/p>\n<p class=\"a\">\u3000\u8fd9\u6b21\u5317\u6d77\u9053\u5927\u5b66\u7684\u8c37\u91ce\u3001\u5409\u6751\u7b49\u4eba\u3001\u8ba1\u5212\u5728\u5408\u6210\u7ec8\u76d8\u901a\u8fc7\u5bf9\u5171\u901a\u4e2d\u95f4\u4f53<b><span lang=\"EN-US\">2<\/span><\/b>\u5b9e\u73b0\u6c28\u57fa\u9178\u7684\u4f4d\u7f6e\uff0c\u5b9e\u73b0\u5bf9<strong>1<\/strong>\u7684\u7f51\u7f57\u5168\u5408\u6210\u3002\u672c\u5168\u5408\u6210\u7684\u5173\u952e\u4e2d\u95f4\u4f53<b><span lang=\"EN-US\">2<\/span><\/b>\u7684<span lang=\"EN-US\">ABC\u73af<\/span>\u3001\u4f5c\u8005\u8ba1\u5212\u4ee5\u65b0\u620a\u4e8c\u9187<span lang=\"EN-US\">(<b>6<\/b>)\u4e3a\u539f\u6599\u7ecf\u8fc7<\/span><span lang=\"EN-US\">10\u6b65\u5148\u5408\u6210\u5316\u5408\u7269<\/span><b><span lang=\"EN-US\">5<\/span><\/b>\uff0c\u7136\u540e\u7ecf\u8fc7\u4e09\u6b21\u7acb\u4f53\u9009\u62e9\u6027\u7684\u5206\u5b50\u5185\u5171\u8f6d\u52a0\u6210\u53cd\u5e94\u83b7\u5f97<span lang=\"EN-US\">(\u56fe<\/span><span lang=\"EN-US\">1C)<\/span>\u3002<\/p>\n<div id=\"attachment_61887\" class=\"wp-caption aligncenter\">\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-24167 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-26_00-46-38.png\" alt=\"\" width=\"960\" height=\"424\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-26_00-46-38.png 960w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-26_00-46-38-300x133.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-26_00-46-38-768x339.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-26_00-46-38-680x300.png 680w\" sizes=\"(max-width: 960px) 100vw, 960px\" \/><\/p>\n<p class=\"wp-caption-text\">\u56fe1. (A)Brasilicardin A-D (B) \u7a74\u7530\u5408\u6210\u6cd5 (C) \u9006\u5408\u6210\u5206\u6790<\/p>\n<\/div>\n<blockquote><p><strong>\u201c<\/strong><strong>Asymmetric Total Synthesis of Brasilicardins<\/strong><strong>\u201d<\/strong><\/p>\n<p>Yoshimura, F.; Itoh, R.; Torizuka, M.; Mori, G.; Tanino, K.<em>Angew. Chem., Int. Ed.<\/em><strong>2018<\/strong>,<em>57<\/em>, 17161.<\/p>\n<p>DOI: <a href=\"http:\/\/dx.doi.org\/10.1002\/anie.201811403\">10.1002\/anie.201811403<\/a><\/p><\/blockquote>\n<h4>\u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd<\/h4>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-24168\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-26_00-51-43.png\" alt=\"\" width=\"156\" height=\"194\" \/><\/p>\n<p>\u7814\u7a76\u8005\uff1a<a href=\"http:\/\/barato.sci.hokudai.ac.jp\/~oc2\/index.html\">\u8c37\u91ce\u572d\u6301<\/a><\/p>\n<p>\u7ecf\u5386\uff1a<br \/>\n1987 \u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66\u5927\u5b66\u9662\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u5316\u5b66\u4e13\u4e1a\u7855\u58eb\u5b66\u4f4d(\u6851\u5cf6\u529f\u6559\u6388)<br \/>\n1989 \u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66\u5927\u5b66\u9662\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u5316\u5b66\u4e13\u4e1a\u535a\u58eb\u4e2d\u9000<br \/>\n1989 \u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66\u7406\u5b66\u90e8\u5316\u5b66\u79d1\u52a9\u624b<br \/>\n1994 \u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66\u535a\u58eb\u5b66\u4f4d\uff08\u7406\u5b66\uff09<br \/>\n1998 \u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u9662\u5316\u5b66\u4e13\u4e1a\u52a9\u624b<br \/>\n1999 \u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u79d1\u5316\u5b66\u4e13\u4e1a\u52a9\u7406\u6559\u6388<br \/>\n2006- \u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u9662\u5316\u5b66\u90e8\u95e8\u6559\u6388<br \/>\n\u7814\u7a76\u5185\u5bb9\uff1a\u6709\u673a\u91d1\u5c5e\u6216\u8005\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u7684\u65b0\u53cd\u5e94\u5f00\u53d1\u3001\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-24169\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-26_00-51-54.png\" alt=\"\" width=\"154\" height=\"199\" \/><\/p>\n<p>\u7814\u7a76\u8005\uff1a<a href=\"https:\/\/www.us-yakuzo.jp\/\">\u5409\u6751\u6587\u5f66<\/a><\/p>\n<p>\u7ecf\u5386\uff1a<br \/>\n2002 \u4e1c\u5317\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u79d1\u535a\u58eb\u5b66\u4f4d(\u5e73\u9593\u6b63\u535a\u6559\u6388)<br \/>\n2002 \u7f8e\u56fd\u65af\u9686-\u51ef\u7279\u7433\u7814\u7a76\u6240\u535a\u58eb\u540e<br \/>\n2004 \u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u79d1\u52a9\u624b<br \/>\n2007 \u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u9662\u52a9\u7406\u6559\u6388<br \/>\n2017- \u9759\u5188\u53bf\u7acb\u5927\u5b66\u836f\u5b66\u90e8\u526f\u6559\u6388<br \/>\n\u7814\u7a76\u5185\u5bb9\uff1a\u590d\u6742\u7ed3\u6784\u7684\u751f\u7269\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u3001\u65b0\u53cd\u5e94\u7684\u5f00\u53d1<\/p>\n<p class=\"1\">\u8bba\u6587\u6982\u8981<\/p>\n<p class=\"a\">\u3000\u4f5c\u8005\u7b49\u4eba\u3001\u8ba1\u5212\u901a\u8fc7\u00a0<span lang=\"EN-US\">(1: \u6784\u5efaA, B\u73af<\/span><span lang=\"EN-US\">) \u4e24\u6b21\u5bf9\u03b1,\u03b2-\u4e0d\u9971\u548c<\/span><span lang=\"EN-US\">Weinreb\u9170\u80fa\u7684<\/span><span lang=\"EN-US\">\u03b1-Cyano carbanions\u7684\u5171\u8f6d\u52a0\u6210<\/span>\u3001<span lang=\"EN-US\">(2: \u6784\u5efaC\u73af<\/span><span lang=\"EN-US\">) \u5bf9\u03b1,\u03b2-\u4e0d\u9971\u548c\u916f\u7684\u4e59\u70ef\u57fa\u94dc\u7684\u5171\u8f6d\u52a0\u6210\uff0c\u8fd9\u4e24\u4e2a\u5206\u5b50\u5185\u53cd\u5e94\u6765\u6784\u5efaABC\u7a20\u73af<\/span><span lang=\"EN-US\">(\u56fe<\/span><span lang=\"EN-US\">2)<\/span>\u3002<\/p>\n<p class=\"a\"><span lang=\"EN-US\">\u5bf9\u4e8e\u53cd\u5e94(1)<\/span>\u3001\u867d\u7136\u4f5c\u8005\u62c5\u5fc3\u8fc7\u5e95\u7269\u7684\u53cd\u5e94\u6027\u4f4e\u3001\u4f46\u662f\u4f7f\u7528<span lang=\"EN-US\">NaHMDS\u4f5c\u4e3a\u78b1\u53ef\u4ee5\u5f62\u6210\u7a33\u5b9a\u7684\u9ccc\u5408\u4e2d\u95f4\u4f53<\/span><b><span lang=\"EN-US\">7<\/span><\/b>\uff0c\u4f7f\u5f97\u53cd\u5e94\u5f88\u9ad8\u6548\u7684\u8fdb\u884c\u3002\u6b64\u5916\uff0c\u5728\u73afA\u7684\u6784\u5efa\u4e2d\uff0c\u901a\u8fc7\u91c7\u8be5\u87af\u5408\u4f5c\u7528\u53ef\u4ee5\u907f\u514d\u4ea7\u751f\u53d1\u751f\u5076\u6781\u6392\u65a5\u7684\u6784\u8c61\uff0c\u4f7f\u5f97\u53cd\u5e94\u5f97\u4ee5\u9ad8\u7acb\u4f53\u9009\u62e9\u6027\u5730\u8fdb\u884c\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5bf9\u4e8eB\u73af\u7684\u6784\u5efa\uff0c\u901a\u8fc7\u4f7f\u7528\u5177\u6709\u66f4\u5927\u4f4d\u963b\u53d6\u4ee3\u57fa\u53d6\u4ee3\u7684<a href=\"\/\/www.gsbet888.com\/reactions\/%e8%bf%98%e5%8e%9f%e5%8f%8d%e5%ba%94\/2014\/06\/%e6%b8%a9%e5%8b%92%e4%bc%af%e9%85%ae%e5%90%88%e6%88%90-weinreb-ketone-synthesis.html\"><span lang=\"EN-US\">Weinreb\u9170\u80fa<\/span><\/a>\u6765\u63a7\u5236\u751f\u6210\u7269\u7684\u7acb\u4f53\u9009\u62e9\u6027\u3002\u5bf9\u4e8e<span lang=\"EN-US\">C\u73af\u7684\u6784\u5efa<\/span><span lang=\"EN-US\">(2)<\/span>\u3001\u4f5c\u8005\u7b49\u4eba\u53c2\u8003\u4e862006\u5e74\u5f00\u53d1\u7684\u4f7f\u7528\u6709\u673a\u94dc\u50ac\u5316\u5242\u5bf91,1-\u4e8c\u6eb4\u70ef\u70c3\u8fdb\u884c\u7684\u73af\u5316\u7684\u65b9\u6cd5<sup><span lang=\"EN-US\">[4]<\/span><\/sup>\u3002\u5728\u996d\u5385\u4f53\u7cfb\u4e2d\u4ea7\u751f\u4e59\u70ef\u57fa\u94dc\u4e4b\u540e\u3001\u5347\u6e29\u8fdb\u884c\u4e0e<span lang=\"EN-US\">\u03b1,\u03b2-\u4e0d\u9971\u548c\u916f\u7684\u5206\u5b50\u5185\u5171\u8f6d\u52a0\u6210\uff0c\u5f97\u5230\u5168\u5408\u6210\u76ee\u6807\u4ea7\u7269\u4eec\u7684\u5171\u540c\u4e2d\u95f4\u4f53<\/span><b><span lang=\"EN-US\">2<\/span><\/b>\u3002\u8be6\u7ec6\u53ef\u4ee5\u5177\u4f53\u7ffb\u9605\u8bba\u6587\u3002\u901a\u8fc7\u5bf9\u5171\u540c\u4e2d\u95f4\u4f53<b><span lang=\"EN-US\">2<\/span><\/b><span lang=\"EN-US\">\uff0c\u5728\u5408\u6210\u7ec8\u76d8\u8fdb\u884c\u6c28\u57fa\u9178\u90e8\u4f4d\u4e0e\u7cd6\u7684\u4f4d\u7f6e\uff0c\u7acb\u4f53\u9009\u62e9\u6027\u7684\u5bfc\u5165\u6700\u7ec8\u5b9e\u73b0\u4e86Brasilicardin\u00a0<\/span><span lang=\"EN-US\">A-D(<b>1<\/b>)\u7684\u5168\u5408\u6210<\/span>\u3002<\/p>\n<div id=\"attachment_61888\" class=\"wp-caption aligncenter\">\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-24170 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-26_00-47-56.png\" alt=\"\" width=\"978\" height=\"437\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-26_00-47-56.png 978w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-26_00-47-56-300x134.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-26_00-47-56-768x343.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-26_00-47-56-680x304.png 680w\" sizes=\"(max-width: 978px) 100vw, 978px\" \/><\/p>\n<p class=\"wp-caption-text\">\u56fe2. \u5171\u540c\u4e2d\u95f4\u4f53<strong>3<\/strong>\u7684\u5408\u6210<\/p>\n<\/div>\n<p class=\"a\">\u7efc\u4e0a\u6240\u8ff0\u3001\u4f5c\u8005\u4ece\u5e02\u552e\u7684\u539f\u6599<b><span lang=\"EN-US\">6<\/span><\/b>\u51fa\u53d1\u3001\u901a\u8fc7<span lang=\"EN-US\">37-42\u6b65\u7684\u53cd\u5e94\uff0c\u5b9e\u73b0\u4e86Brasilicardin\u00a0<\/span><span lang=\"EN-US\">A-D\u7684\u5168\u5408\u6210<\/span>\u3002\u5f88\u671f\u5f85\uff0c\u901a\u8fc7\u8fd9\u9879\u5168\u5408\u6210\u7814\u7a76\u53ef\u4ee5\u52a0\u901f\u8be5\u7c7b\u5929\u7136\u4ea7\u7269\u7684\u836f\u7406\u6d3b\u6027\u7684\u7814\u7a76\u3002<\/p>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<ol>\n<li>(a) Shigemori, H.; Komaki, H.; Yazawa, K.; Mikami, Y.; Nemoto, A.; Tanaka, Y.; Sasaki, T.; In, Y.; Ishida, T.; Kobayashi, J. <em>Org. Chem.<\/em><strong>1998<\/strong>, <em>63<\/em>, 6900. DOI: <a href=\"https:\/\/doi.org\/10.1021\/jo9807114\">10.1021\/jo9807114<\/a>(b) Komatsu, K.; Tsuda, M.; Shiro, M.; Tanaka, Y.; Mikami, Y.; Kobayashi, J. <em>Bioorg. Med. Chem<\/em>. <strong>2004<\/strong>, <em>12<\/em>, 5545. DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.bmc.2004.08.007\">10.1016\/j.bmc.2004.08.007<\/a><\/li>\n<li>(a) Jung, M. E.; Chamberlain, B. T.; Koch, P.; Niazi, K. R. <em>Lett<\/em>. <strong>2015<\/strong>, <em>17<\/em>, 3608\u20133611. DOI:<a href=\"https:\/\/doi.org\/10.1021\/acs.orglett.5b01712\">10.1021\/acs.orglett.5b01712<\/a>(b) Coltart, D. M.; Danishefsky, S. J. <em>Org. Lett<\/em>. <strong>2003<\/strong>, <em>5<\/em>, 1289. DOI: <a href=\"https:\/\/doi.org\/10.1021\/ol034213f\">10.1021\/ol034213f<\/a>(c) Jung, M. E.; Koch, P. <em>Org. Lett<\/em>. <strong>2011<\/strong>, <em>13<\/em>, 3710. DOI: <a href=\"https:\/\/doi.org\/10.1021\/ol2013704\">10.1021\/ol2013704<\/a>(d) Jung, M. E.; Perez, F.; Regan, C. F.; Yi, S. W.; Perron, Q. <em>Angew. Chem., Int. Ed<\/em>. <strong>2013<\/strong>, <em>52<\/em>, 2060. DOI: <a href=\"https:\/\/doi.org\/10.1002\/anie.201208294\">10.1002\/anie.201208294<\/a><\/li>\n<li>Anada, M.; Hanari, T.; Kakita, K.; Kurosaki, Y.; Katsuse, K.; Sunadoi, Y.; Jinushi, Y.; Takeda, K.; Matsunaga, S.; Hashimoto, S. <em>Lett. <\/em><strong>2017<\/strong>, <em>19<\/em>, 5581. DOI: <a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acs.orglett.7b02728\">10.1021\/acs.orglett.7b02728<\/a><\/li>\n<li>Tanino, K.; Arakawa, K.; Satoh, M.; Iwata, Y.; Miyashita, M. <em>Tetrahedron Lett<\/em>. <strong>2006<\/strong>, <em>47<\/em>, 861. DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.tetlet.2005.12.002\">1016\/j.tetlet.2005.12.002<\/a><\/li>\n<\/ol>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"\u5317\u6d77\u9053\u5927\u5b66\u7684\u8c37\u91ce\u8bfe\u9898\u7ec4\u5b9e\u73b0\u4e86\u5177\u6709\u72ec\u7279\u7a20\u73af\u7ed3\u6784\u7684BrasilicardinA-D\u7684\u7f51\u7f57\u5168\u5408\u6210\u3002\u901a\u8fc7\u4e09\u6b21\u5206\u5b50\u5185\u5171\u8f6d\u52a0\u6210\u5b9e\u73b0\u4e86\u9ad8\u7acb\u4f53\u9009\u62e9\u6027\u7684\u4e09\u7f29\u73af\u5171\u901a\u4e2d\u95f4\u4f53\u662f\u672c\u5168\u5408\u6210\u7684\u5173\u952e\u3002 Brasilicardin A-D Brasilicardin A-D(1)\u3001\u662f\u4ece\u653e\u5c04\u6027\u75c5\u539f\u83ccNocardia brasiliensis\u7684\u57f9\u517b\u6db2\u4e2d\u5206\u79bb\u3001\u7ed3\u6784\u5df2\u7ecf\u88ab\u786e\u5b9a\u7684\u4e8c\u5e16\u7c7b\u5316\u5408\u7269(\u56fe1A)[1]\u3002Brasilicardin A(1a)\u5177\u6709\u5f88\u5f3a\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u7531\u4e8e\u4f5c\u7528\u673a\u7406\u4e0e\u73b0\u6709\u7684\u514d\u75ab\u6291\u5236\u5242\u4e0d\u540c\uff0c\u56e0\u6b64\u4f5c\u4e3a\u65b0\u578b\u514d\u75ab\u6291\u5236\u5242\u7684lead compound\uff0c\u4e00\u76f4\u53d7\u5230\u9ad8\u5ea6\u5173\u6ce8\u3002 \u4f46\u662f\uff0c\u8ddf\u5929\u7136\u4ea7\u7269\u4e00\u6837\uff0c\u4ece\u81ea\u7136\u4e2d\u83b7\u53d6\u7684\u91cf\u975e\u5e38\u6709\u9650\uff0c\u56e0\u6b64\u5bfc\u81f4\u5176\u836f\u7406\u65b9\u9762\u7684\u7814\u7a76\u5f88\u8fdf\u7f13\u3002\u53e6\u5916\uff0c1\u5177\u6709anti-syn-anti\u7a20\u73af\u5168\u6c22\u83f2\u9aa8\u67b6(ABC\u73af)\uff0c\u53ef\u4ee5\u4e0e\u6c28\u57fa\u9178\u4e0e\u7cd6\u7ed3\u5408\uff0c\u56e0\u6b64\u4e0d\u4ec5\u4ec5\u662f\u751f\u7269\u6d3b\u6027\uff0c\u4ece\u5316\u5b66\u7ed3\u6784\u4e0a\u4e5f\u662f\u975e\u5e38unique\u7684\u3002 \u5230\u76ee\u524d\u4e3a\u6b62\u5df2\u7ecf\u62a5\u9053\u4e86\u51e0\u79cd\u90e8\u5206\u5408\u6210\u7684\u5b9e\u4f8b[2]\u3001\u800c\u5168\u5408\u6210\u4ec5\u4ec5\u53ea\u67092017\u5e74\u7a74\u7530\u8bfe\u9898\u7ec4\u62a5\u9053\u7684\u4e00\u4e2a\u4f8b\u5b50[3]\u3002\u4ed6\u4eec\u5c06\u4eceWieland-Miescher\u916e\u8f6c\u6362\u7684\u4eb2\u53cc\u70ef\u901a\u8fc7Diels-Alder\u53cd\u5e94\u6784\u5efa\u4e86\u590d\u6742\u7684ABC\u73af(\u56fe1B)\u3002\u7136\u540e\uff0c\u5bf9\u4e8e\u5728\u5408\u6210\u7ec8\u76d8\u7684\u7cd6\u57fa\u5316\u90a3\u6b65\uff0c\u7531\u4e8e\u9009\u62e9\u6027\u8131\u4fdd\u62a4\u6bd4\u8f83\u56f0\u96be\u3001\u56e0\u6b64C2\u4f4d\u7684\u7f9f\u57fa\u5728\u65e9\u671f\u5c31\u4e8b\u5148\u5bfc\u5165\uff0c\u6700\u7ec8\u5b9e\u73b01a, 1c\u7684\u5168\u5408\u6210\u3002 \u3000\u8fd9\u6b21\u5317\u6d77\u9053\u5927\u5b66\u7684\u8c37\u91ce\u3001\u5409\u6751\u7b49\u4eba\u3001\u8ba1\u5212\u5728\u5408\u6210\u7ec8\u76d8\u901a\u8fc7\u5bf9\u5171\u901a\u4e2d\u95f4\u4f532\u5b9e\u73b0\u6c28\u57fa\u9178\u7684\u4f4d\u7f6e\uff0c\u5b9e\u73b0\u5bf91\u7684\u7f51\u7f57\u5168\u5408\u6210\u3002\u672c\u5168\u5408\u6210\u7684\u5173\u952e\u4e2d\u95f4\u4f532\u7684ABC\u73af\u3001\u4f5c\u8005\u8ba1\u5212\u4ee5\u65b0\u620a\u4e8c\u9187(6)\u4e3a\u539f\u6599\u7ecf\u8fc710\u6b65\u5148\u5408\u6210\u5316\u5408\u72695\uff0c\u7136\u540e\u7ecf\u8fc7\u4e09\u6b21\u7acb\u4f53\u9009\u62e9\u6027\u7684\u5206\u5b50\u5185\u5171\u8f6d\u52a0\u6210\u53cd\u5e94\u83b7\u5f97(\u56fe1C)\u3002 \u56fe1. (A)Brasilicardin A-D (B) \u7a74\u7530\u5408\u6210\u6cd5 (C) \u9006\u5408\u6210\u5206\u6790 \u201cAsymmetric Total Synthesis of Brasilicardins\u201d Yoshimura, F.; Itoh, R.; Torizuka, M.; Mori, G.; Tanino, K.Angew. Chem., Int. Ed.2018,57, 17161. DOI: 10.1002\/anie.201811403 \u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd \u7814\u7a76\u8005\uff1a\u8c37\u91ce\u572d\u6301 \u7ecf\u5386\uff1a 1987 \u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66\u5927\u5b66\u9662\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u5316\u5b66\u4e13\u4e1a\u7855\u58eb\u5b66\u4f4d(\u6851\u5cf6\u529f\u6559\u6388) 1989 \u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66\u5927\u5b66\u9662\u7406\u5de5\u5b66\u7814\u7a76\u79d1\u5316\u5b66\u4e13\u4e1a\u535a\u58eb\u4e2d\u9000 1989 \u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66\u7406\u5b66\u90e8\u5316\u5b66\u79d1\u52a9\u624b 1994 \u4e1c\u4eac\u5de5\u4e1a\u5927\u5b66\u535a\u58eb\u5b66\u4f4d\uff08\u7406\u5b66\uff09 1998 \u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u9662\u5316\u5b66\u4e13\u4e1a\u52a9\u624b 1999 \u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u79d1\u5316\u5b66\u4e13\u4e1a\u52a9\u7406\u6559\u6388 2006- \u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u9662\u5316\u5b66\u90e8\u95e8\u6559\u6388 \u7814\u7a76\u5185\u5bb9\uff1a\u6709\u673a\u91d1\u5c5e\u6216\u8005\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u7684\u65b0\u53cd\u5e94\u5f00\u53d1\u3001\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210 \u7814\u7a76\u8005\uff1a\u5409\u6751\u6587\u5f66 \u7ecf\u5386\uff1a 2002 \u4e1c\u5317\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u79d1\u535a\u58eb\u5b66\u4f4d(\u5e73\u9593\u6b63\u535a\u6559\u6388) 2002 \u7f8e\u56fd\u65af\u9686-\u51ef\u7279\u7433\u7814\u7a76\u6240\u535a\u58eb\u540e 2004 \u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u79d1\u52a9\u624b 2007 \u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u9662\u52a9\u7406\u6559\u6388 2017- \u9759\u5188\u53bf\u7acb\u5927\u5b66\u836f\u5b66\u90e8\u526f\u6559\u6388 \u7814\u7a76\u5185\u5bb9\uff1a\u590d\u6742\u7ed3\u6784\u7684\u751f\u7269\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u3001\u65b0\u53cd\u5e94\u7684\u5f00\u53d1 \u8bba\u6587\u6982\u8981 \u3000\u4f5c\u8005\u7b49\u4eba\u3001\u8ba1\u5212\u901a\u8fc7\u00a0(1: \u6784\u5efaA, B\u73af) \u4e24\u6b21\u5bf9\u03b1,\u03b2-\u4e0d\u9971\u548cWeinreb\u9170\u80fa\u7684\u03b1-Cyano carbanions\u7684\u5171\u8f6d\u52a0\u6210\u3001(2: \u6784\u5efaC\u73af) \u5bf9\u03b1,\u03b2-\u4e0d\u9971\u548c\u916f\u7684\u4e59\u70ef\u57fa\u94dc\u7684\u5171\u8f6d\u52a0\u6210\uff0c\u8fd9\u4e24\u4e2a\u5206\u5b50\u5185\u53cd\u5e94\u6765\u6784\u5efaABC\u7a20\u73af(\u56fe2)\u3002 \u5bf9\u4e8e\u53cd\u5e94(1)\u3001\u867d\u7136\u4f5c\u8005\u62c5\u5fc3\u8fc7\u5e95\u7269\u7684\u53cd\u5e94\u6027\u4f4e\u3001\u4f46\u662f\u4f7f\u7528NaHMDS\u4f5c\u4e3a\u78b1\u53ef\u4ee5\u5f62\u6210\u7a33\u5b9a\u7684\u9ccc\u5408\u4e2d\u95f4\u4f537\uff0c\u4f7f\u5f97\u53cd\u5e94\u5f88\u9ad8\u6548\u7684\u8fdb\u884c\u3002\u6b64\u5916\uff0c\u5728\u73afA\u7684\u6784\u5efa\u4e2d\uff0c\u901a\u8fc7\u91c7\u8be5\u87af\u5408\u4f5c\u7528\u53ef\u4ee5\u907f\u514d\u4ea7\u751f\u53d1\u751f\u5076\u6781\u6392\u65a5\u7684\u6784\u8c61\uff0c\u4f7f\u5f97\u53cd\u5e94\u5f97\u4ee5\u9ad8\u7acb\u4f53\u9009\u62e9\u6027\u5730\u8fdb\u884c\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5bf9\u4e8eB\u73af\u7684\u6784\u5efa\uff0c\u901a\u8fc7\u4f7f\u7528\u5177\u6709\u66f4\u5927\u4f4d\u963b\u53d6\u4ee3\u57fa\u53d6\u4ee3\u7684Weinreb\u9170\u80fa\u6765\u63a7\u5236\u751f\u6210\u7269\u7684\u7acb\u4f53\u9009\u62e9\u6027\u3002\u5bf9\u4e8eC\u73af\u7684\u6784\u5efa(2)\u3001\u4f5c\u8005\u7b49\u4eba\u53c2\u8003\u4e862006\u5e74\u5f00\u53d1\u7684\u4f7f\u7528\u6709\u673a\u94dc\u50ac\u5316\u5242\u5bf91,1-\u4e8c\u6eb4\u70ef\u70c3\u8fdb\u884c\u7684\u73af\u5316\u7684\u65b9\u6cd5[4]\u3002\u5728\u996d\u5385\u4f53\u7cfb\u4e2d\u4ea7\u751f\u4e59\u70ef\u57fa\u94dc\u4e4b\u540e\u3001\u5347\u6e29\u8fdb\u884c\u4e0e\u03b1,\u03b2-\u4e0d\u9971\u548c\u916f\u7684\u5206\u5b50\u5185\u5171\u8f6d\u52a0\u6210\uff0c\u5f97\u5230\u5168\u5408\u6210\u76ee\u6807\u4ea7\u7269\u4eec\u7684\u5171\u540c\u4e2d\u95f4\u4f532\u3002\u8be6\u7ec6\u53ef\u4ee5\u5177\u4f53\u7ffb\u9605\u8bba\u6587\u3002\u901a\u8fc7\u5bf9\u5171\u540c\u4e2d\u95f4\u4f532\uff0c\u5728\u5408\u6210\u7ec8\u76d8\u8fdb\u884c\u6c28\u57fa\u9178\u90e8\u4f4d\u4e0e\u7cd6\u7684\u4f4d\u7f6e\uff0c\u7acb\u4f53\u9009\u62e9\u6027\u7684\u5bfc\u5165\u6700\u7ec8\u5b9e\u73b0\u4e86Brasilicardin\u00a0A-D(1)\u7684\u5168\u5408\u6210\u3002 \u56fe2. \u5171\u540c\u4e2d\u95f4\u4f533\u7684\u5408\u6210 \u7efc\u4e0a\u6240\u8ff0\u3001\u4f5c\u8005\u4ece\u5e02\u552e\u7684\u539f\u65996\u51fa\u53d1\u3001\u901a\u8fc737-42\u6b65\u7684\u53cd\u5e94\uff0c\u5b9e\u73b0\u4e86Brasilicardin\u00a0A-D\u7684\u5168\u5408\u6210\u3002\u5f88\u671f\u5f85\uff0c\u901a\u8fc7\u8fd9\u9879\u5168\u5408\u6210\u7814\u7a76\u53ef\u4ee5\u52a0\u901f\u8be5\u7c7b\u5929\u7136\u4ea7\u7269\u7684\u836f\u7406\u6d3b\u6027\u7684\u7814\u7a76\u3002 \u53c2\u8003\u6587\u732e (a) Shigemori, H.; Komaki, H.; Yazawa, K.; Mikami, Y.; Nemoto, A.; Tanaka, Y.; Sasaki, T.; In, Y.; Ishida, T.; Kobayashi, J. Org. Chem.1998, 63, 6900. DOI: [&hellip;]","protected":false},"author":5,"featured_media":24166,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[414,1271],"tags":[2375,275],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-26_01-04-06.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-6hL","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/24165"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=24165"}],"version-history":[{"count":14,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/24165\/revisions"}],"predecessor-version":[{"id":24274,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/24165\/revisions\/24274"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/24166"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=24165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=24165"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=24165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}