{"id":24890,"date":"2019-03-22T06:40:54","date_gmt":"2019-03-21T22:40:54","guid":{"rendered":"\/\/www.gsbet888.com\/?p=24890"},"modified":"2019-03-22T06:40:54","modified_gmt":"2019-03-21T22:40:54","slug":"nobilisitine-a","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/molecule\/2019\/03\/nobilisitine-a.html","title":{"rendered":"Nobilisitine A"},"content":{"rendered":"<p><strong>Nobilisitine A<\/strong>\u3001\u662f\u4ece<em>Clivia nobilis <\/em>\u4e2d\u5206\u79bb\u63d0\u53d6\u51fa\u6765\u7684\u4e00\u79cd\u751f\u7269\u78b1\uff0c\u5177\u6709\u6297\u771f\u83cc\u6d3b\u6027\uff08\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\uff0c\u4eba\u4f53\u767d\u8272\u5ff5\u7403\u83cc\uff09\u30021999\u5e74\u7531Evidente\u7b49\u4eba\u4ece\u690d\u7269\u4e2d\u63d0\u53d6\u83b7\u5f97<sup>[1]<\/sup>\u3002\u5f53\u65f6\u901a\u8fc7<sup>1<\/sup>H NMR\u4e0e<sup>13<\/sup>C NMR\u5206\u6790\uff0c\u63a8\u6d4b\u51fa\u5177\u6709\u4e0b\u56fe(1)\u6240\u793a\u7684\u7ed3\u6784\u3002\u7136\u800c\u30012010\u5e74Banwell\u7b49\u4eba\u5b9e\u73b0\u4e86Nobilisitine A\u7684\u5168\u5408\u6210\u3001\u7136\u800cNMR\u8c31\u56fe\u4e0eEvidente\u7b49\u4eba\u63d0\u53d6\u51fa\u6765\u7684\u4e0d\u540c<sup>[2]<\/sup>\u3002Banwell \u7b49\u4eba\u901a\u8fc7X\u5c04\u7ebf\u5355\u6676\u884d\u5c04\u5206\u6790\u786e\u5b9a\u4e86\u5176\u7ed3\u6784\uff0c\u8fd9\u4e5f\u63ed\u793a\u4e86Evidente\u7b49\u4eba\u5f53\u65f6\u63d0\u5021\u7684\u5316\u5b66\u7ed3\u6784\u662f\u9519\u8bef\u7684\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-24892\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/03\/NobilisitineA-300x174.png\" alt=\"\" width=\"300\" height=\"174\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/03\/NobilisitineA-300x174.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/03\/NobilisitineA.png 475w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<h4>\u901a\u8fc7\u8ba1\u7b97\u5316\u5b66\u7684\u7ed3\u6784\u6821\u6b63<\/h4>\n<p>2011\u5e74<a href=\"\/\/www.gsbet888.com\/chemists\/2019\/03\/dean-j-tantillo.html\">Tantillo<\/a>\u7b49\u4eba\u3001\u901a\u8fc7\u8ba1\u7b97\u5316\u5b66\u8fdb\u884c\u4e86Nobilisitine A\u7684NMR\u8c31\u56fe\u8ba1\u7b97<sup>[3]<\/sup>\u3002<\/p>\n<p>Nobilisitine A\u542b\u670932\u4e2astereo isomer\u3002Dean\u7b49\u4eba\u8be6\u7ec6\u89e3\u6790\u4e86Evidente\u8bfe\u9898\u7ec4\u5206\u79bb\u63d0\u53d6\u5f97\u5230\u7684Nobilisitine A\u7684NMR\u8c31\u56fe\u3001\u4ed6\u4eec\u63a8\u6d4bC\/D\u74b0\u5e94\u8be5\u662fcis\u7f29\u73af\u3002\u4ece\u800c\u628a32\u4e2a\u53ef\u80fd\u6027\u7f29\u5c0f\u5230\u4e868\u4e2astereo isomer\u5f02\u6784\u4f53\u3002<\/p>\n<p>\u4e0d\u4ec5\u4ec5\u8981\u8003\u8651Stereo isomer\u3001\u5728\u8ba1\u7b97flexible\u5316\u5408\u7269\u7684\u8ba1\u7b97\u7684\u65f6\u5019\uff0c\u8fd8\u9700\u8981\u8003\u8651\u6784\u8c61\u95ee\u9898\u3002\u56e0\u6b64\u8003\u8651\u52308\u79cdstereo isomer\u4e2d\u7684\u6bcf\u4e00\u79cd\u90fd\u6709\u6784\u8c61\u5f02\u6784\u4f53\uff0c\u8fd9\u5c06\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u6570\u5b57\u3002Banwell\u7b49\u4eba\u8fdb\u884cX\u5c04\u7ebf\u5355\u6676\u884d\u5c04\u8fdb\u884c\u4e86\u7ed3\u6784\u89e3\u6790\u3001\u6784\u8c61\u4e5f\u5f88\u660e\u786e\uff0c\u56e0\u6b64\u3001Tantillo\u7b49\u4eba\u5c31\u7740\u773c\u4e8eBanwell\u7b49\u4eba\u7684NMR\u8c31\u56fe\uff0c\u8fdb\u884c\u8ba1\u7b97\uff0c<\/p>\n<p>\u901a\u8fc7DFT\u8ba1\u7b97\u3001\u8ba1\u7b97\u503c\u4e0e\u5b9e\u9a8c\u503c\u76f8\u6bd4\uff0c\u4ec5\u4ec5\u5177\u67091H NMR\u5e73\u5747 0.31ppm\u300113C NMR\u5e73\u57473.4 ppm\u7684\u5fae\u5c0f\u504f\u5dee\u3002\u7531\u6b64\u8bc1\u5b9e\uff0c\u4ed6\u4eec\u6240\u7528\u7684\u8ba1\u7b97\u7684\u51fd\u6570\u662f\u975e\u5e38\u5207\u5b9e\u6709\u6548\u7684\uff0c\u901a\u8fc7\u8ba1\u7b97\u5316\u5b66\u53ef\u4ee5\u9884\u6d4bNobilisitine A\u7684\u7ed3\u6784\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-24893 \" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/03\/NobilisitineA2.png\" alt=\"\" width=\"548\" height=\"236\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/03\/NobilisitineA2.png 1016w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/03\/NobilisitineA2-300x129.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/03\/NobilisitineA2-768x330.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/03\/NobilisitineA2-680x292.png 680w\" sizes=\"(max-width: 548px) 100vw, 548px\" \/><\/p>\n<p>\u4e4b\u540e\u3001Tantillo\u7b49\u4eba\u8fdb\u884c\u4e86\u4e0a\u56fe\u6240\u793a\u7684\u5316\u5408\u7269\u7684\u8ba1\u7b97\uff0c\u901a\u8fc7\u5b9e\u6d4b\u503c\u4e0e\u8ba1\u7b97\u503c\u7684\u6bd4\u8f83\uff0c\u8ba4\u4e3a\u504f\u5dee\u6700\u5c0f\u7684\u5316\u5408\u7269<strong>4<\/strong>\u4e3aNobilisitine A\u7684\u7ed3\u6784\u3002\u4eca\u540e\u53ea\u9700\u8981\u5b9e\u73b0\u5316\u5408\u7269<strong>4<\/strong>\u7684\u5168\u5408\u6210\u6765\u9a8c\u8bc1\u8be5\u8ba1\u7b97\u7684\u9884\u6d4b\u662f\u4e0d\u662f\u6b63\u786e\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4>\u95a2\u9023\u6587\u732e<\/h4>\n<ol>\n<li>Evidente, A.; Abou-Donia, A. H.; Darwish, F. A.; Amer, M. E.; Kassem, F. F.; Hammoda, H. A. M.; Motta, A. <em>Phytochemistry<\/em> <strong>1999<\/strong>,<em> 51<\/em>, 1151\u20131155. DOI:\u00a0<a id=\"ddDoi\" class=\"S_C_ddDoi\" href=\"http:\/\/dx.doi.org\/10.1016\/S0031-9422(98)00714-6\" target=\"doilink\">10.1016\/S0031-9422(98)00714-6<\/a><\/li>\n<li>Schwartz, B. D.; Jones, M. T.; Banwell, M. G.; Cade, I. A. <em>Org. Lett.<\/em> <strong>2010<\/strong>, <em>12<\/em>, 5210\u20135213. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/ol102249q\">10.1021\/ol102249q<\/a><\/li>\n<li>Michael W. Lodewyk and Dean J. Tantillo <em>J. Nat. Prod.<\/em> <strong>2011<\/strong>, <em>74<\/em>, 1339\u20131343. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/np2000446\">10.1021\/np2000446<\/a><\/li>\n<\/ol>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"Nobilisitine A\u3001\u662f\u4eceClivia nobilis \u4e2d\u5206\u79bb\u63d0\u53d6\u51fa\u6765\u7684\u4e00\u79cd\u751f\u7269\u78b1\uff0c\u5177\u6709\u6297\u771f\u83cc\u6d3b\u6027\uff08\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\uff0c\u4eba\u4f53\u767d\u8272\u5ff5\u7403\u83cc\uff09\u30021999\u5e74\u7531Evidente\u7b49\u4eba\u4ece\u690d\u7269\u4e2d\u63d0\u53d6\u83b7\u5f97[1]\u3002\u5f53\u65f6\u901a\u8fc71H NMR\u4e0e13C NMR\u5206\u6790\uff0c\u63a8\u6d4b\u51fa\u5177\u6709\u4e0b\u56fe(1)\u6240\u793a\u7684\u7ed3\u6784\u3002\u7136\u800c\u30012010\u5e74Banwell\u7b49\u4eba\u5b9e\u73b0\u4e86Nobilisitine A\u7684\u5168\u5408\u6210\u3001\u7136\u800cNMR\u8c31\u56fe\u4e0eEvidente\u7b49\u4eba\u63d0\u53d6\u51fa\u6765\u7684\u4e0d\u540c[2]\u3002Banwell \u7b49\u4eba\u901a\u8fc7X\u5c04\u7ebf\u5355\u6676\u884d\u5c04\u5206\u6790\u786e\u5b9a\u4e86\u5176\u7ed3\u6784\uff0c\u8fd9\u4e5f\u63ed\u793a\u4e86Evidente\u7b49\u4eba\u5f53\u65f6\u63d0\u5021\u7684\u5316\u5b66\u7ed3\u6784\u662f\u9519\u8bef\u7684\u3002 \u901a\u8fc7\u8ba1\u7b97\u5316\u5b66\u7684\u7ed3\u6784\u6821\u6b63 2011\u5e74Tantillo\u7b49\u4eba\u3001\u901a\u8fc7\u8ba1\u7b97\u5316\u5b66\u8fdb\u884c\u4e86Nobilisitine A\u7684NMR\u8c31\u56fe\u8ba1\u7b97[3]\u3002 Nobilisitine A\u542b\u670932\u4e2astereo isomer\u3002Dean\u7b49\u4eba\u8be6\u7ec6\u89e3\u6790\u4e86Evidente\u8bfe\u9898\u7ec4\u5206\u79bb\u63d0\u53d6\u5f97\u5230\u7684Nobilisitine A\u7684NMR\u8c31\u56fe\u3001\u4ed6\u4eec\u63a8\u6d4bC\/D\u74b0\u5e94\u8be5\u662fcis\u7f29\u73af\u3002\u4ece\u800c\u628a32\u4e2a\u53ef\u80fd\u6027\u7f29\u5c0f\u5230\u4e868\u4e2astereo isomer\u5f02\u6784\u4f53\u3002 \u4e0d\u4ec5\u4ec5\u8981\u8003\u8651Stereo isomer\u3001\u5728\u8ba1\u7b97flexible\u5316\u5408\u7269\u7684\u8ba1\u7b97\u7684\u65f6\u5019\uff0c\u8fd8\u9700\u8981\u8003\u8651\u6784\u8c61\u95ee\u9898\u3002\u56e0\u6b64\u8003\u8651\u52308\u79cdstereo isomer\u4e2d\u7684\u6bcf\u4e00\u79cd\u90fd\u6709\u6784\u8c61\u5f02\u6784\u4f53\uff0c\u8fd9\u5c06\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u6570\u5b57\u3002Banwell\u7b49\u4eba\u8fdb\u884cX\u5c04\u7ebf\u5355\u6676\u884d\u5c04\u8fdb\u884c\u4e86\u7ed3\u6784\u89e3\u6790\u3001\u6784\u8c61\u4e5f\u5f88\u660e\u786e\uff0c\u56e0\u6b64\u3001Tantillo\u7b49\u4eba\u5c31\u7740\u773c\u4e8eBanwell\u7b49\u4eba\u7684NMR\u8c31\u56fe\uff0c\u8fdb\u884c\u8ba1\u7b97\uff0c \u901a\u8fc7DFT\u8ba1\u7b97\u3001\u8ba1\u7b97\u503c\u4e0e\u5b9e\u9a8c\u503c\u76f8\u6bd4\uff0c\u4ec5\u4ec5\u5177\u67091H NMR\u5e73\u5747 0.31ppm\u300113C NMR\u5e73\u57473.4 ppm\u7684\u5fae\u5c0f\u504f\u5dee\u3002\u7531\u6b64\u8bc1\u5b9e\uff0c\u4ed6\u4eec\u6240\u7528\u7684\u8ba1\u7b97\u7684\u51fd\u6570\u662f\u975e\u5e38\u5207\u5b9e\u6709\u6548\u7684\uff0c\u901a\u8fc7\u8ba1\u7b97\u5316\u5b66\u53ef\u4ee5\u9884\u6d4bNobilisitine A\u7684\u7ed3\u6784\u3002 \u4e4b\u540e\u3001Tantillo\u7b49\u4eba\u8fdb\u884c\u4e86\u4e0a\u56fe\u6240\u793a\u7684\u5316\u5408\u7269\u7684\u8ba1\u7b97\uff0c\u901a\u8fc7\u5b9e\u6d4b\u503c\u4e0e\u8ba1\u7b97\u503c\u7684\u6bd4\u8f83\uff0c\u8ba4\u4e3a\u504f\u5dee\u6700\u5c0f\u7684\u5316\u5408\u72694\u4e3aNobilisitine A\u7684\u7ed3\u6784\u3002\u4eca\u540e\u53ea\u9700\u8981\u5b9e\u73b0\u5316\u5408\u72694\u7684\u5168\u5408\u6210\u6765\u9a8c\u8bc1\u8be5\u8ba1\u7b97\u7684\u9884\u6d4b\u662f\u4e0d\u662f\u6b63\u786e\u3002 &nbsp; \u95a2\u9023\u6587\u732e Evidente, A.; Abou-Donia, A. H.; Darwish, F. A.; Amer, M. E.; Kassem, F. F.; Hammoda, H. A. M.; Motta, A. Phytochemistry 1999, 51, 1151\u20131155. DOI:\u00a010.1016\/S0031-9422(98)00714-6 Schwartz, B. D.; Jones, M. T.; Banwell, M. G.; Cade, I. A. Org. Lett. 2010, 12, 5210\u20135213. DOI:\u00a010.1021\/ol102249q Michael W. Lodewyk and Dean J. Tantillo J. Nat. Prod. 2011, 74, 1339\u20131343. DOI:\u00a010.1021\/np2000446 \u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0Chem-Station\u5316\u5b66\u7a7a\u95f4\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01","protected":false},"author":5,"featured_media":24891,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[869],"tags":[275,976],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/03\/NobilisitineA-top.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-6ts","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/24890"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=24890"}],"version-history":[{"count":12,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/24890\/revisions"}],"predecessor-version":[{"id":24907,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/24890\/revisions\/24907"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/24891"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=24890"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=24890"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=24890"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}