{"id":25734,"date":"2019-06-20T10:07:19","date_gmt":"2019-06-20T02:07:19","guid":{"rendered":"\/\/www.gsbet888.com\/?p=25734"},"modified":"2020-05-06T16:14:21","modified_gmt":"2020-05-06T08:14:21","slug":"pd%e5%82%ac%e5%8c%96%e7%9a%84c-h%e8%90%98%e5%9f%ba%e5%8c%96%e5%8f%8d%e5%ba%94%e5%90%88%e6%88%90%e8%bd%b4%e6%89%8b%e6%80%a7%e9%86%9b%e5%82%ac%e5%8c%96%e5%89%82","status":"publish","type":"post","link":"\/\/www.gsbet888.com\/%e5%8c%96%e5%ad%a6%e6%9d%82%e8%ae%b0\/recentpaper\/2019\/06\/pd%e5%82%ac%e5%8c%96%e7%9a%84c-h%e8%90%98%e5%9f%ba%e5%8c%96%e5%8f%8d%e5%ba%94%e5%90%88%e6%88%90%e8%bd%b4%e6%89%8b%e6%80%a7%e9%86%9b%e5%82%ac%e5%8c%96%e5%89%82.html","title":{"rendered":"Pd\u50ac\u5316\u7684C-H\u8418\u57fa\u5316\u53cd\u5e94\u5408\u6210\u8f74\u624b\u6027\u919b\u50ac\u5316\u5242"},"content":{"rendered":"<p>\u624b\u6027\u919b\u50ac\u5316\u5242\u88ab\u8ba4\u4e3a\u662f\u4e0d\u5bf9\u79f0\u5408\u6210\u4e2d\u5f3a\u6709\u529b\u7684\u50ac\u5316\u5242\uff0c\u56e0\u6b64\u5408\u6210\u624b\u6027\u919b\u50ac\u5316\u5242\u5df2\u7ecf\u53d7\u5230\u5316\u5b66\u5bb6\u4eec\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u5408\u6210\u7684\u624b\u6027\u919b\u50ac\u5316\u5242\u4e3b\u8981\u5c40\u9650\u4e8e\u5e73\u9762\u624b\u6027\u548c\u624b\u6027\u4f4d\u70b9(Scheme 1a)\uff0c\u76f4\u52302014\u5e74\uff0cGuo[1]\u548cZhao[2]\u8bfe\u9898\u7ec4\u6210\u529f\u7684\u5f00\u53d1\u51fa\u4e86\u8f74\u624b\u6027\u919b\u50ac\u5316\u5242\uff0c\u8fd9\u4e3a\u4e0d\u5bf9\u79f0\u50ac\u5316\u63d0\u4f9b\u4e86\u4e00\u7c7b\u65b0\u578b\u5f3a\u6709\u529b\u7684\u50ac\u5316\u5242(Scheme 1b)\u3002\u4f46\u8be5\u7c7b\u8f74\u624b\u6027\u919b\u50ac\u5316\u5242\u7684\u5408\u6210\u6b65\u9aa4\u5197\u957f\u3001\u79cd\u7c7b\u5355\u4e00\u3001\u6d3b\u5316\u6548\u7387\u4e0d\u591f\u9ad8\u7b49\u95ee\u9898\u4e25\u91cd\u963b\u788d\u4e86\u8be5\u7c7b\u50ac\u5316\u5242\u5728\u4e0d\u5bf9\u79f0\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7814\u7a76\u80cc\u666f\uff0c\u6d59\u6c5f\u5927\u5b66<a href=\"https:\/\/person.zju.edu.cn\/bfshi\">\u53f2\u70b3\u950b\u8bfe\u9898\u7ec4<\/a>\u8bbe\u60f3\u901a\u8fc7\u4e09\u6b65C-H\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u5408\u6210\u90ed\u6c0f\u8f74\u624b\u6027\u919b\u7684\u7406\u60f3\u7b56\u7565\uff1ai\uff09C-H\u952e\u8418\u57fa\u5316\uff1bii\uff09\u73af\u5185C-H\u952e\u7f9f\u57fa\u5316\uff1biii\uff09C-H\u952e\u6eb4\u5316(Scheme 2a)\u3002\u4e3a\u4e86\u5b9e\u73b0\u8fd9\u4e2a\u7b56\u7565\uff0c\u4f5c\u8005\u9700\u8981\u89e3\u51b3\u4ee5\u4e0b\u95ee\u9898\uff1a\u9996\u5148\uff0c\u4e8c\u82b3\u57fa\u919b1\u7684C-H<em><sub>a<\/sub><\/em>\u6216C-H<em><sub>b<\/sub><\/em>\u662f\u5426\u4f1a\u53d1\u751fC-H\u82b3\u57fa\u5316\u53cd\u5e94(Scheme 2b)\u3002\u5176\u6b21\uff0c\u662f\u5426\u80fd\u627e\u5230\u5408\u9002\u7684\u77ac\u6001\u5bfc\u5411\u57fa\u80fd\u4f7f\u4ea7\u7269\u5177\u6709\u826f\u597d\u7684\u533a\u57df\u9009\u62e9\u6027\u548c\u5bf9\u6620\u9009\u62e9\u6027\u3002\u7b2c\u4e09\uff0c\u919b\u65b9\u5411\u7684C(sp<sup>2<\/sup>)-H\u7f9f\u57fa\u5316\u8f83\u96be\u3002<\/p>\n<p>\u8d77\u521d\uff0c\u4f5c\u8005\u4f7f\u7528<em>rac<\/em>&#8211;<strong>1a<\/strong>\u548c2-\u7898\u8418\u5728\u5404\u79cd\u6761\u4ef6\u4e0b\u53cd\u5e94\uff0c\u4f46\u5747\u65e0\u4ea7\u7269\u751f\u6210\u3002\u53d7\u5230Li\u8bfe\u9898\u7ec4\u5f00\u53d1\u7684Rh(III)\u50ac\u5316\u76842-\u82b3\u57fa\u5421\u5576\u548c1,4-\u4e8c\u6c22-1,4-\u73af\u6c27\u57fa\u8418\u7684C-H\u8418\u57fa\u5316\u53cd\u5e94\u7684\u542f\u53d1\uff0c\u4f5c\u8005\u62a5\u9053\u4e86Pd\u50ac\u5316\u4e8c\u82b3\u57fa\u919b\u4e0e1,4-\u4e8c\u6c22-1,4-\u73af\u6c27\u57fa\u8418\u7684\u4e0d\u5bf9\u79f0C-H\u8418\u57fa\u5316\u53cd\u5e94\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u63a8\u6d4b\u53ef\u80fd\u7684\u673a\u7406\uff1a<em>rac<\/em>&#8211;<strong>1<\/strong>\u4e0e\u624b\u6027\u6c28\u57fa\u9178TDG\u53d1\u751f\u53ef\u9006\u53cd\u5e94\uff0c\u751f\u6210\u4e9a\u80fa<strong>A1<\/strong>\u548c<strong>B1<\/strong>\u3002\u7531\u4e8e\u7a7a\u95f4\u4f4d\u963b\u7684\u76f8\u4e92\u4f5c\u7528\uff0cB1\u4f1a\u4f18\u5148\u4e0ePd(OAc)<sub>2<\/sub>\u4f5c\u7528\u4e0b\u751f\u6210\u4e2d\u95f4\u4f53\u3002\u7d27\u63a5\u7740\uff0c<strong>2a<\/strong>\u63d2\u5165\u5230<strong>C1<\/strong>\u4e2d\u5e76\u53d1\u751f\u03b2-\u6c27\u6d88\u9664\u53cd\u5e94\u751f\u6210\u4e2d\u95f4\u4f53<strong>E1<\/strong>\u3002\u5728HOAc\u7684\u4f5c\u7528\u4e0b\uff0c<strong>E1<\/strong>\u7684Pd-O\u952e\u65ad\u88c2\u91ca\u653e\u4e8c\u6c22\u8418\u915a<strong>F1<\/strong>\uff0c\u540c\u65f6\uff0cPd(OAc)<sub>2<\/sub>\u548c\u624b\u6027\u6c28\u57fa\u9178TDG\u518d\u751f\u3002\u6700\u540e\uff0cF1\u8131\u6c34\u5f97\u5230\u8418\u57fa\u5316\u4ea7\u7269<strong>3<\/strong>\u3002<strong>3<\/strong>\u518d\u7ecf\u5386\u4e24\u6b21C-H\u952e\u5b98\u80fd\u56e2\u5316\u5f97\u5230\u8f74\u624b\u6027\u919b\u50ac\u5316\u5242(Scheme 2b)\u3002\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e<\/p>\n<blockquote><p>Synthesis of Chiral Aldehyde Atroposelective C\u2212H NaphthylCaatitoanly sts via Pd-Catalyzed\u201d<\/p>\n<p>Liao, G.; Chen, H.-M.; Xia, Y.-N.; Li, B.; Yao, Q.-J.; Shi, B.-F.* <em>Angew. Chem. Int. Ed. <\/em>2019, Just Accepted Manuscript<\/p>\n<p>DOI: 10.1002\/anie.201906700<\/p><\/blockquote>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/2-21.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25736 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/2-21.png\" alt=\"\" width=\"583\" height=\"570\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/2-21.png 583w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/2-21-300x293.png 300w\" sizes=\"(max-width: 583px) 100vw, 583px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/3-18.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25737 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/3-18.png\" alt=\"\" width=\"554\" height=\"588\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/3-18.png 554w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/3-18-283x300.png 283w\" sizes=\"(max-width: 554px) 100vw, 554px\" \/><\/a><\/p>\n<h4><strong>\u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd\uff1a<\/strong><\/h4>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/4-18.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25738 size-medium\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/4-18-226x300.png\" alt=\"\" width=\"226\" height=\"300\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/4-18-226x300.png 226w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/4-18.png 280w\" sizes=\"(max-width: 226px) 100vw, 226px\" \/><\/a><\/p>\n<p><strong>\u8bba\u6587\u4f5c\u8005\uff1a<\/strong>\u53f2\u70b3\u950b\u6559\u6388<\/p>\n<h4><strong>\u7814\u7a76\u7ecf\u5386\uff1a<\/strong><\/h4>\n<ul>\n<li>1997\/09-2001\/07\uff1a\u5b66\u58eb\uff0c\u5357\u5f00\u5927\u5b66\u5316\u5b66\u7cfb \uff08\u5bfc\u5e08\uff1a\u5b5f\u7ee7\u672c\u6559\u6388\uff09<\/li>\n<li>2001\/09-2006\/07\uff1a\u535a\u58eb\uff0c\u4e2d\u79d1\u9662\u4e0a\u6d77\u6709\u673a\u6240\u751f\u547d\u6709\u673a\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4 (\u5bfc\u5e08: \u4fde\u98da\u7814\u7a76\u5458)<\/li>\n<li>2006\/10-2007\/08\uff1a\u535a\u58eb\u540e\uff0c\u52a0\u5dde\u5927\u5b66\u5723\u8fed\u6208\u5206\u6821\u5316\u5b66\u7cfb (\u5bfc\u5e08\uff1aProf. Michael S. VanNieuwenhze)<\/li>\n<li>2007\/08-2010\/4\uff1a\u7814\u7a76\u52a9\u7406\uff0cThe Scripps Research Institute\u5316\u5b66\u7cfb (\u5bfc\u5e08\uff1aProf. Jin-Quan Yu\uff09<\/li>\n<li>2010\/4-2014\/12\uff1a\u6d59\u6c5f\u5927\u5b66\u5316\u5b66\u7cfb\u7279\u8058\u7814\u7a76\u5458 \u3001\u535a\u5bfc\u3001\u72ec\u7acbPI<\/li>\n<li>2015\/01-\u81f3\u4eca\uff1a\u6d59\u6c5f\u5927\u5b66\u5316\u5b66\u7cfb \u6559\u6388\u3001\u535a\u5bfc\u3001\u72ec\u7acbPI<\/li>\n<li>2017\/08-\u81f3\u4eca\uff1a\u517c\u4efb\u5316\u5b66\u7cfb\u526f\u7cfb\u4e3b\u4efb\u3001\u6709\u673a\u4e0e\u836f\u7269\u5316\u5b66\u7814\u7a76\u6240\u6240\u957f<\/li>\n<\/ul>\n<h4><strong>\u7814\u7a76\u65b9\u5411\uff1a<\/strong><\/h4>\n<p>1.\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u7684\u78b3\u6c22\u952e\u6d3b\u5316<\/p>\n<p>2.\u5929\u7136\u4ea7\u7269\u591a\u6837\u6027\u5408\u6210\u53ca\u5176\u5316\u5b66\u751f\u7269\u5b66\u7814\u7a76<\/p>\n<h4><strong>\u5956\u52b1\u8363\u8a89\uff1a<\/strong><\/h4>\n<ul>\n<li>\u660e\u6cbb\u4e73\u4e1a\u751f\u547d\u79d1\u5b66\u5956<\/li>\n<li>2006\uff0cRoche Creative Chemistry Award<\/li>\n<li>2008\uff0cGordon Research Conference (GRC) Chair&#8217;s Award<\/li>\n<li>2013\uff0c\u94b1\u6c5f\u4eba\u624d<\/li>\n<li>2015\uff0cThieme Chemistry Journal Award<\/li>\n<li>2015\uff0cDistinguished Lectureship Award from Chemical Society of Japan<\/li>\n<li>2016\uff0c\u6d59\u6c5f\u7701\u6770\u51fa\u9752\u5e74\u57fa\u91d1<\/li>\n<li>2016\uff0c\u6d59\u6c5f\u7701151\u4eba\u624d<\/li>\n<li>2018\uff0c\u836f\u660e\u5eb7\u5fb7\u751f\u547d\u5316\u5b66\u7814\u7a76\u5956<\/li>\n<\/ul>\n<h4><strong>\u8bba\u6587\u6982\u8981\uff1a<\/strong><\/h4>\n<p>\u4ee52-\u82b3\u57fa\u919b<em>rac<\/em>&#8211;<strong>1a<\/strong>\u548c1,4-\u4e8c\u6c22-1,4-\u73af\u6c27\u57fa\u8418<strong>2a<\/strong>\u4f5c\u4e3a\u6a21\u677f\u5e95\u7269\uff0c\u4f5c\u8005\u5bf9\u5404\u79cd\u53cd\u5e94\u6761\u4ef6\u8fdb\u884c\u53cd\u590d\u7b5b\u9009\uff0c\u786e\u5b9a\u6700\u4f73\u6761\u4ef6\u4e3a(Table S1)\uff1a10 mol\uff05 Pd(OAc)<sub>2<\/sub>\u548c30 mol\uff05L-\u53d4\u4eae\u6c28\u9178\u4e3a\u50ac\u5316\u5242\uff0c2.5 equiv AdCH<sub>2<\/sub>CO<sub>2<\/sub>H\u548c2.0 equiv <em><sup>n<\/sup><\/em>PrCO<sub>2<\/sub>Na\u4e3a\u6dfb\u52a0\u7269\uff0cTFE\/HOAc \u4e3a\u6eb6\u5242\uff0c\u572860\u2103\u6761\u4ef6\u4e0b\u53cd\u5e9448\u5c0f\u65f6\uff0c\u80fd\u4ee571%\u7684\u6536\u7387\u548c&gt; 99\uff05\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u7269\u3002<\/p>\n<p>\u5728\u6700\u4f18\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u8003\u5bdf\u4e86\u8be5\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4(Table 1)\u3002\u5404\u79cdOMe, CF<sub>3<\/sub>, Me, F, Cl, -SPh\u53d6\u4ee3\u76842-\u82b3\u57fa\u919b\u5747\u80fd\u8f83\u597d\u7684\u9002\u5e94\u53cd\u5e94\u6761\u4ef6\uff0c\u80fd\u4ee5\u4e2d\u7b49\u81f3\u826f\u597d\u7684\u6536\u7387\u548c\u4f18\u79c0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u7269\u3002\u800c\u8418\u90e8\u5206\u5e26\u6709\u6c1f\u53d6\u4ee3\u57fa\u7684\u4e8c\u82b3\u57fa\u919b\u7684\u53cd\u5e94\u975e\u5e38\u7f13\u6162\uff0c\u53ea\u80fd\u4ee526\uff05\u7684\u6536\u7387\u5f97\u5230\u76f8\u5e94\u4ea7\u7269\u3002\u53e6\u5916\uff0c\u5404\u79cd\u53d6\u4ee3\u76841,4-\u4e8c\u6c22-1,4-\u73af\u6c27\u57fa\u8418\u4e5f\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u80fd\u4ee5\u4e2d\u7b49\u7684\u6536\u7387\u548c\u4f18\u5f02\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u7269\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/5-15.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25739 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/5-15.png\" alt=\"\" width=\"386\" height=\"584\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/5-15.png 386w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/5-15-198x300.png 198w\" sizes=\"(max-width: 386px) 100vw, 386px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/84696d315b9215d702e8d331dcabf4da.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25747 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/84696d315b9215d702e8d331dcabf4da.png\" alt=\"\" width=\"407\" height=\"197\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/84696d315b9215d702e8d331dcabf4da.png 407w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/84696d315b9215d702e8d331dcabf4da-300x145.png 300w\" sizes=\"(max-width: 407px) 100vw, 407px\" \/><\/a><\/p>\n<p>\u4e3a\u4e86\u8bc1\u660e\u8be5\u53cd\u5e94\u7684\u5e94\u7528\u6f5c\u529b\uff0c\u4f5c\u8005\u53c8\u8fdb\u884c\u4e86\u514b\u7ea7\u53cd\u5e94\u53ca\u884d\u751f\u53cd\u5e94(Scheme 3)\u3002\u5c06<em>rac<\/em>&#8211;<strong>1a<\/strong>\u7684\u91cf\u589e\u81f35 mmol\uff0c\u5728\u6807\u51c6\u6761\u4ef6\u4e0b\u53cd\u5e94\uff0c\u8be5\u53cd\u5e94\u7684\u6536\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u4e0e\u6a21\u677f\u4fdd\u6301\u4e00\u81f4\u3002\u5f97\u5230\u7684\u4ea7\u7269<strong>3a<\/strong>\u53ef\u88ab\u6c27\u5316\u6210\u76f8\u5e94\u7684\u7fa7\u9178<strong>4a<\/strong>\u30024a\u53ef\u4ee5\u8fdb\u4e00\u6b65\u8f6c\u5316\u4e3a\u5e26\u6c28\u57fa\u9187\u548c\u4e8c\u80bd\u7684\u8f74\u624b\u6027\u4e8c\u82b3\u57fa\u5316\u5408\u7269\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/7-10.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25741 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/7-10-680x414.png\" alt=\"\" width=\"680\" height=\"414\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/7-10-680x414.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/7-10-300x183.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/7-10-768x467.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/7-10.png 945w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>\u5728\u6210\u529f\u7684\u83b7\u5f97\u4ea7\u7269<strong>3<\/strong>\u540e\uff0c\u4f5c\u8005\u7ecf\u8fc7\u6761\u4ef6\u7b5b\u9009\uff0c\u6700\u7ec8\u901a\u8fc73\u6b65C-H\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\uff0c\u80fd\u4ee5\u826f\u597d\u81f3\u4f18\u79c0\u7684\u6536\u7387\u548c\u4f18\u79c0\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u90ed\u6c0f\u8f74\u624b\u6027\u919b(Scheme 4)\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/8-7.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25742 size-large\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/8-7-680x526.png\" alt=\"\" width=\"680\" height=\"526\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/8-7-680x526.png 680w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/8-7-300x232.png 300w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/8-7-768x594.png 768w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/8-7.png 781w\" sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/a><\/p>\n<p>\u4e0a\u8ff0\u6b65\u9aa4\u4e2d\u5f97\u5230\u7684\u624b\u6027\u919b\u50ac\u5316\u5242<strong>6<\/strong>\u53ef\u7528\u4e8e\u50ac\u5316(<em>E<\/em>)-\u67e5\u5c14\u916e\u548c\u7518\u6c28\u9178\u884d\u751f\u7684\u9170\u80fa\u6216\u4e8c\u80bd<strong>7<\/strong>\u7684\u4e0d\u5bf9\u79f0\u53cd\u5e94(Scheme 5)\u3002\u5176\u4e2d\uff0c6a\u7684\u50ac\u5316\u6548\u679c\u6700\u597d\u3002\u540c\u65f6\uff0c\u5728\u8be5\u50ac\u5316\u4f53\u7cfb\u4e0b\uff0c\u54cc\u5576\uff0c\u5417\u5549\uff0c1,4-\u4e8c\u6c27\u6742-8-\u6c2e\u6742\u87ba[4.5]\u7678\u70f7\u884d\u751f\u7684\u7518\u6c28\u9170\u80fa\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5747\u80fd\u4ee5\u826f\u597d\u7684\u6536\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u7684\u4ea7\u7269<strong>8<\/strong>\u3002<\/p>\n<p><a href=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/9-4.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-25743 size-full\" src=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/9-4.png\" alt=\"\" width=\"667\" height=\"600\" srcset=\"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/9-4.png 667w, https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/9-4-300x270.png 300w\" sizes=\"(max-width: 667px) 100vw, 667px\" \/><\/a><\/p>\n<h4><strong>\u8bba\u6587\u603b\u7ed3\u8bc4\u4ef7\uff1a<\/strong><\/h4>\n<p>\u6d59\u6c5f\u5927\u5b66<a href=\"https:\/\/person.zju.edu.cn\/bfshi\">\u53f2\u70b3\u950b\u8bfe\u9898\u7ec4<\/a>\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86Pd\u50ac\u53162-\u82b3\u57fa\u919b\u548c1,4-\u4e8c\u6c22-1,4-\u73af\u6c27\u57fa\u8418\u7684\u4e0d\u5bf9\u79f0C-H\u8418\u57fa\u5316\u53cd\u5e94\uff0c\u80fd\u4ee5\u4e2d\u7b49\u81f3\u826f\u597d\u7684\u6536\u7387\u548c\u4f18\u5f02\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u7269<strong>3<\/strong>\u3002<strong>3<\/strong>\u518d\u901a\u8fc7\u73af\u5185C-H\u952e\u7f9f\u57fa\u5316\u548cC-H\u952e\u6eb4\u5316\u53cd\u5e94\u53ef\u4ee5\u5f97\u5230\u90ed\u6c0f\u8f74\u624b\u6027\u919b6\u3002\u624b\u6027\u919b\u50ac\u5316\u5242<strong>6a<\/strong>\u53ef\u7528\u4e8e\u50ac\u5316(<em>E<\/em>)-\u67e5\u5c14\u916e\u548c\u7518\u6c28\u9178\u884d\u751f\u7684\u9170\u80fa\u6216\u4e8c\u80bd<strong>7<\/strong>\u7684\u4e0d\u5bf9\u79f0\u53cd\u5e94,\u80fd\u4ee5\u826f\u597d\u7684\u6536\u7387\u548c\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u7269\u3002<\/p>\n<h4><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/h4>\n<ol>\n<li>Chen, ; Luo, M.-J.; Zhu, F.; Wen, W.; Guo, Q.-X. <em>J. Am. Chem. Soc.<\/em> <strong>2019<\/strong>, <em>141<\/em>, 5159. DOI: <a href=\"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.9b01910\">10.1021\/jacs.9b01910<\/a><\/li>\n<li>Chen, J.; Gong, X.; Li, J.; Li, Y.; Ma, J.; Hou, C.; Zhao, G.; Yuan, W.; Zhao, B. <em>Science<\/em>, <strong>2018<\/strong>, <em>360<\/em>, \u00a0DOI: <a href=\"https:\/\/science.sciencemag.org\/content\/360\/6396\/1438\">10.1126\/science.aat4210<\/a><\/li>\n<\/ol>\n<p><strong>\u672c\u6587\u7248\u6743\u5c5e\u4e8e\u00a0<a href=\"\/\/www.gsbet888.com\/\">Chem-Station\u5316\u5b66\u7a7a\u95f4<\/a>\uff0c \u6b22\u8fce\u70b9\u51fb\u6309\u94ae\u5206\u4eab\uff0c\u672a\u7ecf\u8bb8\u53ef\uff0c\u8c22\u7edd\u8f6c\u8f7d\uff01<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"\u624b\u6027\u919b\u50ac\u5316\u5242\u88ab\u8ba4\u4e3a\u662f\u4e0d\u5bf9\u79f0\u5408\u6210\u4e2d\u5f3a\u6709\u529b\u7684\u50ac\u5316\u5242\uff0c\u56e0\u6b64\u5408\u6210\u624b\u6027\u919b\u50ac\u5316\u5242\u5df2\u7ecf\u53d7\u5230\u5316\u5b66\u5bb6\u4eec\u7684\u5e7f\u6cdb\u5173\u6ce8\u3002\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u91cc\uff0c\u5408\u6210\u7684\u624b\u6027\u919b\u50ac\u5316\u5242\u4e3b\u8981\u5c40\u9650\u4e8e\u5e73\u9762\u624b\u6027\u548c\u624b\u6027\u4f4d\u70b9(Scheme 1a)\uff0c\u76f4\u52302014\u5e74\uff0cGuo[1]\u548cZhao[2]\u8bfe\u9898\u7ec4\u6210\u529f\u7684\u5f00\u53d1\u51fa\u4e86\u8f74\u624b\u6027\u919b\u50ac\u5316\u5242\uff0c\u8fd9\u4e3a\u4e0d\u5bf9\u79f0\u50ac\u5316\u63d0\u4f9b\u4e86\u4e00\u7c7b\u65b0\u578b\u5f3a\u6709\u529b\u7684\u50ac\u5316\u5242(Scheme 1b)\u3002\u4f46\u8be5\u7c7b\u8f74\u624b\u6027\u919b\u50ac\u5316\u5242\u7684\u5408\u6210\u6b65\u9aa4\u5197\u957f\u3001\u79cd\u7c7b\u5355\u4e00\u3001\u6d3b\u5316\u6548\u7387\u4e0d\u591f\u9ad8\u7b49\u95ee\u9898\u4e25\u91cd\u963b\u788d\u4e86\u8be5\u7c7b\u50ac\u5316\u5242\u5728\u4e0d\u5bf9\u79f0\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7814\u7a76\u80cc\u666f\uff0c\u6d59\u6c5f\u5927\u5b66\u53f2\u70b3\u950b\u8bfe\u9898\u7ec4\u8bbe\u60f3\u901a\u8fc7\u4e09\u6b65C-H\u5b98\u80fd\u56e2\u5316\u53cd\u5e94\u5408\u6210\u90ed\u6c0f\u8f74\u624b\u6027\u919b\u7684\u7406\u60f3\u7b56\u7565\uff1ai\uff09C-H\u952e\u8418\u57fa\u5316\uff1bii\uff09\u73af\u5185C-H\u952e\u7f9f\u57fa\u5316\uff1biii\uff09C-H\u952e\u6eb4\u5316(Scheme 2a)\u3002\u4e3a\u4e86\u5b9e\u73b0\u8fd9\u4e2a\u7b56\u7565\uff0c\u4f5c\u8005\u9700\u8981\u89e3\u51b3\u4ee5\u4e0b\u95ee\u9898\uff1a\u9996\u5148\uff0c\u4e8c\u82b3\u57fa\u919b1\u7684C-Ha\u6216C-Hb\u662f\u5426\u4f1a\u53d1\u751fC-H\u82b3\u57fa\u5316\u53cd\u5e94(Scheme 2b)\u3002\u5176\u6b21\uff0c\u662f\u5426\u80fd\u627e\u5230\u5408\u9002\u7684\u77ac\u6001\u5bfc\u5411\u57fa\u80fd\u4f7f\u4ea7\u7269\u5177\u6709\u826f\u597d\u7684\u533a\u57df\u9009\u62e9\u6027\u548c\u5bf9\u6620\u9009\u62e9\u6027\u3002\u7b2c\u4e09\uff0c\u919b\u65b9\u5411\u7684C(sp2)-H\u7f9f\u57fa\u5316\u8f83\u96be\u3002 \u8d77\u521d\uff0c\u4f5c\u8005\u4f7f\u7528rac&#8211;1a\u548c2-\u7898\u8418\u5728\u5404\u79cd\u6761\u4ef6\u4e0b\u53cd\u5e94\uff0c\u4f46\u5747\u65e0\u4ea7\u7269\u751f\u6210\u3002\u53d7\u5230Li\u8bfe\u9898\u7ec4\u5f00\u53d1\u7684Rh(III)\u50ac\u5316\u76842-\u82b3\u57fa\u5421\u5576\u548c1,4-\u4e8c\u6c22-1,4-\u73af\u6c27\u57fa\u8418\u7684C-H\u8418\u57fa\u5316\u53cd\u5e94\u7684\u542f\u53d1\uff0c\u4f5c\u8005\u62a5\u9053\u4e86Pd\u50ac\u5316\u4e8c\u82b3\u57fa\u919b\u4e0e1,4-\u4e8c\u6c22-1,4-\u73af\u6c27\u57fa\u8418\u7684\u4e0d\u5bf9\u79f0C-H\u8418\u57fa\u5316\u53cd\u5e94\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u63a8\u6d4b\u53ef\u80fd\u7684\u673a\u7406\uff1arac&#8211;1\u4e0e\u624b\u6027\u6c28\u57fa\u9178TDG\u53d1\u751f\u53ef\u9006\u53cd\u5e94\uff0c\u751f\u6210\u4e9a\u80faA1\u548cB1\u3002\u7531\u4e8e\u7a7a\u95f4\u4f4d\u963b\u7684\u76f8\u4e92\u4f5c\u7528\uff0cB1\u4f1a\u4f18\u5148\u4e0ePd(OAc)2\u4f5c\u7528\u4e0b\u751f\u6210\u4e2d\u95f4\u4f53\u3002\u7d27\u63a5\u7740\uff0c2a\u63d2\u5165\u5230C1\u4e2d\u5e76\u53d1\u751f\u03b2-\u6c27\u6d88\u9664\u53cd\u5e94\u751f\u6210\u4e2d\u95f4\u4f53E1\u3002\u5728HOAc\u7684\u4f5c\u7528\u4e0b\uff0cE1\u7684Pd-O\u952e\u65ad\u88c2\u91ca\u653e\u4e8c\u6c22\u8418\u915aF1\uff0c\u540c\u65f6\uff0cPd(OAc)2\u548c\u624b\u6027\u6c28\u57fa\u9178TDG\u518d\u751f\u3002\u6700\u540e\uff0cF1\u8131\u6c34\u5f97\u5230\u8418\u57fa\u5316\u4ea7\u72693\u30023\u518d\u7ecf\u5386\u4e24\u6b21C-H\u952e\u5b98\u80fd\u56e2\u5316\u5f97\u5230\u8f74\u624b\u6027\u919b\u50ac\u5316\u5242(Scheme 2b)\u3002\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u4e8e Synthesis of Chiral Aldehyde Atroposelective C\u2212H NaphthylCaatitoanly sts via Pd-Catalyzed\u201d Liao, G.; Chen, H.-M.; Xia, Y.-N.; Li, B.; Yao, Q.-J.; Shi, B.-F.* Angew. Chem. Int. Ed. 2019, Just Accepted Manuscript DOI: 10.1002\/anie.201906700 \u8bba\u6587\u4f5c\u8005\u4ecb\u7ecd\uff1a \u8bba\u6587\u4f5c\u8005\uff1a\u53f2\u70b3\u950b\u6559\u6388 \u7814\u7a76\u7ecf\u5386\uff1a 1997\/09-2001\/07\uff1a\u5b66\u58eb\uff0c\u5357\u5f00\u5927\u5b66\u5316\u5b66\u7cfb \uff08\u5bfc\u5e08\uff1a\u5b5f\u7ee7\u672c\u6559\u6388\uff09 2001\/09-2006\/07\uff1a\u535a\u58eb\uff0c\u4e2d\u79d1\u9662\u4e0a\u6d77\u6709\u673a\u6240\u751f\u547d\u6709\u673a\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4 (\u5bfc\u5e08: \u4fde\u98da\u7814\u7a76\u5458) 2006\/10-2007\/08\uff1a\u535a\u58eb\u540e\uff0c\u52a0\u5dde\u5927\u5b66\u5723\u8fed\u6208\u5206\u6821\u5316\u5b66\u7cfb (\u5bfc\u5e08\uff1aProf. Michael S. VanNieuwenhze) 2007\/08-2010\/4\uff1a\u7814\u7a76\u52a9\u7406\uff0cThe Scripps Research Institute\u5316\u5b66\u7cfb (\u5bfc\u5e08\uff1aProf. Jin-Quan Yu\uff09 2010\/4-2014\/12\uff1a\u6d59\u6c5f\u5927\u5b66\u5316\u5b66\u7cfb\u7279\u8058\u7814\u7a76\u5458 \u3001\u535a\u5bfc\u3001\u72ec\u7acbPI 2015\/01-\u81f3\u4eca\uff1a\u6d59\u6c5f\u5927\u5b66\u5316\u5b66\u7cfb \u6559\u6388\u3001\u535a\u5bfc\u3001\u72ec\u7acbPI 2017\/08-\u81f3\u4eca\uff1a\u517c\u4efb\u5316\u5b66\u7cfb\u526f\u7cfb\u4e3b\u4efb\u3001\u6709\u673a\u4e0e\u836f\u7269\u5316\u5b66\u7814\u7a76\u6240\u6240\u957f \u7814\u7a76\u65b9\u5411\uff1a 1.\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u7684\u78b3\u6c22\u952e\u6d3b\u5316 2.\u5929\u7136\u4ea7\u7269\u591a\u6837\u6027\u5408\u6210\u53ca\u5176\u5316\u5b66\u751f\u7269\u5b66\u7814\u7a76 \u5956\u52b1\u8363\u8a89\uff1a \u660e\u6cbb\u4e73\u4e1a\u751f\u547d\u79d1\u5b66\u5956 2006\uff0cRoche Creative Chemistry Award 2008\uff0cGordon Research Conference (GRC) Chair&#8217;s Award 2013\uff0c\u94b1\u6c5f\u4eba\u624d 2015\uff0cThieme Chemistry Journal Award 2015\uff0cDistinguished Lectureship Award from Chemical Society of Japan 2016\uff0c\u6d59\u6c5f\u7701\u6770\u51fa\u9752\u5e74\u57fa\u91d1 2016\uff0c\u6d59\u6c5f\u7701151\u4eba\u624d 2018\uff0c\u836f\u660e\u5eb7\u5fb7\u751f\u547d\u5316\u5b66\u7814\u7a76\u5956 \u8bba\u6587\u6982\u8981\uff1a \u4ee52-\u82b3\u57fa\u919brac&#8211;1a\u548c1,4-\u4e8c\u6c22-1,4-\u73af\u6c27\u57fa\u84182a\u4f5c\u4e3a\u6a21\u677f\u5e95\u7269\uff0c\u4f5c\u8005\u5bf9\u5404\u79cd\u53cd\u5e94\u6761\u4ef6\u8fdb\u884c\u53cd\u590d\u7b5b\u9009\uff0c\u786e\u5b9a\u6700\u4f73\u6761\u4ef6\u4e3a(Table S1)\uff1a10 mol\uff05 Pd(OAc)2\u548c30 mol\uff05L-\u53d4\u4eae\u6c28\u9178\u4e3a\u50ac\u5316\u5242\uff0c2.5 equiv AdCH2CO2H\u548c2.0 equiv nPrCO2Na\u4e3a\u6dfb\u52a0\u7269\uff0cTFE\/HOAc \u4e3a\u6eb6\u5242\uff0c\u572860\u2103\u6761\u4ef6\u4e0b\u53cd\u5e9448\u5c0f\u65f6\uff0c\u80fd\u4ee571%\u7684\u6536\u7387\u548c&gt; 99\uff05\u7684\u5bf9\u6620\u9009\u62e9\u6027\u5f97\u5230\u76f8\u5e94\u4ea7\u7269\u3002 \u5728\u6700\u4f18\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u4f5c\u8005\u8003\u5bdf\u4e86\u8be5\u53cd\u5e94\u7684\u5e95\u7269\u8303\u56f4(Table 1)\u3002\u5404\u79cdOMe, CF3, [&hellip;]","protected":false},"author":24,"featured_media":25746,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1271],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/assets.www.gsbet888.com\/uploads\/2019\/06\/58b5478f94d3c53ba12ef640e3f82034.png","jetpack_shortlink":"https:\/\/wp.me\/p96op1-6H4","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/25734"}],"collection":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/comments?post=25734"}],"version-history":[{"count":5,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/25734\/revisions"}],"predecessor-version":[{"id":31999,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/posts\/25734\/revisions\/31999"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media\/25746"}],"wp:attachment":[{"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/media?parent=25734"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/categories?post=25734"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.gsbet888.com\/wp-json\/wp\/v2\/tags?post=25734"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}