{"id":24530,"date":"2019-02-11T09:24:55","date_gmt":"2019-02-11T01:24:55","guid":{"rendered":"\/\/www.gsbet888.com\/?p=24530"},"modified":"2019-02-11T09:24:55","modified_gmt":"2019-02-11T01:24:55","slug":"%e7%94%9f%e7%89%a9%e7%94%b5%e5%ad%90%e7%ad%89%e6%8e%92%e4%bd%93-bioisostere","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/2019\/02\/%e7%94%9f%e7%89%a9%e7%94%b5%e5%ad%90%e7%ad%89%e6%8e%92%e4%bd%93-bioisostere.html","title":{"rendered":"\u751f\u7269\u7535\u5b50\u7b49\u6392\u4f53 Bioisostere"},"content":{"rendered":"

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<\/span>
\n\u5386\u53f2\u7ecf\u8fc7<\/h4>\n

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\u5173\u8054\u6587\u732e<\/h4>\n
    \n
  1. \u201cSynopsis of Some Recent Tactical Application of Bioisosteres in Drug Design\u201d Meanwell, N. A. J. Med. Chem.<\/em> 2011<\/strong>, 54<\/em>, 2529. DOI: 10.1021\/jm1013693<\/a><\/li>\n
  2. \u201cBioisosterism:\u2009 A Rational Approach in Drug Design\u201d Patani, G. A.; LaVoie, E. J. Chem. Rev.<\/em> 1996<\/strong>, 96<\/em>, 3147. DOI: 10.1021\/cr950066q<\/a><\/li>\n
  3. \u201cOrganosilicon Molecules with Medicinal Applications\u201d Franz, A. K.; Wilson, S. O. J. Med. Chem.<\/em> 2013<\/strong>, 56<\/em>, 388. DOI: 10.1021\/jm3010114<\/a><\/li>\n
  4. \u00a0\u201c\u30da\u30d7\u30c1\u30c9\u30df\u30e1\u30c6\u30a3\u30c3\u30af\u306b\u3088\u308b\u5275\u85ac\u7814\u7a76\u201d \u9cf4\u6d77\u54f2\u592b,\u7389\u6751\u5553\u548c, \u751f\u5316\u5b66<\/em> 2010<\/strong>, 82<\/em>, 515. [PDF]<\/a><\/li>\n
  5. \u00a0\u201cOxetanes as Versatile Elements in Drug Discovery and Synthesis\u201d Burkhard, J. A.; Wuitschik, G.; Rogers-Evans, M.; Muller, K.; Carreira, E. M. Angew. Chem. Int. Ed.<\/em>2010<\/strong>, 49<\/em>, 9052. DOI: 10.1002\/anie.200907155<\/a><\/li>\n
  6. \u201cApplication of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active \u03b3-Secretase Inhibitor\u201d Stepan, A. F. et al. J. Med. Chem.<\/em> 2012<\/strong>, 55<\/em>, 3414. DOI: 10.1021\/jm300094u<\/a><\/li>\n<\/ol>\n

    \u5173\u8054\u4e66\u7c4d\uff08\u65e5\u4e9a\uff09<\/h4>\n
    \n
    \"Bioisosteres<\/a><\/div>\n
    \n

    Bioisosteres in Medicinal Chemistry (Methods and Principles in Medicinal Chemistry Book 54) (English Edition)<\/a><\/h4>\n