{"id":25427,"date":"2019-05-28T10:21:21","date_gmt":"2019-05-28T02:21:21","guid":{"rendered":"\/\/www.gsbet888.com\/?p=25427"},"modified":"2019-05-28T10:21:21","modified_gmt":"2019-05-28T02:21:21","slug":"barton-zard%e5%8f%8d%e5%ba%94%e4%b8%ad%e9%97%b4%e4%bd%93%e7%9a%84%e5%8a%a8%e5%8a%9b%e5%ad%a6%e6%8b%86%e5%88%86","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2019\/05\/barton-zard%e5%8f%8d%e5%ba%94%e4%b8%ad%e9%97%b4%e4%bd%93%e7%9a%84%e5%8a%a8%e5%8a%9b%e5%ad%a6%e6%8b%86%e5%88%86.html","title":{"rendered":"Barton-Zard\u53cd\u5e94\u4e2d\u95f4\u4f53\u7684\u52a8\u529b\u5b66\u62c6\u5206"},"content":{"rendered":"<p>\u8f74\u624b\u6027\u5316\u5408\u7269\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5929\u7136\u4ea7\u7269\u3001\u836f\u7269\u3001\u914d\u4f53\u53ca\u50ac\u5316\u5242\u4e2d\uff0c\u56e0\u6b64\u5408\u6210\u624b\u6027\u8054\u82b3\u57fa\u5316\u5408\u7269\u4e00\u76f4\u662f\u5316\u5b66\u5bb6\u5173\u6ce8\u7684\u91cd\u4e2d\u4e4b\u91cd\u3002\u5408\u6210\u8f74\u624b\u6027\u5316\u5408\u7269\u7684\u65b9\u6cd5\u4e3b\u8981\u67094\u79cd\uff1aa\uff09\u4e24\u4e2a\u82b3\u57fa\u5355\u4f4d\u53d1\u751f\u4e0d\u5bf9\u79f0\u5076\u8054\u53cd\u5e94; b\uff09\u5df2\u5b58\u5728\u7684\u8054\u82b3\u57fa\u5316\u5408\u7269\u53bb\u5bf9\u79f0\u5316\uff1bc\uff09\u53d6\u4ee3\u82b3\u57fa\u5316\u5408\u7269\u7684\u963b\u8f6c\u9009\u62e9\u6027; d\uff09\u8054\u82b3\u57fa\u5316\u5408\u7269\u7684\u52a8\u529b\u5b66\u62c6\u5206\u3002Scheme 1a\u5219\u662f\u6b64\u524d\u62a5\u9053\u7684\u53d6\u4ee3\u82b3\u57fa\u5316\u5408\u7269\u7684\u4e0d\u5bf9\u79f0\u52a0\u6210\u4ea7\u7269\u53d1\u751f\u624b\u6027\u4e2d\u5fc3\u5411\u8f74\u624b\u6027\u7684\u4f20\u9012\u8fc7\u7a0b\uff0c\u5f97\u5230\u542b\u4e94\u5143\u6742\u73af\u7684\u8f74\u624b\u6027\u5316\u5408\u7269\u3002\u8fd9\u79cd\u5408\u6210\u8f74\u624b\u6027\u7684\u65b9\u6cd5\u5f88\u65e9\u5c31\u88ab\u63d0\u51fa\uff0c\u4e14\u53d6\u5f97\u4e86\u4e0d\u9519\u7684\u8fdb\u5c55\uff0c\u4f46\u5173\u4e8e\u901a\u8fc7\u81ea\u8eab\u8f6c\u5316\u6784\u5efa\u542b\u4e94\u5143\u6742\u73af\u7684\u8f74\u624b\u6027\u9aa8\u67b6\u7684\u62a5\u9053\u8fd8\u6bd4\u8f83\u5c11\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5916\u6d88\u65cb\u4e8c\u82b3\u57fa\u5316\u5408\u7269\u7684\u52a8\u529b\u5b66\u62c6\u5206\u53ef\u901a\u8fc7\u9187\u89e3\u3001N-\u9170\u5316\/\u70f7\u57fa\u5316\u3001O-\u9170\u5316\u4ee5\u53ca\u76f4\u63a5\u82b3\u57fa\u5b98\u80fd\u56e2\u5316\u5b9e\u73b0\uff0c\u4f46\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8fd8\u6ca1\u6709\u5173\u4e8e\u5916\u6d88\u65cb\u975e\u4e8c\u82b3\u57fa\u5316\u5408\u7269\u7684\u52a8\u529b\u5b66\u62c6\u5206\u7684\u62a5\u9053\u3002\u6700\u8fd1\uff0c\u745e\u58eb\u6d1b\u6851\u8054\u90a6\u7406\u5de5\u5927\u5b66<a href=\"https:\/\/www.epfl.ch\/labs\/lspn\/publications\/\">\u795d\u4ecb\u5e73\u8bfe\u9898\u7ec4<\/a>\u62a5\u9053\u4e86\u5f02\u6c30\u4e59\u9178\u916f\u548c\u7094\u57fa\u916e\u7684\u4e0d\u5bf9\u79f0\u6742\u73af\u53cd\u5e94\uff0c\u6784\u5efa\u8f74\u624b\u6027\u82b3\u57fa\u5421\u54af\u9aa8\u67b6[1]\u3002\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u4f5c\u8005\u60f3\u8981\u5c06\u52a8\u529b\u5b66\u62c6\u5206\u5f15\u5165\u8f74\u624b\u6027\u82b3\u57fa\u5421\u54af\u5316\u5408\u7269\u7684\u5408\u6210\u4e2d\uff0c\u5373\u5b98\u80fd\u56e2\u53d6\u4ee3\u7684\u82b3\u73af\u53d1\u751f\u73af\u5316\u53cd\u5e94\u53ef\u5f97\u5230\u6d88\u65cb\u7684\u4ea7\u7269<strong>2<\/strong>\u3002\u5728\u5408\u9002\u7684\u50ac\u5316\u5242\u4f5c\u7528\u4e0b\uff0c<strong>2<\/strong>\u53ef\u53d1\u751f\u6c27\u5316\u53cd\u5e94\u6216\u6d88\u9664\u53cd\u5e94\u4ece\u800c\u5b9e\u73b0<strong>2<\/strong>\u7684\u52a8\u529b\u5b66\u62c6\u5206\u8fc7\u7a0b\uff0c\u5f97\u5230\u8f74\u624b\u6027\u5316\u5408\u7269<strong>3<\/strong>\u3002\u540c\u65f6\uff0c\u56de\u6536\u7684<strong>2<\/strong>\u53ef\u8f6c\u5316\u4e3a\u53cd\u6784\u578b\u7684\u4ea7\u7269<strong>3<\/strong>\uff08Scheme 1b\uff09\u30023,4-\u4e8c\u6c22-2<em>H<\/em>-\u5421\u54af<strong>6<\/strong>\u4e3aBarton-Zard\u53cd\u5e94\u7684\u4e2d\u95f4\u4f53\uff0c\u4f5c\u8005\u63a8\u6d4b6\u53ef\u6210\u529f\u5b9e\u73b0\u52a8\u529b\u5b66\u62c6\u5206\u8fc7\u7a0b\u3002\u56e0\u6b64\uff0c<a href=\"https:\/\/www.epfl.ch\/labs\/lspn\/publications\/\">\u795d\u4ecb\u5e73\u8bfe\u9898\u7ec4<\/a>\u6210\u529f\u5f00\u53d1\u4e86\u78b1\u6027\u50ac\u5316\u4f5c\u7528\u4e0b\u785d\u57fa\u70ef\u70c3<strong>4<\/strong>\u4e0e\u03b1-\u5f02\u6c30\u57fa\u4e59\u9178\u916f<strong>5<\/strong>\u53d1\u751f\u73af\u5316\u53cd\u5e94\u751f\u6210\u6d88\u65cb\u4ea7\u7269<strong>6<\/strong>\u3002\u5728\u594e\u5b81\u884d\u751f\u7684\u786b\u8132\u50ac\u5316\u5242\u4f5c\u7528\u4e0b\uff0c\u4f5c\u8005\u6210\u529f\u5b9e\u73b0\u4e86<strong>6<\/strong>\u7684\u52a8\u529b\u5b66\u62c6\u5206\uff0c\u5408\u6210\u8f74\u624b\u6027\u82b3\u57fa\u5316\u5408\u7269\uff08Scheme 1c\uff09\u3002<\/p>\n<blockquote><p>Catalytic Kinetic Resolution via Enantioselective Aromatization: Conversion of Racemic Intermediates of the Barton-Zard Reaction to Enantioenriched 3-Arylpyrroles<\/p>\n<p>Zheng, S.-C.; Wang, Q.; Zhu, J.*<em> Angew. Chem. Int. Ed. <\/em>2019, Just Accepted Manuscript<\/p>\n<p>DOI: 10.1002\/anie.201903589<\/p><\/blockquote>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/2-13.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25429 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/2-13.png\" alt=\"\" width=\"560\" height=\"622\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/2-13.png 560w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/2-13-270x300.png 270w\" sizes=\"(max-width: 560px) 100vw, 560px\" \/><\/a><\/p>\n<h4><strong>\u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd\uff1a<\/strong><\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-13.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25430 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-13-680x378.png\" alt=\"\" width=\"680\" height=\"378\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-13-680x378.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-13-300x167.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-13-768x427.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/3-13.png 872w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p><strong>\u8bba\u6587<\/strong><strong>\u4f5c\u8005<\/strong>\uff1a\u795d\u4ecb\u5e73\u6559\u6388<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u6559\u80b2\u80cc\u666f<\/strong>\uff1a<\/h4>\n<ul>\n<li>1984, B.Sc., Hanzhou Normal University, P. R. China<\/li>\n<li>1987, M.Sc., Lanzhou University (Prof. Y.-L. Li), P. R. China<\/li>\n<li>1991, Ph.D., Universit\u00e9 Paris XI (Prof. H.-P. Husson and Prof. J.-C. Quirion), France<\/li>\n<li>1991-1992, Post-doct., Texas A &amp; M University (Prof. Sir D. H. R. Barton), USA Academic Positions<\/li>\n<li>1992-2000, \u201cCharge de Recherche\u201d at ICSN, CNRS, France<\/li>\n<li>2000-2006, Director of Research, 2nd class, at ICSN CNRS, France<\/li>\n<li>2006-2010, Director of Research, 1st class at ICSN, CNRS, France 2010-September 1st- Professor, ISIC, EPFL<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h4><strong>\u83b7\u5956\u60c5\u51b5<\/strong>\uff1a<\/h4>\n<ul>\n<li>1996, CNRS bronze medal (1996)<\/li>\n<li>1999, French Chemical Society SCF-Acros award (1999)<\/li>\n<li>2002, AstraZeneca Award in Organic Chemistry (UK)<\/li>\n<li>2002, Japan Society for Promotion of Science (JSPS) fellow<\/li>\n<li>2003, Prix Emile Jungfleisch of French Academy of Sciences<\/li>\n<li>2003, National Science Foundation Outstanding Young Oversea Scientist award (China)<\/li>\n<li>2004, Liebig Lectureship of the German Chemical Society<\/li>\n<li>2008, Novartis Chemistry Lecture Award (Switzerland)<\/li>\n<li>2009, CNRS Silver medal<\/li>\n<li>2010, French Chemical Society-Division of Organic Chemistry SCF-DCO award. 2015, Nankai University Lectureship on Organic Chemistry, Nankai University, Tianjing, P. R: China<\/li>\n<li>2016, Royal Society of Chemistry (RSC) Natural Product Chemistry Award, UK<\/li>\n<li>2017, KAIST-BK21 School of Molecular Science Lectureship award, South Korea<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h4><strong>\u7814\u7a76\u9886\u57df<\/strong>\uff1a<\/h4>\n<p>\u4e3b\u8981\u4ece\u4e8b\u590d\u6742\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u3001\u4e0d\u5bf9\u79f0\u50ac\u5316\u4e0e\u5408\u6210\u548c\u591a\u7ec4\u5206\u4e32\u8054\u53cd\u5e94\u9886\u57df\u7684\u7814\u7a76\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u8bba\u6587\u6982\u8981\uff1a<\/strong><\/h4>\n<p>\u6587\u732e\u8c03\u7814\u663e\u793a\u5df2\u6709\u5173\u4e8e\u785d\u57fa\u70ef\u70c3<strong>4<\/strong>\u4e0e\u03b1-\u5f02\u6c30\u57fa\u4e59\u9178\u916f<strong>5<\/strong>\u53d1\u751f[3+2]\u73af\u52a0\u6210\u53cd\u5e94\u5408\u62102,3-\u4e8c\u6c22\u5421\u54af\u7684\u62a5\u9053\uff0c\u4f46\u7531\u4e8e\u5728DBU\u6216\u80cd\u50ac\u5316\u4f5c\u7528\u4e0b\uff0c\u4ea7\u7269\u4f1a\u8fc5\u901f\u8131\u6389HNO<sub>2<\/sub>\uff0c\u6240\u4ee5\u672a\u5206\u79bb\u51fa\u4e2d\u95f4\u4f53<strong>6<\/strong>\u3002\u56e0\u6b64\uff0c\u4e3a\u5206\u79bb\u51fa\u4e2d\u95f4\u4f53<strong>6a<\/strong>\uff0c\u4f5c\u8005\u4ee5<strong>4a<\/strong>\u548c<strong>5a<\/strong>\u4e3a\u6a21\u677f\u5e95\u7269\uff0c\u5bf9\u53cd\u5e94\u6761\u4ef6\u8fdb\u884c\u53cd\u590d\u7b5b\u9009\uff0c\u786e\u5b9a\u6700\u4f73\u6761\u4ef6\u4e3a(Table 1)\uff1a1.0 equiv KHMDS\uff080.5 N\u5728\u7532\u82ef\u4e2d\uff09\u4e3a\u6700\u4f18\u78b1\uff0cDCE\u4e3a\u6700\u4f18\u6eb6\u5242\uff0c\u5728-25 \u00b0C\u6761\u4ef6\u4e0b\u53cd\u5e9448 h\uff0c\u80fd\u4ee567\uff05\u7684\u6536\u7387\u5f97\u5230\u4e2d\u95f4\u4f53<strong>6a<\/strong>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-12.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25431 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-12-680x508.png\" alt=\"\" width=\"680\" height=\"508\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-12-680x508.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-12-300x224.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-12-768x574.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-12-265x197.png 265w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/4-12.png 824w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>\u7d27\u63a5\u7740\uff0c\u4f5c\u8005\u5bf9(\u00b1)-<strong>6a<\/strong>\u7684\u52a8\u529b\u5b66\u62c6\u5206\u6761\u4ef6\u8fdb\u884c\u4f18\u5316\uff0c\u53d1\u73b00.1 equiv\u594e\u5b81\u884d\u751f\u7269\u786b\u8132A\u4e3a\u50ac\u5316\u5242\uff0c1.2 equiv K<sub>3<\/sub>PO<sub>4<\/sub>\u4e3a\u78b1\uff0c100 mg 5\u00c5\u5206\u5b50\u7b5b\u4e3a\u6dfb\u52a0\u7269\uff0c\u5728\u5ba4\u6e29\u6761\u4ef6\u4e0b\u53cd\u5e9448 h\uff0c\u80fd\u4ee551%\u7684\u6536\u7387\u548c86%\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u7269(+)-<strong>7a<\/strong>\uff1b\u540c\u65f6\uff0c\u53ef\u4ee549%\u7684\u6536\u7387\u548c88%\u7684\u5bf9\u6620\u9009\u62e9\u6027\u56de\u6536(+)-<strong>6a<\/strong>(Table 2) \u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-11.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25432 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-11-680x476.png\" alt=\"\" width=\"680\" height=\"476\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-11-680x476.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-11-300x210.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-11-768x538.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/5-11.png 884w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>\u5728\u6700\u4f18\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u5bf9\u8be5\u52a8\u529b\u5b66\u62c6\u5206\u7684\u5e95\u7269\u8303\u56f4\u8fdb\u884c\u8003\u5bdf\uff08Scheme 2\uff09\u3002\u5404\u79cd\u8418\u57fa\u53d6\u4ee3\u3001C-4\u4f4d\u7532\u57fa\u3001\u4e59\u57fa\u3001\u5f02\u4e19\u57fa\u3001\u82c4\u57fa\u53d6\u4ee3\u3001C-2\u4f4d\u7532\u6c27\u57fa\u7fb0\u57fa\u3001\u4e59\u6c27\u57fa\u7fb0\u57fa\u53d6\u4ee3\u5421\u54af\u30013-\uff082&#8242;-\u7532\u6c27\u57fa-6&#8242;-\u7532\u57fa\u82ef\u57fa\uff09\u5421\u54af\u5747\u80fd\u8f83\u597d\u7684\u9002\u5e94\u53cd\u5e94\u6761\u4ef6\uff0c\u80fd\u4ee5\u8f83\u9ad8\u7684\u6536\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u7269\u3002\u800cC-2\u4f4d\u53d4\u4e01\u6c27\u57fa\u7fb0\u57fa\u548c\u82c4\u6c27\u57fa\u7fb0\u57fa\u53d6\u4ee3\u7684\u5421\u54af\u7684\u5bf9\u6620\u9009\u62e9\u6027\u7565\u5fae\u6709\u6240\u964d\u4f4e\u3002\u5e26\u4e24\u4e2a5\u5143\u6742\u73af\u7684\u5421\u54af\u4ee5\u53ca\uff08\u00b1\uff09-3,4-\u4e8c\u6c22-2H-\u5421\u54af\u4e5f\u80fd\u9002\u5e94\u53cd\u5e94\u6761\u4ef6\uff0c\u4f46\u5176\u6536\u7387\u8f83\u4f4e\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/6-6.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25433 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/6-6.png\" alt=\"\" width=\"953\" height=\"609\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/6-6.png 953w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/6-6-300x192.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/6-6-768x491.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/6-6-680x435.png 680w\" sizes=\"(max-width: 953px) 100vw, 953px\" \/><\/a><\/p>\n<p>\u4ee5\u594e\u5c3c\u4e01\u884d\u751f\u7684\u786b\u8132B\u4e3a\u50ac\u5316\u5242\uff0c5\u00c5\u5206\u5b50\u7b5b\u4e3a\u6dfb\u52a0\u7269\uff0c\u7532\u82ef\u4e3a\u6eb6\u5242\uff0c 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decoding=\"async\" class=\"aligncenter wp-image-25435 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/8-3.png\" alt=\"\" width=\"608\" height=\"621\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/8-3.png 608w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/8-3-294x300.png 294w\" sizes=\"(max-width: 608px) 100vw, 608px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u8bba\u6587\u603b\u7ed3\u8bc4\u4ef7\uff1a<\/strong><\/h4>\n<p>\u745e\u58eb\u6d1b\u6851\u8054\u90a6\u7406\u5de5\u5927\u5b66\u795d\u4ecb\u5e73\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u7b2c\u4e00\u4f8b\u785d\u57fa\u70ef\u70c3\u4e0e\u03b1-\u5f02\u6c30\u57fa\u4e59\u9178\u916f\u53d1\u751fBarton-Zard\u53cd\u5e94\uff0c\u5f97\u5230\u7684\u6d88\u65cb2-\u82b3\u57fa\u5421\u54af\u5728\u91d1\u9e21\u7eb3\u751f\u7269\u78b1\u884d\u751f\u53cc\u529f\u80fd\u50ac\u5316\u5242\u4f5c\u7528\u4e0b\u53ef\u987a\u5229\u7684\u53d1\u751f\u52a8\u529b\u5b66\u62c6\u5206\u8fc7\u7a0b\u3002\u8fd9\u662f\u7b2c\u4e00\u4f8b\u5916\u6d88\u65cb\u5316\u5408\u7269\u901a\u8fc7\u4e0d\u5bf9\u79f0\u82b3\u6784\u5316\u53cd\u5e94\u5b9e\u73b0\u52a8\u529b\u5b66\u62c6\u5206\uff0c\u5408\u6210\u624b\u6027\u8054\u82b3\u57fa\u5316\u5408\u7269\u7684\u62a5\u9053\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ol>\n<li>Zheng, S.-C.; Wang, Q.; Zhu, J. <em> Chem. Int. Ed<\/em>. <strong>2019<\/strong>, <em>58<\/em>, 1494. DOI:<a href=\"https:\/\/doi.org\/10.1002\/anie.201812654%20Cited%20by:%204\"> 10.1002\/anie.201812654<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"\u8f74\u624b\u6027\u5316\u5408\u7269\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5929\u7136\u4ea7\u7269\u3001\u836f\u7269\u3001\u914d\u4f53\u53ca\u50ac\u5316\u5242\u4e2d\uff0c\u56e0\u6b64\u5408\u6210\u624b\u6027\u8054\u82b3\u57fa\u5316\u5408\u7269\u4e00\u76f4\u662f\u5316\u5b66\u5bb6\u5173\u6ce8\u7684\u91cd\u4e2d\u4e4b\u91cd\u3002\u5408\u6210\u8f74\u624b\u6027\u5316\u5408\u7269\u7684\u65b9\u6cd5\u4e3b\u8981\u67094\u79cd\uff1aa\uff09\u4e24\u4e2a\u82b3\u57fa\u5355\u4f4d\u53d1\u751f\u4e0d\u5bf9\u79f0\u5076\u8054\u53cd\u5e94; b\uff09\u5df2\u5b58\u5728\u7684\u8054\u82b3\u57fa\u5316\u5408\u7269\u53bb\u5bf9\u79f0\u5316\uff1bc\uff09\u53d6\u4ee3\u82b3\u57fa\u5316\u5408\u7269\u7684\u963b\u8f6c\u9009\u62e9\u6027; d\uff09\u8054\u82b3\u57fa\u5316\u5408\u7269\u7684\u52a8\u529b\u5b66\u62c6\u5206\u3002Scheme 1a\u5219\u662f\u6b64\u524d\u62a5\u9053\u7684\u53d6\u4ee3\u82b3\u57fa\u5316\u5408\u7269\u7684\u4e0d\u5bf9\u79f0\u52a0\u6210\u4ea7\u7269\u53d1\u751f\u624b\u6027\u4e2d\u5fc3\u5411\u8f74\u624b\u6027\u7684\u4f20\u9012\u8fc7\u7a0b\uff0c\u5f97\u5230\u542b\u4e94\u5143\u6742\u73af\u7684\u8f74\u624b\u6027\u5316\u5408\u7269\u3002\u8fd9\u79cd\u5408\u6210\u8f74\u624b\u6027\u7684\u65b9\u6cd5\u5f88\u65e9\u5c31\u88ab\u63d0\u51fa\uff0c\u4e14\u53d6\u5f97\u4e86\u4e0d\u9519\u7684\u8fdb\u5c55\uff0c\u4f46\u5173\u4e8e\u901a\u8fc7\u81ea\u8eab\u8f6c\u5316\u6784\u5efa\u542b\u4e94\u5143\u6742\u73af\u7684\u8f74\u624b\u6027\u9aa8\u67b6\u7684\u62a5\u9053\u8fd8\u6bd4\u8f83\u5c11\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5916\u6d88\u65cb\u4e8c\u82b3\u57fa\u5316\u5408\u7269\u7684\u52a8\u529b\u5b66\u62c6\u5206\u53ef\u901a\u8fc7\u9187\u89e3\u3001N-\u9170\u5316\/\u70f7\u57fa\u5316\u3001O-\u9170\u5316\u4ee5\u53ca\u76f4\u63a5\u82b3\u57fa\u5b98\u80fd\u56e2\u5316\u5b9e\u73b0\uff0c\u4f46\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8fd8\u6ca1\u6709\u5173\u4e8e\u5916\u6d88\u65cb\u975e\u4e8c\u82b3\u57fa\u5316\u5408\u7269\u7684\u52a8\u529b\u5b66\u62c6\u5206\u7684\u62a5\u9053\u3002\u6700\u8fd1\uff0c\u745e\u58eb\u6d1b\u6851\u8054\u90a6\u7406\u5de5\u5927\u5b66\u795d\u4ecb\u5e73\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u5f02\u6c30\u4e59\u9178\u916f\u548c\u7094\u57fa\u916e\u7684\u4e0d\u5bf9\u79f0\u6742\u73af\u53cd\u5e94\uff0c\u6784\u5efa\u8f74\u624b\u6027\u82b3\u57fa\u5421\u54af\u9aa8\u67b6[1]\u3002\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u4f5c\u8005\u60f3\u8981\u5c06\u52a8\u529b\u5b66\u62c6\u5206\u5f15\u5165\u8f74\u624b\u6027\u82b3\u57fa\u5421\u54af\u5316\u5408\u7269\u7684\u5408\u6210\u4e2d\uff0c\u5373\u5b98\u80fd\u56e2\u53d6\u4ee3\u7684\u82b3\u73af\u53d1\u751f\u73af\u5316\u53cd\u5e94\u53ef\u5f97\u5230\u6d88\u65cb\u7684\u4ea7\u72692\u3002\u5728\u5408\u9002\u7684\u50ac\u5316\u5242\u4f5c\u7528\u4e0b\uff0c2\u53ef\u53d1\u751f\u6c27\u5316\u53cd\u5e94\u6216\u6d88\u9664\u53cd\u5e94\u4ece\u800c\u5b9e\u73b02\u7684\u52a8\u529b\u5b66\u62c6\u5206\u8fc7\u7a0b\uff0c\u5f97\u5230\u8f74\u624b\u6027\u5316\u5408\u72693\u3002\u540c\u65f6\uff0c\u56de\u6536\u76842\u53ef\u8f6c\u5316\u4e3a\u53cd\u6784\u578b\u7684\u4ea7\u72693\uff08Scheme 1b\uff09\u30023,4-\u4e8c\u6c22-2H-\u5421\u54af6\u4e3aBarton-Zard\u53cd\u5e94\u7684\u4e2d\u95f4\u4f53\uff0c\u4f5c\u8005\u63a8\u6d4b6\u53ef\u6210\u529f\u5b9e\u73b0\u52a8\u529b\u5b66\u62c6\u5206\u8fc7\u7a0b\u3002\u56e0\u6b64\uff0c\u795d\u4ecb\u5e73\u8bfe\u9898\u7ec4\u6210\u529f\u5f00\u53d1\u4e86\u78b1\u6027\u50ac\u5316\u4f5c\u7528\u4e0b\u785d\u57fa\u70ef\u70c34\u4e0e\u03b1-\u5f02\u6c30\u57fa\u4e59\u9178\u916f5\u53d1\u751f\u73af\u5316\u53cd\u5e94\u751f\u6210\u6d88\u65cb\u4ea7\u72696\u3002\u5728\u594e\u5b81\u884d\u751f\u7684\u786b\u8132\u50ac\u5316\u5242\u4f5c\u7528\u4e0b\uff0c\u4f5c\u8005\u6210\u529f\u5b9e\u73b0\u4e866\u7684\u52a8\u529b\u5b66\u62c6\u5206\uff0c\u5408\u6210\u8f74\u624b\u6027\u82b3\u57fa\u5316\u5408\u7269\uff08Scheme 1c\uff09\u3002 Catalytic Kinetic Resolution via Enantioselective Aromatization: Conversion of Racemic Intermediates of the Barton-Zard Reaction to Enantioenriched 3-Arylpyrroles Zheng, S.-C.; Wang, Q.; Zhu, J.* Angew. Chem. Int. Ed. 2019, Just Accepted Manuscript DOI: 10.1002\/anie.201903589 \u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd\uff1a \u8bba\u6587\u4f5c\u8005\uff1a\u795d\u4ecb\u5e73\u6559\u6388 &nbsp; \u6559\u80b2\u80cc\u666f\uff1a 1984, B.Sc., Hanzhou Normal University, P. R. China 1987, M.Sc., Lanzhou University (Prof. Y.-L. Li), P. R. China 1991, Ph.D., Universit\u00e9 Paris XI (Prof. H.-P. Husson and Prof. J.-C. Quirion), France 1991-1992, Post-doct., Texas A &amp; M University (Prof. Sir D. H. R. Barton), USA Academic Positions 1992-2000, \u201cCharge de Recherche\u201d at ICSN, CNRS, France 2000-2006, Director of Research, 2nd class, at ICSN CNRS, France 2006-2010, Director [&hellip;]","protected":false},"author":8,"featured_media":25428,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1271],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/05\/1-13.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-6C7","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/25427"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=25427"}],"version-history":[{"count":5,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/25427\/revisions"}],"predecessor-version":[{"id":25457,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/25427\/revisions\/25457"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/25428"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=25427"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=25427"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=25427"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}