{"id":24175,"date":"2019-01-22T19:24:55","date_gmt":"2019-01-22T11:24:55","guid":{"rendered":"\/\/www.gsbet888.com\/?p=24175"},"modified":"2019-01-22T19:24:55","modified_gmt":"2019-01-22T11:24:55","slug":"angew-chem-int-ed-%e5%bc%95%e5%85%a5%e5%8f%a0%e6%b0%ae%e7%9a%84%e5%85%a8%e9%83%a8%e4%b8%89%e4%b8%aa%e6%b0%ae%e5%8e%9f%e5%ad%90","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2019\/01\/angew-chem-int-ed-%e5%bc%95%e5%85%a5%e5%8f%a0%e6%b0%ae%e7%9a%84%e5%85%a8%e9%83%a8%e4%b8%89%e4%b8%aa%e6%b0%ae%e5%8e%9f%e5%ad%90.html","title":{"rendered":"Angew. Chem., Int. Ed. \u5f15\u5165\u53e0\u6c2e\u7684\u5168\u90e8\u4e09\u4e2a\u6c2e\u539f\u5b50"},"content":{"rendered":"<p><b>\u590d\u65e6\u5927\u5b66\u5f20\u4fca\u826f\u8bfe\u9898\u7ec4\u4f7f\u7528\u81a6\u50ac\u5316\u5242\uff0c\u5f00\u53d1\u4e86\u7531\u53e0\u6c2e\u5316\u5408\u7269\u548c\u03b1\uff0c\u03b2-\u70ef\u916e\u5408\u6210\u03b2-\u6c28\u57fa\u03b1-\u4e8c\u6c2e\u7fb0\u57fa\u5316\u5408\u7269\u7684\u5408\u6210\u65b9\u6cd5\u3002\u7531\u4e8e\u78f7\u53e0\u6c2e\u4e2d\u95f4\u4f53\u4e0d\u4f1a\u653e\u51fa\uff08\u79bb\u53bb\uff09\u6c2e\u6c14\u3001\u56e0\u6b64\u53ef\u4ee5\u5c06\u6240\u6709\u4e09\u4e2a\u6c2e\u539f\u5b50\u5f15\u5165\u03b1\uff0c\u03b2-\u70ef\u916e\u4e2d\u3002<\/b><\/p>\n<h4 class=\"1\">\u4f7f\u7528\u78f7\u50ac\u5316\u7684\u53e0\u6c2e\u5316\u7269\u7684\u8f6c\u5316\u53cd\u5e94<\/h4>\n<p class=\"a\">\u53e0\u6c2e\u5316\u5408\u7269\u662f\u5e38\u89c1\u7684\u975e\u5e38\u6709\u7528\u7684building block<sup><span lang=\"EN-US\">[1]<\/span><\/sup>\u3002\u4f5c\u4e3a\u4ee3\u8868\u6027\u7684\u53e0\u6c2e\u5316\u7269\u7684\u8f6c\u5316\u53cd\u5e94\uff0c\u5e38\u5e38\u4f7f\u7528\u5316\u5b66\u5f53\u91cf\u6216\u8005\u50ac\u5316\u91cf\u7684\u81a6\u50ac\u5316\u5242\u8fdb\u884c\u53cd\u5e94\u3002\u5176\u4e2d\uff0c\u4ee5<a href=\"\/\/www.gsbet888.com\/reactions\/%e8%bf%98%e5%8e%9f%e5%8f%8d%e5%ba%94\/2014\/04\/%e6%96%bd%e9%99%b6%e4%b8%81%e6%a0%bc%e5%8f%8d%e5%bf%9c-staudinger-reaction.html\"><span lang=\"EN-US\">Staudinger\u53cd\u5e94<\/span><\/a>\u4e3a\u4ee3\u8868\u7684\u901a\u8fc7\u78f7\u53e0\u6c2e\u4e2d\u95f4\u4f53<b><span lang=\"EN-US\">1<\/span><\/b>\u8131\u6c2e\u6c14\u751f\u6210\u6c28\u57fa\u81a6\u70f7<b><span lang=\"EN-US\">2<\/span><\/b>\uff0c\u7136\u540e\u518d\u5229\u7528\u8be5\u4e2d\u95f4\u4f53\u8fdb\u884c\u5404\u79cd\u5b98\u80fd\u56e2\u8f6c\u6362<span lang=\"EN-US\">(\u56fe<\/span><span lang=\"EN-US\">1A)<\/span>\u3002<b><span lang=\"EN-US\">2<\/span><\/b>\u7684\u6c34\u89e3\u53ef\u4ee5\u751f\u6210\u80fa<span lang=\"EN-US\">(<em>Staudinger\u53cd\u5e94<\/em><\/span><span lang=\"EN-US\">)<\/span>\u3001\u4e0e\u7fa7\u9178\u884d\u751f\u7269\u53cd\u5e94\u53ef\u4ee5\u751f\u6210\u9170\u80fa<span lang=\"EN-US\">(<em>Staudinger Ligation<\/em><\/span><span lang=\"EN-US\">)<\/span>\u3001\u4e0e\u919b\u6216\u8005\u916e\u53cd\u5e94\u751f\u6210imine<span lang=\"EN-US\">(<em><a href=\"\/\/www.gsbet888.com\/reactions\/2014\/06\/%e6%b0%ae%e6%9d%82%e7%bb%b4%e8%92%82%e5%b8%8c%e5%8f%8d%e5%ba%94-aza-wittig-reaction.html\">aza-Wittig\u53cd\u5e94<\/a><\/em><\/span><span lang=\"EN-US\">)<\/span>\u3002\u4ee5\u4e0a\u662f\u5c06\u53e0\u6c2e\u8f6c\u5316\u6210\u542b\u6709\u4e00\u4e2a\u6c2e\u539f\u5b50\u7684\u5b98\u80fd\u56e2\u7684\u624b\u6cd5\uff0c\u5f53\u7136\u8f6c\u6362\u6210\u542b\u6709\u4e24\u4e2a\u6c2e\u539f\u5b50\u7684\u5b98\u80fd\u56e2\u6bd4\u5982\u8bf4\u91cd\u6c2e\u7684\u65b9\u6cd5\u4e5f\u5df2\u7ecf\u88ab\u62a5\u9053\u3002<span lang=\"EN-US\">Raines\u7b49\u4eba<\/span>\u3001\u5c06\u53e0\u6c2e\u4e0e\u4f7f\u7528\u5177\u6709\u6d3b\u6027\u916f\u90e8\u5206\u7684\u81a6\u8bd5\u5242\u53cd\u5e94\uff0c\u6210\u529f\u8f6c\u5316\u6210\u4e86\u91cd\u6c2e\u4ea7\u7269<span lang=\"EN-US\">(\u56fe<\/span><span lang=\"EN-US\">1B)<sup>[2]<\/sup><\/span>\u3002\u901a\u8fc7\u53e0\u6c2e\u81a6\u8bd5\u5242<b><span lang=\"EN-US\">1<\/span><\/b>\u3001\u5c06\u53e0\u6c2e\u7684\u4e09\u4e2a\u6c2e\u539f\u5b50\u5168\u90e8\u5f15\u5165\u7684\u4f8b\u5b50\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\u53ea\u6709<span lang=\"EN-US\">Molina\u7b49\u4eba\u62a5\u9053\u7684\u542b\u6709\u4e9a\u80fa\u5b98\u80fd\u56e2\u7684\u82b3\u9999\u65cf\u53e0\u6c2e\u8f6c\u5316\u6210<\/span><span lang=\"EN-US\">2<i>H<\/i>\u2013\u5432\u5511\u9aa8\u67b6\u8fd9\u4e00\u4e2a\u4f8b\u5b50<\/span><span lang=\"EN-US\">(\u56fe<\/span><span lang=\"EN-US\">1C)<sup>[3]<\/sup><\/span>\u3002<\/p>\n<p>\u672c\u6b21\u3001\u590d\u65e6\u5927\u5b66\u7684\u5f20\u4fca\u826f\u6559\u6388\u8bfe\u9898\u7ec4\u4f7f\u7528\u50ac\u5316\u91cf\u7684\u81a6\u8bd5\u5242\u3001\u5c06\u6c1f\u4ee3\u03b1,\u03b2-\u70ef\u916e<b><span lang=\"EN-US\">3<\/span><\/b>\u4e8e<span lang=\"EN-US\">TMS-azide\u4f5c\u7528\uff0c\u6210\u529f\u5408\u6210\u4e86<\/span>\u03b2<span lang=\"EN-US\">\u2013amino\u00a0<\/span>\u03b1<span lang=\"EN-US\">\u2013diazide cabonyl<\/span>\u5316\u5408\u7269<b><span lang=\"EN-US\">4<\/span><\/b><span lang=\"EN-US\">(\u56fe<\/span><span lang=\"EN-US\">1D)<\/span>\u3002\u5e76\u4e14\u5982\u679c\u4f7f\u7528\u624b\u6027\u81a6\u50ac\u5316\u5242\u4e5f\u53ef\u4ee5\u4ea7\u751f\u5bf9\u6620\u9009\u62e9\u6027\u3002<\/p>\n<div id=\"attachment_61864\" class=\"wp-caption aligncenter\">\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-24177 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-25_22-54-09.png\" alt=\"\" width=\"982\" height=\"408\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-25_22-54-09.png 982w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-25_22-54-09-300x125.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-25_22-54-09-768x319.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-25_22-54-09-680x283.png 680w\" sizes=\"(max-width: 982px) 100vw, 982px\" \/><\/p>\n<p class=\"wp-caption-text\">\u56fe1. \u4f7f\u7528\u81a6\u8bd5\u5242\u7684\u53e0\u6c2e\u7684\u8f6c\u5316\u53cd\u5e94 (A) Staudinger\u53cd\u5e94\u7b49\u3001 (B) Raines\u7b49\u4eba\u7684\u65b9\u6cd5\u3001 (C) Molina\u7b49\u4eba\u7684\u65b9\u6cd5\u3001 (D) \u8fd9\u6b21\u7684\u53cd\u5e94<\/p>\n<\/div>\n<blockquote><p><strong>\u201cPhosphine-Catalyzed Difunctionalization of <\/strong><strong>b<\/strong><strong>-Fluoroalkyl\u00a0<\/strong><strong>a,b<\/strong><strong>-Enones: A Direct Approach to <\/strong><strong>b<\/strong><strong>-Amino <\/strong><strong>a<\/strong><strong>-Diazo Carbonyl Compounds\u201d<\/strong><\/p>\n<p>Wang, H.; Zhang, Li.; Tu, Y.; Xiang, R.; Guo, Y.-L.; Zhang, J.\u00a0<em>Angew. Chem., Int. Ed.<\/em><strong>2018<\/strong>, <em>57<\/em>, 15787<\/p>\n<p>DOI: <a href=\"https:\/\/doi.org\/10.1002\/anie.201810253\">10.1002\/anie.201810253<\/a><\/p><\/blockquote>\n<h4>\u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd<\/h4>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-24178\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-25_23-07-21.png\" alt=\"\" width=\"159\" height=\"212\" \/><\/p>\n<p><a href=\"http:\/\/www.chemistry.fudan.edu.cn\/En\/Data\/View\/3105\"><strong>Junliang Zhang<\/strong><\/a><\/p>\n<p>\u7ecf\u5386\uff1a<\/p>\n<p>1993-1997 BSc, Tianjin University (Prof. Wenqin Zhang and Prof. Chunbao Li)<br \/>\n1997-2002 PhD, Shanghai Institute of Organic Chemistry (Prof. Shengming Ma)<br \/>\n2002-2003 Research Chemist, Shanghai Institute of Organic Chemistry (Prof. Shengming Ma)<br \/>\n2003-2004 Humboldt Fellow, University of Colongne (Prof. Hans-G\u00fcnther Schmalz)<br \/>\n2005-2006 Postdoc, The University of Chicago (Prof. Chuan He and Prof. Stephen Kent)<br \/>\n2006-2017.9 Professor and Vice Dean, East China Normal University<br \/>\n2017.10-present Professor, Fudan University<\/p>\n<p>\u7814\u7a76\u5185\u5bb9\uff1a\u4ee5\u5171\u8f6d\u5316\u5408\u7269\u4e0e\u5c0f\u5143\u73af\u4e3a\u5e95\u7269\u7684\u53cd\u5e94\u65b9\u6cd5\u5b66\u5f00\u53d1\u3001\u624b\u6027\u914d\u4f53\u7684\u5f00\u53d1\u4e0e\u5e94\u7528\u3001\u805a\u5408\u50ac\u5316\u5242\u7684\u5f00\u53d1<\/p>\n<h4 class=\"1\">\u8bba\u6587\u6982\u8981<\/h4>\n<p class=\"a\">\u5728\u8be5\u65b9\u6cd5\u4e2d\uff0c\u901a\u8fc7\u4f7f\u7528dppb\u4f5c\u4e3a\u81a6\u50ac\u5316\u5242\uff0c\u5e76\u4e14\u4f7fTMSN3\u548c\u5728\u03b2-\u5177\u6709\u6c1f\u70f7\u57fa\uff08Rf\uff09\u7684\u03b1,\u03b2-\u70ef\u916e<strong>3<\/strong>\uff0c\u53ef\u4ee5\u9ad8\u4ea7\u7387\u5730\u83b7\u5f97\u03b2-\u6c28\u57fa\u03b1-\u53e0\u6c2e\u7fb0\u57fa\u5316\u5408\u7269<strong>4<\/strong><span lang=\"EN-CA\">(\u56fe<\/span><span lang=\"EN-US\">2A<\/span><span lang=\"EN-CA\">)<\/span>\u3002\u6b64\u5916\uff0c\u5f53\u4f7f\u7528\u4ed6\u4eec\u81ea\u5df1\u7684\u624b\u6027\u81a6\u50ac\u5316\u5242P1\u4ee3\u66ffdppb\u65f6\uff0c\u53ef\u4ee5\u4ee5\u9ad8\u4ea7\u7387\u548c\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\u5408\u6210<strong>4<\/strong>\u3002\u6709\u8da3\u7684\u662f\uff0c\u5c06\u8be5\u53cd\u5e94\u6761\u4ef6\u5e94\u7528\u4e8e\u03b2\u4f4d\u542b\u6709\u4e09\u6c1f\u7532\u57fa\u7684\u03b2\uff0c\u03b2-\u4e8c\u53d6\u4ee3\u70ef\u916e\u6216\u03b2\u4f4d\u4e0d\u542b\u6c1f\u70f7\u57fa\u7684\u70ef\u916e<strong>5<\/strong>\uff0c\u4e0d\u80fd\u5f97\u5230\u91cd\u6c2e\u53d6\u4ee3\u4ea7\u7269\uff0c\u800c\u662f\u4ea7\u751f\u53e0\u6c2e\u57fa1,4-\u52a0\u6210\u7684\u4ea7\u7269<strong>6<\/strong><span lang=\"EN-CA\">(\u56fe<\/span><span lang=\"EN-US\">2B<\/span><span lang=\"EN-CA\">)<\/span>\u3002<\/p>\n<p class=\"a\">\u672c\u53cd\u5e94\u7684\u5047\u5b9a\u53cd\u5e94\u673a\u7406\u5982\u56fe<span lang=\"EN-US\">2C\u6240\u793a<\/span>\u3002\u9996\u5148\u3001\u81a6\u50ac\u5316\u5242\u5bf9\u53e0\u6c2e\u7684\u672b\u7aef\u6c2e\u539f\u5b50\u8fdb\u884c\u4eb2\u6838\u8fdb\u653b\uff0c\u5f62\u6210\u53e0\u6c2e\u81a6\u8bd5\u5242\u4e2d\u95f4\u4f53<b><span lang=\"EN-US\">7<\/span><\/b>\u3002\u7136\u540e\u4e0e\u03b2<span lang=\"EN-CA\">\u2013\u6c1f\u4ee3\u70f7\u57fa<\/span>\u03b1<span lang=\"EN-US\">,\u03b2<\/span><span lang=\"EN-US\">\u2013\u70ef\u916e<\/span><b><span lang=\"EN-US\">3<\/span><\/b>\u8fdb\u884c<span lang=\"EN-CA\">1,4-\u52a0\u6210<\/span>\u3001\u5f97\u5230\u70ef\u9187\u4e2d\u95f4\u4f53<b><span lang=\"EN-US\">8<\/span><\/b>\u3001\u7ee7\u800c\u53d1\u751f\u5206\u5b50\u5185\u4eb2\u6838\u52a0\u6210\u5f97\u5230\u4e2d\u95f4\u4f53<b><span lang=\"EN-US\">9<\/span><\/b>\u3002<b><span lang=\"EN-US\">9<\/span><\/b>\u518d\u901a\u8fc7\u6c34\u89e3<span lang=\"EN-US\">(\u6c34\u7684\u6765\u6e90\u672a\u77e5<\/span><span lang=\"EN-US\">)\u4f7f\u5f97\u81a6\u8bd5\u5242\u518d\u751f\u7684\u540c\u65f6\u751f\u6210<\/span><b><span lang=\"EN-US\">10<\/span><\/b>\u3002\u6700\u540e<b><span lang=\"EN-US\">10<\/span><\/b>\u53d1\u751f\u5206\u5b50\u5185\u73af\u5f00\u88c2<sup><span lang=\"EN-CA\">[<\/span><\/sup><sup><span lang=\"EN-US\">4<\/span><\/sup><sup><span lang=\"EN-CA\">]<\/span><\/sup>\u3001\u751f\u6210\u4ea7\u7269<b><span lang=\"EN-US\">4<\/span><\/b>\u3002\u8be5\u53cd\u5e94\u673a\u7406\u7684\u4e00\u4e2a\u5173\u952e\u70b9\u662f\uff0c\u7531\u4e8e\u4f7f\u7528\u7684TMS\u53e0\u6c2e\u4f4d\u963b\u5927\uff0c\u6240\u4ee5\u6709\u6548\u6291\u5236\u4e86\u5f02\u6784\u4f53<b><i><span lang=\"EN-US\">Z<\/span><\/i><\/b><b><span lang=\"EN-US\">-7<\/span><\/b>\u7684\u751f\u6210\u3001\u4ece\u800c\u6291\u5236\u4e86\u8131\u6c2e\u6c14\u526f\u53cd\u5fdc\u3002<\/p>\n<div id=\"attachment_61865\" class=\"wp-caption aligncenter\">\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-24179 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-25_22-55-19.png\" alt=\"\" width=\"987\" height=\"353\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-25_22-55-19.png 987w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-25_22-55-19-300x107.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-25_22-55-19-768x275.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-25_22-55-19-680x243.png 680w\" sizes=\"(max-width: 987px) 100vw, 987px\" \/><\/p>\n<p class=\"wp-caption-text\">\u56fe2. (A) \u4f7f\u75283\u4e0eTMSN3\u7684\u03b2<span lang=\"EN-US\">\u2013amino\u00a0<\/span>\u03b1<span lang=\"EN-US\">\u2013diazide cabonyl<\/span>\u5316\u5408\u7269\u5408\u6210\u6cd5 (B) \u53cc\u53d6\u4ee3\u70ef\u916e<strong>5<\/strong>\u76841,4-\u52a0\u6210\u53cd\u5e94 (C) \u5047\u5b9a\u673a\u7406<\/p>\n<\/div>\n<p class=\"a\">\u7efc\u4e0a\u3001\u901a\u8fc7\u53e0\u6c2e\u81a6\u4e2d\u95f4\u4f53\u6210\u529f\u5728\u03b1<span lang=\"EN-US\">,\u03b2<\/span><span lang=\"EN-US\">\u2013\u70ef\u916e\u4e0a\u5bfc\u5165\u4e86\u4e09\u4e2a\u6c2e\u539f\u5b50<\/span>\u3001\u5408\u6210\u4e86\u03b2<span lang=\"EN-US\">\u2013\u80fa\u57fa<\/span>\u03b1<span lang=\"EN-US\">\u2013\u53e0\u6c2e\u7fb0\u57fa\u5316\u5408\u7269<\/span>\u3002\u9884\u8ba1\u8be5\u53cd\u5e94\u5c06\u8fdb\u4e00\u6b65\u63a8\u52a8\u53e0\u6c2e\u5316\u7269\u7684\u8f6c\u5316\u6cd5\u4e0eRh\u5361\u5bbe\u50ac\u5316\u7684\u53d1\u5c55\u3002<\/p>\n<h4>\u53c2\u8003\u6587\u732e<\/h4>\n<ol>\n<li>(a) Br\u00e4se, S.; Gil, C.; Knepper, K.; Zimmermann, V. <em>Angew<\/em>\u00a0<em>Chem., Int. Ed. <\/em><strong>2005<\/strong>, <em>44<\/em>, 5188. DOI: <a href=\"https:\/\/doi.org\/10.1002\/anie.200400657\">10.1002\/anie.200400657<\/a>(b) Shin, K.; Kim, H.; Chang, S. <em>Acc. Chem. Res.\u00a0<\/em><strong>2015<\/strong>, <em>48<\/em>, 1040. DOI: <a href=\"https:\/\/doi.org\/10.1021\/acs.accounts.5b00020\">10.1021\/acs.accounts.5b00020<\/a><\/li>\n<li>(a)Myers, E. L.; Raines, R. T. <em>Angew.<\/em>\u00a0<em>Chem., Int. Ed<\/em>. <strong>2009<\/strong>, <em>48<\/em>, 2359. DOI:<a href=\"https:\/\/doi.org\/10.1002\/anie.200804689\">10.1002\/anie.200804689<\/a>(b)Chou, H.-H.; Raines, R. T. <em>J. Am. Chem. Soc.<\/em><strong>2013<\/strong>, <em>135<\/em>, 14936. DOI:<a href=\"https:\/\/doi.org\/10.1021\/ja407822b\">10.1021\/ja407822b<\/a><\/li>\n<li>Molina, P.; Arques, A.; Vinader, M. V. <em>Tetrahedron Lett.<\/em><strong>1989<\/strong>, <em>30<\/em>, 6237. DOI:<a href=\"https:\/\/doi.org\/10.1016\/S0040-4039(01)93353-2\">1016\/S0040-4039(01)93353-2<\/a><\/li>\n<li>Ouali, M. S.; Vaultier, M.; Carri\u00e9, R. <em>Tetrahedron<\/em><strong>1980<\/strong>, <em>36<\/em>, 1821. DOI: <a href=\"https:\/\/doi.org\/10.1016\/0040-4020(80)80081-0\">1016\/0040-4020(80)80081-0<\/a><\/li>\n<\/ol>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"\u590d\u65e6\u5927\u5b66\u5f20\u4fca\u826f\u8bfe\u9898\u7ec4\u4f7f\u7528\u81a6\u50ac\u5316\u5242\uff0c\u5f00\u53d1\u4e86\u7531\u53e0\u6c2e\u5316\u5408\u7269\u548c\u03b1\uff0c\u03b2-\u70ef\u916e\u5408\u6210\u03b2-\u6c28\u57fa\u03b1-\u4e8c\u6c2e\u7fb0\u57fa\u5316\u5408\u7269\u7684\u5408\u6210\u65b9\u6cd5\u3002\u7531\u4e8e\u78f7\u53e0\u6c2e\u4e2d\u95f4\u4f53\u4e0d\u4f1a\u653e\u51fa\uff08\u79bb\u53bb\uff09\u6c2e\u6c14\u3001\u56e0\u6b64\u53ef\u4ee5\u5c06\u6240\u6709\u4e09\u4e2a\u6c2e\u539f\u5b50\u5f15\u5165\u03b1\uff0c\u03b2-\u70ef\u916e\u4e2d\u3002 \u4f7f\u7528\u78f7\u50ac\u5316\u7684\u53e0\u6c2e\u5316\u7269\u7684\u8f6c\u5316\u53cd\u5e94 \u53e0\u6c2e\u5316\u5408\u7269\u662f\u5e38\u89c1\u7684\u975e\u5e38\u6709\u7528\u7684building block[1]\u3002\u4f5c\u4e3a\u4ee3\u8868\u6027\u7684\u53e0\u6c2e\u5316\u7269\u7684\u8f6c\u5316\u53cd\u5e94\uff0c\u5e38\u5e38\u4f7f\u7528\u5316\u5b66\u5f53\u91cf\u6216\u8005\u50ac\u5316\u91cf\u7684\u81a6\u50ac\u5316\u5242\u8fdb\u884c\u53cd\u5e94\u3002\u5176\u4e2d\uff0c\u4ee5Staudinger\u53cd\u5e94\u4e3a\u4ee3\u8868\u7684\u901a\u8fc7\u78f7\u53e0\u6c2e\u4e2d\u95f4\u4f531\u8131\u6c2e\u6c14\u751f\u6210\u6c28\u57fa\u81a6\u70f72\uff0c\u7136\u540e\u518d\u5229\u7528\u8be5\u4e2d\u95f4\u4f53\u8fdb\u884c\u5404\u79cd\u5b98\u80fd\u56e2\u8f6c\u6362(\u56fe1A)\u30022\u7684\u6c34\u89e3\u53ef\u4ee5\u751f\u6210\u80fa(Staudinger\u53cd\u5e94)\u3001\u4e0e\u7fa7\u9178\u884d\u751f\u7269\u53cd\u5e94\u53ef\u4ee5\u751f\u6210\u9170\u80fa(Staudinger Ligation)\u3001\u4e0e\u919b\u6216\u8005\u916e\u53cd\u5e94\u751f\u6210imine(aza-Wittig\u53cd\u5e94)\u3002\u4ee5\u4e0a\u662f\u5c06\u53e0\u6c2e\u8f6c\u5316\u6210\u542b\u6709\u4e00\u4e2a\u6c2e\u539f\u5b50\u7684\u5b98\u80fd\u56e2\u7684\u624b\u6cd5\uff0c\u5f53\u7136\u8f6c\u6362\u6210\u542b\u6709\u4e24\u4e2a\u6c2e\u539f\u5b50\u7684\u5b98\u80fd\u56e2\u6bd4\u5982\u8bf4\u91cd\u6c2e\u7684\u65b9\u6cd5\u4e5f\u5df2\u7ecf\u88ab\u62a5\u9053\u3002Raines\u7b49\u4eba\u3001\u5c06\u53e0\u6c2e\u4e0e\u4f7f\u7528\u5177\u6709\u6d3b\u6027\u916f\u90e8\u5206\u7684\u81a6\u8bd5\u5242\u53cd\u5e94\uff0c\u6210\u529f\u8f6c\u5316\u6210\u4e86\u91cd\u6c2e\u4ea7\u7269(\u56fe1B)[2]\u3002\u901a\u8fc7\u53e0\u6c2e\u81a6\u8bd5\u52421\u3001\u5c06\u53e0\u6c2e\u7684\u4e09\u4e2a\u6c2e\u539f\u5b50\u5168\u90e8\u5f15\u5165\u7684\u4f8b\u5b50\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\u53ea\u6709Molina\u7b49\u4eba\u62a5\u9053\u7684\u542b\u6709\u4e9a\u80fa\u5b98\u80fd\u56e2\u7684\u82b3\u9999\u65cf\u53e0\u6c2e\u8f6c\u5316\u62102H\u2013\u5432\u5511\u9aa8\u67b6\u8fd9\u4e00\u4e2a\u4f8b\u5b50(\u56fe1C)[3]\u3002 \u672c\u6b21\u3001\u590d\u65e6\u5927\u5b66\u7684\u5f20\u4fca\u826f\u6559\u6388\u8bfe\u9898\u7ec4\u4f7f\u7528\u50ac\u5316\u91cf\u7684\u81a6\u8bd5\u5242\u3001\u5c06\u6c1f\u4ee3\u03b1,\u03b2-\u70ef\u916e3\u4e8eTMS-azide\u4f5c\u7528\uff0c\u6210\u529f\u5408\u6210\u4e86\u03b2\u2013amino\u00a0\u03b1\u2013diazide cabonyl\u5316\u5408\u72694(\u56fe1D)\u3002\u5e76\u4e14\u5982\u679c\u4f7f\u7528\u624b\u6027\u81a6\u50ac\u5316\u5242\u4e5f\u53ef\u4ee5\u4ea7\u751f\u5bf9\u6620\u9009\u62e9\u6027\u3002 \u56fe1. \u4f7f\u7528\u81a6\u8bd5\u5242\u7684\u53e0\u6c2e\u7684\u8f6c\u5316\u53cd\u5e94 (A) Staudinger\u53cd\u5e94\u7b49\u3001 (B) Raines\u7b49\u4eba\u7684\u65b9\u6cd5\u3001 (C) Molina\u7b49\u4eba\u7684\u65b9\u6cd5\u3001 (D) \u8fd9\u6b21\u7684\u53cd\u5e94 \u201cPhosphine-Catalyzed Difunctionalization of b-Fluoroalkyl\u00a0a,b-Enones: A Direct Approach to b-Amino a-Diazo Carbonyl Compounds\u201d Wang, H.; Zhang, Li.; Tu, Y.; Xiang, R.; Guo, Y.-L.; Zhang, J.\u00a0Angew. Chem., Int. Ed.2018, 57, 15787 DOI: 10.1002\/anie.201810253 \u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd Junliang Zhang \u7ecf\u5386\uff1a 1993-1997 BSc, Tianjin University (Prof. Wenqin Zhang and Prof. Chunbao Li) 1997-2002 PhD, Shanghai Institute of Organic Chemistry (Prof. Shengming Ma) 2002-2003 Research Chemist, Shanghai Institute of Organic Chemistry (Prof. Shengming Ma) 2003-2004 Humboldt Fellow, University of Colongne (Prof. Hans-G\u00fcnther Schmalz) 2005-2006 Postdoc, The University of Chicago (Prof. Chuan He and Prof. Stephen Kent) 2006-2017.9 Professor and Vice [&hellip;]","protected":false},"author":5,"featured_media":24176,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[414,1271],"tags":[720,2374,717],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/01\/2018-12-25_23-11-16.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-6hV","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/24175"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=24175"}],"version-history":[{"count":18,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/24175\/revisions"}],"predecessor-version":[{"id":24197,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/24175\/revisions\/24197"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/24176"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=24175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=24175"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=24175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}