{"id":25062,"date":"2019-04-12T11:04:33","date_gmt":"2019-04-12T03:04:33","guid":{"rendered":"\/\/www.gsbet888.com\/?p=25062"},"modified":"2019-04-12T11:04:33","modified_gmt":"2019-04-12T03:04:33","slug":"varinder-kumar-aggarwal","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemists\/2019\/04\/varinder-kumar-aggarwal.html","title":{"rendered":"Varinder Kumar Aggarwal"},"content":{"rendered":"
Varinder Kumar Aggarwal\uff081961\u5e741\u67081\u65e5\u2014\u2014\uff09\uff0c\u73b0\u4e3a\u82f1\u56fd\u5e03\u91cc\u65af\u6258\u5927\u5b66(University of Bristol)\u6559\u6388\u3002\u56fe\u7247\uff1a\u5b9e\u9a8c\u5ba4\u4e3b\u9875<\/a>\u3002<\/p>\n <\/p>\n <\/p>\n <\/p>\n 1.<\/em><\/strong>\u9502\u5316-\u787c\u5316\u53cd\u5e94<\/em><\/strong><\/p>\n \u9502\u5316-\u787c\u5316\u53cd\u5e94\u662f\u79cd\u53ef\u7528\u4e8e\u5408\u6210C-C\u952e\u7684\u65b9\u6cd5\uff0c\u5b83\u88abAggarwal\u6559\u6388\u8bfe\u9898\u7ec4\u7528\u6765\u9ad8\u6536\u7387\u9ad8\u624b\u6027\u63a7\u5236\u7684\u5408\u6210\u70f7\u57fa\u787c\u7269\u79cd\uff0c\u4ece\u800c\u5f97\u5230\u4f20\u7edf\u53cd\u5e94\u96be\u4ee5\u5f97\u5230\u7684\u590d\u6742\u7ed3\u6784[1]<\/sup>\u3002\u8fd9\u79cd\u53ef\u7528\u4e8e\u589e\u78b3\u7684\u6709\u673a\u787c\u5316\u5b66\u6709\u591a\u79cd\u7528\u9014\uff0c\u4ee5\u7ebf\u6027\u7ec4\u88c5\u5408\u6210(Assembly-Line Synthesis)\u4e3a\u4f8b\uff0c\u5728\u540e\u5904\u7406\u524d\uff0c4\u4e2a\u8fde\u7eed\u9ad8\u6548\u7684\u9502\u5316-\u787c\u5316\u53cd\u5e94\u80fd\u591f\u5f97\u5230\u624b\u6027\u7cbe\u51c6\u63a7\u5236\u7684\u591a\u624b\u6027\u4e2d\u5fc3\u7684\u4ea7\u7269[2]<\/sup>\u3002<\/p>\n Assembly-Line\u5408\u6210\u6a21\u62df\u4e86\u81ea\u7136\u754c\u5408\u6210\u5929\u7136\u4ea7\u7269\u7684\u65b9\u6cd5\uff0c\u7cbe\u51c6\u7684\u63a7\u5236\u4e86\u5206\u5b50\u7684\u7acb\u4f53\u7ed3\u6784\u3002\u5b83\u5728\u590d\u6742\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u4e2d\u6709\u8bb8\u591a\u5e94\u7528[3]<\/sup>\u3002<\/p>\n \u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u5360C-C\u952e\u5408\u6210\u768460%\u3002\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u7684\u4f20\u7edf\u5076\u8054\u53cd\u5e94\u5927\u90fd\u4f9d\u8d56\u6602\u8d35\u4e14\u90e8\u5206\u5177\u6709\u6bd2\u6027\u7684\u91d1\u5c5e\u50ac\u5316\u5242\u3002\u56e0\u6b64\uff0cAggarwal\u6559\u6388\u5bf9\u5f00\u53d1\u65e0\u9700\u8fc7\u6e21\u91d1\u5c5e\u7684\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u5177\u6709\u6d53\u539a\u7684\u7814\u7a76\u5174\u8da3\u3002<\/p>\n \u6839\u636e\u81ea\u5df1\u5f00\u53d1\u7684\u9502\u5316-\u787c\u5316\u5316\u5b66\uff0c\u4ed6\u4eec\u5f00\u53d1\u4e86\u4e00\u79cd\u65e0\u9700\u8fc7\u6e21\u91d1\u5c5e\u7684\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\uff0c\u751f\u6210\u7684\u624b\u6027\u787c\u9178\u590d\u5408\u7269\u8bf1\u5bfc\u53d1\u751f1,2-metallate\u91cd\u6392\u5f97\u5230\u5076\u8054\u4ea7\u7269\u3002\u8fd9\u79cd\u53ef\u9760\u7684\u65b9\u6cd5\u53ef\u7528\u4e8e\u4e8c\u7ea7\u6216\u4e09\u7ea7\u787c\u9178\u548c\u4e00\u7cfb\u5217\u82b3\u57fa\u53d1\u751f\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\u7684\u5076\u8054\u53cd\u5e94{4}<\/sup>\u3002<\/p>\n Aggarwal\u6559\u6388\u53c2\u7167Zweifel\u70ef\u57fa\u5316\u53cd\u5e94<\/a>\u5f00\u53d1\u4e86\u70ef\u57fa\u5364\u5316\u7269\u548c\u787c\u9178\u916f\u95f4\uff0c\u65e0\u9700\u8fc7\u6e21\u91d1\u5c5e\u7684\u7acb\u4f53\u9009\u62e9\u6027\u5076\u8054\u53cd\u5e94\u3002\u6b64\u8fc7\u7a0b\u53ef\u7528\u4e8esp2<\/em>\u548c\u624b\u6027sp3<\/em>\u787c\u9178\u916f\u7684\u624b\u6027\u4fdd\u6301\u7684\u5076\u8054\u53cd\u5e94\uff0c\u5e76\u4e14\uff0c\u8be5\u53cd\u5e94\u53ef\u4f7f\u70ef\u57fa\u5364\u5316\u7269\u9009\u62e9\u6027\u7684\u53d1\u751f\u53cd\u5e94\u5f97\u5230E\u5f0f\u6216Z\u5f0f\u70ef\u70c3\u3002<\/p>\n \u4f9d\u636eZweifel\u70ef\u57fa\u5316\u53cd\u5e94\uff0cAggarwal\u6559\u6388\u8fd8\u5f00\u53d1\u4e86\u5bf9\u6620\u6027\u4fdd\u6301\u7684\u8131\u787c\u7094\u57fa\u5316\u53cd\u5e94\uff0c\u787c\u9178\u916f\u53ef\u4e3a\u624b\u6027\u4e8c\u7ea7\u6216\u4e09\u7ea7\u787c\u9178\u916f\u3002<\/p>\n \u524d\u5217\u817a\u7d20\u662f\u4e00\u7c7b\u6709\u91cd\u8981\u751f\u7269\u529f\u80fd\u7684\u5929\u7136\u4ea7\u7269\uff0c\u5982\u8840\u538b\u8c03\u63a7\u3001\u8840\u5c0f\u677f\u5408\u6210\u7b49\u3002\u81ea1970\u5e74\u6765\uff0c\u5438\u5f15\u4e86\u8bb8\u591a\u5408\u6210\u5316\u5b66\u5bb6\u7684\u5174\u8da3\uff0cAggarwal\u6559\u6388\u4e5f\u5bf9\u524d\u5217\u817a\u7d20\u53ca\u5176\u884d\u751f\u7269\u8fdb\u884c\u4e86\u5408\u6210\u7814\u7a76\u3002\u4ed6\u4eec\u901a\u8fc7\u6709\u673a\u5c0f\u5206\u5b50\u50ac\u5316\u4e01\u4e8c\u919b\u4e8c\u805a\uff0c\u7acb\u4f53\u9009\u62e9\u6027\u7684\u5408\u6210\u4e86\u4e00\u79cd\u70ef\u919b\u9ad8\u7ea7\u4e2d\u95f4\u4f53\uff0c\u6b64\u53cd\u5e94\u53ef\u514b\u7ea7\u89c4\u6a21\u653e\u5927\uff0c\u5e76\u4e14\u53ef\u6709\u6548\u7684\u8fd0\u7528\u5230\u5929\u7136\u4ea7\u7269\u7684\u5408\u6210\u4e2d\u3002<\/p>\n \u5149\u5316\u5b66\u5728\u590d\u6742\u5206\u5b50\u5316\u5b66\u5408\u6210\u7684\u65b9\u6cd5\u5b66\u7814\u7a76\u4e2d\u6709\u91cd\u8981\u7684\u4f5c\u7528\u3002Aggarwal\u6559\u6388\u5f00\u53d1\u4e86\u70ef\u57fa\u787c\u9178\u916f\u548c\u70f7\u57fa\u81ea\u7531\u57fa\u7ed3\u5408\u9ad8\u6536\u7387\u5f97\u5230\u70f7\u57fa\u5316\u4ea7\u7269\u7684\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u7531\u787c\u9178\u916f\u4e0e\u9502\u8bd5\u5242\u53cd\u5e94\u5f97\u5230\u7684\u787c\u9178\u590d\u5408\u7269\u4e0e\u7f3a\u7535\u5b50\u81ea\u7531\u57fa\u7684\u591a\u7ec4\u5206\u53cd\u5e94\u4e5f\u5f97\u5230\u5f00\u53d1\u3002\u6700\u8fd1\uff0cAggarwal\u6559\u6388\u5f00\u53d1\u4e86\u4e00\u79cd\u5c06\u7fa7\u9178\u884d\u751f\u5316\u5f97\u5230\u7684\u9ad8\u6d3b\u6027\u7269\u8d28\u53d1\u751f\u5149\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u540e\u5f97\u5230\u591a\u6837\u7684\u787c\u5316\u4ea7\u7269\u7684\u65b9\u6cd5\uff0c\u8be5\u5de5\u4f5c\u53d1\u8868\u4e0e2017\u5e74science<\/em>\u4e0a\u3002<\/p>\n <\/p>\n 1.a: Leonori, D., Aggarwal, V. K., Acc. Chem. Res<\/em>., 2014<\/strong>, 47<\/em>, 3174. DOI: 10.1021\/ar5002473<\/a>; b: Essafi, S., Tomasi, S., Aggarwal, V. K., Harvey, J. N., J. Org. Chem<\/em>., 2014<\/strong>, 79<\/em>, 12148.DOI: 10.1021\/jo502020e<\/a>; c: Fawcett, A., Nitsch, D., Ali, M., Bateman, J. M., Myers, E. L., Aggarwal, V. K., Angew. Chem. Int. Ed<\/em>., 2016<\/strong>, 55<\/em>, 14663. doi.org\/10.1002\/anie.201608406<\/a>; d: Varela, A., Garve, L. K. B., Leonori, D., Aggarwal, V. K., Angew. Chem. Int. Ed<\/em>., 2017<\/strong>, 56<\/em>, 2127. doi.org\/10.1002\/anie.201611273<\/a>;<\/p>\n 2: a: Burns, M., Essafi, S., Bame, J. R., Bull, S. P., Webster, M. P., Balieu, S., Dale, J. W., Butts, C. P., Harvey, J. N., Aggarwal, V. K., Nature<\/em>, 2014<\/strong>, 513<\/em>, 183. doi.org\/10.1038\/nature13711<\/a>; b: Balieu, S., Hallett, G. E., Burns, M., Bootwicha, T., Studley, J., Aggarwal, V. K., J. Am. Chem. Soc<\/em>., 2015<\/strong>, 137<\/em>, 4398. DOI: 10.1021\/ja512875g<\/a>;<\/p>\n 3: a: Noble, A., Roesner, S., Aggarwal, V. K., Angew. Chem. Int. Ed<\/em>., 2016<\/strong>, 55<\/em>, 15920. doi.org\/10.1002\/anie.201609598<\/a>; b: Bootwicha, T., Feilner, J. M., Myers, E. L., Aggarwal, V. K., Nature Chem<\/em>., 2017<\/strong>, 9<\/em>, 896. doi.org\/10.1038\/nchem.2757<\/a>; c:: Wu, J., Lorenzo, P., Zhong, S., Ali, M., Butts, C. P., Myers, E. L., Aggarwal, V. K., Nature<\/em>, 2017<\/strong>, 547<\/em>, 436. doi.org\/10.1038\/nature23265<\/a>;<\/p>\n 4: a: Bonet, A., Odachowski, M., Leonori, D., Essafi, S., Aggarwal, V. K., Nat. Chem<\/em>., 2014<\/strong>, 6<\/em>, 584. doi.org\/10.1038\/nchem.1971<\/a>; b: Odachowski, M., Bonet, A., Essafi, S., Conti-Ramsden, P., Harvey, J. N., Leonori, D., Aggarwal, V. K., J. Am. Chem. Soc<\/em>., 2016<\/strong>, 138<\/em>, 9521. DOI: 10.1021\/jacs.6b03963<\/a>; c: Llaveria J., Leonori D., Aggarwal, V. K., J. Am. Chem. Soc.<\/em>, 2015<\/strong>, 137<\/em>, 10958. DOI: 10.1021\/jacs.5b07842<\/a>; d: Aichhorn S, Bigler R., Myers E. L., Aggarwal V. K., J. Am. Chem. Soc.<\/em>, 2017<\/strong>, 139<\/em>, 9519. DOI: 10.1021\/jacs.7b05880<\/a>; e: Ganesh V., Odachowski M., Aggarwal V. K., Angew. Chem. Int. Ed.<\/em>, 2017<\/strong>, 56<\/em>, 9752. doi.org\/10.1002\/anie.201703894<\/a>; f: Wilson C. M., Venkataraman G., Noble A., Aggarwal V. K., Angew. Chem. Int. Ed.<\/em>, 2017<\/strong>, 56<\/em>, 16318. doi.org\/10.1002\/anie.201710777<\/a>;<\/p>\n 6.a: Coulthard, G., Erb, W., Aggarwal, V. K.,Nature<\/em>, 2012<\/strong>, 489<\/em>, 278. doi.org\/10.1038\/nature11411<\/a>; b: Pr\u00e9vost, S., Thai, K., Sch\u00fctzenmeister, N., Coulthard, G., Erb, W., Aggarwal, V. K., Org. Lett.<\/em>, 2015<\/strong>, 17<\/em>, 504. DOI: 10.1021\/ol503520f<\/a>; c: H. Baars, M. J. Classen, V. K. Aggarwal, Org. Lett.<\/em>, 2017<\/strong>, 19<\/em>, 6008. DOI: 10.1021\/acs.orglett.7b03057<\/a>;<\/p>\n <\/p>\n\u7ecf\u5386<\/strong><\/h4>\n
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