{"id":25669,"date":"2019-06-22T08:00:59","date_gmt":"2019-06-22T00:00:59","guid":{"rendered":"\/\/www.gsbet888.com\/?p=25669"},"modified":"2019-06-20T10:08:50","modified_gmt":"2019-06-20T02:08:50","slug":"%e4%b8%96%e7%95%8c%e8%91%97%e5%90%8d%e5%8c%96%e5%ad%a6%e5%ae%b6-lutz-ackermann","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/chemists\/2019\/06\/%e4%b8%96%e7%95%8c%e8%91%97%e5%90%8d%e5%8c%96%e5%ad%a6%e5%ae%b6-lutz-ackermann.html","title":{"rendered":"\u4e16\u754c\u8457\u540d\u5316\u5b66\u5bb6 Lutz Ackermann"},"content":{"rendered":"
\u672c\u6587\u4f5c\u8005 alberto-caeiro<\/p>\n
Lutz Ackermann\uff0c\u5fb7\u56fd\u54e5\u5ef7\u6839\u5927\u5b66(Georg-August-University G\u00f6ttingen)\u6709\u673a\u5316\u5b66\u6559\u6388\uff0c\u4e3b\u8981\u4ece\u4e8b\u4e8eC-H\u952e\u6d3b\u5316\u53ca\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\uff0c\u66fe\u4efb\u54e5\u5ef7\u6839\u5927\u5b66\u5316\u5b66\u7cfb\u4e3b\u4efb(2011-2015)\u3002(\u56fe\u7247\uff1a\u5b9e\u9a8c\u5ba4\u4ecb\u7ecd<\/a>)<\/p>\n <\/p>\n \u5de5\u4f5c\u4ecb\u7ecd<\/strong><\/p>\n 1.C-H<\/em><\/strong>\u952e\u5b98\u80fd\u56e2\u5316<\/em><\/strong>(C-H BondFunctionalization)<\/em><\/strong><\/p>\n \u533a\u57df\u9009\u62e9\u6027\u7684C-H\u952e\u6d3b\u5316\u53cd\u5e94\u5e38\u89c1\u4e8e\u71b5\u5141\u8bb8\u7684\u5206\u5b50\u5185\u53cd\u5e94\uff0c\u7535\u6027\u63a7\u5236\u7684\u82b3\u6742\u73af\u5316\u5408\u7269\u7684\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u6216\u4e34\u8fd1\u6548\u5e94\u5bfc\u81f4\u7684\u90bb\u4f4dC-H\u952e\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u3002\u800cAckermann\u6559\u6388\u5229\u7528Ru\u50ac\u5316\u5242\u5b9e\u73b0\u4e86\u8fdc\u7a0bC-H\u952e\u5b98\u80fd\u56e2\u5316\u53cd\u5e94[1]<\/sup>\u3002<\/p>\n \u9664Ru\u50ac\u5316\u7684\u8fdc\u7a0bC-H\u952e\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\uff0cAckermann\u6559\u6388\u5229\u7528\u91d1\u5c5eNi\u548cMn\u5728C-H\u952e\u6d3b\u5316\u4e2d\u4e5f\u6709\u5e94\u7528\u3002\u57282019\u5e74\uff0c\u4f5c\u8005\u5206\u522b\u53d1\u8868\u4e86Ni\/JoSPOphos\u50ac\u5316\u7684\u7ecfC-H\u952e\u6d3b\u5316\u5206\u5b50\u5185\u4e0d\u5bf9\u79f0\u70ef\u70c3\u6c22\u82b3\u57fa\u5316\u53cd\u5e94[2a]<\/sup>\uff0cMnCl2<\/sub>\u50ac\u5316\u7684\u82b3\u6742\u73af\u5316\u5408\u7269\u7684C-H\u952e\u70f7\u57fa\u5316\u53cd\u5e94[2b]<\/sup>\u3002<\/p>\n \u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u53cd\u5e94<\/em><\/strong>(Photocatalysis)<\/em><\/strong><\/p>\n \u5728\u8fd1\u4e9b\u5e74\uff0c\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u5242\u4e0ePd\uff0cRu\u548cRh\u7b49\u50ac\u5316\u5242\u4e00\u9f50\u7528\u4e8eC-H\u952e\u6d3b\u5316\u53cd\u5e94\u4e2d\u3002Ackermann\u6559\u6388\u5c06earth-abundant3d transition metals\uff08\u5982Cu\uff09\u4e0e\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u5242\u7ed3\u5408\u7684\u50ac\u5316\u4f53\u7cfb\u5229\u7528\u4e8eC-H\u952e\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u4e2d[3]<\/sup>\u3002<\/p>\n Flow Chemistry<\/em><\/strong><\/p>\n Ackermann\u6559\u6388\u5c06Flow Chemistry\u7684\u65b9\u6cd5\u53ef\u5f88\u597d\u7684\u5e94\u7528\u4e8eC-H\u952e\u6d3b\u5316\u4f53\u7cfb\u7684\u653e\u5927\u53cd\u5e94\u4e2d[4]<\/sup>\uff0c\u5e76\u4e14\u5b83\u53ef\u5f88\u597d\u5730\u4e0e\u5f02\u76f8\u50ac\u5316\u5242\u9002\u914d\uff0c\u4ece\u800c\u51cf\u5c11\u53cd\u5e94\u6eb6\u5242\u4f7f\u7528\u91cf\uff0c\u63d0\u9ad8\u50ac\u5316\u5242\u7684\u4f7f\u7528\u7a33\u5b9a\u6027\u3002<\/p>\n \u7535\u5316\u5b66<\/em><\/strong>(Electrochemistry)<\/em><\/strong><\/p>\n \u7535\u5316\u5b66\u4f5c\u4e3a\u4e00\u79cd\u533a\u522b\u4e0e\u70ed\u5316\u5b66\u7684\u53cd\u5e94\u6a21\u5f0f\uff0c\u5b83\u80fd\u591f\u4e3a\u5316\u5b66\u53cd\u5e94\u4e2d\u7684\u6c27\u5316\u8fd8\u539f\u8bd5\u5242\u63d0\u4f9b\u53e6\u5916\u4e00\u79cd\u66f4\u4e3a\u7eff\u8272\u7684\u9009\u62e9\u3002Ackermann\u6559\u6388\u5c06\u7535\u5316\u5b66\u5e94\u7528\u4e8eC-H\u952e\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\uff0c\u5b9e\u73b0\u4e86\u539f\u5b50\u7ecf\u6d4e\u548c\u5408\u6210\u6b65\u6570\u7ecf\u6d4e\u7684\u5316\u5b66\u5408\u6210[5]<\/sup>\u3002\u5229\u7528\u6b64\u53cd\u5e94\uff0cAckermann\u6559\u6388\u5b9e\u73b0\u4e86\u7a20\u73af\u5316\u5408\u7269\u7684\u5408\u6210[5c]<\/sup>\u3002 <\/p>\n 2.<\/em><\/strong>\u914d\u4f53\u8bbe\u8ba1\u4e0e\u8ba1\u7b97\u5316\u5b66<\/em><\/strong><\/p>\n Ackermann\u6559\u6388\u8bbe\u8ba1\u4e86\u4e00\u7c7b\u5bf9\u6c27\u6c14\u548c\u6c34\u7a33\u5b9a\u7684secondary phosphine oxide (SPO)\u914d\u4f53\uff0c\u5b83\u5728\u6742\u73af\u5316\u5408\u7269C-H\u952e\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u4e2d\u6709\u597d\u7684\u7acb\u4f53\u548c\u533a\u57df\u9009\u62e9\u6027\u63a7\u5236[6]<\/sup>\u3002\u4e3a\u4e86\u66f4\u597d\u7684\u7406\u89e3\u5176\u4f5c\u7528\u673a\u7406\uff0c\u4ed6\u4eec\u5229\u7528\u8ba1\u7b97\u5316\u5b66\u7684\u65b9\u6cd5\u5bf9\u5176\u50ac\u5316\u6a21\u5f0f\u8fdb\u884c\u6a21\u62df\u8ba1\u7b97\uff0c\u91cf\u5316\u4e86\u914d\u4f53\u548c\u6eb6\u5242\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u5bf9\u9009\u62e9\u6027\u8fdb\u884c\u4e86\u9884\u6d4b\u3002<\/p>\n 3.<\/em><\/strong>\u591a\u80bd\u884d\u751f\u5316<\/em><\/strong>(Peptides Diversifications)<\/em><\/strong><\/p>\n \u5728C-H\u952e\u5b98\u80fd\u56e2\u5316\u5f97\u5230\u6781\u5927\u53d1\u5c55\u7684\u6761\u4ef6\u4e0b\uff0cAckermann\u6559\u6388\u5229\u7528\u5316\u5b66\u53cd\u5e94\u5bf9\u6c28\u57fa\u9178\u548c\u591a\u80bd\u8fdb\u884c\u5316\u5b66\u4fee\u9970\u548c\u884d\u751f\u5316\uff0c\u5f97\u5230\u6781\u5177\u5e94\u7528\u4ef7\u503c\u7684\u975e\u5929\u7136\u591a\u80bd\u548c\u6c28\u57fa\u9178\uff0c\u7528\u4e8e\u86cb\u767d\u7ec4\u5b66\uff0c\u836f\u7269\u7814\u53d1\u7b49[7]<\/sup>\u3002<\/p>\n\u4e2a\u4eba\u7ecf\u5386<\/strong><\/h4>\n
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