{"id":25329,"date":"2019-05-23T10:51:36","date_gmt":"2019-05-23T02:51:36","guid":{"rendered":"\/\/www.gsbet888.com\/?p=25329"},"modified":"2019-05-23T10:51:36","modified_gmt":"2019-05-23T02:51:36","slug":"%e8%84%82%e8%82%aa%e9%86%87%e7%9a%84%e8%bf%9c%e7%ab%afcsp3-h%e8%83%ba%e5%8c%96%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2019\/05\/%e8%84%82%e8%82%aa%e9%86%87%e7%9a%84%e8%bf%9c%e7%ab%afcsp3-h%e8%83%ba%e5%8c%96%e5%8f%8d%e5%ba%94.html","title":{"rendered":"\u8102\u80aa\u9187\u7684\u8fdc\u7aefC(sp3)-H\u80fa\u5316\u53cd\u5e94"},"content":{"rendered":"<h4><strong>\u80cc\u666f\u7814\u7a76<\/strong><\/h4>\n<p>\u6c28\u57fa\u9187\u9aa8\u67b6\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5404\u79cd\u5929\u7136\u4ea7\u7269\u3001\u5177\u6709\u836f\u7406\u6d3b\u6027\u7684\u5316\u5408\u7269\u4e2d\u3002\u800c\u5408\u6210\u8be5\u9aa8\u67b6\u6700\u6709\u529b\u7684\u7b56\u7565\u5373\u8102\u80aa\u9187\u53d1\u751f\u5b9a\u5411\u4f4d\u70b9\u9009\u62e9\u6027C(sp<sup>3<\/sup>)-H\u80fa\u5316\u53cd\u5e94\u3002\u5176\u4e2d\uff0c\u6bd4\u8f83\u7ecf\u5178\u7684\u65b9\u6cd5\u5373\u5c06\u8fc7\u6e21\u91d1\u5c5e-\u6c2e\u5316\u7269\u4e2d\u95f4\u4f53A\u63d2\u5165\u5230\u8fdc\u7aef\u672a\u6d3b\u5316\u7684C(sp<sup>3<\/sup>)-H\u952e\u4e2d(Scheme 1,<em>a<\/em>)\uff0c\u4f46\u8be5\u65b9\u6cd5\u4ec5\u5c40\u9650\u4e8e\u03b3\u548c\u03b2-\u4f4d\u5b98\u80fd\u56e2\u5316\u3002\u6700\u8fd1\uff0c\u80fd\u5728\u6e29\u548c\u6761\u4ef6\u4e0b\u4ea7\u751f\u81ea\u7531\u57fa\u4e14\u5177\u6709\u591a\u6837\u7684HAT\u53cd\u5e94\u6027\u7684\u81ea\u7531\u57fa\u53cd\u5e94\u5f15\u8d77\u5316\u5b66\u56e2\u4f53\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u57fa\u4e8e\u81ea\u7531\u57fa\u7b56\u7565\uff0c\u8102\u80aa\u9187\u53d1\u751f\u8fdc\u7aef\u4f4d\u70b9\u9009\u62e9\u6027C(sp<sup>3<\/sup>)-H\u80fa\u5316\u53cd\u5e94\u7684\u62a5\u9053\u53ea\u6709\u4e24\u4f8b\uff1aNagib\u8bfe\u9898\u7ec4[1]\u62a5\u9053\u7684\u65e0\u9700\u91d1\u5c5e\u50ac\u5316\u7684\u53ef\u89c1\u5149\u8bf1\u5bfc\u9187\u7684\u81ea\u7531\u57fa\u53cd\u5e94\uff0c\u5408\u6210\u03b2-\u6c28\u57fa\u9187\u5316\u5408\u7269(Scheme 1, <em>b<\/em>)\u4ee5\u53caZuo\u8bfe\u9898\u7ec4[2]\u62a5\u9053\u7684\u53ef\u89c1\u5149\u8bf1\u5bfc\u5408\u6210\u03b4-\u6c28\u57fa\u9187\u5316\u5408\u7269\u7684\u81ea\u7531\u57fa\u53cd\u5e94(Scheme 1, <em>c<\/em>)\u3002\u8fd9\u4e24\u4f8b\u81ea\u7531\u57fa\u53cd\u5e94\u4e3b\u8981\u5c40\u9650\u4e8e1,5-HAT\u81ea\u7531\u57fa\uff0c\u8fd9\u6781\u5927\u5730\u9650\u5236\u4e86\u81ea\u7531\u57fa\u53cd\u5e94\u7684\u8303\u56f4\u3002\u5728\u4e0a\u8ff0\u80cc\u666f\u7814\u7a76\u7684\u57fa\u7840\u4e0a\uff0c\u7f8e\u56fd\u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66<a href=\"http:\/\/www2.chem.uic.edu\/vggroup\/\">Vladimir Gevorgyan<\/a>\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u7b2c\u4e00\u4f8b\u65e0\u9700\u91d1\u5c5e\u50ac\u5316\u548c\u5149\u50ac\u5316\uff0c\u5728\u6e29\u548c\u7684\u78b1\u6027\u6761\u4ef6\u548c\u91cd\u6c2e\u76d0\u4f5c\u7528\u4e0b\uff0c\u8102\u80aa\u9187\u7684\u03b2-\u3001\u03b3-\u548c\u03b4-C(sp<sup>3<\/sup>)-H\u80fa\u5316\u53cd\u5e94(Scheme 1, <em>d<\/em>)\u3002\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e<\/p>\n<p>&nbsp;<\/p>\n<blockquote><p>Transition Metal-and Ligh-free Directed Amination of Remote UnactivatedC(sp3)-H Bonds of Alcohols<\/p>\n<p>Kurandina\u00e0, D.; Yadagiri\u00e0, D.; Rivas\u00e0, M.; Kavun, A.; Chuentragool, P.; Hayama, K.; Gevorgyan, V. *\u00a0 J. Am. Chem. Soc. 2019, Just Accepted Manuscript<\/p>\n<p>DOI: 10.1021\/jacs.9b04189<\/p><\/blockquote>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/Scheme-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-25349\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/Scheme-1-680x800.jpg\" alt=\"\" width=\"680\" height=\"800\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/Scheme-1-680x800.jpg 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/Scheme-1-255x300.jpg 255w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/Scheme-1.jpg 734w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 1.\u9187\u7684\u8fdc\u7a0bC-H\u80fa\u5316\u53cd\u5e94<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd\uff1a<\/strong><\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-7.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25332 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-7-680x333.png\" alt=\"\" width=\"680\" height=\"333\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-7-680x333.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-7-300x147.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-7-768x376.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-7-550x270.png 550w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-7.png 1109w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p><strong>\u7814\u7a76\u8005\uff1a<\/strong>Vladimir Gevorgyan<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u7814\u7a76\u8005<\/strong><strong>\u7ecf\u5386<\/strong><\/h4>\n<ul>\n<li>1978 Kuban State University \u6bd5\u4e1a<\/li>\n<li>1984 Latvian Institute of Organic Synthesis \u535a\u58eb\u5b66\u4f4d<\/li>\n<li>1986-1991 Latvian Institute of Organic Synthesis Group leader<\/li>\n<li>1992-1994 \u65e5\u672c\u4e1c\u5317\u5927\u5b66 \u535a\u58eb\u540e\u7814\u7a76\u5458<\/li>\n<li>1995 CNR, Bologna \u5ba2\u5ea7\u6559\u6388<\/li>\n<li>1996 \u65e5\u672c\u4e1c\u5317\u5927\u5b66 \u52a9\u7406\u6559\u6388<\/li>\n<li>1997-1999 \u65e5\u672c\u4e1c\u5317\u5927\u5b66 \u526f\u6559\u6388<\/li>\n<li>1999-2003 \u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66\u829d\u52a0\u54e5\u5206\u6821 \u526f\u6559\u6388<\/li>\n<li>2003\u81f3\u4eca \u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66\u829d\u52a0\u54e5\u5206\u6821 \u6559\u6388<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h4><strong>\u83b7\u5956\u7ecf\u5386<\/strong><\/h4>\n<ul>\n<li>2008 UIC Researcher of the Year<\/li>\n<li>2012 Honorary Professor of St. Petersburg State University<\/li>\n<li>2012 Distinguished Professor of Liberal Arts and Sciences<\/li>\n<li>2012 University Scholar (University of Illinois)<\/li>\n<li>2014 Visiting Professor, Sorbonne Universities, Paris<\/li>\n<li>2015 Lilly Lectureship at Imperial College London<\/li>\n<li>2016 Foreign Member of Latvian Academy of Sciences<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h4><strong>\u7814\u7a76\u6982\u8981<\/strong><\/h4>\n<p>\u50ac\u5316\u5408\u6210\u6cd5\u7684\u5f00\u53d1\uff0cC-H\u952e\u6d3b\u5316\uff0c\u73af\u5316\u5f02\u6784\u5316\u53cd\u5e94\uff0c\u4ee5\u53ca\u5728\u590d\u6742\u5316\u5408\u7269\u5408\u6210\u65b9\u9762\u7684\u5e94\u7528\u7814\u7a76\u3002<\/p>\n<p>Gevorgyan\u8bfe\u9898\u7ec4\u4e00\u76f4\u5728\u5f00\u53d1\u57fa\u672c\u7684\u50ac\u5316\u65b9\u6cd5\u5e76\u63a2\u7d22\u5176\u5728\u5e7f\u6cdb\u5408\u6210\u4e2d\u7684\u5e94\u7528\uff0c\u4ed6\u4eec\u4fa7\u91cd\u70b9\u5728\u673a\u7406\u63a2\u7a76\u6765\u83b7\u5f97\u63a7\u5236\u5316\u5b66\u3001\u7acb\u4f53\u9009\u62e9\u8fc7\u7a0b\u7684\u7075\u611f\u3002\u6df1\u5165\u7406\u89e3\u53cd\u5e94\u7684\u673a\u7406\u6765\u4f7f\u4ed6\u4eec\u66f4\u597d\u5730\u786e\u5b9a\u6700\u597d\u65b9\u6848\uff0c\u5e76\u62d3\u5c55\u65b0\u53cd\u5e94\u7684\u9002\u7528\u8303\u56f4\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u8bba\u6587\u6982\u8981\uff1a<\/strong><\/h4>\n<p>\u4ee5<strong>1a<\/strong>\u548c<strong>2a<\/strong>\u4e3a\u6a21\u677f\u5e95\u7269\uff0c\u4f5c\u8005\u5bf9\u53cd\u5e94\u6761\u4ef6\u8fdb\u884c\u53cd\u590d\u7b5b\u9009\uff0c\u786e\u5b9a\u6700\u4f73\u6761\u4ef6\u4e3a\uff08Table 1\uff09\uff1a5 equiv HCO<sub>2<\/sub>Li\u00b7H2O\u4e3a\u6700\u4f18\u78b1\uff0cDMA\/MeOH(1:1)\u4e3a\u6700\u4f18\u6eb6\u5242\uff0c\u57280 \u2103\u5230\u5ba4\u6e29\u6761\u4ef6\u4e0b\u53cd\u5e942 h,\u80fd\u4ee576%\u7684\u6536\u7387\u5f97\u5230\u76ee\u6807\u4ea7\u7269\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-7.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25333 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-7-680x560.png\" alt=\"\" width=\"680\" height=\"560\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-7-680x560.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-7-300x247.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-7.png 765w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Table 1. \u6761\u4ef6\u4f18\u5316<\/p>\n<p>&nbsp;<\/p>\n<p>\u5728\u6700\u4f18\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u8003\u5bdf\u4e86\u91cd\u6c2e\u76d0\u7684\u5e95\u7269\u8303\u56f4\u3002\u4e0d\u8bba\u662f\u5438\u7535\u5b50\u53d6\u4ee3\u8fd8\u662f\u7ed9\u7535\u5b50\u53d6\u4ee3\u7684\u91cd\u6c2e\u76d0\u90fd\u80fd\u5f88\u597d\u5730\u9002\u5e94\u53cd\u5e94\u6761\u4ef6\uff0c\u53ef\u4ee5\u826f\u597d\u81f3\u4f18\u79c0\u7684\u6536\u7387\u5f97\u5230\u76f8\u5e94\u4ea7\u7269\u3002\u5176\u4e2d\uff0c<strong>1a<\/strong>\u4e0e<strong>2b<\/strong>\u53cd\u5e94\uff0c\u80fd\u4ee586%\u7684\u6536\u7387\u5f97\u5230\u76f8\u5e94\u4ea7\u7269\u3002<\/p>\n<p>\u7d27\u63a5\u7740\uff0c\u4f5c\u8005\u8003\u5bdf\u4e86<strong>1<\/strong>\u548c<strong>2b<\/strong>\u7684\u53cd\u5e94\u60c5\u51b5\u3002\u5bf9\u4e8e\u5927\u90e8\u5206\u03b3\u4f4d\u4e3a\u53d4\u78b3\u624b\u6027\u4e2d\u5fc3\u7684\u5e95\u7269\u90fd\u80fd\u5f88\u597d\u7684\u9002\u5e94\u53cd\u5e94\u6761\u4ef6\uff0c\u80fd\u4ee5\u826f\u597d\u81f3\u4f18\u79c0\u7684\u6536\u7387\u5f97\u5230\u03b3-C(sp<sup>3<\/sup>)-H\u80fa\u5316\u4ea7\u7269\uff0c\u4f46R<sup>5<\/sup>\u4f4d\u4e3a\u4f2f\u9187\u3001\u80fa\u6216\u6eb4\u5316\u7269\u7684\u5e95\u7269\u5219\u4e0d\u80fd\u5f97\u5230\u76f8\u5e94\u4ea7\u7269(Scheme 2, a)\u3002\u6b64\u5916\uff0c\u4ef2\u9187\u3001\u73af\u9187\u3001\u53cc\u73af\u9187\u3001\u53d4\u9187\u4ee5\u53ca\u4f2f\u9187\u5747\u80fd\u4ee5\u8f83\u9ad8\u7684\u6536\u7387\u5f97\u5230\u52a8\u529b\u5b66\u4e0d\u592a\u652f\u6301\u7684\u03b2-C(sp<sup>3<\/sup>)-H\u80fa\u5316\u4ea7\u7269(Scheme 2, b)\u3002\u4ef2\u9187(<strong>1ao<\/strong>, <strong>1ap<\/strong>)\u548c\u4f2f\u9187(<strong>1aq<\/strong>)\u80fd\u5f97\u5230 \u03b4\u548c\u03b3-C(sp<sup>3<\/sup>)-H\u80fa\u5316\u4ea7\u7269\u7684\u6df7\u5408\u7269\u30022<sup>o <\/sup>C\u2212H\u548c1<sup>o\u00a0<\/sup>C\u2212H\u4e5f\u80fd\u9002\u5e94\u53cd\u5e94\u6761\u4ef6\uff0c\u80fd\u4ee5\u8f83\u9ad8\u7684\u6536\u7387\u5f97\u5230\u03b2-\u548c\u03b3-C(sp<sup>3<\/sup>)-H\u80fa\u5316\u4ea7\u7269\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-6.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25334 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-6.png\" alt=\"\" width=\"780\" height=\"635\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-6.png 780w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-6-300x244.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-6-768x625.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-6-680x554.png 680w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 2.\u5e95\u7269\u6269\u5c55<\/p>\n<p>&nbsp;<\/p>\n<p>\u4e3a\u4e86\u8bc1\u660e\u8be5\u53cd\u5e94\u7684\u6f5c\u5728\u4ef7\u503c\uff0c\u4f5c\u8005\u505a\u4e86\u4e00\u7cfb\u5217\u7684\u884d\u751f\u53cd\u5e94\u3002\u5404\u79cd\u53d4\u73af\u4ea7\u7269\u548c\u975e\u73af\u72b6\u4ea7\u7269\u90fd\u80fd\u4ee5\u8f83\u9ad8\u7684\u6536\u7387\u8f6c\u5316\u4e3a\u76841,2-\uff0c1,3-\u548c1,4-\u6c28\u57fa\u9187\u3002\u503c\u5f97\u9ad8\u5174\u7684\u662f\uff0c\u4e8c\u7ea7\u91cd\u6c2e\u5316\u5408\u7269\u5bb9\u6613\u5f02\u6784\u6210\u8159\u8fdb\u800c\u88ab\u6c27\u5316\u4e3a\u916e\u7c7b\u5316\u5408\u7269\u3002\u916e\u7c7b\u5316\u5408\u7269\u53ef\u88ab\u8f6c\u5316\u4e3a\u4e0d\u6613\u83b7\u5f97\u7684\u4e01\u95f4\u9187\u919b\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u8bba\u6587\u603b\u7ed3\u8bc4\u4ef7\uff1a<\/strong><\/h4>\n<p>\u7f8e\u56fd\u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66Vladimir Gevorgyan\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u7b2c\u4e00\u4f8b\u65e0\u9700\u91d1\u5c5e\u50ac\u5316\u548c\u5149\u50ac\u5316\uff0c\u5728\u6e29\u548c\u7684\u78b1\u6027\u6761\u4ef6\u548c\u91cd\u6c2e\u76d0\u4f5c\u7528\u4e0b\uff0c\u8102\u80aa\u9187\u7684\u03b2-\u3001\u03b3-\u548c\u03b4-C(sp<sup>3<\/sup>)-H\u80fa\u5316\u53cd\u5e94\u3002\u8be5\u53cd\u5e94\u5e95\u7269\u8303\u56f4\u5e7f\uff0c\u80fd\u4ee5\u8f83\u9ad8\u7684\u6536\u7387\u5f97\u5230\u5404\u79cd\u03b2-\u3001\u03b3-\u548c\u03b4-C(sp<sup>3<\/sup>)-H\u80fa\u5316\u4ea7\u7269\u3002\u901a\u8fc7\u7b80\u5355\u7684\u884d\u751f\u53cd\u5e94\uff0c\u53ef\u4ee5\u9ad8\u6536\u7387\u5f97\u52301,2-\uff0c1,3-\u548c1,4-\u6c28\u57fa\u9187\u548c\u916e\u7c7b\u5316\u5408\u7269\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ol>\n<li>(a) Wappes, E. A.; Nakafuku, K. M.; Nagib, D. A. <em> Am. Chem. Soc.<\/em><strong>2017<\/strong>,<em>139<\/em>, 10204.DOI: <a href=\"https:\/\/pubs.acs.org.ccindex.cn\/doi\/abs\/10.1021\/jacs.7b05214?journalCode=jacsat&amp;quickLinkVolume=139&amp;quickLinkPage=10204&amp;selectedTab=citation&amp;volume=139\">10.1021\/jacs.7b05214<\/a>(b) Stateman, L. M.; Wappes, E. A.;Nakafuku, K. M.; Edwards, K. M.; Nagib, D. <em>Chem. Sci. <\/em><strong>2019<\/strong>, <em>10<\/em>, 2693. DOI:<a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2019\/sc\/c8sc05685d?page=search\">10.1039\/c8sc05685d<\/a><\/li>\n<li>Hu, A.; Guo, J.-J.; Pan, H.; Tang, H.; Gao, Z.; Zuo, Z. <em> Am. Chem. Soc. <\/em><strong>2018<\/strong>, <em>140<\/em>, 1612. DOI:<a href=\"https:\/\/pubs.acs.org.ccindex.cn\/doi\/abs\/10.1021\/jacs.6b06908?journalCode=jacsat&amp;quickLinkVolume=138&amp;quickLinkPage=10132&amp;selectedTab=citation&amp;volume=138\">10.1021\/jacs.6b06908<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"\u80cc\u666f\u7814\u7a76 \u6c28\u57fa\u9187\u9aa8\u67b6\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5404\u79cd\u5929\u7136\u4ea7\u7269\u3001\u5177\u6709\u836f\u7406\u6d3b\u6027\u7684\u5316\u5408\u7269\u4e2d\u3002\u800c\u5408\u6210\u8be5\u9aa8\u67b6\u6700\u6709\u529b\u7684\u7b56\u7565\u5373\u8102\u80aa\u9187\u53d1\u751f\u5b9a\u5411\u4f4d\u70b9\u9009\u62e9\u6027C(sp3)-H\u80fa\u5316\u53cd\u5e94\u3002\u5176\u4e2d\uff0c\u6bd4\u8f83\u7ecf\u5178\u7684\u65b9\u6cd5\u5373\u5c06\u8fc7\u6e21\u91d1\u5c5e-\u6c2e\u5316\u7269\u4e2d\u95f4\u4f53A\u63d2\u5165\u5230\u8fdc\u7aef\u672a\u6d3b\u5316\u7684C(sp3)-H\u952e\u4e2d(Scheme 1,a)\uff0c\u4f46\u8be5\u65b9\u6cd5\u4ec5\u5c40\u9650\u4e8e\u03b3\u548c\u03b2-\u4f4d\u5b98\u80fd\u56e2\u5316\u3002\u6700\u8fd1\uff0c\u80fd\u5728\u6e29\u548c\u6761\u4ef6\u4e0b\u4ea7\u751f\u81ea\u7531\u57fa\u4e14\u5177\u6709\u591a\u6837\u7684HAT\u53cd\u5e94\u6027\u7684\u81ea\u7531\u57fa\u53cd\u5e94\u5f15\u8d77\u5316\u5b66\u56e2\u4f53\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u57fa\u4e8e\u81ea\u7531\u57fa\u7b56\u7565\uff0c\u8102\u80aa\u9187\u53d1\u751f\u8fdc\u7aef\u4f4d\u70b9\u9009\u62e9\u6027C(sp3)-H\u80fa\u5316\u53cd\u5e94\u7684\u62a5\u9053\u53ea\u6709\u4e24\u4f8b\uff1aNagib\u8bfe\u9898\u7ec4[1]\u62a5\u9053\u7684\u65e0\u9700\u91d1\u5c5e\u50ac\u5316\u7684\u53ef\u89c1\u5149\u8bf1\u5bfc\u9187\u7684\u81ea\u7531\u57fa\u53cd\u5e94\uff0c\u5408\u6210\u03b2-\u6c28\u57fa\u9187\u5316\u5408\u7269(Scheme 1, b)\u4ee5\u53caZuo\u8bfe\u9898\u7ec4[2]\u62a5\u9053\u7684\u53ef\u89c1\u5149\u8bf1\u5bfc\u5408\u6210\u03b4-\u6c28\u57fa\u9187\u5316\u5408\u7269\u7684\u81ea\u7531\u57fa\u53cd\u5e94(Scheme 1, c)\u3002\u8fd9\u4e24\u4f8b\u81ea\u7531\u57fa\u53cd\u5e94\u4e3b\u8981\u5c40\u9650\u4e8e1,5-HAT\u81ea\u7531\u57fa\uff0c\u8fd9\u6781\u5927\u5730\u9650\u5236\u4e86\u81ea\u7531\u57fa\u53cd\u5e94\u7684\u8303\u56f4\u3002\u5728\u4e0a\u8ff0\u80cc\u666f\u7814\u7a76\u7684\u57fa\u7840\u4e0a\uff0c\u7f8e\u56fd\u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66Vladimir Gevorgyan\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u7b2c\u4e00\u4f8b\u65e0\u9700\u91d1\u5c5e\u50ac\u5316\u548c\u5149\u50ac\u5316\uff0c\u5728\u6e29\u548c\u7684\u78b1\u6027\u6761\u4ef6\u548c\u91cd\u6c2e\u76d0\u4f5c\u7528\u4e0b\uff0c\u8102\u80aa\u9187\u7684\u03b2-\u3001\u03b3-\u548c\u03b4-C(sp3)-H\u80fa\u5316\u53cd\u5e94(Scheme 1, d)\u3002\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e &nbsp; Transition Metal-and Ligh-free Directed Amination of Remote UnactivatedC(sp3)-H Bonds of Alcohols Kurandina\u00e0, D.; Yadagiri\u00e0, D.; Rivas\u00e0, M.; Kavun, A.; Chuentragool, P.; Hayama, K.; Gevorgyan, V. *\u00a0 J. Am. Chem. Soc. 2019, Just Accepted Manuscript DOI: 10.1021\/jacs.9b04189 Scheme 1.\u9187\u7684\u8fdc\u7a0bC-H\u80fa\u5316\u53cd\u5e94 &nbsp; \u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd\uff1a \u7814\u7a76\u8005\uff1aVladimir Gevorgyan &nbsp; \u7814\u7a76\u8005\u7ecf\u5386 1978 Kuban State University \u6bd5\u4e1a 1984 Latvian Institute of Organic Synthesis \u535a\u58eb\u5b66\u4f4d 1986-1991 Latvian Institute of Organic Synthesis Group leader 1992-1994 \u65e5\u672c\u4e1c\u5317\u5927\u5b66 \u535a\u58eb\u540e\u7814\u7a76\u5458 1995 CNR, Bologna \u5ba2\u5ea7\u6559\u6388 1996 \u65e5\u672c\u4e1c\u5317\u5927\u5b66 \u52a9\u7406\u6559\u6388 1997-1999 \u65e5\u672c\u4e1c\u5317\u5927\u5b66 \u526f\u6559\u6388 1999-2003 \u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66\u829d\u52a0\u54e5\u5206\u6821 \u526f\u6559\u6388 2003\u81f3\u4eca \u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66\u829d\u52a0\u54e5\u5206\u6821 \u6559\u6388 &nbsp; \u83b7\u5956\u7ecf\u5386 2008 UIC Researcher of the Year 2012 Honorary Professor of St. Petersburg State University [&hellip;]","protected":false},"author":24,"featured_media":25330,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1271],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/1-7.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-6Ax","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/25329"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=25329"}],"version-history":[{"count":4,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/25329\/revisions"}],"predecessor-version":[{"id":25351,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/25329\/revisions\/25351"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/25330"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=25329"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=25329"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=25329"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}