{"id":24918,"date":"2019-03-29T18:38:44","date_gmt":"2019-03-29T10:38:44","guid":{"rendered":"\/\/www.gsbet888.com\/?p=24918"},"modified":"2019-03-29T18:38:44","modified_gmt":"2019-03-29T10:38:44","slug":"nicholas-turner","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemists\/2019\/03\/nicholas-turner.html","title":{"rendered":"Nicholas Turner"},"content":{"rendered":"<p>Nicholas Turner, 1960\u5e746\u67082\u65e5\u82f1\u56fd\u3001\u80af\u7279\u5ddeOrpington\u51fa\u751f\uff0c\u662f\u82f1\u56fd\u8457\u540d\u7684\u9176\u5316\u5b66\u5bb6\u3002\u66fc\u5f7b\u65af\u7279\u5927\u5b66\u6559\u6388(\u7167\u7247\uff1a\u66fc\u5f7b\u65af\u7279\u5927\u5b66\u5316\u5b66\u7cfb)\u3002<\/p>\n<h4>\u5c65\u5386<\/h4>\n<ul>\n<li>1979\u20101982 University of Bristol, Chemistry (BSc)<\/li>\n<li>1982\u20101985 University of Oxford, \u535a\u58eb\u5b66\u4f4d (Prof. J. E. Baldwin)<\/li>\n<li>1985\u20101987 Royal Society Junior Research Fellow<\/li>\n<li>1985\/86 Oxford University, (Dyson Perrins Laboratory)<\/li>\n<li>1986\/87 Harvard, Department of Chemistry, (Prof. G. M. Whitesides)<\/li>\n<li>1987\u20101995 University of Exeter, Department of Chemistry, \u8bb2\u5e08<\/li>\n<li>1995\u20101998 University of Edinburgh, Reader in Bio\u2010Organic Chemistry<\/li>\n<li>1998\u20102004\u00a0University of Edinburgh, Chemical Biology, \u6559\u6388<\/li>\n<li>2003 Co\u2010founder and Chief Scientific Officer of <a href=\"https:\/\/www.ingenza.com\/\">Ingenza Ltd<\/a><\/li>\n<li>2004- University of Manchester, chemical biology, \u6559\u6388<\/li>\n<li>2005\u00a0\u2010\u00a0Director of <a href=\"http:\/\/www.coebio3.manchester.ac.uk\/\">Centre of Excellence in Biocatalysis, Biotransformation and Biocatalytic Manufacturing<\/a> (CoEBio3)<\/li>\n<li>2012\u00a0Co\u2010founder and <a href=\"http:\/\/xn--discoverybc-tf3f.co.uk\/\">Director of Discovery Biocatalysts<\/a><\/li>\n<\/ul>\n<p>\u987e\u95ee\u517c\u4efb: AstraZeneca (UK), Johnson Matthey (UK), Lonza (Switzerland), Evolva (Switzerland), Bactevo (UK), Asymchem (China), Dr. Reddy\u2019s Research Laboratories \u5176\u4ed6\u8fd8\u517c\u4efb\u591a\u4e2aAdvisory Board<\/p>\n<h4>\u83b7\u5956\u7ecf\u5386<\/h4>\n<ul>\n<li>1992 RSC Medal for Carbohydrate Chemistry<\/li>\n<li>1995 Pfizer Academic Award for Organic Chemistry<\/li>\n<li>1996 RSC Corday\u2010Morgan Medal and Prize<\/li>\n<li>2004 Biocat Award<\/li>\n<li>2007 AZ\/GSK\/Pfizer UK Prize for Process Chemistry Research<\/li>\n<li>2009 Royal Society of Chemistry Industrial Organic Award<\/li>\n<li>2011 Royal Society Wolfson Research Merit Award<\/li>\n<li>2017 ERC Advanced Grant Fellowship 2017-2022<\/li>\n<li>2017 RSC Organic Stereochemistry Award<\/li>\n<li>2018 ACS Catalysis Award<\/li>\n<\/ul>\n<h4>\u7814\u7a76\u4e1a\u7ee9<\/h4>\n<p>\u80fa\u5728\u5929\u7136\u4ea7\u7269\uff0cAPI\uff0cBulk chemical\u7b49\u591a\u79cd\u5730\u65b9\u51fa\u73b0\u7684\u5b98\u80fd\u56e2\u3001\u56e0\u6b64\u5728\u5408\u6210\u5316\u5b66\u4e2d\uff0c\u80fa\u7684\u5408\u6210\u4e5f\u663e\u5f97\u5c24\u4e3a\u91cd\u8981\u3002Turner\u56e0\u4e3amonoamine oxidase (MAO)[1]\u4e0e\u6700\u8fd1imine reductase (IRED)[2]reductive aminase [3]\u80fa\u5408\u6210\u9176\u7684\u5f00\u53d1\u800c\u95fb\u540d\u3002\u7531\u4e8e\u80fd\u591f\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\u5730\u5408\u6210\u672a\u4fdd\u62a4\u7684\u624b\u6027\u80fa\uff0c\u8fd9\u4e9b\u9176\u7684\u5f00\u53d1\u5438\u5f15\u4e86\u4e1a\u754c\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u9664\u4e86\u6d3b\u7528wild type\u7684\u9176\u4e4b\u5916\uff0c\u4ed6\u4e5f\u901a\u8fc7\u4f7f\u7528Directed Evolution\u5bf9\u9176\u8fdb\u884c\u4fee\u9970\uff0c\u4ee5\u8fbe\u5230\u6269\u5927\u5e95\u7269\u9002\u7528\u8303\u56f4\u4ee5\u53ca\u5b9e\u73b0\u5de5\u4e1a\u751f\u4ea7[4]\u3002<\/p>\n<p>\u540c\u65f6\u3001\u4e5f\u5728\u8fdb\u884c\u8fd0\u7528Biocatalyst\u8fdb\u884c\u5929\u7136\u4ea7\u7269\u4e0e\u533b\u836f\u54c1\u7684\u5408\u6210\u7684\u7814\u7a76[5]\u3002<\/p>\n<h4>\u5176\u4ed6<\/h4>\n<ul>\n<li>\u4ed6\u7684\u59bb\u5b50<a href=\"http:\/\/flitschlab.com\/\">Sabine L. Flitsch<\/a>\u4e5f\u5728\u540c\u4e00\u4e2a\u7814\u7a76\u6240\uff0c\u4e3b\u5bb0\u8fd9\u53e6\u4e00\u4e2a\u7814\u7a76\u5ba4\u3002\u592b\u59bb\u4fe9\u4e5f\u5728\u8fdb\u884c\u7740\u5408\u4f5c\u7814\u7a76\u3002<\/li>\n<\/ul>\n<h4>\u76f8\u5173\u89c6\u9891<\/h4>\n<p><span class=\"embed-youtube\" style=\"text-align:center; display: block;\"><iframe loading=\"lazy\" class=\"youtube-player\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/-IXYaxuec3s?version=3&#038;rel=1&#038;showsearch=0&#038;showinfo=1&#038;iv_load_policy=1&#038;fs=1&#038;hl=en-US&#038;autohide=2&#038;wmode=transparent\" allowfullscreen=\"true\" style=\"border:0;\" sandbox=\"allow-scripts allow-same-origin allow-popups allow-presentation allow-popups-to-escape-sandbox\"><\/iframe><\/span><\/p>\n<h4>\u76f8\u5173\u6587\u732e<\/h4>\n[1]\u00a0K\u00f6hler, V.; Bailey, K. R.; Znabet, A.; Raftery, J.; Helliwell, M.; Turner, N. J. <em>Angew. Chem. Int. Ed.<\/em> <strong>2010<\/strong>, <em>49<\/em> (12), 2182.DOI: <a href=\"http:\/\/doi.wiley.com\/10.1002\/anie.200906655\">10.1002\/anie.200906655<\/a>.[2]\u00a0Grogan, G.; Turner, N. J. <em>Chem. A Eur. J.<\/em> <strong>2016<\/strong>, <em>22<\/em> (6), 1900. DOI: <a href=\"http:\/\/doi.wiley.com\/10.1002\/chem.201503954\">10.1002\/chem.201503954<\/a>.[3]\u00a0Aleku, G. A.; France, S. P.; Man, H.; Mangas-Sanchez, J.; Montgomery, S. L.; Sharma, M.; Leipold, F.; Hussain, S.; Grogan, G.; Turner, N. J. <em>Nat. Chem.<\/em> <strong>2017<\/strong>, <em>9<\/em>(10), 961. DOI:\u00a0<a href=\"http:\/\/www.nature.com\/doifinder\/10.1038\/nchem.2782\">10.1038\/nchem.2782<\/a>.[4] Turner, N. J. <em>Nat. Chem. Biol.<\/em> <strong>2009<\/strong>, <em>5<\/em> (8), 567.DOI: <a href=\"http:\/\/www.nature.com\/articles\/nchembio.203\">10.1038\/nchembio.203<\/a>.[5] Turner, N. J.; O\u2019Reilly, E. <em>Nat. Chem. Biol.<\/em> <strong>2013<\/strong>, <em>9<\/em> (5), 285. DOI:<a href=\"http:\/\/www.nature.com\/articles\/nchembio.1235\">10.1038\/nchembio.1235<\/a>.;\u00a0Green, A. P.; Turner, N. J. <em>Perspect. Sci.<\/em> <strong>2016<\/strong>, <em>9<\/em>, 42.DOI: <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2213020916302269?via%3Dihub\">10.1016\/j.pisc.2016.04.106.;\u00a0<\/a>H\u00f6nig, M.; Sondermann, P.; Turner, N. J.; Carreira, E. M. <em>Angew. Chem. Int. Ed.<\/em> <strong>2017<\/strong>, <em>56<\/em> (31), 8942. DOI:<a href=\"http:\/\/doi.wiley.com\/10.1002\/anie.201612462\">10.1002\/anie.201612462<\/a>.<\/p>\n<h4>\u76f8\u5173\u4e66\u7c4d\uff08\u65e5\u4e9a\u4ef7\u683c\uff09<\/h4>\n<div class=\"amazonjs_item amazonjs_book\">\n<div class=\"amazonjs_image\"><a class=\"amazonjs_link\" title=\"Biocatalysis in Organic Synthesis: The Retrosynthesis Approach (English Edition)\" href=\"https:\/\/www.amazon.co.jp\/Biocatalysis-Organic-Synthesis-Retrosynthesis-Approach-ebook\/dp\/B079WDGCJ2?SubscriptionId=AKIAI6Q3RDQBU2J6P3JQ&amp;tag=chemstation-22&amp;linkCode=xm2&amp;camp=2025&amp;creative=165953&amp;creativeASIN=B079WDGCJ2\" target=\"_blank\" rel=\"noopener\" data-role=\"amazonjs_product\" data-asin=\"B079WDGCJ2\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/images-fe.ssl-images-amazon.com\/images\/I\/41k6kZTaH3L._SL160_.jpg\" alt=\"Biocatalysis in Organic Synthesis: The Retrosynthesis Approach (English Edition)\" width=\"107\" height=\"160\" \/><\/a><\/div>\n<div class=\"amazonjs_info\">\n<h4><a class=\"amazonjs_link\" title=\"Biocatalysis in Organic Synthesis: The Retrosynthesis Approach (English Edition)\" href=\"https:\/\/www.amazon.co.jp\/Biocatalysis-Organic-Synthesis-Retrosynthesis-Approach-ebook\/dp\/B079WDGCJ2?SubscriptionId=AKIAI6Q3RDQBU2J6P3JQ&amp;tag=chemstation-22&amp;linkCode=xm2&amp;camp=2025&amp;creative=165953&amp;creativeASIN=B079WDGCJ2\" target=\"_blank\" rel=\"noopener\" data-role=\"amazonjs_product\" data-asin=\"B079WDGCJ2\">Biocatalysis in Organic Synthesis: The Retrosynthesis Approach (English Edition)<\/a><\/h4>\n<ul>\n<li><b>\u4f5c\u8005<\/b>Nicholas J Turner,Luke Humphreys<\/li>\n<li><b>\u51fa\u7248\u65e5<\/b>2018\/02\/15<\/li>\n<li><b>Kindle\u7248<\/b>429\u9875<\/li>\n<li><b>\u51fa\u7248\u793e<\/b>Royal Society of Chemistry<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"amazonjs_item amazonjs_book\">\n<div class=\"amazonjs_image\"><a class=\"amazonjs_link\" title=\"Introduction to Biocatalysis Using Enzymes and Microorganisms\" href=\"https:\/\/www.amazon.co.jp\/Introduction-Biocatalysis-Using-Enzymes-Microorganisms\/dp\/0521436850?SubscriptionId=AKIAI6Q3RDQBU2J6P3JQ&amp;tag=chemstation-22&amp;linkCode=xm2&amp;camp=2025&amp;creative=165953&amp;creativeASIN=0521436850\" target=\"_blank\" rel=\"noopener\" data-role=\"amazonjs_product\" data-asin=\"0521436850\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/images-fe.ssl-images-amazon.com\/images\/I\/41InesH1p9L._SL160_.jpg\" alt=\"Introduction to Biocatalysis Using Enzymes and Microorganisms\" width=\"107\" height=\"160\" \/><\/a><\/div>\n<div class=\"amazonjs_info\">\n<h4><a class=\"amazonjs_link\" title=\"Introduction to Biocatalysis Using Enzymes and Microorganisms\" href=\"https:\/\/www.amazon.co.jp\/Introduction-Biocatalysis-Using-Enzymes-Microorganisms\/dp\/0521436850?SubscriptionId=AKIAI6Q3RDQBU2J6P3JQ&amp;tag=chemstation-22&amp;linkCode=xm2&amp;camp=2025&amp;creative=165953&amp;creativeASIN=0521436850\" target=\"_blank\" rel=\"noopener\" data-role=\"amazonjs_product\" data-asin=\"0521436850\">Introduction to Biocatalysis Using Enzymes and Microorganisms<\/a><\/h4>\n<ul>\n<li><b>\u4f5c\u8005<\/b>S. M. Roberts,Nicholas J. Turner,Andrew J. Willetts,Michael K. Turner<\/li>\n<li class=\"amazonjs_price\" title=\"\u4fa1\u683c\u304a\u3088\u3073\u767a\u9001\u53ef\u80fd\u6642\u671f\u306f\u8868\u793a\u3055\u308c\u305f\u65e5\u4ed8\/\u6642\u523b\u306e\u6642\u70b9\u306e\u3082\u306e\u3067\u3042\u308a\u3001\u5909\u66f4\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u5546\u54c1\u306e\u8ca9\u58f2\u306b\u304a\u3044\u3066\u306f\u3001\u8cfc\u5165\u306e\u6642\u70b9\u3067 [Amazon.co.jp \u307e\u305f\u306f Javari.jp] \u306b\u8868\u793a\u3055\u308c\u3066\u3044\u308b\u4fa1\u683c\u304a\u3088\u3073\u767a\u9001\u53ef\u80fd\u6642\u671f\u306e\u60c5\u5831\u304c\u9069\u7528\u3055\u308c\u307e\u3059\u3002\"><span class=\"amazonjs_listprice\"><b>\u53c2\u8003\u4ef7<\/b>\uffe5 5,294<\/span><br \/>\n<b>\u4ef7\u683c<\/b>\uffe5 5,268(2019\/03\/22 21:58\u6642\u70b9)<\/li>\n<li><b>\u51fa\u7248\u65e5<\/b>1995\/01\/27<\/li>\n<li><b>\u9875\u7801 <\/b>208\u9875<\/li>\n<li><b>ISBN-10<\/b>0521436850<\/li>\n<li><b>ISBN-13<\/b>9780521436854<\/li>\n<li><b>\u51fa\u7248\u793e<\/b>Cambridge University Press<\/li>\n<\/ul>\n<\/div>\n<div class=\"amazonjs_footer\"><\/div>\n<\/div>\n<h4>\u76f8\u5173\u94fe\u63a5<\/h4>\n<ul>\n<li>N. Turner: <a href=\"https:\/\/orcid.org\/0000-0002-8708-0781\">ORCID<\/a><\/li>\n<li><a href=\"https:\/\/orcid.org\/0000-0002-8708-0781\">Turner \u7814\u7a76\u5ba4<\/a><\/li>\n<li>N.\u2005Turner: <a href=\"https:\/\/pubs.acs.org\/doi\/pdfplus\/10.1021\/acscatal.8b00261\">ACS Catalysis Award<\/a><\/li>\n<li>N.\u2005Turner: <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.201600187\">ACIE Authors Profile<\/a><\/li>\n<li>N.\u2005Turner: <a href=\"https:\/\/www.chemistryworld.com\/feature\/survival-of-the-fittest\/3004804.article\">Chemistry World<\/a><\/li>\n<li>N. Turner: <a href=\"https:\/\/biocat.arel.edu.tr\/files\/website\/biocat\/committees-cv\/nicholas_turner_cv.pdf\">CV<\/a><\/li>\n<\/ul>\n<p>\u672c\u6587\u7248\u6743\u5c5e\u4e8e<strong>\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c<\/strong> \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"Nicholas Turner, 1960\u5e746\u67082\u65e5\u82f1\u56fd\u3001\u80af\u7279\u5ddeOrpington\u51fa\u751f\uff0c\u662f\u82f1\u56fd\u8457\u540d\u7684\u9176\u5316\u5b66\u5bb6\u3002\u66fc\u5f7b\u65af\u7279\u5927\u5b66\u6559\u6388(\u7167\u7247\uff1a\u66fc\u5f7b\u65af\u7279\u5927\u5b66\u5316\u5b66\u7cfb)\u3002 \u5c65\u5386 1979\u20101982 University of Bristol, Chemistry (BSc) 1982\u20101985 University of Oxford, \u535a\u58eb\u5b66\u4f4d (Prof. J. E. Baldwin) 1985\u20101987 Royal Society Junior Research Fellow 1985\/86 Oxford University, (Dyson Perrins Laboratory) 1986\/87 Harvard, Department of Chemistry, (Prof. G. M. Whitesides) 1987\u20101995 University of Exeter, Department of Chemistry, \u8bb2\u5e08 1995\u20101998 University of Edinburgh, Reader in Bio\u2010Organic Chemistry 1998\u20102004\u00a0University of Edinburgh, Chemical Biology, \u6559\u6388 2003 Co\u2010founder and Chief Scientific Officer of Ingenza Ltd 2004- University of Manchester, chemical biology, \u6559\u6388 2005\u00a0\u2010\u00a0Director of Centre of Excellence in Biocatalysis, Biotransformation and Biocatalytic Manufacturing (CoEBio3) 2012\u00a0Co\u2010founder and Director of Discovery Biocatalysts \u987e\u95ee\u517c\u4efb: AstraZeneca (UK), Johnson Matthey (UK), Lonza (Switzerland), Evolva (Switzerland), Bactevo (UK), Asymchem (China), [&hellip;]","protected":false},"author":5,"featured_media":24919,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[212],"tags":[2394,1127],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/03\/2019-03-21_23-52-08.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-6tU","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/24918"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=24918"}],"version-history":[{"count":5,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/24918\/revisions"}],"predecessor-version":[{"id":51366,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/24918\/revisions\/51366"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/24919"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=24918"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=24918"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=24918"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}