{"id":25379,"date":"2019-05-24T08:00:51","date_gmt":"2019-05-24T00:00:51","guid":{"rendered":"\/\/www.gsbet888.com\/?p=25379"},"modified":"2019-05-23T23:25:13","modified_gmt":"2019-05-23T15:25:13","slug":"%e7%83%af%e8%83%ba%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0%e6%b0%a2%e8%83%ba%e5%8c%96%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2019\/05\/%e7%83%af%e8%83%ba%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0%e6%b0%a2%e8%83%ba%e5%8c%96%e5%8f%8d%e5%ba%94.html","title":{"rendered":"\u70ef\u80fa\u7684\u4e0d\u5bf9\u79f0\u6c22\u80fa\u5316\u53cd\u5e94"},"content":{"rendered":"<h4><strong>\u8bfe\u9898\u7684\u63d0\u51fa<\/strong><\/h4>\n<p>\u6c22\u80fa\u5316\u53cd\u5e94\u662f\u4e00\u7c7b\u5f62\u5f0f\u4e0a\u5c06N-H\u952e\u52a0\u6210\u5230\u70ef\u70c3\u6216\u7094\u70c3\u7684\u78b3\u78b3\u4e0d\u9971\u548c\u952e\u4e0a\uff0c\u76f4\u63a5\u5f62\u6210C-N\u952e\u7684\u53cd\u5e94\u3002\u901a\u8fc7\u6c22\u80fa\u5316\u53cd\u5e94\u80fd\u8fc5\u901f\u5f97\u5230\u70f7\u57fa\u80fa\u6216\u70ef\u80fa\u4ea7\u7269\uff0c\u6240\u4ee5\u8be5\u53cd\u5e94\u53d7\u5230\u7814\u7a76\u56e2\u4f53\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u624b\u60271,2-\u4e8c\u80fa\u7ed3\u6784\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5929\u7136\u4ea7\u7269\u3001\u5177\u6709\u6d3b\u6027\u7684\u5316\u5408\u7269\u3001\u50ac\u5316\u5242\u548c\u914d\u4f53\u4e2d\u3002\u5c3d\u7ba11,2-\u4e8c\u80fa\u5316\u5408\u7269\u7684\u5408\u6210\u5df2\u7ecf\u53d6\u5f97\u4e86\u4e0d\u9519\u7684\u8fdb\u5c55\uff0c\u4f46\u76f4\u63a5\u5408\u6210\u624b\u60271,2-\u4e8c\u80fa\u5316\u5408\u7269\u4ecd\u7136\u9762\u4e34\u5de8\u5927\u6311\u6218[1]\u3002\u6c22\u80fa\u5316\u53cd\u5e94\u4f3c\u4e4e\u662f\u5316\u89e3\u8be5\u56f0\u5883\u7684\u4e00\u4e2a\u7a81\u7834\u53e3\u3002\u636e\u6587\u732e\u8c03\u7814\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5173\u4e8e\u6c22\u80fa\u5316\u53cd\u5e94\u5408\u6210\u624b\u60271,2-\u4e8c\u80fa\u5316\u5408\u7269\u7684\u62a5\u9053\u53ea\u6709\u624b\u6027\u919b\u50ac\u5316\u70ef\u4e19\u57fa\u80fa\u7684\u4e0d\u5bf9\u79f0\u6c22\u80fa\u5316\u53cd\u5e94[2]\u548c\u624b\u6027Rh\u50ac\u5316\u5242\u50ac\u5316\u70ef\u4e19\u57fa\u80fa\u7684\u4e0d\u5bf9\u79f0\u6c22\u80fa\u5316\u53cd\u5e94\u8fd9\u4e24\u4f8b\u62a5\u9053[3](Scheme 1)\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/2-9.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25381 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/2-9.png\" alt=\"\" width=\"874\" height=\"618\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/2-9.png 874w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/2-9-300x212.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/2-9-768x543.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/2-9-680x481.png 680w\" sizes=\"(max-width: 874px) 100vw, 874px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 1. \u4e0d\u5bf9\u79f0\u6c22\u80fa\u5316\u53cd\u5e94<\/p>\n<p>&nbsp;<\/p>\n<p>\u57fa\u4e8e\u4e0a\u8ff0\u80cc\u666f\u7814\u7a76\uff0c\u745e\u5178\u9686\u5fb7\u5927\u5b66<a href=\"http:\/\/petersomfai.chem.lu.se\/wordpress\/\">Peter Somfai<\/a>\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86Cu\u50ac\u5316\u70ef\u80fa\u7684\u4e0d\u5bf9\u79f0\u6c22\u80fa\u5316\u53cd\u5e94,\u80fd\u4ee5\u826f\u597d\u7684\u6536\u7387\u548c\u8f83\u9ad8\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u624b\u60271,2-\u4e8c\u80fa\u5316\u5408\u7269\u3002\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e<\/p>\n<blockquote><p>Regio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines<\/p>\n<p>Yu,L.; Somfai, P.*\u00a0<em>Angew. Chem. Int. Ed.<\/em> 2019, early view\u00a0DOI: 10.1002\/anie.201902642<\/p><\/blockquote>\n<p>&nbsp;<\/p>\n<h4><strong>\u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd\uff1a<\/strong><\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-9.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25382 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-9-680x384.png\" alt=\"\" width=\"680\" height=\"384\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-9-680x384.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-9-300x170.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-9-768x434.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-9.png 782w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p><strong>\u7814\u7a76\u8005\uff1a<\/strong>Peter Somfai<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u7814\u7a76\u8005\u7ecf\u5386<\/strong><\/h4>\n<ul>\n<li>1960<strong>\u5e74\u51fa\u751f\u4e8e<\/strong>G\u00f6teborg, Sweden<strong>\uff0c\u5e76\u5728<\/strong>Chalmers Institute of Technology<strong>\u83b7\u5f97\u5316\u5b66\u7855\u58eb\u5b66\u4f4d\u548c\u6709\u673a\u5316\u5b66\u535a\u58eb\u5b66\u4f4d\uff1b<\/strong><\/li>\n<li>1999<strong>\u5e74\uff0c<\/strong>Royal Institute of Technology<strong>\uff08<\/strong>KTH<strong>\uff09\u6709\u673a\u5316\u5b66\u6559\u6388\uff1b<\/strong><\/li>\n<li>2001<strong>\u5e74\uff0c<\/strong>Royal Institute of Technology<strong>\uff08<\/strong>KTH<strong>\uff09\u5316\u5b66\u7cfb\u4e3b\u4efb\uff1b<\/strong><\/li>\n<li>2005<strong>\u5e74\uff0c<\/strong>Royal Institute of Technology<strong>\uff08<\/strong>KTH<strong>\uff09\u5316\u5b66\u79d1\u5b66\u4e0e\u5de5\u7a0b\u5b66\u9662\u9662\u957f\uff1b<\/strong><\/li>\n<li>2007<strong>\u5e74\uff0c<\/strong>Institute of Technology, University of Tartu<strong>\u9ad8\u7ea7\u7814\u7a76\u5458\uff1b<\/strong><\/li>\n<li>2010<strong>\u5e74\uff0c<\/strong>Royal Swedish Academy of Sciences<strong>\u6210\u5458\uff1b<\/strong><\/li>\n<li>2012<strong>\u5e74\uff0c<\/strong>Royal Swedish Academy of Sciences<strong>\u6709\u673a\u5316\u5b66\u6559\u6388\uff1b<\/strong><\/li>\n<li>2015<strong>\u5e74\uff0c<\/strong>Royal Physiografiphic Society of Lund\u6210\u5458\u3002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>\u7814\u7a76\u5185\u5bb9<\/strong><strong>:<\/strong>\u5f00\u53d1\u6709\u673a\u5408\u6210\u7684\u65b0\u65b9\u6cd5\u4ee5\u53ca\u5929\u7136\u4ea7\u7269\u7684\u5168\u5408\u6210\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u8bba\u6587\u6982\u8981<\/strong><\/h4>\n<p>\u4ee5\u70ef\u80fa<strong>1a<\/strong>\u548cR= NMe<sub>2<\/sub>\u7f9f\u80fa<strong>2a<\/strong>\u4f5c\u4e3a\u6a21\u677f\u5e95\u7269\uff0c\u4f5c\u8005\u5bf9\u5e95\u7269\u53d6\u4ee3\u57fa\u3001\u50ac\u5316\u5242\u3001\u6c22\u6e90\u7b49\u53cd\u5e94\u6761\u4ef6\u8fdb\u884c\u53cd\u590d\u7b5b\u9009\uff0c\u786e\u5b9a\u6700\u4f73\u6761\u4ef6\u4e3a(Table 1)\uff1a\u70ef\u80fa<strong>1a<\/strong>\u548cR= NEt<sub>2<\/sub>\u7f9f\u80fa\u4e3a\u6700\u4f18\u5e95\u7269\uff0c10 mol% Cu(OAc)<sub>2<\/sub>\u548c11 mol% (<em>R<\/em>)-BINAP(<strong>L6<\/strong>)\u4e3a\u6700\u4f18\u50ac\u5316\u5242\uff0c1.1 equiv(EtO)<sub>2<\/sub>MeSiH(DMMS)\u4e3a\u6700\u4f18\u6c22\u6e90\uff0cTHF\u4e3a\u6700\u4f18\u6eb6\u5242\uff0c\u572850 \u2103\u6761\u4ef6\u4e0b\u53cd\u5e9448\u5c0f\u65f6\uff0c\u80fd\u4ee569%\u7684\u6536\u7387\u548c94%\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76ee\u6807\u4ea7\u7269\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-8.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25383 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-8.png\" alt=\"\" width=\"521\" height=\"617\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-8.png 521w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-8-253x300.png 253w\" sizes=\"(max-width: 521px) 100vw, 521px\" \/><\/a><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-8.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25386 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-8.png\" alt=\"\" width=\"542\" height=\"525\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-8.png 542w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-8-300x291.png 300w\" sizes=\"(max-width: 542px) 100vw, 542px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Table 1.\u6c22\u80fa\u5316\u53cd\u5e94\u7684\u6761\u4ef6\u4f18\u5316<\/p>\n<p>&nbsp;<\/p>\n<p>\u5728\u6700\u4f18\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u8003\u5bdf\u4e86\u70ef\u80fa\u548c<em>O<\/em>-\u9170\u57fa\u7f9f\u80fa\u7684\u5e95\u7269\u8303\u56f4\u3002\u5404\u79cdN-\u53d6\u4ee3\u3001\u82ef\u57fa\u53d6\u4ee3\u3001\u6742\u73af\u53d6\u4ee3\u7684\u70ef\u80fa\u3001\u5417\u5549\u30014-\u54cc\u5576\u916e\u3001\u54cc\u55ea\u4ee5\u53ca3-\u4e59\u57fa\u6c27\u4ee3\u4e19\u9178\u916f\u884d\u751f\u7684\u70ef\u80fa\u5747\u80fd\u5f88\u597d\u7684\u9002\u5e94\u53cd\u5e94\u6761\u4ef6\uff0c\u53ef\u4ee5\u4e2d\u7b49\u81f3\u8f83\u597d\u7684\u6536\u7387\u548c\u8f83\u9ad8\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u7269\u3002\u4f46N-Boc\u3001N-Ts\u4fdd\u62a4\u7684\u70ef\u80fa\u3001\u70f7\u57fa\u53d6\u4ee3\u7684\u70ef\u80fa\u4ee5\u53ca9-\u4e59\u70ef\u57fa\u5494\u5511\u884d\u751f\u7684\u70ef\u80fa\u7684\u8010\u53d7\u6027\u4e0d\u592a\u597d\uff0c\u4e0d\u80fd\u6216\u53ea\u80fd\u4ee5\u6781\u4f4e\u7684\u6536\u7387\u5f97\u5230\u76f8\u5e94\u4ea7\u7269\u3002\u540c\u65f6\uff0c\u5404\u79cd\u82c4\u57fa\u53d6\u4ee3\u3001\u6742\u73af\u53d6\u4ee3\u30011-\u5627\u5576\u57fa\u54cc\u55ea\u53d6\u4ee3\u4ee5\u53ca\u4e8c\u70f7\u57fa\u53d6\u4ee3\u7684\u7f9f\u80fa\u4e5f\u80fd\u5f88\u597d\u7684\u9002\u5e94\u53cd\u5e94\u6761\u4ef6\uff0c\u80fd\u4ee5\u826f\u597d\u7684\u6536\u7387\u548c\u826f\u597d\u81f3\u4f18\u79c0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u7269\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u57fa\u4e8e\u4e4b\u524d\u62a5\u9053\u7684Cu\u50ac\u5316\u70ef\u70c3\u7684\u4e0d\u5bf9\u79f0\u6c22\u80fa\u5316\u53cd\u5e94\u7684\u673a\u7406\u7814\u7a76\uff0c\u4f5c\u8005\u63a8\u6d4b\u8be5\u53cd\u5e94\u7684\u673a\u7406\uff1a\u70ef\u80fa\u4e0e\u539f\u4f4d\u751f\u6210\u7684Cu(I)-H\u53cd\u5e94\uff0c\u751f\u6210\u70f7\u57fa\u94dc\u4e2d\u95f4\u4f53<strong>II<\/strong>\u3002\u7136\u540e\uff0c<strong>II<\/strong>\u4e0e\u7f9f\u80fa<strong>2c<\/strong>\u53d1\u751f\u6c27\u5316\u53cd\u5e94\uff0c\u751f\u6210\u4e0d\u5bf9\u79f01,2-\u4e8c\u80fa\u4ea7\u7269<strong>3a<\/strong>\u548c\u82ef\u7532\u9178\u94dc<strong>III<\/strong>\u3002<strong>III<\/strong>\u4e0e\u7845\u70f7<strong>IV<\/strong>\u53d1\u751f\u91d1\u5c5e\u8f6c\u79fb\u53cd\u5e94\uff0c<strong>III<\/strong>\u53c8\u4f1a\u91cd\u65b0\u8f6c\u5316\u4e3a<strong>I<\/strong>\u3002\u5c11\u91cf\u7684<strong>II<\/strong>\u4f1a\u53d1\u751f\u03b2-\u6d88\u9664\u53cd\u5e94\uff0c\u751f\u6210\u7684\u82ef\u4e59\u70ef\u4f1a\u8fdb\u4e00\u6b65\u53d1\u751f\u6c22\u80fa\u5316\u53cd\u5e94\u751f\u6210\u5316\u5408\u7269<strong>4<\/strong>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/6-5.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25385 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/6-5.png\" alt=\"\" width=\"810\" height=\"637\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/6-5.png 810w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/6-5-300x236.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/6-5-768x604.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/6-5-680x535.png 680w\" sizes=\"(max-width: 810px) 100vw, 810px\" \/><\/a><\/p>\n<p style=\"text-align: center;\">Scheme 2. \u53cd\u5e94\u673a\u7406\u89e3\u6790<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u8bba\u6587\u603b\u7ed3\u8bc4\u4ef7<\/strong><\/h4>\n<p>\u745e\u5178\u9686\u5fb7\u5927\u5b66<a href=\"http:\/\/petersomfai.chem.lu.se\/wordpress\/\">Peter Somfai<\/a>\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86Cu\u50ac\u5316\u70ef\u80fa\u7684\u4e0d\u5bf9\u79f0\u6c22\u80fa\u5316\u53cd\u5e94,\u80fd\u4ee5\u826f\u597d\u7684\u6536\u7387\u548c\u8f83\u9ad8\u7684\u5bf9\u6620\u9009\u62e9\u6027\u76f4\u63a5\u5f97\u5230\u624b\u60271,2-\u4e8c\u80fa\u5316\u5408\u7269\u3002\u8003\u8651\u5230Cu\u50ac\u5316\u4f53\u7cfb\u5728\u4e0d\u5bf9\u79f0\u6c22\u80fa\u5316\u53cd\u5e94\u4e2d\u8868\u73b0\u51fa\u7684\u4f18\u5f02\u7684\u50ac\u5316\u6d3b\u6027\u548c\u5bf9\u6620\u9009\u62e9\u6027\uff0c\u5c06\u5176\u5f15\u5165\u4e0d\u5bf9\u79f0C-N\u952e\u5408\u6210\u9886\u57df\uff0c\u5fc5\u5c06\u7ed9C-N\u952e\u5408\u6210\u8fd9\u4e00\u9886\u57df\u6ce8\u5165\u65b0\u7684\u6d3b\u529b\u548c\u5e7f\u9614\u7684\u5951\u673a\u3002\u4f46\u5f00\u53d1\u65b0\u7684\u6709\u6548\u7684\u76f4\u63a5\u5408\u6210\u4e0d\u5bf9\u79f01,2-\u4e8c\u80fa\u5316\u5408\u7269\u7684\u65b9\u6cd5\u4ecd\u7136\u9762\u4e34\u5de8\u5927\u6311\u6218\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ol>\n<li>Shao, X.; Li, K.; Malcolmson, S. <em>J. Am. Chem. Soc.<\/em><strong>2018<\/strong>, <em>140<\/em>, 7083.DOI: <a href=\"https:\/\/pubs.acs.org.ccindex.cn\/doi\/pdf\/10.1021\/jacs.8b04750\">10.1021\/jacs.8b04750<\/a><\/li>\n<li>Miki, Y.; Hirano, K.; Satoh, T.; Miura, M.<em>\u00a0Angew. Chem. Int. Ed.<\/em><strong>2013<\/strong>, <em>52<\/em>, 10830.DOI:<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.201304365\">10.1002\/anie.201304365<\/a><\/li>\n<li>Zhu, S.;Niljianskul, N.; Buchwald, S. L.<em>\u00a0J. Am. Chem. Soc. <\/em><strong>2013<\/strong>, <em>135<\/em>,15746. DOI: <a href=\"http:\/\/sci-hub.tw\/10.1021\/ja4092819\">10.1021\/ja4092819<\/a><\/li>\n<\/ol>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"\u8bfe\u9898\u7684\u63d0\u51fa \u6c22\u80fa\u5316\u53cd\u5e94\u662f\u4e00\u7c7b\u5f62\u5f0f\u4e0a\u5c06N-H\u952e\u52a0\u6210\u5230\u70ef\u70c3\u6216\u7094\u70c3\u7684\u78b3\u78b3\u4e0d\u9971\u548c\u952e\u4e0a\uff0c\u76f4\u63a5\u5f62\u6210C-N\u952e\u7684\u53cd\u5e94\u3002\u901a\u8fc7\u6c22\u80fa\u5316\u53cd\u5e94\u80fd\u8fc5\u901f\u5f97\u5230\u70f7\u57fa\u80fa\u6216\u70ef\u80fa\u4ea7\u7269\uff0c\u6240\u4ee5\u8be5\u53cd\u5e94\u53d7\u5230\u7814\u7a76\u56e2\u4f53\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u624b\u60271,2-\u4e8c\u80fa\u7ed3\u6784\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5929\u7136\u4ea7\u7269\u3001\u5177\u6709\u6d3b\u6027\u7684\u5316\u5408\u7269\u3001\u50ac\u5316\u5242\u548c\u914d\u4f53\u4e2d\u3002\u5c3d\u7ba11,2-\u4e8c\u80fa\u5316\u5408\u7269\u7684\u5408\u6210\u5df2\u7ecf\u53d6\u5f97\u4e86\u4e0d\u9519\u7684\u8fdb\u5c55\uff0c\u4f46\u76f4\u63a5\u5408\u6210\u624b\u60271,2-\u4e8c\u80fa\u5316\u5408\u7269\u4ecd\u7136\u9762\u4e34\u5de8\u5927\u6311\u6218[1]\u3002\u6c22\u80fa\u5316\u53cd\u5e94\u4f3c\u4e4e\u662f\u5316\u89e3\u8be5\u56f0\u5883\u7684\u4e00\u4e2a\u7a81\u7834\u53e3\u3002\u636e\u6587\u732e\u8c03\u7814\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5173\u4e8e\u6c22\u80fa\u5316\u53cd\u5e94\u5408\u6210\u624b\u60271,2-\u4e8c\u80fa\u5316\u5408\u7269\u7684\u62a5\u9053\u53ea\u6709\u624b\u6027\u919b\u50ac\u5316\u70ef\u4e19\u57fa\u80fa\u7684\u4e0d\u5bf9\u79f0\u6c22\u80fa\u5316\u53cd\u5e94[2]\u548c\u624b\u6027Rh\u50ac\u5316\u5242\u50ac\u5316\u70ef\u4e19\u57fa\u80fa\u7684\u4e0d\u5bf9\u79f0\u6c22\u80fa\u5316\u53cd\u5e94\u8fd9\u4e24\u4f8b\u62a5\u9053[3](Scheme 1)\u3002 Scheme 1. \u4e0d\u5bf9\u79f0\u6c22\u80fa\u5316\u53cd\u5e94 &nbsp; \u57fa\u4e8e\u4e0a\u8ff0\u80cc\u666f\u7814\u7a76\uff0c\u745e\u5178\u9686\u5fb7\u5927\u5b66Peter Somfai\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86Cu\u50ac\u5316\u70ef\u80fa\u7684\u4e0d\u5bf9\u79f0\u6c22\u80fa\u5316\u53cd\u5e94,\u80fd\u4ee5\u826f\u597d\u7684\u6536\u7387\u548c\u8f83\u9ad8\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u624b\u60271,2-\u4e8c\u80fa\u5316\u5408\u7269\u3002\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e Regio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines Yu,L.; Somfai, P.*\u00a0Angew. Chem. Int. Ed. 2019, early view\u00a0DOI: 10.1002\/anie.201902642 &nbsp; \u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd\uff1a \u7814\u7a76\u8005\uff1aPeter Somfai &nbsp; \u7814\u7a76\u8005\u7ecf\u5386 1960\u5e74\u51fa\u751f\u4e8eG\u00f6teborg, Sweden\uff0c\u5e76\u5728Chalmers Institute of Technology\u83b7\u5f97\u5316\u5b66\u7855\u58eb\u5b66\u4f4d\u548c\u6709\u673a\u5316\u5b66\u535a\u58eb\u5b66\u4f4d\uff1b 1999\u5e74\uff0cRoyal Institute of Technology\uff08KTH\uff09\u6709\u673a\u5316\u5b66\u6559\u6388\uff1b 2001\u5e74\uff0cRoyal Institute of Technology\uff08KTH\uff09\u5316\u5b66\u7cfb\u4e3b\u4efb\uff1b 2005\u5e74\uff0cRoyal Institute of Technology\uff08KTH\uff09\u5316\u5b66\u79d1\u5b66\u4e0e\u5de5\u7a0b\u5b66\u9662\u9662\u957f\uff1b 2007\u5e74\uff0cInstitute of Technology, University of Tartu\u9ad8\u7ea7\u7814\u7a76\u5458\uff1b 2010\u5e74\uff0cRoyal Swedish Academy of Sciences\u6210\u5458\uff1b 2012\u5e74\uff0cRoyal Swedish Academy of Sciences\u6709\u673a\u5316\u5b66\u6559\u6388\uff1b 2015\u5e74\uff0cRoyal Physiografiphic Society of Lund\u6210\u5458\u3002 &nbsp; 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\u57fa\u4e8e\u4e4b\u524d\u62a5\u9053\u7684Cu\u50ac\u5316\u70ef\u70c3\u7684\u4e0d\u5bf9\u79f0\u6c22\u80fa\u5316\u53cd\u5e94\u7684\u673a\u7406\u7814\u7a76\uff0c\u4f5c\u8005\u63a8\u6d4b\u8be5\u53cd\u5e94\u7684\u673a\u7406\uff1a\u70ef\u80fa\u4e0e\u539f\u4f4d\u751f\u6210\u7684Cu(I)-H\u53cd\u5e94\uff0c\u751f\u6210\u70f7\u57fa\u94dc\u4e2d\u95f4\u4f53II\u3002\u7136\u540e\uff0cII\u4e0e\u7f9f\u80fa2c\u53d1\u751f\u6c27\u5316\u53cd\u5e94\uff0c\u751f\u6210\u4e0d\u5bf9\u79f01,2-\u4e8c\u80fa\u4ea7\u72693a\u548c\u82ef\u7532\u9178\u94dcIII\u3002III\u4e0e\u7845\u70f7IV\u53d1\u751f\u91d1\u5c5e\u8f6c\u79fb\u53cd\u5e94\uff0cIII\u53c8\u4f1a\u91cd\u65b0\u8f6c\u5316\u4e3aI\u3002\u5c11\u91cf\u7684II\u4f1a\u53d1\u751f\u03b2-\u6d88\u9664\u53cd\u5e94\uff0c\u751f\u6210\u7684\u82ef\u4e59\u70ef\u4f1a\u8fdb\u4e00\u6b65\u53d1\u751f\u6c22\u80fa\u5316\u53cd\u5e94\u751f\u6210\u5316\u5408\u72694\u3002 Scheme 2. \u53cd\u5e94\u673a\u7406\u89e3\u6790 &nbsp; \u8bba\u6587\u603b\u7ed3\u8bc4\u4ef7 \u745e\u5178\u9686\u5fb7\u5927\u5b66Peter Somfai\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86Cu\u50ac\u5316\u70ef\u80fa\u7684\u4e0d\u5bf9\u79f0\u6c22\u80fa\u5316\u53cd\u5e94,\u80fd\u4ee5\u826f\u597d\u7684\u6536\u7387\u548c\u8f83\u9ad8\u7684\u5bf9\u6620\u9009\u62e9\u6027\u76f4\u63a5\u5f97\u5230\u624b\u60271,2-\u4e8c\u80fa\u5316\u5408\u7269\u3002\u8003\u8651\u5230Cu\u50ac\u5316\u4f53\u7cfb\u5728\u4e0d\u5bf9\u79f0\u6c22\u80fa\u5316\u53cd\u5e94\u4e2d\u8868\u73b0\u51fa\u7684\u4f18\u5f02\u7684\u50ac\u5316\u6d3b\u6027\u548c\u5bf9\u6620\u9009\u62e9\u6027\uff0c\u5c06\u5176\u5f15\u5165\u4e0d\u5bf9\u79f0C-N\u952e\u5408\u6210\u9886\u57df\uff0c\u5fc5\u5c06\u7ed9C-N\u952e\u5408\u6210\u8fd9\u4e00\u9886\u57df\u6ce8\u5165\u65b0\u7684\u6d3b\u529b\u548c\u5e7f\u9614\u7684\u5951\u673a\u3002\u4f46\u5f00\u53d1\u65b0\u7684\u6709\u6548\u7684\u76f4\u63a5\u5408\u6210\u4e0d\u5bf9\u79f01,2-\u4e8c\u80fa\u5316\u5408\u7269\u7684\u65b9\u6cd5\u4ecd\u7136\u9762\u4e34\u5de8\u5927\u6311\u6218\u3002 &nbsp; \u53c2\u8003\u6587\u732e\uff1a Shao, X.; Li, K.; Malcolmson, S. 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